• cells
  • Loss of only one of the two functional CD79a/b ITAMs resulted in impaired B cell development but B cell functions such as the T cell independent type II response and BCR mediated calcium flux in the available B cells were intact. (wikipedia.org)
  • Superantigens (SAgs) are a class of antigens that cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release. (wikipedia.org)
  • Compared to a normal antigen-induced T-cell response where 0.0001-0.001% of the body's T-cells are activated, these SAgs are capable of activating up to 20% of the body's T-cells. (wikipedia.org)
  • After this mutation, the FCoV acquires a tropism for macrophages (see also: immune cells, leucocyte, monocyte, dendritic cells, mononuclear cell, antigen-presenting cell) while losing intestinal tropism. (wikipedia.org)
  • whereas
  • The larger CD79a isoform contains an insert in position 88-127 of human CD79a resulting in a complete immunoglobulin domain, whereas the smaller isoform has only a truncated Ig-like domain. (wikipedia.org)
  • occurs
  • This occurs in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface. (wikipedia.org)
  • This occurs because a cognate antigen activates a T cell not because of its structure per se, but because its affinity allows it to bind the TCR for a lengthy enough time period, and the SAg mimics this temporal bonding. (wikipedia.org)
  • term
  • The women had a gestational age of ≥39 weeks or an expected delivery within ≤1 week (independent of the week of pregnancy), hence including term and preterm deliveries. (biomedcentral.com)
  • variable
  • Pembrolizumab is an immunoglobulin G4, with a variable region against the human programmed cell death 1 receptor, a humanized mouse monoclonal [228-L-proline(H10-S>P)]γ4 heavy chain (134-218') disulfide and a humanized mouse monoclonal κ light chain dimer (226-226:229-229)-bisdisulfide. (wikipedia.org)