• Lymphoid lineage DCs primarily differentiate into plasmacytoid DCs and occupy approximately 0.5% of peripheral blood mononuclear cells (PBMCs) in humans [ 2 ], but the cell population percentage is unclear in horses. (biomedcentral.com)
  • Jurkat cells and peripheral blood mononuclear cells ( PBMC ) incubated with the monoclonal antibody Ad22 results in apoptosis within 3 hours. (wikidoc.org)
  • We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. (cdc.gov)
  • IgEs conversation Ginsenoside Rg3 with CD23 modulates both IgE production and functional activities.CD23 is a noncanonical immunoglobulin receptor, unrelated to receptors of other antibody isotypes. (treatmentforprostatecancer.info)
  • Immunoglobulin E (IgE) is usually a glycosylated protein belonging to the immunoglobulin family and plays Ginsenoside Rg3 a central role in allergic disease, exerting its effector functions through two receptors: FcRI and CD23 [2]. (treatmentforprostatecancer.info)
  • Besides AGE, RAGE binds amyloid beta -peptide, S100/calgranulin family proteins, high mobility group B1 (HMGB1, also know as amphoterin) and leukocyte integrins (1, 2). (rndsystems.com)
  • CD47 belongs to the immunoglobulin superfamily [1] and partners with membrane integrins and also binds the ligands thrombospondin-1 ( TSP-1 ) and signal-regulatory protein alpha ( SIRPα ). (wikidoc.org)
  • The basic and common immunologic defect in common variable immunodeficiency is a failure of B-lymphocyte differentiation into plasma cells that produce the various immunoglobulin (Ig) isotypes. (medscape.com)
  • In adult tissues, RAGE is expressed at low levels in multiple tissues including endothelial and smooth muscle cells, mononuclear phagocytes, pericytes, microglia, neurons, cardiac myocytes and hepatocytes (6). (rndsystems.com)
  • 13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
  • Finally, mononuclear cells isolated from lung (L-MCs), which are used as precursors for L-DCs, expressed more antigen-presenting cell-associated markers such as MHC class II and CD172α compared to their counterparts from blood. (biomedcentral.com)
  • Many tumor specimens have some inflammatory macrophages and mononuclear leukocytes. (abcam.com)
  • inhibited mitogen-induced lymphocyte proliferation, cytokine release and leukocyte migration under inflammatory stimulation, which were associated with inhibition of the MAP kinase pathway and intracellular calcium influx. (bvsalud.org)
  • We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). (cdc.gov)
  • Buckley et al expanded the clinical picture in 1972 and reported the association with elevated immunoglobulin E (IgE) in patients with hyperimmunoglobulin E syndrome. (medscape.com)
  • Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the immunoglobulin superfamily. (wikipedia.org)
  • A presence/absence matrix is generated using protein domain architecture data for all genomes in SUPERFAMILY. (cam.ac.uk)
  • A presence/absence matrix is generated using protein domains and supradomains for all genomes in SUPERFAMILY. (cam.ac.uk)
  • Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system. (anaspec.com)
  • Also known as T4, and Leu-3, CD4 is a 55 kDa type I transmembrane glycoprotein and member of the immunoglobulin superfamily. (studybuff.com)
  • There is ample evidence that PD-1, a member of the immunoglobulin superfamily, regulates the magnitude and quality of T cell responses. (frontiersin.org)
  • The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily that encompasses, among others, estrogen receptor and peroxisome proliferators-activated receptor. (ashpublications.org)
  • A major component of medical care is anti-infective and prevention of further infectious episodes by regular infusion of human immunoglobulin and antimicrobial therapy. (medscape.com)
  • This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. (wikipedia.org)
  • Macrophages and monocytes are members of the mononuclear phagocyte system. (medscape.com)
  • A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. (lookformedical.com)
  • Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene. (wikipedia.org)
  • It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. (wikipedia.org)
  • This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. (wikipedia.org)
  • The HB15e monoclonal antibody specifically binds to a 45 kDa type 1 transmembrane glycoprotein member of the Ig superfamily. (bdbiosciences.com)
  • 5. [Adhesion molecules in the interactions of leukocytes, endothelium, and extracellular matrix (I). Structure, distribution, and biological function]. (nih.gov)
  • The basic route and mechanisms for leukocyte migration across the endothelium remain poorly defined. (rupress.org)
  • These findings suggest a novel mechanism, the "transmigratory cup", by which the endothelium provides directional guidance to leukocytes for extravasation. (rupress.org)
  • 20. Imbalance of mononuclear cell infiltrates in the placental tissue from foetuses after spontaneous abortion versus therapeutic termination from 8th to 12th weeks of gestational age. (nih.gov)
  • They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. (lookformedical.com)
  • As such it contains seven EGF-like domains on its extracellular N-terminus, seven transmembrane spanning sequences, and an intracellular C-terminal domain showing homology to other TM7 superfamily members. (thermofisher.com)
  • Activin-A is a transforming growth factor (TGF)-β superfamily member and shares with TGF-β the Smad intracellular signaling proteins. (ashpublications.org)
  • Sialic acid-binding immunoglobulin-like lectins (Siglecs) belong to a family of transmembrane proteins able to dampen host immune responses and set appropriate immune activation thresholds upon ligation with their natural ligands, the sialylated carbohydrates. (frontiersin.org)
  • Siglecs belong to a family of transmembrane proteins that display a variable numbers of C2-set immunoglobulin domains (from 1 in CD33 to 16 in Siglec-1), an amino-terminal V-set immunoglobulin domain that recognizes sialic acid residues ( 1 - 3 ) and a conserved arginine residue that binds carbohydrates. (frontiersin.org)
  • We hypothesized that WNV-induced migration of protective leukocytes into the brain is attenuated in the presence of diabetes, leading to a high viral load in the brain and severe disease in diabetic mice. (biomedcentral.com)
  • This is the first study to elucidate the expression of CAM and their correlation with the migration of leukocytes, specifically cytotoxic CD8 + T cells, in increasing disease severity in the diabetic mouse model. (biomedcentral.com)
  • It is known that diabetes adversely affects leukocyte adherence and transendothelial migration. (biomedcentral.com)
  • However the effect of diabetes on the expression of CAM and the migration of leukocytes, specifically across the blood-brain barrier (BBB), in response to viral infections such as West Nile virus (WNV) remains largely unknown. (biomedcentral.com)
  • These data suggest that reduced leukocytes recruitment, in part, due to lower levels of CAM results in failure to clear WNV infection from the brain leading to increased production of inflammatory molecules, which mediates increased neuronal death and mortality in db/db mice. (biomedcentral.com)