• protein
  • The structures reveal virus conformational changes, the Fab-binding mode to the capsid, the residues comprising the epitope and indicate a potential interaction of U4 with the minor structural protein, L2. (bioportfolio.com)
  • Antibody reactivities with deletion mutants of a fusion protein containing PIM and Pepscan analysis of the Muguga version of the molecule with 13 of the MAb indicate that there are at least 10 different epitopes throughout the molecule. (cgiar.org)
  • TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium. (wikipedia.org)
  • HLA-DO is a dimeric Major Histocompatibility Complex (MHC) Class II protein composed of α- and β-subunits which interacts with HLA-DM in order to fine tune immunodominant epitope selection. (wikipedia.org)
  • monoclonal
  • By epitope mapping, we show that the protective human monoclonal antibody (humAb) 1D9 recognizes a conserved 62-residue N-terminal domain of IsaA. (eur.nl)
  • responses
  • Although this is one of the largest immunodominant T cell responses described for any infection, most mice fail to clear T. cruzi and subsequently develop chronic disease. (jimmunol.org)
  • Previously, we showed that the magnitude of the HIV-2 gag-specific T-cell response is inversely correlated with plasma viral load, particularly when responses are directed against an epitope, 165 DRFYKSLRA173 , within the highly conserved Major Homology Region of gag-p26. (ox.ac.uk)
  • Since this proline motif was also associated with stronger gag-specific CTL responses, we investigated the impact of these prolines on proteasomal processing of the protective 165 DRFYKSLRA173 epitope. (ox.ac.uk)
  • Viral
  • The aim of this study was to characterize the forces that contribute to viral evolution in an HLA-A*01-restricted epitope in HCV NS3. (pubmedcentralcanada.ca)
  • Our data demonstrate that the 165 DRFYKSLRA173 epitope is most efficiently processed from precursors that contain two flanking proline residues, found naturally in low viral-load patients. (ox.ac.uk)
  • cells
  • We hypothesised that ZnT8 is also recognised by CD8(+) T cells and aimed to identify HLA-A2 (A*02:01)-restricted epitope targets. (nih.gov)
  • White HLA-A2(+) adults (83%) and children (60%) with type 1 diabetes displayed ZnT8-reactive CD8(+) T cells that recognised a single ZnT8(186-194) (VAANIVLTV) epitope. (nih.gov)
  • selection
  • Moreover, population-based studies revealed that at least in some CD8 epitopes selection of escape mutations is reproducible in subjects sharing the same restricting HLA alleles ( 16 , 34 , 35 , 42 ). (pubmedcentralcanada.ca)
  • show
  • Color lines below X-axis show the position of each epitope within the ZnT8 structure, following the color code of panel a. c Binding of ZnT8 peptides to recombinant HLA-A2.1 in vitro . (nih.gov)
  • domain
  • Most immunodominant epitopes lie within the NC16A domain, and the binding of the autoantibodies perturbs adhesive functions of the collagen XVII, and this (together with inflammation-related processes) leads to epidermal-dermal separation and skin blistering. (wikipedia.org)