• pathogen
  • Of interest, the Ipr1 gene also controls innate immunity to another intracellular pathogen Listeria monocytogenes, a parasitic disease transferred to humans generally from consuming infected animal products and that causes flu-like symptoms, swelling of the brain and for pregnant women potential loss of fetus. (rxpgnews.com)
  • An effective innate immune response relies on the detection of pathogen associated molecular patterns (PAMPs) by various host pattern recognition receptors (PRRs) that result in the production of pro-inflammatory cytokines and chemokines. (ovid.com)
  • Recently, it has become apparent that infected or dying cells can transmit PAMPs and host PRR signalling proteins to uninfected bystander cells to thereby bypass pathogen evasion strategies, and potentiate innate immune signalling. (ovid.com)
  • In this review, we discuss what is currently known about the intercellular transfer of pathogen- or host-derived RNA, DNA and proteins from infected cells to neighbouring cells and how this impacts on host innate immunity. (ovid.com)
  • The protein encoded by this gene is a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. (wikipedia.org)
  • They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. (wikipedia.org)
  • immune response
  • The Human Antifungal Response RT² Profiler PCR Array profiles the expression of 84 key genes involved in the innate immune response to fungi. (qiagen.com)
  • The Human Antiviral Response RT² Profiler PCR Array profiles the expression of 84 key genes involved in the innate antiviral immune response. (qiagen.com)
  • Much work has been done to show that miRNA are key regulators of the innate immune system and this year alone there has been a number of key papers showing that long noncoding RNA are also essential mediators of the immune response. (frontiersin.org)
  • Viruses and bacteria have co-evolved with the immune system and developed multiple strategies to usurp or circumvent host machinery and blunt the innate immune response in infected cells. (ovid.com)
  • The complement system is a part of the innate immune response. (wikipedia.org)
  • Interaction
  • In conclusion, this Research Topic focuses on the role of staphylococcal virulence factors in adhesion, invasion and biofilm formation on one hand and on their interaction with innate immunity on the other. (frontiersin.org)
  • functional
  • Progress in these general areas would provide a better understanding of the functional links between innate and acquired immunity, and would lead to new approaches for immunomodulation, vaccine development, and design of broad-spectrum antimicrobial agents. (nih.gov)
  • studies
  • Full Text PA-97-079 INNATE IMMUNITY NIH GUIDE, Volume 26, Number 24, July 25, 1997 PA NUMBER: PA-97-079 P.T. 34 Keywords: Immunology National Institute of Allergy and Infectious Diseases National Institute of Dental Research PURPOSE The National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Dental Research (NIDR), National Institutes of Health (NIH), invite applications for research studies of the innate immune system. (nih.gov)
  • lead
  • Finding a specific gene in a mouse that has a human equivalent within a highly conserved genetic region suggests that the human equivalent may also be involved in innate immunity to the disease and may further lead to development of diagnostic tests and prevention approaches. (rxpgnews.com)
  • research
  • The Clinical Sciences Research Institute is hosting a seminar entitled 'Glycomics and innate immunity in human disease' from 12:30pm to 1:30pm on Thursday 21 January 2010 in the Large Seminar Room, CSRI, CSB Building UHCW. (warwick.ac.uk)
  • It is published by SAGE Publications on behalf of the International Endotoxin & Innate Immunity Society and the editor-in-chief is Otto Holst (Research Centre Borstel, Germany). (wikipedia.org)
  • People
  • I believe this is a field that is in its infancy, which is generating much excitement and this topic within Frontiers will be of much interest to all people involved in the study of innate immunity. (frontiersin.org)
  • surface
  • When an artificial material makes contact with blood, the first event is a rapid adsorption of plasma protein on the material surface, on top of which the innate immune system is triggered, with potentially detrimental consequences. (diva-portal.org)
  • applications
  • The Division of Pulmonary and Critical Care Medicine at Duke University invites applications for a postdoctoral position to investigate innate immunity using the model organism C. elegans. (bio.net)