• protein
  • Immunoglobulins or immunoglobulin fragments are obtained by salt fractionation and enzymatic processing, using different methods for the elimination of ballast proteins and impurities (chromatography, membrane filtration, fermentation, and other appropriate chemical and physical methods) that should ensure that the obtained product is free from contamination and serum protein aggregates and fragments that can affect its safety and quality. (pharmacopoeia.ru)
  • The patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain, bromelain, or papaya extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use ovine digoxin immune fab. (wikipedia.org)
  • Protein molecules that pass through the glomerular pores are either absorbed unchanged (such as albumin), degraded in the proximal tubular cells and absorbed (such as free light chains), or excreted as fragments. (wikipedia.org)
  • If immunoglobulin light chains are produced in sufficient amounts to overwhelm the proximal tubules' absorption mechanisms (usually due to the presence of a plasma cell tumour) the light chains enter the distal tubules and can appear in the urine (Bence Jones protein). (wikipedia.org)
  • C07K16
  • A patent to use digoxin immunoglobulins C07k16/44 as a regulator of the preeclamptic/eclamptic patient's sodium/potassium ATPase activity was approved in 2003 to Charles David Adair under application number WO2004011028A1. (wikipedia.org)
  • recombinant
  • In case the IgG immunoglobulin was more suitable for the treatment or some other particular application, experiments have also been conducted, in which the recombinant Fab fragments were converted into recombinant IgG form. (wikipedia.org)
  • In the beginning phases of the recombinant antibody production it was important to achieve the assembly of a functional Fv fragment in Escherichia coli. (wikipedia.org)
  • enzyme
  • The enzyme IdeS (Immunoglobulin degrading enzyme from Streptococcus pyogenes, trade name FabRICATOR) cleaves IgG in a sequence specific manner at neutral pH. (wikipedia.org)
  • Region
  • The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. (wikipedia.org)
  • regions
  • These include chemically linked Fabs, consisting of only the Fab regions, and various types of bivalent and trivalent single-chain variable fragments (scFvs). (wikipedia.org)
  • methods
  • For products containing immunoglobulin fragments, the methods that demonstrate the correctness of established normative requirements should be specified to guarantee that the fragmentation procedure is performed as required. (pharmacopoeia.ru)