• epithelial cells
  • The oligomeric forms of IgA in the external (mucosal) secretions also contain a polypeptide of a much larger molecular mass (70 kD) called the secretory component that is produced by epithelial cells. (wikipedia.org)
  • The high prevalence of IgA in mucosal areas is a result of a cooperation between plasma cells that produce polymeric IgA (pIgA), and mucosal epithelial cells that express an immunoglobulin receptor called the polymeric Ig receptor (pIgR). (wikipedia.org)
  • This results in transportation of IgA across mucosal epithelial cells and its cleavage from pIgR for release into external secretions. (wikipedia.org)
  • CCL28 is expressed by columnar epithelial cells in the gut, lung, breast and the salivary glands and drives the mucosal homing of T and B lymphocytes that express CCR10, and the migration of eosinophils expressing CCR3. (wikipedia.org)
  • innate
  • A. Dwivedy and P. Aich, "Importance of innate mucosal immunity and the promises it holds," International Journal of General Medicine , vol. 4, pp. 299-311, 2011. (hindawi.com)
  • Aside from the immunoglobulin content, glycocompounds and oligosaccharides in breast milk play a critical role in the innate immunity against diarrheagenic E. coli strains. (mdpi.com)
  • tissues
  • CCL28 has also been implicated in the migration of IgA-expressing cells to the mammary gland, salivary gland, intestine and other mucosal tissues. (wikipedia.org)
  • The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. (wikipedia.org)
  • In terms of migration, MADCAM is selectively expressed on mucosal endothelial cells, driving memory T-cell re-circulation through mucosal tissues. (wikipedia.org)
  • AIDS
  • Because of its front-line status within the immune system, the mucosal immune system is being investigated for use in vaccines for various afflictions, including AIDS and allergies. (wikipedia.org)
  • microbicides
  • Prevention might also be complemented by microbicides and circumcision, two alternative approaches to mucosal protection. (www.gov.uk)
  • barrier
  • We aim to understand the feed-forward and feedback mechanisms between microbiota and the immune system at the mucosal barrier. (riken.jp)
  • This suggests a role for early psychological factors in the regulation of colonic mucosal barrier in later life. (bmj.com)
  • antibodies
  • While vaccination provides a lasting effect, it usually takes several weeks to develop, while passive immunity (the transfer of antibodies) has immediate effect. (wikipedia.org)
  • relatively
  • In conclusion, salivary cortisol did not change between the two weeks, and thus competition stress was relatively low, and mucosal immunity was unaffected in these young athletes prior to competition. (hindawi.com)
  • elimination
  • widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the elimination of diseases such as polio, measles, and tetanus from much of the world. (wikipedia.org)
  • cell
  • HVEM therefore represents a critical signal for MPECs and development of protective mucosal CD8 T cell memory. (jimmunol.org)
  • Immunity is achieved when the immune system resolves a biological contact with a cell that the system perceives as foreign with a steady state. (wikipedia.org)
  • Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene. (wikipedia.org)