• responses
  • Previously, we showed that the magnitude of the HIV-2 gag-specific T-cell response is inversely correlated with plasma viral load, particularly when responses are directed against an epitope, 165 DRFYKSLRA173 , within the highly conserved Major Homology Region of gag-p26. (ox.ac.uk)
  • Since this proline motif was also associated with stronger gag-specific CTL responses, we investigated the impact of these prolines on proteasomal processing of the protective 165 DRFYKSLRA173 epitope. (ox.ac.uk)
  • cell
  • Failure of HCV-specific T cells can result from mutational escape in targeted T-cell epitopes ( 10 ). (pubmedcentralcanada.ca)
  • Full-length tumor Ags intrinsically contain all possible CD4 + and CD8 + T cell epitopes for any type of HLA allele and thus they should potentially activate both T cell subsets. (jimmunol.org)
  • HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives. (nih.gov)
  • demonstrate
  • Our data demonstrate that the 165 DRFYKSLRA173 epitope is most efficiently processed from precursors that contain two flanking proline residues, found naturally in low viral-load patients. (ox.ac.uk)
  • affinity
  • On the opposite end of the scale where BCRs have low affinity for the epitopes, these B cells are outcompeted for stimulation by B cells with BCRs that have higher affinities for their respective epitopes. (wikipedia.org)
  • The immunodominant epitope will be a BCR that has a particular 'goldilocks' amount of affinity for its epitope determined by equilibrium binding affinity. (wikipedia.org)
  • selection
  • Moreover, population-based studies revealed that at least in some CD8 epitopes selection of escape mutations is reproducible in subjects sharing the same restricting HLA alleles ( 16 , 34 , 35 , 42 ). (pubmedcentralcanada.ca)
  • domain
  • Most immunodominant epitopes lie within the NC16A domain, and the binding of the autoantibodies perturbs adhesive functions of the collagen XVII, and this (together with inflammation-related processes) leads to epidermal-dermal separation and skin blistering. (wikipedia.org)