Immunogenicity vaccines conjugate. Medical search. Frequent questions

Since only immunogenicity and safety data were available for PCV15 or PCV20, the search included PCV13 and PPSV23 efficacy or effectiveness studies to help interpret PCV15 and PCV20 immunogenicity study findings. (cdc.gov)
Although the vaccine was highly effective in trials in Finland among children greater than or equal to 18 months of age (3), postmarketing efficacy studies in the United States demonstrated variable efficacy (4,5). (cdc.gov)
Some companies have tested candidate vaccines in clinical trials, but evidence failed to show the adequate antibody responses or exhibit superior efficacy to factors concerning placebo. (wikipedia.org)
Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. (cdc.gov)
Efficacy of the vaccine was 97.4% for invasive disease caused by a vaccine serotype, for fully vaccinated (four doses) children. (bcmj.org)
Efficacy is a relative term and no vaccine will induce complete immunity to all animals in the field. (keywen.com)
Extensive testing for efficacy (effectiveness) and safety is carried out before the vaccine is licensed. (keywen.com)
Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. (keywen.com)
Vaccine!Efficacy! (researchgate.net)
Many clinical studies on AD immunotherapies have failed due to low safety and efficacy, calling for a highly potent AD vaccine which induces sufficient antibody titer while avoiding side effects. (mdpi.com)
The study compared the safety and immunogenicity of Menveo against each of the four serogroups it is designed to protect against with the safety and efficacy of the other currently U.S.-licensed ACW-135Y meningococcal conjugate vaccine. (genengnews.com)
A GBS type III capsular polysaccharide (CPS)-tetanus toxoid conjugate (III-TT) vaccine was evaluated for safety and efficacy in preventing acquisition of GBS colonization. (emmes.com)
These new vaccines have shown to have high efficacy and safety, and promise to reduce even more the burden of disease in human populations. (univalle.edu.co)
Studies assessing the safety, immunogenicity, and efficacy of pneumococcal conjugate vaccines in both healthy and high-risk 6 - 17-year-old children and adolescents are covered and the potential impact of PCV-13 in these populations is discussed. (uzh.ch)
But there is no substantial evidence of efficacy for ETEC and shigella vaccines, although several promising vaccine concepts are moving from the development and testing pipeline towards efficacy and Phase 3 trials. (biomedcentral.com)
Older generation injectable cholera vaccines have been abandoned since the 1970s owing to their limited efficacy and local side effects. (biomedcentral.com)
Lisa A. Jackson, MD, MPH, is an internist and infectious disease epidemiologist who has conducted clinical and epidemiologic studies of vaccine safety and efficacy since 1991. (kpwashingtonresearch.org)
Due to the limited body of evidence on vaccine efficacy and safety among persons with most immunocompromising conditions, both vaccines were evaluated using data for HIV-infected adults. (bvsalud.org)

Current recommendations for universal vaccination of infants require parenteral administration of three different vaccines (diphtheria-tetanus-pertussis {DTP}, Hib conjugate, and hepatitis B) during two or three different visits to a health-care provider. (cdc.gov)
The conjugate vaccine produces a strong immunogenic response from the body by stimulating the production of antibodies, which is administered through a vaccination. (wikipedia.org)
Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease-United States, 1998-2003. (cdc.gov)
Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study. (cdc.gov)
Experts cite vaccination disruptions during the COVID-19 pandemic, coupled with challenges of antibiotic resistance and poor immunogenicity of serogroup B strains as key factors. (medpagetoday.com)
The US Advisory Committee on Immunization Practices recommends routine MenACWY vaccination to adolescents and meningitis serogroup B (MenB) vaccines to certain high-risk groups. (medpagetoday.com)
Pneumococcal conjugate vaccines (PCVs), which were primarily developed for vaccination of infants under 2 years of age, have significantly decreased invasive pneumococcal diseases worldwide in all age groups by herd protection effects [ 5 , 6 ]. (ersjournals.com)
PCV7 was replaced by either the 10-valent conjugate vaccine or, mainly, PCV13 in the German infant vaccination programme in 2010. (ersjournals.com)
In adults, the German Standing Committee on Immunization (STIKO) recommends the 23-valent pneumococcal polysaccharide vaccine (PPV23) as routine pneumococcal vaccination for all adults of 60 years and above and for all patients with defined chronic comorbidities predisposing to pneumococcal disease, regardless of age. (ersjournals.com)
Live, attenuated vaccines should be administered only when an inactivated version does not exist and the risk of the disease clearly outweighs the theoretical risk of vaccination. (hivguidelines.org)
Use live, attenuated vaccines only if an inactivated alternative is not available and the risk of disease is greater than the risk of vaccination. (hivguidelines.org)
BACKGROUND: T cell receptor (TCR) peptide vaccination is a novel approach to treating multiple sclerosis (MS). The low immunogenicity of previous vaccines has hindered the development of TCR peptide vaccination for MS. OBJECTIVE: To compare the immunogenicity of intramuscular injections of TCR BV5S2, BV6S5 and BV13S1 CDR2 peptides in incomplete Freunds adjuvant (IFA) with intradermal injections of the same peptides without IFA. (vakciny.net)
BACKGROUND: A low-level risk of intussusception following rotavirus vaccination has been observed in some settings and may vary by vaccine type. (cdc.gov)
But it can also mean the same thing as vaccination, which is getting a vaccine to become protected against a disease. (medlineplus.gov)

During 2018-2019, approximately 60%-75% of all IPD in adults was caused by the 24 pneumococcal serotypes that were included in the formulations of commercially available polysaccharide conjugate vaccine (PCV) or pneumococcal polysaccharide vaccine (PPSV) vaccines (i.e. (cdc.gov)
However, serotype replacement, i.e. replacement of vaccine serotypes by non-vaccine serotypes, has decreased the serotype coverage of PCVs over time [ 6 , 7 ]. (ersjournals.com)
For Germany, we have described earlier the distribution of vaccine serotypes covered by the first but no longer available 7-valent pneumococcal conjugate vaccine (PCV7) and the 13-valent conjugate vaccine (PCV13) between 2002 and 2016 in adult patients with CAP enrolled into the prospective multicentre study CAPNETZ [ 8 , 9 ]. (ersjournals.com)
In particular, the recommendations provide guidance on the design of immunogenicity studies that should be performed in order to support the licensure of new pneumococcal conjugate vaccines (including those containing conjugated capsular polysaccharides of serotypes additional to or different from those in already licensed vaccines). (who.int)
Pfizer Inc. (NYSE:PFE) today announced that the U.S. Food and Drug Administration (FDA) accepted for priority review a Biologics License Application (BLA) for its 20-valent pneumococcal conjugate vaccine (20vPnC) candidate, as submitted for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae serotypes in the vaccine in adults ages 18 years and older. (pfizer.com)
If approved, 20vPnC will cover more serotypes responsible for the majority of pneumococcal disease than any other pneumococcal conjugate vaccine currently licensed or currently in late-stage clinical development. (pfizer.com)
One of the vaccines, the most extensively assessed, has seven serotypes that cause more than 85% of the disease in United Sates, but have a lower coverage in Colombia 1 . (univalle.edu.co)
The serotypes in this vaccine are 4, 23F, 6B, 19F, 18C, 14 and 9V, which have an average coverage of 62% for pneumococcal invasive disease in Colombia. (univalle.edu.co)
The introduction of pneumococcal conjugate vaccines into infant immunization schedules has successfully reduced the incidence of pneumococcal disease caused by vaccine serotypes. (uzh.ch)
Conclusion: Vaccine with expanded valence of serotypes is necessary to offer broad preven- tion to IPD. (bvsalud.org)

Pneumococcal infections are globally the most frequent vaccine-preventable cause of death [ 1 ], and community-acquired pneumonia (CAP) caused by Streptococcus pneumoniae is the main burden of pneumococcal disease in the elderly [ 2 ]. (ersjournals.com)
The development of pneumococcal conjugate vaccines, in which each of the selected bacterial capsular polysaccharides is coupled to a protein carrier molecule, has been a major advance in the prevention of invasive pneumococcal disease. (who.int)
On the basis of indication, pneumococcal disease segment commanded the largest share of the overall vaccines market in 2019. (globenewswire.com)
The FDA's acceptance of our application for 20vPnC is yet another significant milestone in Pfizer's continuing efforts to help protect adults against pneumococcal disease," said Kathrin U. Jansen, Ph.D., Senior Vice President and Head of Vaccine Research and Development, Pfizer. (pfizer.com)
One of the possible ways of action is to introduce the vaccine in high risk populations, low birth weight, that have a much higher incidence of pneumococcal disease compared with normal weight children 3 - 5 . (univalle.edu.co)
The benefits considered critical outcomes in GRADE included prevention of death, invasive pneumococcal disease (IPD), pneumococcal pneumonia, hospitalizations due to pneumococcal disease, and vaccine-induced immunogenicity was considered an important outcome. (bvsalud.org)

To estimate the economic impact of the introduction of heptavalent pneumococcal conjugate vaccine (PCV-7) in high risk populations of Colombia. (univalle.edu.co)
The introduction of the Heptavalent Pneumococcal Conjugate Vaccine in populations of high risk is highly cost effective in Colombia. (univalle.edu.co)

Current pneumococcal vaccines use the pneumococcal capsular polysaccharides as antigens to generate serotype-specific antibodies, which facilitate serotype-specific clearance of pneumococci through opsonophagocytosis ( 4 ). (cdc.gov)
Nicotine vaccine uses active immunization as the methodology to create polyclonal antibodies to the antigens, which is then used to treat drug abuse. (wikipedia.org)
Conjugated immunogens are injected to deliver the vaccine, which activates B and T cells in a T cell-dependent manner to create polyclonal anti-nicotine antibodies. (wikipedia.org)
Studies that examined use of two doses of conjugate pneumococcal vaccine in early infancy followed by a further dose closer to age 1 year (a total of three doses) indicated excellent induction of memory response as ascertained by high levels of antibodies. (bcmj.org)
In a conjugate vaccine prototype, a synthetic sugar component mimics the bacterial antigen which induces antibodies. (pasteur.fr)
SARS-CoV-2 mRNA vaccines induce greater complement activation and decreased viremia and Nef antibodies in men with HIV-1. (amedeo.com)
In addition to its use for maternal immunization to passively protect infants with maternally derived antibodies, a multivalent vaccine might also serve to reduce fetal and neonatal exposure to GBS. (emmes.com)
Secondary outcomes include antibodies against other vaccine antigens in the primary schedule and their safety. (biomedcentral.com)
The synthesis and applications of the peptides are gaining increasing popularity as a result of the developments in biotechnology and bioengineering areas and for a number of research purposes including cancer diagnosis and treatment, antibiotic drug development, epitope mapping, production of antibodies, and vaccine design. (intechopen.com)
Aluminium phosphate (AIPO(4)) adsorbed HibT vaccine or HibT as a combination with AIPO(4)adsorbed DTaP vaccine showed significant increases in IgG antibodies to tetanus toxin in mice as well increased tetanus antitoxin levels in guinea pigs as compared to soluble HibT vaccine. (rostlab.org)
In general, combining DTaP and HibT vaccines did not affect the antibody levels to tetanus and diphtheria toxoids whereas DTaP-HibT combination vaccine elicited significantly lower IgG antibodies to pertussis toxin and filamentous haemagglutinin than DTaP vaccine alone, particularly after first injection. (rostlab.org)

Immunogenicity of three versus four doses of 13-valent pneumococcal conjugate vaccine followed by 23-valent pneumococcal polysaccharide vaccine in allogeneic haematopoietic stem cell transplantation recipients: a multicentre, randomized controlled trial. (bvsalud.org)
This multicentre, phase 2, randomized, controlled study of allogeneic haematopoietic stem cell transplantation (allo-HSCT) recipients compared the immunogenicity of two anti- pneumococcal vaccine regimens four doses of 13-valent pneumococcal conjugate vaccine (PCV13) followed by 23-valent pneumococcal polysaccharide vaccine (PPSV23) (3+1+1 experimental group), and three doses of PCV13 followed by PPSV23 (3+0+1 group). (bvsalud.org)
Before 2021, ACIP recommended 23-valent pneumococcal polysaccharide vaccine (PPSV23) alone (up to 2 doses), or both a single dose of 13-valent pneumococcal conjugate vaccine (PCV13) in combination with 1-3 doses of PPSV23 in series (PCV13 followed by PPSV23), for use in U.S. adults depending on age and underlying risk for pneumococcal disease. (cdc.gov)
In addition, ACIP recommends use of either a single dose of PCV20 or ≥1 dose of PPSV23 for adults who have started their pneumococcal vaccine series with PCV13 but have not received all recommended PPSV23 doses. (cdc.gov)
Universal immunization of BC infants with four doses of conjugate pneumococcal vaccine was introduced in September 2003. (bcmj.org)
The immune response to conjugate vaccine is proving sufficiently robust-post-marketing studies now provide evidence that three doses will prove as immunogenic as four in healthy infants. (bcmj.org)
[6] Preliminary results indicated that three doses of vaccine provided protection equivalent to four doses. (bcmj.org)
Immunogenicity, vaccine response monitoring, and requirements for additional booster doses for patients with HIV are discussed on pages for individual vaccines. (hivguidelines.org)
Four key research areas were highlighted: the optimal timing of the first DTP-containing vaccine, the number of doses in the priming series (two versus three), the interval between priming doses and lastly, the need for and timing of a booster dose to optimise immunity. (biomedcentral.com)
Immunogenicity of two paediatric doses of monovalent hepatitis B or combined hepatitis A and B vaccine in 8-10-year-old children. (vakciny.net)
13-valent pneumococcal conjugate vaccine (PCV13) is a licenced product, procured by the Gambia Government EPI, delivered in two schedules, one with doses scheduled at ages 6, 10 and 14 weeks (3+0 schedule) and the other with doses scheduled at ages 6 weeks and 9 months (1+1 schedule). (who.int)
No clustering of cases occurred in any of the risk windows after any of the vaccine doses. (cdc.gov)
It includes who should get the vaccines, how many doses they need, and when they should get them. (medlineplus.gov)

Shared clinical decision-making is recommended regarding use of a supplemental PCV20 dose for adults aged ≥65 years who have completed their recommended vaccine series with both PCV13 and PPSV23. (cdc.gov)
GRADE was used to evaluate 13-valent Pneumococcal Conjugate Vaccine (PCV13) for routine use among adults aged ≥65 years. (cdc.gov)
The intervention evaluated was a single dose of PCV13 compared to a dose of 23-valent polysaccharide vaccine (PPSV23). (cdc.gov)
immunogenicity evidence was assessed using two phase III RCTs of PCV13 compared to PPSV23, which measured antibody responses by opsonophagocytic assay (OPA) and four RCTs of PCV7 compared to PPSV23, which measured antibody responses by enzyme-linked immunosorbent assay (ELISA). (cdc.gov)
In one arm of this substudy, PCV13 will be given at 9 months of age and YF vaccine at 10 months of age. (who.int)
Immunogenicity of PCV13 compared to PPSV23 was evaluated based on 2 phase III RCTs among healthy adults[3] and 4 RCTs of PCV7 in HIV-infected adults. (bvsalud.org)

This report compiles and summarizes all published recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) for use of pneumococcal vaccines in adults aged ≥19 years in the United States. (cdc.gov)
In 2021, two new pneumococcal conjugate vaccines (PCVs), a 15-valent and a 20-valent PCV (PCV15 and PCV20), were licensed for use in U.S. adults aged ≥18 years by the Food and Drug Administration. (cdc.gov)
PPSV23 (Pneumovax23) is a 23-valent vaccine that has been recommended for use since the 1980s for persons aged ≥2 years with certain underlying medical conditions and for adults aged ≥65 years ( Table 1 ) (Figure). (cdc.gov)
Unconjugated PS vaccines have been available for many years and have received some use in adults. (bmj.com)
Initial FDA clearance for use of the vaccine in adolescents and adults aged 11-55 years was granted in May 2010. (genengnews.com)
The US Food and Drug Administration has approved a meningococcal vaccine against the five most common serogroups causing disease in children and young adults. (medscape.com)
In a single vaccine, Penbraya has the potential to protect more adolescents and young adults from this severe and unpredictable disease by providing the broadest meningococcal coverage in the fewest shots. (medscape.com)
It's important for both children and adults to get their vaccines according to the schedule. (medlineplus.gov)

These recommendations include information on two vaccines recently licensed for use among infants: Haemophilus b Conjugate Vaccine (PRP-T {ActHIB(TM), OmniHIB(TM)}), manufactured by Pasteur Merieux Vaccins, and TETRAMUNE{TM}, manufactured by Lederle Laboratories/Praxis Biologics. (cdc.gov)
The immunogenicity and safety of a new Haemophilus influenzae type b conjugate vaccine, PRP-T, was studied in 107 infants from the Oxford district. (ox.ac.uk)
The introduction of Haemophilus influenzae type b conjugate vaccines during the 1990s was followed by dramatic decreases both in the incidence of Haemophilus influenzae type b related invasive disease and in nasopharyngeal carriage of the organism. (bmj.com)
The extent of this effect has been influenced by the fact that Haemophilus influenzae type b conjugate vaccines reduce nasopharyngeal carriage and induce herd immunity. (bmj.com)
Based on the success of Haemophilus influenzae type b conjugate vaccines, chemical conjugation has been applied to the development of pneumococcal and meningococcal polysaccharide conjugate vaccines. (bmj.com)
A guinea pig model to assess the immunogenicity of a combination vaccine containing diphtheria, tetanus and acellular pertussis (DTaP) vaccine and Haemophilus influenzae type b (Hib) capsular polysaccharide conjugated to tetanus toxoid (HibT) was evaluated comparatively with the mouse immunogenicity test to study the effect of combining these antigens on the immunogenicity of various components. (rostlab.org)

The current vaccine schedules are complex. (bcmj.org)
Introduction Reduced-dose schedules offer a more efficient and affordable way to use pneumococcal conjugate vaccines (PCVs). (bmj.com)
Schedules will be compared in relation to their effect on nasopharyngeal carriage and immunogenicity. (bmj.com)
Secondary outcomes are carriage at 6, 12 and 18 months of age and the comparative immunogenicity of the different schedules in terms of antibody responses, functional antibody responses and memory B cell responses. (bmj.com)
Conducted in a country without routine pneumococcal conjugate vaccine (PCV) use, allowing inclusion of an unvaccinated control group and measurement of the reduction in carriage afforded by the reduced-dose schedules. (bmj.com)
Head-to-head and combined pneumococcal conjugate vaccine (PCV) schedules: secondary immunogenicity outcomes to 7 months of age. (bsms.ac.uk)
Since 2006, WHO has recommended that all countries incorporate pneumococcal conjugate vaccines in routine immunization schedules for children aged less than two years with priority being given to their introduction in countries with high child mortality rates and/or high rates of HIV infection. (who.int)
However, globally, more than 17 unique DTP-containing vaccine schedules are in use. (biomedcentral.com)

For patients with HIV and CD4 counts ≥200 cells/mm 3 , inactivated forms of vaccines such as those for polio, influenza, typhoid, and zoster are preferred over the live vaccine options. (hivguidelines.org)
A further sub-study will compare the co-administration of typhoid vaccine with other routine vaccines at one year of age. (biomedcentral.com)
Methods: We have recruited strong grown-up volunteers who matured anywhere between an 18- to 60-year cycle without any prior history of typhoid vaccines, infection or pause of residence in a typhoid-endemic district in this randomized, stage 2b sample using a wise, ambulatory human typhoid infection pattern. (iajps.com)

On the basis of findings establishing comparable immunogenicity, a third conjugate vaccine, PRP-T (ActHIB{TM}, OmniHIB{TM}) has now been licensed for use among infants. (cdc.gov)
Specific characteristics of the four conjugate vaccines available for infants and children vary (e.g., the type of protein carrier, the size of the polysaccharide, and the chemical linkage between the polysaccharide and carrier) ( Table 1 ). (cdc.gov)
and c) provides updated recommendations from the Advisory Committee on Immunization Practices (ACIP) for use of conjugate Hib vaccines and TETRAMUNE{TM} for infants and children. (cdc.gov)
Studies have been performed with all four Hib conjugate vaccines to determine immunogenicity in infants 2-6 months of age. (cdc.gov)
The pseudo-likelihood adaptation of self-controlled case-series method was used to assess the association between RotaTeq administration and intussusception in the 1-7, 8-21, and 1-21 day periods after each vaccine dose in infants 28 to 245 days of age. (cdc.gov)

TETRAMUNE{TM} is the first licensed combination vaccine that provides protection against diphtheria, tetanus, pertussis, and Hib disease. (cdc.gov)
A Phase 2, Randomized, Control Trial of Group B Streptococcus (GBS) Type III Capsular Polysaccharide-tetanus Toxoid (GBS III-TT) Vaccine to Prevent Vaginal Colonization With GBS III. (emmes.com)
Healthy, nonpregnant women aged 18-40 years and screened to be GBS III vaginal and rectal culture negative were randomized to receive III-TT conjugate or tetanus diphtheria toxoid vaccine in a multicenter, observer-blinded trial. (emmes.com)
Universal immunisation is the cornerstone of preventive medicine for children, The World Health Organisation (WHO) recommends diphtheria-tetanus-pertussis (DTP) vaccine administered at 6, 10 and 14 weeks of age as part of routine immunisation. (biomedcentral.com)

On the basis of this evidence, BC's Communicable Disease Policy Committee has advised that BC follow Quebec, Australia, and the United Kingdom and provide a three-dose schedule of conjugated pneumococcal vaccine beginning January 2007. (bcmj.org)
One of these studies made direct comparison with a four-dose series and found no disadvantage in immunogenicity for the three-dose series. (bcmj.org)
Effectiveness (intention to treat analysis) included all children who received at least one dose of the vaccine. (bcmj.org)
Vaccine shortages offered an opportunity for the Centers for Disease Control to conduct a case control study comparing the effectiveness of a three-dose series with a four-dose series. (bcmj.org)
The National Advisory Committee on Immunization statement on conjugate pneumococcal immunization permits a reduced dose schedule. (bcmj.org)
Prospective assessment of humoral and cellular immune responses to a 3rd COVID-19 mRNA vaccine dose among immunocompromised individuals. (amedeo.com)
Protein dose-sparing effect of AS01B adjuvant in a randomized preventive HIV vaccine trial of ALVAC-HIV (vCP2438) and adjuvanted bivalent subtype C gp120. (amedeo.com)
The immunogenicity test in mice was performed by subcutaneous injection of groups of 10 animals twice at an interval of four weeks with 1/10 of a single human dose of various formulations of combination vaccines, DTaP or HibT vaccine. (rostlab.org)
The guinea pig immunogenicity model included groups of animals injected subcutaneously twice at an interval of six weeks with 1.5 times the single human dose of various formulations. (rostlab.org)
Poly B conjugated vaccines have elicited Ab immune response in animal models (different potency according to formulation adjuvant, dose, etc.)but not SBA. (cdc.gov)

Our results demonstrated that the Y-5A15 remarkably enhanced the Aβ epitope immunogenicity and elicited high antibody titers against Aβ in AD mice. (mdpi.com)
The OptImms trial will assess whether antibody titres against pertussis and other antigens in childhood can be maintained whilst adjusting the current Expanded Programme on Immunisation (EPI) schedule to provide space for the introduction of new vaccines. (biomedcentral.com)
Suppression of Hib antibody response in combination vaccines has also been reported from recent clinical trials. (rostlab.org)

In the future, new vaccines may be added to the EPI schedule, such as those for respiratory syncytial virus (RSV) and group B streptococcus. (biomedcentral.com)

FDA has approved Novartis' quadrivalent meningococcal conjugate vaccine, Menveo®, for use in children from 2-10 years of age. (genengnews.com)
Title : FLUCELVAX quadrivalent (ccIIV4) a phase III randomized controlled trial : immunogenicity & safety results in young children (6 through 47 months of age) Personal Author(s) : Sylvester, Gregg C. Corporate Authors(s) : Seqirus Conference Author(s) : United States. (cdc.gov)

Evidence has begun to accumulate that these new polysaccharide based conjugate vaccines can also reduce nasopharyngeal carriage and can induce immune responses at the local mucosal level, which may be responsible for these effects. (bmj.com)
Recent studies show that parenterally administered capsular polysaccharide (PS) based vaccines can induce mucosal immune responses. (bmj.com)
To be effective against colonisation, vaccines must induce local immune responses, which promote elimination of the pathogen, break the chain of transmission, and induce herd immunity. (bmj.com)
New generation vaccines, in which the polysaccharide is conjugated to protein carriers, induce a better immune response in the population under 2 years of age. (scielo.sa.cr)
The development of vaccines that provide wider serotype coverage, especially against serotype B, and induce protection to the population at greatest risk remains a challenge. (scielo.sa.cr)
GBPS conjugated failed to induce SBA. (cdc.gov)

MenB vaccines use peptides or proteins instead of polysaccharides, and coverage can vary by MenB strain distribution, cross-reactivity, and surface expression. (medpagetoday.com)
It is estimated that around a million children less than 5 years old die annually due to invasive infections associated to Streptococcus pneumoniae, even when there are two polysaccharides vaccines in children under 2 years. (univalle.edu.co)

The major share of this segment is attributed to rising incidence of pneumococcal diseases like pneumonia, meningitis, febrile bacteraemia, otitis media, and sinusitis, development of quality vaccines such as PPSV23, and initiatives by government organizations and private sectors to prevent and control outbreak of pneumococcal diseases. (globenewswire.com)

The use of the 23-valent pneumococcal polysaccharide vaccine, PPV-23, in high-risk children and adolescents is also considered. (uzh.ch)

Live attenuated mucosal influenza vaccine has been licensed in the USA, but it will probably be some time before others go into general use. (bmj.com)
The continuing development and public health use of influenza vaccines made from live attenuated influenzavirus strains made it appropriate to review and update the WHO recommendations for such vaccines. (who.int)
The purpose of the revised recommendations is to provide vaccine manufacturers and national regulatory authorities with guidance on the specific processes for production and control of human, live attenuated influenza vaccines, plus guidance on the nonclinical and clinical evaluation of such vaccines. (who.int)
The successful deployment of live attenuated influenza vaccines depends on ensuring an appropriate balance between attenuation and immunogenicity. (who.int)

Despite the broader serotype coverage of PPV-23, the benefits of this vaccine in high-risk populations are uncertain. (uzh.ch)
Vaccine-serotype-coverage was estimated. (bvsalud.org)

Today marks an important step forward in the prevention of meningococcal disease in the US," Annaliesa Anderson, PhD, head of vaccine research and development at Pfizer, said in a news release. (medscape.com)

Conjugation of the PRP polysaccharide with protein carriers confers T-cell- dependent characteristics to the vaccine and substantially enhances the immunologic response to the PRP antigen. (cdc.gov)
The constitution of nicotine vaccines involves the addition of adjuvants to the conjugation between synthetic drug-derived haptens which share structural similarities to nicotine, and the immunogenic carrier protein. (wikipedia.org)
The immunogenic portion of the vaccine is linked to the hapten by a conjugated protein/macromolecular carrier. (wikipedia.org)
The entire configuration is called a hapten-conjugated protein/macromolecular carrier. (wikipedia.org)
This article reviews recent studies on mucosal immune responses induced by polysaccharide based vaccines and some protein vaccine antigens against several pathogenic nasopharyngeal bacteria, and discusses the mechanisms and functions of these immune responses that may help our understanding of mucosal immune responses to both immunisation and infection. (bmj.com)
Conjugate vaccine technology, where a polysaccharide antigen is coupled chemically to a protein carrier, either by direct linkage or by indirect coupling via diamino spacer molecules, can render the PS specific immune response T cell dependent. (bmj.com)
The compositions and methods include immunogenic conjugates containing peptide carriers derived from heat shock protein 60 (HSP60). (justia.com)
mRNA vaccines use messenger RNA, which gives your cells instructions for how to make a protein (or piece of a protein) of the germ. (medlineplus.gov)
Viral vector vaccines use genetic material, which gives your cells instructions for making a protein of the germ. (medlineplus.gov)

London, June 05, 2020 (GLOBE NEWSWIRE) -- Vaccines represent one of the greatest achievements of science and medicine in the fight against infectious diseases. (globenewswire.com)
Development of vaccine has led to eradication of various infectious diseases such as smallpox and polio, which are now completely eliminated from many countries, including countries located within North & Latin America and Europe. (globenewswire.com)

The conjugated vaccine is exposed to lymphocytes by antigen-presenting cells. (wikipedia.org)
Cell vaccine compositions comprising antigen presenting cells loaded with multimeric p458 conjugates are also provided. (justia.com)

PRP vaccines were ineffective in children less than 18 months of age because of the T-cell-independent nature of the immune response to PRP polysaccharide (3). (cdc.gov)
However, there is concern that individuals with HIV-associated immunodeficiency may not be able to mount and maintain an appropriate immune response to vaccines and may be harmed by live virus vaccines. (hivguidelines.org)
Vaccines are biological agents that elicit an immune response against a specific antigen derived from disease-causing pathogen. (globenewswire.com)
The induced immune response against disease-causing organism through vaccine configures the body's immune cells in such a way so that they become capable of quickly recognizing and reacting to the same antigen in a more powerful manner when encountered again. (globenewswire.com)
A substance or combination of substances used in conjunction with a vaccine antigen to enhance (for example, increase, accelerate, prolong and/or possibly target) or modulate a specific immune response to the vaccine antigen in order to enhance the clinical effectiveness of the vaccine. (who.int)
Vaccines work in different ways, but they all spark an immune response. (medlineplus.gov)
And for a few vaccines, getting vaccinated can actually give you a better immune response than getting the disease would. (medlineplus.gov)

In the United States, multiple meningococcal serogroup A, C, W, and Y (MenACWY) conjugate vaccines as well as meningitis serogroup B vaccines are licensed. (medpagetoday.com)

Based on the evidence, we propose a 74% mortality reduction in rotavirus specific mortality, 52% reduction in cholera incidence due to their respective vaccines. (biomedcentral.com)

Cite this: New Meningococcal Vaccine Wins FDA Approval - Medscape - Oct 23, 2023. (medscape.com)

A systematic literature search was completed to review all available evidence on the immunogenicity and safety of PCV15 and PCV20 among age groups for which the vaccines were approved. (cdc.gov)

Firm will, however, have to resubmit sBLA for Menveo vaccine in 2-12 month age group. (genengnews.com)

Also, in 2018, Indian government launched comprehensive multi-year plan (2018-22) to reduce mortality and morbidity due to vaccine preventable diseases. (globenewswire.com)
Vaccines for rotavirus and cholera have the potential to reduce diarrhea morbidity and mortality burden. (biomedcentral.com)
An AMC is a legally-binding agreement for an amount of funds to subsidize the purchase, at a given price, of an as yet unavailable vaccine against a specific disease causing high morbidity and mortality in low-income countries. (who.int)

Increasing the inclusion of meningococcal vaccines into the NIPs [national immunization programs] of North American countries beyond the US, Canada, and Cuba, is an important milestone that should remain a focus of public health authorities. (medpagetoday.com)
Meningococcal vaccines have helped to both reduce IMD rates among vaccinated individuals and provide some herd immunity against A, C, W, and Y (but not B) serogroups. (medpagetoday.com)
The new formulation called Penbraya is manufactured by Pfizer and combines the components from two existing meningococcal vaccines, Trumenba the group B vaccine and Nimenrix groups A, C, W-135, and Y conjugate vaccine. (medscape.com)
The FDA's decision is based on the positive results from phase 2 and phase 3 trials, including a randomized, active-controlled and observer-blinded phase 3 trial assessing the safety, tolerability, and immunogenicity of the pentavalent vaccine candidate compared with currently licensed meningococcal vaccines. (medscape.com)

Live-attenuated vaccines use a weakened form of the germ. (medlineplus.gov)

In preclinical studies, nicotine vaccines have demonstrated the ability to combat the negative effects of nicotine abuse, but none of the developed vaccines has been authorized for use in clinical trials as a smoking cessation strategy. (wikipedia.org)

CONCLUSIONS: The trivalent TCR peptide in IFA vaccine represents a significant improvement in immunogenicity over previous TCR peptide vaccines and warrants investigation of its ability to treat MS. (vakciny.net)

An mRNA vaccine against SARS-CoV-2 - preliminary report. (kpwashingtonresearch.org)

Anatomy10

Organisms36

Diseases22

Chemicals and Drugs129

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes23

Disciplines and Occupations3

Technology, Industry, Agriculture3

Information Science2

Named Groups1

Health Care8

Efficacy18

Vaccination14

Serotypes10

Pneumococcal disease6

Heptavalent pneumococcal conjuga2

Antibodies11

Doses13

PCV136

Adults8

Haemophilus6

Schedules8

Typhoid3

Infants5

Tetanus4

Dose10

Antibody3

Group B Streptococc1

Quadrivalent2

Induce6

Polysaccharides2

PPSV231

Polysaccharide vaccine1

Influenza4

Serotype coverage2

Head of Vaccine Research and Develop1

Protein9

Infectious Diseases2

Antigen-prese2

Immune response7

Serogroup B vaccines1

Incidence1

20231

PCV201

Menveo1

Mortality3

Meningococcal vaccines4

Live attenuated1

Preclinical studies1

Peptide vaccines1

MRNA vaccine1