Immunogenic vaccines synthetic. Medical search. Frequent questions

Nicotine vaccine uses active immunization as the methodology to create polyclonal antibodies to the antigens, which is then used to treat drug abuse. (wikipedia.org)
A modular synthetic route to size-defined immunogenic Haemophilus influenzae b antigens is key to the identification of an octasaccharide lead vaccine candidate. (mpg.de)
GEO-CM04S1 is based on GeoVax's MVA viral vector platform, which supports the presentation of multiple vaccine antigens to the immune system in a single dose. (news10.com)
Kabanova, Anna (2010) Evaluation of glycoconjugate antigens as vaccine candidates against group A Streptococcus and human immunodeficiency virus infections , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. (unibo.it)
Based on GAS-PS structural analysis, the study evaluates the potential to exploit a synthetic design approach to GAS vaccine development and compares the efficiency of synthetic antigens with the long isolated GAS polysaccharide. (unibo.it)
The polyepitope DNA vaccine platform was first optimized using model antigens in vitro and in vivo. (wustl.edu)
Whole genome sequencing provides the ability to predict and derive novel antigens for use as vaccines. (biomedcentral.com)
Here, we aimed to identify novel immunogenic Shigella antigens that could serve as Shigella vaccine candidates, either alone, or when conjugated to Shigella O-antigen. (biomedcentral.com)
Using a reverse vaccinology approach, where genomic analysis informed the Shigella immunome via an antigen microarray, we aimed to identify novel immunogenic Shigella antigens. (biomedcentral.com)
A core genome analysis of Shigella species, pathogenic and non-pathogenic Escherichia coli , led to the selection of 234 predicted immunogenic Shigella antigens. (biomedcentral.com)
These findings provide six novel immunogenic Shigella proteins that could serve as candidate vaccine antigens, species-specific carrier proteins, or targeted adjuvants. (biomedcentral.com)
Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. (lookformedical.com)
Some vaccines containing antigens are recombinantly produced. (lookformedical.com)
Current subunit vaccines based on weakly immunogenic carbohydrate and glycopeptide antigens are not being very successful in eliciting a strong immune response against cancer, and no such carbohydrate-based anticancer vaccine has yet been approved for humans despite extensive research efforts and several clinical trials. (cicbiogune.es)
Tiba's fully synthetic mRNA vaccines target multiple coronavirus antigens, in addition to the spike protein. (edu.sa)
Efforts to develop a subunit vaccine against genital herpes have been hampered by lack of knowledge of the protective antigens of HSV-2, the causative agent of the disease. (nih.gov)
Vaccines based either on selected antigens or attenuated live virus approaches have not demonstrated meaningful clinical activity. (nih.gov)
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. (bvsalud.org)

They claimed the COVID-19 vaccines were mRNA & that meant MESSENGER RNA (which occurs in life everywhere). (republicbroadcasting.org)

Investigation of the immunogenic properties of cyclic peptides with potential applications in anti-cancer vaccines. (cardiff.ac.uk)
Peptides, as immunogens that induce immune response from effector cells in vivo, have become a new type of vaccine. (omizzur.com)
Tumor peptide vaccine refers to antigen peptides eluted from the surface of tumor cells or obtained from tumor cells, which can improve the humoral and cellular immunity of the body after immunization. (omizzur.com)
The synthesis and applications of the peptides are gaining increasing popularity as a result of the developments in biotechnology and bioengineering areas and for a number of research purposes including cancer diagnosis and treatment, antibiotic drug development, epitope mapping, production of antibodies, and vaccine design. (intechopen.com)
The use of synthetic peptides approved by the health authorities for vaccine, for cancer, and in drug delivery systems is increasing with these developments. (intechopen.com)
The aim of this book chapter is to review the recent developments in the use of peptides in the diagnosis of drug and vaccine systems and to present them to the reader with commercially available illustrations. (intechopen.com)
The aim of this chapter is to review some applications of synthetic peptides providing a brief knowledge about peptide synthesis. (intechopen.com)
Then the synthetic peptide vaccine application of peptides was reviewed. (intechopen.com)
Once appropriately modified (mHABPs), these minimal, subunit-based, chemically synthesized peptides can be used in a system covering the human immune system's main genetic variables (the human leukocyte antigen HLA-DR isotype) inducing a suitable, immunogenic, and protective immune response in most of the world's populations. (urosario.edu.co)
Immunization with this formulation indicated to be safe, well tolerated, and immunogenic.25 All three peptides induced production of high titers of specific antibodies that cross-reacted with the protein around the parasite and production of interferon-gamma (IFN-) in most vaccinated subjects. (likemap.me)
Even though N peptide induced the highest antibody titers at three different doses tested (10, 30, and 100 g/dose), peptides R and C were also immunogenic at Azelaic acid high doses. (likemap.me)
In the search for an optimal vaccine formulation for human use we have conducted pre-clinical studies in mice, monkeys, and clinical trials in malaria-naive volunteers, and we performed a new series of studies to assess the security and immunogenicity of a combination of the three peptides formulated either in Montanide ISA 720 or in Montanide ISA 51. (likemap.me)
We tested the safety and immunogenicity of vaccines composed of P. vivax CS-derived synthetic peptides. (unifesp.br)
Both proteomics, peptidomics and bioinformatics represent powerful complementary tools to discover specific immunoreactive peptides useful for diagnosis or vaccine. (degruyter.com)
We present here results of a therapeutic vaccine candidate, HerpV (formerly called AG-707), consisting of 32 HSV-2 peptides derived from 22 HSV-2 proteins, complexed non-covalently to the HSP70 chaperone and formulated with QS-21 saponin adjuvant. (nih.gov)

Additional vaccine candidates are available for testing as preventive vaccines. (cdc.gov)
Investigation of the protective properties of glycosylphosphatidylinositol-based vaccine candidates in a Toxoplasma gondii mouse challenge model. (mpg.de)
The most promising vaccine candidates I am working on are Ft subunit vaccines on a nanoparticle platform known as functionalized catanionic surfactant vesicles (FCSV). (umaryland.edu)
Fifty-one vaccine candidates were designed mainly to mimic fusion intermediate conformations of gp41 and in some instance to increase exposure of the 2F5/4E10 epitopes. (europa.eu)
Although there have been significant breakthroughs in the Ebola virus disease vaccine development field, there remains an important need for prophylactic anti-Ebola virus vaccine candidates that elicit long-lasting immune responses. (infectiousdiseaseadvisor.com)
Most vaccine candidates are in phase I trials and have had an acceptable safety profile. (urosario.edu.co)
Despite binding regions tending to be conserved, they are usually poorly antigenic and/or immunogenic, being frequently discarded as vaccine candidates when the conventional immunological approach is followed. (urosario.edu.co)
Over the last four decades, there have been several attempts to develop a vaccine for schistosomiasis by testing many different vaccine candidates, which were selected on the basis of known location on the parasite and on putative function of the candidate proteins, but the results have been disappointing and there is no vaccine available against the disease to date. (fapesp.br)
Sequencing the phages that are captured in the screening and are significantly enriched across the patient cohort will identify the immunogenic parasite epitopes, which will be considered potential vaccine candidates. (fapesp.br)
This set of potential candidates will then be tested for protective efficacy in a mouse model using a phage-display delivery system, which is known to promote a strong immune response and to stabilize the vaccine antigen candidate. (fapesp.br)
With our unbiased high-throughput screening and in vivo testing we expect to identify a set of novel vaccine candidates that achieve WHO goals for a satisfactory protection level against S. mansoni challenge in mice. (fapesp.br)
The categories of species pangenome such as core, accessory, and unique genes sets can be analyzed for the identification of vaccine candidates through reverse vaccinology. (biomedcentral.com)
The proposed pipeline has proved to be the first comprehensive automated pipeline that can precisely identify putative vaccine candidates exploiting the microbial pangenome. (biomedcentral.com)
A significant decrease in time and cost is observed using this strategy instead of culturing the whole microorganism to identify potential vaccine candidates (PVCs) [ 9 ]. (biomedcentral.com)

The primary strategy of developing an efficacious Shigella vaccine has been to elicit antibody responses targeting Shigella O-antigen [ 10 ]. (biomedcentral.com)
Adenoviruses are immunogenic and elicit strong innate and adaptive immune responses. (medscape.com)
Almost at the same time, reverse vaccinology (RV) emerges as one of the applied approaches to assess the genomic sequences for prediction of novel candidate proteins and their immunogenic epitopes which may elicit protective immune responses [ 7 , 8 ]. (biomedcentral.com)

And Australia continues to steadfastly follow WHO's advice, with the Australian Department of Health website advocating Covid-19 vaccines for anyone 5 years or older. (cairnsnews.org)

The immunogenic portion of the vaccine is linked to the hapten by a conjugated protein/macromolecular carrier. (wikipedia.org)

During this innovative study, researchers sought to make a new BCG vaccine strain that lacks some of the proteins that are shared with the pathogen Mycobacterium bovis by identifying genes that contain encoded immunogenic proteins that could be removed from BCG without affecting its ability to work as a live vaccine. (surrey.ac.uk)
These dispensable genes encoding immunogenic proteins were then deleted from the BCG chromosome to make a BCG-minus strain. (surrey.ac.uk)
The deleted immunogenic proteins were then used to develop a new synthetic skin test that, like PPD, will be positive for animals that have been exposed to TB but, unlike PPD, will be negative for animals that have been vaccinated with the BCG-minus strain. (surrey.ac.uk)
Peptide vaccines can be divided into two categories: genetic engineering peptide vaccines and synthetic peptide vaccines: the former is also known as genetic engineering subunit vaccines, mainly using genetic engineering technology, the isolated antigen protein genes with strong immunogenicity are loaded into the expression vector through the host cell to express recombinant antigen proteins, so as to isolate and purify recombinant proteins as vaccines. (omizzur.com)
Sixty-nine healthy, malaria-naive volunteers were randomized to receive three injections of placebo or synthetic proteins N, R, or C (10 30, or 100 mu g/dose) in a double-blinded fashion. (unifesp.br)
The idea of creating a vaccine with messenger RNA, or mRNA, the substance that help to convert DNA into proteins, goes back decades. (wilhelmexner.org)
Our project aims at identifying new vaccine candidate targets with the use of a novel unbiased screening methodology, namely the use of a phage-display Schistosoma mansoni peptide library constructed by our group with synthetic oligonucleotides that encode the entire set of parasite proteins. (fapesp.br)

There are two kinds of synthetic peptide vaccines, which are those with continuous epitopes and those with discontinuous epitopes. (omizzur.com)
The continuous immunogenic epitopes are determined by protein antigen DNA cloning and nucleic acid sequence as well as serological studies. (omizzur.com)
In addition, a number of different bioinformatics tools have been developed in recent years to improve candidate selection and identification for novel epitopes for vaccine design. (omizzur.com)
From the perspective of global research and development of peptide vaccines, the research on the design of peptide vaccines targeting T and B cell epitopes has achieved good results, but there are still many problems to be further solved, including the optimal selection of epitopes, the optimal connection of epitopes, the development of suitable adjuvants and the application of vectors. (omizzur.com)
Results: Our data support an optimized polyepitope neoantigen DNA vaccine design encoding long (≥20-mer) epitopes with a mutant form of ubiquitin (Ub mut ) fused to the N-terminus for antigen processing and presentation. (wustl.edu)
We have developed a recombinant Salmonella typhi Ty21a vaccine candidate (rSTvacIII) displaying a multi-epitopes mycobacterial antigen called the VacIII (containing ubiquitin and 4 immunogenic mycobacterial epitopes of ESAT-6, PhoS1, Hsp 16.3 and MTB 8.4 genes) on the surface of S. typhi Ty21a (Ty21a) using PgsA protein as a carrier. (academicjournals.org)

It has been generally safe, well tolerated, and immunogenic in adults and children, and it has been combined in a small trial with the canarypox recombinant vector CMV vaccine. (cdc.gov)
currently who researchers are working on more potent anti-fertility vaccines using recombinant dna. (cognitive-liberty.online)

The envelope glycoprotein gB vaccine, originally developed by Chiron and acquired by Aventis, has been studied the most extensively. (cdc.gov)
Therefore, this study designed a novel synthetic anti-Ebola virus glycoprotein DNA vaccine as a strategy to expand protective breadth against diverse Ebola virus strains and evaluated the impact of vaccine dosing and route of administration on protection against lethal Ebola virus-Makona challenge in nonhuman primates. (infectiousdiseaseadvisor.com)
Results showed that multiple-injection regimens of the anti-Ebola virus glycoprotein DNA vaccine delivered by intramuscular administration followed by electroporation were 100% protective against the lethal Ebola virus-Makona challenge. (infectiousdiseaseadvisor.com)
Of note, when the anti-Ebola virus glycoprotein DNA vaccine was by 2 injections delivered intradermally followed by electroporation, a strong immunogenicity was generated and was also 100% protective against the lethal Ebola virus-Makona challenge. (infectiousdiseaseadvisor.com)
Further, although reports of long-term immunogenicity following DNA or other experimental vaccine administration are lacking, results showed that the anti-Ebola virus glycoprotein DNA vaccine induced long-term immune responses in the nonhuman primates. (infectiousdiseaseadvisor.com)
As a result, effective vaccines must target the viral spike glycoprotein. (springeropen.com)

Some companies have tested candidate vaccines in clinical trials, but evidence failed to show the adequate antibody responses or exhibit superior efficacy to factors concerning placebo. (wikipedia.org)
The assessment of the gB vaccine for efficacy should be complete within 5 years. (cdc.gov)
The Langer Prize will support Kunjapur's work to boost the efficacy of live vaccines by engineering cells to produce an immunogenic amino acid. (aiche.org)
Monophosphoryl Lipid A enhances efficacy of a Francisella tularensis LVS-catanionic nanoparticle subunit vaccine against F. tularensis Schu S4 challenge by augmenting both humoral and cellular immunity. (umaryland.edu)
The utility and technical advantages of synthetic nucleic acid platforms (SNAP), including their efficacy, safety, speed of development, and ease of vaccine manufacture, were revealed during the COVID-19 pandemic, thus instilling hope that these technologies can be leveraged for the development of an effective HIV vaccine and broadly neutralizing antibody (bNAb) delivery. (nih.gov)
This review analyzes the formulation, methodological design, and results of active clinical trials for merozoite-stage vaccines, regarding their safety profile, immunological response (phase Ia/Ib), and protective efficacy levels (phase II). (urosario.edu.co)
The Fernández-Tejada Lab is funded primarily by the European Research Council through an ERC Starting Grant, which provides €1.5 million funding for a transformative and timely research program aimed at developing novel synthetic self-adjuvanting vaccines with improved properties and efficacy, as well as unraveling the molecular basis and three-dimensional structure underlying the biological activity of these constructs. (cicbiogune.es)
Klaus Steger, Ph.D. reveals why this made the widely-mandated shots not only dangerous, but poorly-designed "vaccines" in terms of efficacy. (momsacrossamerica.com)

Cattle that are vaccinated with the BCG vaccine, which contains a harmless strain of the bovine TB pathogen Mycobacterium bovis, produce a positive PPD test for TB making it impossible to distinguish, with the PPD skin test, if the animal has TB or has simply been vaccinated. (surrey.ac.uk)
My research focuses on vaccine development against the pathogen Francisella tularensis ( Ft ) through the host's innate and adaptive immune responses. (umaryland.edu)
The so-called peptide vaccine is a vaccine prepared by chemical peptide synthesis technology according to the amino acid sequence of a certain epitope known or predicted in the antigen gene of the pathogen. (omizzur.com)
Create a contagious synthetic pathogen that's relatively benign, but induces immunity to the major pathogen -- and spread it actively. (kateva.org)
The oral vaccine was an active contagious pathogen that was excreted in stool. (kateva.org)
The difference is the successful Polio strategy was probably unintentional (I suspect some people understood even in the 1950s), but in the future we'd be deliberately exposing an entire population to an immunogenic pathogen that would almost certainly harm many people. (kateva.org)
Shigella is a major diarrheal pathogen for which there is presently no vaccine. (biomedcentral.com)

New vaccines in development hold promise for protection of women and their infants against additional infectious diseases. (cdc.gov)
With the success of COVID-19 vaccines, newly created mRNA vaccines against other infectious diseases are beginning to emerge. (mdpi.com)
ATLANTA, GA, Sept. 19, 2023 (GLOBE NEWSWIRE) -- via NewMediaWire - GeoVax Labs, Inc. (Nasdaq: GOVX), a biotechnology company developing human vaccines and immunotherapies against infectious diseases and cancer, announced today the publication of data from the ongoing Phase 2 trial of its next-generation COVID-19 vaccine (GEO-CM04S1) in the journal Vaccines . (news10.com)
At present, one of the important directions of vaccine research is peptide vaccine, and many peptide vaccines have been developed for some infectious diseases (AIDS, hepatitis C) and tumors. (omizzur.com)
As of now, more than 100 DNA- and RNA-based vaccines have advanced to clinical development for SARS-CoV-2, HIV, other infectious diseases, and cancers. (nih.gov)

Nicotine vaccines are immunogens made up of synthetic drug haptens connected to immunogenic carriers, which are then packaged in adjuvants to boost immunogenicity. (wikipedia.org)
NCT04977024 ) is evaluating the safety and immunogenicity of GEO-CM04S1, compared to either the Pfizer/BioNTech or Moderna mRNA-based vaccine, in patients who have previously received either an allogeneic hematopoietic cell transplant, an autologous hematopoietic cell transplant or chimeric antigen receptor (CAR) T cell therapy (i.e., patients who have reduced immune system function as a result of treatment). (news10.com)
The present invention provides improved vaccine compositions having enhanced immunogenicity and methods of using same. (justia.com)
The known synthetic peptide carrier, p458, provides significantly improved immunogenicity when provided as a multimeric conjugate comprising a plurality of peptide carrier units conjugated to each antigen. (justia.com)
Optimized polyepitope neoantigen DNA vaccines specific for the murine breast tumor E0771 and 4T1 were designed and their immunogenicity was tested in vivo. (wustl.edu)
The clinical success of anticancer and antiviral vaccines often requires co-administration of an adjuvant, a substance that enhances the immunogenicity of the antigen and potentiates the immune response. (cicbiogune.es)
This was a phase I double-blind, controlled vaccine trial, evaluating security, tolerability, and immunogenicity of mixtures of N, R and C LSP derived from the CS protein formulated in two adjuvants Montanide ISA 720 and Montanide ISA 51. (likemap.me)
While working at the University of Pennsylvania Medical School, Katalin Karikó found that transfer RNAs known to contain many modified nucleosides were non-immunogenic, when delivered into immune cells, thus suggesting that modified nucleosides might suppressing the immunogenicity of the RNA. (wilhelmexner.org)

Altogether, this formulation is known as a conjugate vaccine. (wikipedia.org)
The conjugate vaccine produces a strong immunogenic response from the body by stimulating the production of antibodies, which is administered through a vaccination. (wikipedia.org)
A semi-synthetic oligosaccharide conjugate vaccine candidate confers protection against Streptococcus pneumoniae serotype 3 infection. (mpg.de)

Conjugated immunogens are injected to deliver the vaccine, which activates B and T cells in a T cell-dependent manner to create polyclonal anti-nicotine antibodies. (wikipedia.org)
The first HIV vaccines tested were designed to induce neutralizing antibodies that would prevent HIV infection. (cdc.gov)
The overall objective of EuroNeut-41 was to design a vaccine that raises antibodies able to prevent HIV cell fusion by blocking the virus fusion protein gp41 in its pre-fusogenic conformation. (europa.eu)

Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic transcription reactions. (mdpi.com)
The unprecedently speedy development of mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was enabled with previous innovations in nucleoside modifications during in vitro transcription and lipid nanoparticle delivery materials of mRNA. (mdpi.com)
My recent work studying macrophage responses to Ft infection and in comparing different vaccine adjuvants in vitro have lead to the investigation of cell energetic changes during the course of infection/immunization. (umaryland.edu)

Therapeutic DC or peptide vaccines enhance anti-tumor immune response by promoting DC maturation, B-cell antibody secretion, cytotoxic T cell proliferation and killing. (omizzur.com)
This challenge may be overcome by a vaccine that elicits either a broadly reactive immune response or numerous species-specific responses against the globally dominant Shigella species (i.e. (biomedcentral.com)
However, a vaccine using "natural" mRNA would not last long enough to initiate an immune response before being destroyed by our immune system. (momsacrossamerica.com)
After establishing an initial protective immune response with Tiba's mRNA vaccines as a prime dose, the KAUST all-protein booster vaccines are expected to enhance antibody production and longer-lasting immunity. (edu.sa)
The choice of a particular vaccine is influenced by several factors including mode of action, storage conditions, group of the vaccinee, immune response mounted, cost, dosage protocol, age, and side effects. (springeropen.com)

The constitution of nicotine vaccines involves the addition of adjuvants to the conjugation between synthetic drug-derived haptens which share structural similarities to nicotine, and the immunogenic carrier protein. (wikipedia.org)
Vaccine adjuvants are frequently used to curb drug abuse. (wikipedia.org)
With this idea in mind, the Chemical Immunology Lab established by Dr. Fernández-Tejada at CIC bioGUNE will develop new improved adjuvants and novel chemical strategies towards more effective, self-adjuvanting synthetic vaccines. (cicbiogune.es)

Each vaccine has been extensively tested for safety and is immunogenic in macaques. (cdc.gov)
Together with her colleagues at the University, they used modified mRNA formulated with LNP as vaccine and protected mice and macaques against a variety of viruses. (wilhelmexner.org)

Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5. (mpg.de)
We report herein the encapsulation of a semisynthetic glycoconjugate (GC) composed of a synthetic tetrasaccharide mimicking theS. (univ-nantes.fr)

peptide vaccine has the function of anti-virus, anti-tumor, anti-bacteria, anti-parasitic infection and so on. (omizzur.com)
Because peptide vaccine is completely synthetic, there is no virulence recovery or inactivation of incomplete problems, with low cost, safety, strong specificity, easy to save and application of the advantages, more and more attention to the industry. (omizzur.com)
Tumor peptide vaccine has the advantages of strong specificity and high safety, and has broad market prospects. (omizzur.com)
From the analysis of the mechanism of action of tumor peptide vaccine, immature DC (dendritic cells) secrete the inhibitory factor indoleamine 2,3 dioxygenase (IDO) to inhibit tumor immunity in immunosuppressive state. (omizzur.com)

Several vaccines are in development for CMV. (cdc.gov)
The NS-2 deletion is a cornerstone for future vaccine development. (cdc.gov)
My long-term goal is to become an independent investigator in vaccine development. (umaryland.edu)
It is believed that with the progress of science and technology, the research of peptide vaccines will continue to deepen in the future, in order to continuously improve the research and development efficiency of peptide vaccines, reduce research and development costs, and bring new hope to patients with global diseases. (omizzur.com)
Her studies subsequently led to the development of a synthetic polymer of amino acids, similar to a protein involved in multiple sclerosis. (jpost.com)
This PhD thesis discusses the rationale for design and use of synthetic oligosaccharides for the development of glycoconjugate vaccines and the role of physicochemical methods in the characterization of these vaccines. (unibo.it)
This oligomannose epitope has been a subject to the synthetic vaccine development. (unibo.it)
I describe the development of neoglycoconjugates displaying clustered HIV-1 related oligomannose carbohydrates and their immunogenic properties. (unibo.it)
The purpose of this Notice of Funding Opportunity (NOFO) is to advance synthetic nucleic acid platforms for the rapid development and iterative testing of active and passive immunization strategies for HIV prevention, treatment, and cure. (nih.gov)
Information is also highlighted concerning the development of new synthetic strategies that could help in drug design and in the work on SAR or QSAR. (benthamscience.com)
Further underscoring the need for next-generation COVID-19 vaccines such as GEO-CM04S1, GeoVax scientists co-authored an article titled, " MVA-Vectored Universal Beta-Coronavirus Vaccine Design & Development ", published in the June 2023 issue of the online journal Vaccine Insights . (binghamtonhomepage.com)
Further optimization and development of this vaccine is being attempted to conduct phase 11 clinical trials. (unifesp.br)
The development of new potential diagnostic strategies for the immunodetection of pathogens is closely linked to the discovery of small polypeptides with immunogenic or immunoreactive activity. (degruyter.com)
The novel mRNA platform not only accelerate development of new vaccines and other drugs, but makes all the mRNA-based medicine more affordable since using the human body to generate their own medicine. (wilhelmexner.org)
however, cure rates of less than 50 % have been recorded and drug tolerance has been already reported, reinforcing the need for new and more effective approaches in reducing morbidity and/or in achieving disease eradication, such the development of a vaccine. (fapesp.br)
Most COVID-19 vaccines in development today focus on the surface spike protein, the antigen that gives coronavirus its "crown" name. (edu.sa)
The ever-increasing genomic and proteomic data has greatly facilitated the vaccine designing and development process. (biomedcentral.com)
The Advisory Committee reviewed the work of each centre and pharmaceutical companies cooperating in the authorized programme of research for the development of diagnostic tests, smallpox vaccines, and antiviral and therapeutic agents. (who.int)
The rapid emergence of the SARS-CoV-2 virus necessitated the development of vaccines targeting the spike protein in an unprecedented timeframe [ 20 ]. (springeropen.com)

2017, Heplisav-B (HepB-CpG), a single-antigen HepB vac- meetings to review the quality of evidence for immunogenic- cine with a novel immunostimulatory sequence adjuvant, was ity and safety of HepB-CpG and implementation issues. (cdc.gov)

The conjugated vaccine is exposed to lymphocytes by antigen-presenting cells. (wikipedia.org)
Cell vaccine compositions comprising antigen presenting cells loaded with multimeric p458 conjugates are also provided. (justia.com)

RSV vaccine trials have identified a matrix of attenuating mutations and whole genes critical for in vivo replication, even though most such strains grow with little limitation in tissue culture. (cdc.gov)
The extent to which a vaccine inducing cell-mediated immunity would have to match the circulating strains of HIV is unknown. (cdc.gov)
A year later I wondered if there were multiple strains circulating , all mutually immunogenic, some more toxic than others. (kateva.org)
The company is now in the final stage of human clinical trials, with studies to date showing the vaccine to be safe, well-tolerated and immunogenic to a broad range of influenza strains. (jpost.com)
Assuming that we immunize with a synthetic molecule containing the regions conserved among many strains of influenza, then this material will be able to provide immunity against many strains of the virus. (jpost.com)
HerpV is observed to be immunogenic, generating CD4(+) and CD8(+) T cell responses in three mouse strains including HLA-A2 transgenic mice. (nih.gov)

Deciphering antigenic determinants of Streptococcus pneumoniae serotype 4 capsular polysaccharide using synthetic oligosaccharides. (mpg.de)
The RV is a stepwise computational screening process that analyzes each protein from the whole set of bacterial proteome for its antigenic and immunogenic potentials. (biomedcentral.com)

The compositions and methods include immunogenic conjugates containing peptide carriers derived from heat shock protein 60 (HSP60). (justia.com)
Common forms of peptide vaccines include: directly extracted peptide vaccines, amino acid residues or sequence modified peptide vaccines, heat shock protein peptide complex vaccines, polyvalent peptide vaccines. (omizzur.com)

As such, these patients are at greater risk for developing severe disease if infected and would likely benefit from the types of immune responses induced by the GEO-CM04S1 vaccine, which are more broadly specific and include activation of both the antibody and T cell arms of the immune system. (news10.com)
The mRNA vaccines and monoclonal antibody therapies have been shown to be inadequate in providing protective immunity in such immunocompromised patients. (news10.com)
As a booster vaccine in immunocompromised patients with chronic lymphocytic leukemia (CLL), a recognized high-risk group for whom current mRNA vaccines and monoclonal antibody (MAb) therapies appear inadequate relative to providing protective immunity. (news10.com)
Analysis of the immunogenic response within at-risk populations suggests an inverse correlation between high anti-GAS-PS antibody titres and GAS infection cases. (unibo.it)

Scientists at the University of Surrey have developed a novel vaccine and complementary skin test to protect cattle against bovine tuberculosis (bovine TB). (surrey.ac.uk)

The other candidate consists of the attenuated smallpox vaccine, Modified Vaccinia Ankara, with the same genetic insert. (cdc.gov)
The Group A Streptococcus cell membrane polysaccharide (GAS-PS) is an attractive vaccine antigen candidate based on its conserved, constant expression pattern and the ability to confer immunoprotection in a relevant mouse model. (unibo.it)
The cluster nature of the 2G12 epitope suggested that multivalent antigen presentation was important to develop a carbohydrate based vaccine candidate. (unibo.it)
A synthetic DNA vaccine may be a reasonable candidate because it is non-live, nonviral, and able to drive humoral and T-cell immunity along with establishing a long-term immunologic memory. (infectiousdiseaseadvisor.com)
Since the protective immunity against tuberculosis is mediated by Th1-type response, the rSTvacIII have potential as effective vaccine candidate against tuberculosis. (academicjournals.org)
Substantial experimental evidence indicates that the Plasmodium circurnsporozoite (CS) protein has great potential as a vaccine candidate. (unifesp.br)

Recent updates are briefly described in the status of mRNA vaccines against SARS-CoV-2, influenza virus, and other viral pathogens. (mdpi.com)
Both pathogens possess distinctive carbohydrate structures that have been described as suitable targets for the vaccine design. (unibo.it)

or (2) COMIRNATY (COVID-19 Vaccine, mRNA) or the Pfizer-BioNTech COVID-19 Vaccine authorized for use in individuals 12 years of age and older ( each 0.3 mL dose containing 30 mcg modRNA, supplied in multiple dose vials with gray caps and multiple dose vials with purple caps). (republicbroadcasting.org)
Intradermal-electroporation delivery is an alternate route for vaccine administration that is immunogenic and potentially dose sparing, which are potential advantages for vaccine delivery in an outbreak setting and for more sensitive populations. (infectiousdiseaseadvisor.com)
Correlation Between Third Dose of COVID-19 Vaccines and Regional Case Fatality Rates During the Omicron Wave in Korea. (cdc.gov)

Efforts are under way to develop a vaccine against CMV, with particular emphasis on the potential for prevention of congenital CMV disease in infants. (cdc.gov)

Vaccines currently in clinical trials are designed to induce cell-mediated immunity, which would lead to destruction of HIV-infected cells. (cdc.gov)
When combined with immune checkpoint blockade therapy, optimized polyepitope neoantigen DNA vaccines were capable of inducing antitumor immunity in preclinical models. (wustl.edu)
Vaccines are critical in boosting immunity, lowering COVID-19-related illnesses, reducing the infectious burden on the healthcare system, and reducing economic loss, according to current data. (springeropen.com)

In this context, building upon the PI's previous background and expertise in the area, the research program in the Fernández-Tejada Group has a double, ultimate goal based on applying chemistry to address the above clear gaps in the adjuvant/vaccine field. (cicbiogune.es)
Research in the Chemical Immunology Lab connects chemical synthesis and chemical/structural biology with cellular and molecular immunology to explore key unresolved mechanistic questions in the adjuvant/vaccine arena with extraordinary chemical precision. (cicbiogune.es)
HepB) vaccines use an aluminum adjuvant. (cdc.gov)

As a booster vaccine for healthy patients who have previously received the Pfizer or Moderna mRNA vaccine. (news10.com)
Despite these dire shortcomings, Pfizer-BioNTech and Moderna launched a large-scale production of COVID-19 "vaccines" using modRNA. (momsacrossamerica.com)
Nucleoside-modified mRNA were successfully used to create the anti-SARS-CoV-2 mRNA vaccines by BioNTech/Pfizer and Moderna/NIH, and both approved for human use. (wilhelmexner.org)

In preclinical studies, nicotine vaccines have demonstrated the ability to combat the negative effects of nicotine abuse, but none of the developed vaccines has been authorized for use in clinical trials as a smoking cessation strategy. (wikipedia.org)

Nicotine vaccine is a novel immunological strategy for treating nicotine addiction. (wikipedia.org)
Already in my PhD, I studied synthetic polymers in order to look at their universal properties and to see whether there is a correlation between the structure of the protein-like polymers and immunological properties," Arnon said. (jpost.com)
Moreover, leveraging the extraordinary facilities and scientific expertise available at CIC bioGUNE, we will also focus on investigating the molecular mechanisms of the synthetic constructs by combining extensive immunological evaluations with molecular target identification studies and detailed conformational analysis. (cicbiogune.es)

The Advisory Committee also received reports on the status of the WHO Smallpox Vaccine Emergency Stockpile. (who.int)

Type I interferon licenses enhanced innate recognition and transcriptional responses to Francisella tularensis live vaccine strain. (umaryland.edu)

A live oral vaccine against adenovirus types 4 and 7 was approved for use in this population by the US Food and Drug Administration (FDA) in 2011, and subsequent incidence of acute respiratory disease declined. (medscape.com)

One vaccine is based on a plasmid (naked DNA) with an inserted synthetic gene representing the HIV-1 structural protein Gag and additional immunogenic portions of other genes. (cdc.gov)
Additionally, specific genes can be inserted into the virus that then can repair defective metabolic, enzymatic, or synthetic pathways in the host. (medscape.com)

Despite the paper, which admittedly is a one off, and only addresses multiple sclerosis as being an adverse side effect of the vaccine, WHO is still very pro-Covid vaccination . (cairnsnews.org)
Vaccines were well tolerated and no serious adverse events were observed. (unifesp.br)

The latter vaccines may also be whole viruses whose nucleic acids have been modified. (bvsalud.org)

We therefore sought to optimize the design of polyepitope DNA vaccines and test optimized polyepitope neoantigen DNA vaccines in preclinical models and in clinical translation. (wustl.edu)
Conclusions: We have developed and optimized a novel polyepitope neoantigen DNA vaccine platform that can target multiple neoantigens and induce antitumor immune responses in preclinical models and neoantigen-specific responses in clinical translation. (wustl.edu)

Understanding this role has the potential to reveal efficient strategies not only for allergy diagnosis but also for prediction of the immunogenic potential of new chemicals. (frontiersin.org)
Experts are currently examining the potential consequences of commercial vaccines on variants. (springeropen.com)

Less immunogenic (it evokes reduced stimulation of the innate immune system). (momsacrossamerica.com)

The vaccine was safe and well tolerated, induced potent serum IgG & IgA responses waning post last vaccination, and low and intermittent mucosal IgG, but did not induce neutralizing activity neither in serum nor vaginal samples. (europa.eu)

Synthetic GAS-PS structural analogues were specifically designed and generated to explore the impact of antigen length and terminal residue composition. (unibo.it)
However, there are worries about the vaccines' safety, the protection they provide, and whether future structural changes are required for these vaccines to be more effective. (springeropen.com)

Lawyer Tom Renz has exposed that the COVID-19 vaccines, widely advertised as mRNA (messenger RNA) vaccines, are in fact lab-created hybrids known as modRNA. (republicbroadcasting.org)
If you searched the word "modRNA" on Pfizer's labeling/fact-sheet for health care providers administering the vaccine, it will show 21 results. (republicbroadcasting.org)
The COVID "vaccine" technically contains modRNA (not MRNA as we were told) of a viral gene sequence. (momsacrossamerica.com)
Perhaps most astonishing is that, when creating the COVID-19 vaccines and boosters, scientists already knew that targeted delivery of modRNA was impossible. (momsacrossamerica.com)

This is the main active ingredient in the Pfizer-BioNTech COVID-19 vaccine. (republicbroadcasting.org)

Chemical and enzymatic synthesis of flavins and their analogues and application of these cofactors in protein photoswitches for synthetic biology. (cardiff.ac.uk)

Globally studied tumor peptide vaccines include those that target folate receptors (FR) or those developed against HER2 targets. (omizzur.com)
To look for broad-spectrum immunogenic targets and analysis of closely-related bacterial species, the assimilation of pangenome concept into reverse vaccinology approach is essential. (biomedcentral.com)

Of interest is the role of adenoviruses as viral vectors in vaccination and in gene therapy.For example, in viral vector vaccines against SARS-CoV2, the vector virus is used to deliver RNA encoding SARS-CoV2 spike protein into target cells. (medscape.com)

Anatomy11

Organisms34

Diseases27

Chemicals and Drugs113

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes29

Disciplines and Occupations3

Technology, Industry, Agriculture3

Information Science3

Named Groups1

Health Care9

Geographicals1

Antigens18

Claimed the COVID-19 vaccines1

Peptides15

Candidates14

Elicit3

Advocating Covid-19 vaccines1

Conjugated protein1

Proteins7

Epitopes6

Recombinant2

Glycoprotein6

Efficacy8

Pathogen7

Infectious diseases5

Immunogenicity8

Conjugate3

Antibodies3

Vitro3

Immune response5

Adjuvants3

Macaques2

Semisynthetic2

Peptide vaccine4

Development19

20171

Antigen-prese2

Strains6

Antigenic2

Heat shock p2

Antibody4

Developed a novel1

Candidate6

Pathogens2

Dose3

Develop a vaccine1

Immunity3

Adjuvant3

Moderna3

Clinical trials1

Immunological3

Smallpox1

Live vaccine1

Oral vaccine1

Genes2

Adverse2

Nucleic1

Preclinical2

Potential2

Stimulation1

Potent1

Structural2

ModRNA4

BioNTech1

Chemical1

Targets2

Viral vector1