• induction
  • One model for the induction of tolerance during the very early stages of pregnancy is the Eutherian Fetoembryonic Defense System (eu-FEDS) hypothesis. (wikipedia.org)
  • An exploratory, open-labeled study of patients with Pompe disease, who have previously received Myozyme (alglucosidase alfa) treatment, to evaluate the efficacy, safety and clinical benefit of 2 Immune Tolerance Induction (ITI) regimens in combination with Myozyme. (clinicaltrials.gov)
  • Specifically, the Contractor shall design and conduct clinical trials at all phases to evaluate the safety, toxicity and efficacy of promising tolerance induction strategies in these disease areas, and design and conduct studies of the underlying mechanisms involved in the induction, maintenance and loss of tolerance as an integral part of Network-sponsored clinical trials, as well as clinical trials supported by other Federal and private organizations and companies. (nih.gov)
  • The immune tolerance to OVA antigen topically applied to the conjunctiva measured by cutaneous delayed type hypersensitivity (DTH) reaction, OVA-specific T cell proliferation, Foxp3 induction, and IFN-γ production observed in WT mice was lost in the Spdef-KO mice. (jci.org)
  • Rather there is focus on their role in tolerance induction. (diva-portal.org)
  • suppress
  • The eu-FEDS model further suggests that specific carbohydrate sequences (oligosaccharides) are covalently linked to these immunosuppressive glycoproteins and act as "functional groups" that suppress the immune response. (wikipedia.org)
  • When the immune system is imbalanced, either due to overly-active cells or cells that suppress its function, it causes a wide range of diseases, from psoriasis to cancer. (medicalxpress.com)
  • Immunotherapies designed to elicit or amplify an immune response are classified as activation immunotherapies, while immunotherapies that reduce or suppress are classified as suppression immunotherapies. (wikipedia.org)
  • Efficacy
  • Advancing immune science will lead to new approaches to investigate the biological mechanisms of disease and functional properties of foods to better determine and predict the efficacy and safety of emerging products," said Mike Luther of the DHMRI. (centerwatch.com)
  • cells
  • The phenomenon of immune tolerance was first described by Ray D. Owens in 1945, who noted that dizygotic twin cattle sharing a common placenta also shared a stable mixture of each other's red blood cells (though not necessarily 50/50), and retained that mixture throughout life. (wikipedia.org)
  • Still, the placental barrier is not the sole means to evade the immune system, as foreign fetal cells also persist in the maternal circulation, on the other side of the placental barrier. (wikipedia.org)
  • Myeloid cells, innate lymphoid cells, and the cytokines they secrete cooperate to maintain immune tolerance in the gut. (sciencemag.org)
  • Epigenetic analysis of immune cells is performed at Epiontis GmbH, a biotechnology company located in Berlin, Germany. (immunetolerance.org)
  • Lack of goblet cells abrogates conjunctival mucosal tolerance. (jci.org)
  • This material is then displayed to other cells of the immune system. (wikipedia.org)
  • In 1882, he studied motile (freely moving) cells in the larvae of starfishes, believing they were important to the animals' immune defenses. (wikipedia.org)
  • This prevents recognition and destruction of self host cells, making it a type of negative selection or central tolerance. (wikipedia.org)
  • The biggest weakness in Burnet's theory was that he had no explanation for how the body selected for immune cells that only identified non-self. (wikipedia.org)
  • Topical immunotherapy utilizes an immune enhancement cream (imiquimod) which produces interferon, causing the recipient's killer T cells to destroy warts, actinic keratoses, basal cell cancer, vaginal intraepithelial neoplasia, squamous cell cancer, cutaneous lymphoma, and superficial malignant melanoma. (wikipedia.org)
  • He reasoned, the immune system would be able to play a factor via a 'bystander effect' in eradicating chemotherapy-resistant cancer cells. (wikipedia.org)
  • However, extensive research is still needed on how the immune response is triggered against dying tumour cells. (wikipedia.org)
  • The suppressing and tolerance-inducing effect of Tr1 cells is mediated mainly by cytokines. (wikipedia.org)
  • mechanism
  • This is the same mechanism used by parasitic nematodes to avoid detection by the immune system of their host. (wikipedia.org)
  • Researchers have identified a brain mechanism that could be a drug target to help prevent tolerance and addiction to opioid pain medication, such as morphine, according to a study by Georgia State University and Emory University. (medicalxpress.com)
  • Thus, we propose that SOCS1 and PGE2, potentially interacting together, act as an alternative intestinal tolerance mechanism distinct from IL-10 and Tregs. (sigmaaldrich.com)
  • tumors
  • Cancer immunosurveillance and immunoediting are based on protection against development of tumors in animal systems and (ii) identification of targets for immune recognition of human cancer. (wikipedia.org)
  • tolerogenic
  • The goals of this Collaborative Network are to: (1) design a long-term research agenda to accelerate the application of tolerogenic approaches for the treatment of multiple immune system diseases, including autoimmune diseases, asthma and allergic diseases, and graft rejection on solid organ, cell and tissue transplantation. (nih.gov)
  • Therefore, the study proposed is a laboratory investigation (using blood samples collected from the subjects) comparing immune tolerance and alloreactivity profiles in LT recipients on monotherapy IS or converted to rapamycin monotherapy, to determine tolerogenic properties of the different IS agents. (clinicaltrials.gov)
  • These dietary changes, which appear to be providing less tolerogenic conditions during early immune programming, may provide important avenues for preventing disease. (diva-portal.org)
  • organ
  • This study is being done with the purpose of trying to understand if and why transplant recipients may develop tolerance to their transplanted organ. (clinicaltrials.gov)
  • Tolerance means being able to lower or take away immunosuppression (anti-rejection medications) without causing organ rejection. (clinicaltrials.gov)
  • rejection
  • Many cases of spontaneous abortion may be described in the same way as maternal transplant rejection, and a chronic insufficient tolerance may cause infertility. (wikipedia.org)
  • Since individuals almost always have different "banks" of HLAs, the immune system of the recipient recognizes the transplanted tissue as non-self and destroys the foreign tissue, leading to transplant rejection. (wikipedia.org)
  • fetus
  • It is believed that the ancestors of modern viviparous mammals evolved after an infection by this virus, enabling the fetus to better resist the immune system of the mother. (wikipedia.org)
  • The placenta does not block maternal IgG antibodies, which thereby may pass through the human placenta, providing immune protection to the fetus against infectious diseases. (wikipedia.org)
  • Tregs
  • Additionally, we find an essential role for prostaglandin E2 (PGE2) in the maintenance of tolerance within the intestine in the absence of Tregs. (sigmaaldrich.com)
  • fetal
  • This is done so that the fetal rhesus D positive erythrocytes are destroyed before the immune system of the mother can discover them and become sensitized. (wikipedia.org)
  • allergic
  • Here, we explore the effects of key perinatal dietary exposures on immune development and susceptibility to allergic disease. (diva-portal.org)
  • describe
  • Though some pathogens can evolve to become less virulent in host-pathogen coevolution, tolerance does not refer to the change in the pathogen, but can be used to describe the changes in host physiology. (wikipedia.org)
  • diseases
  • The David H. Murdock Research Institute (DHMRI) has acquired the Immune Tolerance Institute (ITI) as part of the North Carolina-based Institute's mission to accelerate the discovery and development of breakthrough treatments for a range of immune-related diseases. (centerwatch.com)
  • cell
  • Adaptive Biotechnologies performs immune profiling of T cell and B cell receptors using ImmunoSEQ technology. (immunetolerance.org)
  • The Rutgers University Cell & DNA Repository serves as the Immune Tolerance Network's Central Cell Isolation Facility. (immunetolerance.org)
  • CONCLUSIONS Although nasal insulin did not retard loss of residual β-cell function in adults with established T1D, evidence that it induced immune tolerance to insulin provides a rationale for its application to prevent diabetes in at-risk individuals. (diabetesjournals.org)
  • disease
  • Adults with recent-onset T1D in whom the disease process is subacute afford an opportunity to determine whether mucosal insulin induces tolerance to insulin subsequently injected for treatment. (diabetesjournals.org)
  • treatment
  • Margaret Petroff believes that decoding additional secrets to immune tolerance could lead to treatment breakthroughs for a variety of conditions. (msu.edu)
  • Margaret Petroff, an associate professor in the Department of Pathobiology and Diagnostic Investigation at Michigan State University (MSU), believes that decoding additional secrets to immune tolerance could lead to treatment breakthroughs for a variety of conditions. (msu.edu)