• It is also associated with other diseases such as Burkitt's lymphoma, Hodgkin's disease, and gastric carcinoma . (osmosis.org)
  • Epstein-Barr virus (EBV)-associated smooth muscle tumor (SMT) is an uncommon neoplasm typically manifesting in immunodeficient individuals. (allenpress.com)
  • In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
  • A primary central nervous system lymphoma (PCNSL) is a primary intracranial tumor appearing mostly in patients with severe immunosuppression (typically patients with AIDS). (wikipedia.org)
  • Both viruses play an important role in human multistep carcinogenesis, especially in immunodeficient patients. (cdc.gov)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
  • Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
  • In addition, metformin potentiated the antitumor efficacy of cytarabine (Ara-C) in vivo in an NCG immunodeficient mouse xenograft model by inhibiting the mitochondrial transfer and OXPHOS activity in the engrafted human AML cells. (biomed.news)
  • Responses were observed across a variety of subtypes of PTCL, including PTCL (not otherwise specified), ALK- negative anaplastic large-cell lymphoma and enteropathy-associated T-cell lymphoma. (medscape.com)
  • In mantle cell lymphoma lines with the t(11;14)(q13,32), romidepsin was able to induce H3 acetylation and downregulate levels of Bcl2, BcxL and Mcl-1, inducing apoptosis via the mitochondrial pathway, in a dose-dependent fashion. (medscape.com)
  • [ 62 ] Vorinostat is able to cause a marked decrease in cyclin D1 in mantle cell lymphoma lines, despite mRNA levels and protein stability of cyclin D1 remaining minimally affected. (medscape.com)
  • Because the Working Formulation is limited to classification based upon morphology, it cannot encompass the complex spectrum of NHL disease, excluding important subtypes such as mantle cell lymphoma or T cell/natural killer cell lymphomas. (medscape.com)
  • A primary CNS lymphoma usually presents with seizure, headache, cranial nerve findings, altered mental status, or other focal neurological deficits typical of a mass effect. (wikipedia.org)
  • Lymphoblastic lymphoma, a high-grade lymphoma, often manifests with an anterior superior mediastinal mass, superior vena cava (SVC) syndrome, and leptomeningeal disease with cranial nerve palsies. (medscape.com)
  • A record-linkage study conducted in Uganda showed an association between Hodgkin lymphoma and HIV infection with a standardized incidence ratio of 5.7 (1.2-17) although OR in case-referent studies ranged from 1.4 (0.7-2.8) to 1.6 (1.0-2.7). (plos.org)
  • Cancers such as Kaposi Sarcoma (KS), Non Hodgkin Lymphoma (NHL) and Invasive Cancer of the Cervix (ICC) have been recognized for a long time as associated with HIV infection and have been classified as AIDS-defining diseases. (plos.org)
  • The clinical manifestations of non-Hodgkin lymphoma (NHL) vary with such factors as the location of the lymphomatous process, the rate of tumor growth, and the function of the organ being compromised or displaced by the malignant process. (medscape.com)
  • 10% from baseline within 6 mo) are not common at presentation, but they are common in patients with advanced, malignant transformation (ie, evolution from a low-grade to an intermediate- or high-grade lymphoma) or end-stage disease. (medscape.com)
  • Leukemias and lymphomas represent malignant, clonal expansions of white blood cell populations. (nih.gov)
  • 9. Diploid human lymphoblastoid and Burkitt lymphoma cell lines: susceptibility to murine NK cells and heterotransplantation to nude mice. (nih.gov)
  • 12. [Invasive, metastatic growth of lymphoblastoid B cells in immunodeficient SCID mice]. (nih.gov)
  • A Model for Human Islet Transplantation to Immunodeficient Streptozotocin-Induced Diabetic Mice. (nih.gov)
  • Immunodeficient NMRI-(nu/nu)-nude mice were purchased from a specific pathogen free colony at the University of Essen (Germany) at the age of 4-6 weeks. (biomedcentral.com)
  • Indeed, Kaposi sarcoma and EBV-associated Burkitt lymphoma currently represent the most frequent cancers in some geographic areas, especially in Africa. (cdc.gov)
  • PCNSLs represent around 20% of all cases of lymphomas in HIV infections. (wikipedia.org)
  • It is a subtype and one of the most aggressive of the diffuse large B-cell lymphomas. (wikipedia.org)
  • Most PCNSLs are diffuse large B cell non-Hodgkin lymphomas. (wikipedia.org)
  • 10. Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines. (nih.gov)
  • 14. Cytokine signatures of transformed B cells with distinct Epstein-Barr virus latencies as a potential diagnostic tool for B cell lymphoma. (nih.gov)
  • Primary CNS lymphomas are high-grade neoplasms of B-cell origin. (medscape.com)
  • Most lymphomas originating in the CNS are large cell lymphomas or immunoblastomas, and they account for 1% of all intracranial neoplasms. (medscape.com)
  • The first case represents a systemic EBV+ T-cell lymphoma of childhood and the second case an EBV+ mucocutaneous ulcer. (medscape.com)
  • These types of lymphomas cause a more varied clinical presentation. (medscape.com)