HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. (wikipedia.org)
Cell-mediated immune2
Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. (mdpi.com)
filovirus vaccine research efforts still need to determine the roles of humoral and cell-mediated immune responses in protection from ebola virus infection. (liverpool.ac.uk)
Hematopoietic3
This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. (lookformedical.com)
Tumor2
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
Lymphatic system2
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. (lookformedical.com)
Peritoneal stomata constitute the principal pathways for the drainage of intraperitoneal contents from the PERITONEAL CAVITY to the LYMPHATIC SYSTEM. (bvsalud.org)
Cells2
Evidence from animal models shows that T cells can provide heterosubtypic protection and are crucial for immune control of influenza virus infections. (mdpi.com)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
Infection2
While it is not clear what role A1 has in infectious disease, some linkage with infection rates in HIV remain associated within the A1 region of the haplotype. (wikipedia.org)
A1 with B8 showed an increase risk of measles infection, however, the significance was not consistent. (wikipedia.org)
Infectious diseases1
Within the early studies, A1 was found associate with or protected against some infectious diseases. (wikipedia.org)
Minor2
CD8 + CTL clones recognizing minor H antigens were isolated from five patients studied. (aacrjournals.org)
Our identification of the first non-human primate-specific minor histocompatibility antigen now published at Frontiers in Immunology. (wisc.edu)
Group2
For A1, the alpha "A" chain are encoded by the HLA-A*01 allele group and the β-chain are encoded by B2M locus. (wikipedia.org)
Group A has 15 serotypes, group B has 8 serotypes, group C has 19 serotypes, and group D has 1 serotype. (medscape.com)
Study2
A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
Early in the study of HLA an association was found between HL A1,B8 in allergic disease, these are found to link to extended HLA A1-B8 region. (wikipedia.org)
Common1
A1 is more common in Europe than elsewhere, it is part of a long haplotype that appears to have been frequent in the ancient peoples of Northwestern Europe. (wikipedia.org)
Studies1
Because of its linkage within the AH8.1 haplotype many studies showed association with A1 or A1,B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. (wikipedia.org)
Antibody5
The serotype is determined by the antibody recognition of α1 subset of HLA-A α-chains. (wikipedia.org)
A1-B58 haplotype (A1-B17 where B58 is dominant) may remain associated with anti-neutrophil cytoplasmic antibody (ANCA) With the exception of type 1 diabetes, most of the evidence for direct association of A1 with autoimmune diseases evaporated as DR3 and DQ2 genes were characterized. (wikipedia.org)
The spectrum of antibody deficiency is broad, ranging from decreased total IgG levels to normal IgG levels and from primary B-cell defects to combined immunodeficiencies with antibody abnormalities associated with other immune and often nonimmune abnormalities. (medscape.com)
Although this article discusses agammaglobulinemia and hypogammaglobulinemia, the emphasis is on selective Ig deficiencies, including the decreased production of IgA and the various IgG subclasses and impaired antibody responses to specific antigens such as polysaccharide proteins present on certain bacteria. (medscape.com)
Methods: PWH from a previous population-based study, the Botswana Prevention Combination Project, which enrolled adults in 30 communities across Botswana (2013-2018), were screened for HBV surface antigen (HBsAg) and HBV core antibody (anti-HBc). (bvsalud.org)
Alleles3
Because of its linkage within the AH8.1 haplotype many studies showed association with A1 or A1,B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. (wikipedia.org)
In all instances so far, HLA-A1 has been found to be linked to disease by association, but there are few that define HLA-A1 has a predominant genetic risk relative to other gene-alleles in the vicinity of the A1 gene on the larger haplotype. (wikipedia.org)
HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy. (nih.gov)
Positivity2
A1 serotype positivity is roughly linked to a large number of inflammatory diseases and conditions believed to have immune system involvement. (wikipedia.org)
hence, a normal HBV serology profile is characterized by HBV surface antigen (HBsAg) and anti-HBc positivity. (bvsalud.org)
Allele3
For A1, the alpha "A" chain are encoded by the HLA-A*01 allele group and the β-chain are encoded by B2M locus. (wikipedia.org)
High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD). (nih.gov)
Association between the HLA-DQA1 rs1391371 risk allele and chronic rhinosinusitis. (nih.gov)
Peptide1
4. A peptide must associate with a given MHC of that individual, otherwise no immune response can occur. (slideshare.net)
Antibodies3
The importance of IgG-subclass deficiency is reflected in the isotypes of IgG antibodies produced against microbial antigens. (medscape.com)
Antibodies against pneumococcal polysaccharide antigens are predominantly IgG2 and, to a lesser degree, IgG4. (medscape.com)
A1 is more common in Europe than elsewhere, it is part of a long haplotype that appears to have been frequent in the ancient peoples of Northwestern Europe. (wikipedia.org)
A1 is a frequent component of the AH8.1 haplotype. (wikipedia.org)
While it is not clear what role A1 has in infectious disease, some linkage with infection rates in HIV remain associated within the A1 region of the haplotype. (wikipedia.org)
While type 1 diabetes shows an extended association on the HLA A1-B8-DR3-DQ2 haplotype, the association appears not to extend beyond the HLA-B locus. (wikipedia.org)
Some diseases found associated with A1 actually link to the extended A1-B8 haplotype, viral induced hepatitis and accelerated progression of HIV are examples. (wikipedia.org)
The A1-B8-DR3-DQ2 haplotype has a known association with Enteropathy-associated T-cell lymphoma, approximately 70% of patients are homozygotes for DQ2 with at least one copy of DR3-DQ2. (wikipedia.org)
In this report, we described clinical findings, long-term treatment outcomes, and the HLA haplotype in TINU cases. (hindawi.com)
Microglobulin1
Urinary β 2 microglobulin level and HLA typing may help in the diagnosis of TINU. (hindawi.com)
PMID1
PMID- 669647 TI - System cuts red tape for patients from admission to discharge. (nih.gov)
Proteins1
It plays a central role in the immune system by presenting peptides derived from extracellular proteins. (nih.gov)
11 The control of transplantation, autoimmunity, and the other immune responses are the phenotypic consequences of the function of molecules encoded in the MHC. (slideshare.net)
Genes2
A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
Antigens encoded by the genes in the group II took part in the rejection of transplanted tumors and other tissues. (slideshare.net)
Autoimmune2
Other concomitant immune defects may be required to increase the risk for respiratory and GI infections and various autoimmune diseases frequently described in patients with IgA deficiency. (medscape.com)
We believe that selenium treatment might lower TPOAb titer through reducing oxidative tension, which is served being a potential root system of inhibiting thyroid autoimmune response in the introduction of AIT. (cancer-ecosystem.com)
Risk3
A1 with B8 showed an increase risk of measles infection, however, the significance was not consistent. (wikipedia.org)
Most of the disease risk conferred by A*01:01 are represented by either A1 serotype risks, or A1-B8 serotype risk (In Europe A1-B8 is almost always composed of A*01:01 and B*08:01). (wikipedia.org)
We used Behavioral Risk Factor Surveillance System data to compare these trends with trends among non-Hispanic Whites and non-Hispanic Blacks in the United States and in the 10 states where REACH communities were located, and with a propensity score-matched national sample of non-Hispanic Blacks. (cdc.gov)
Association3
Early in the study of HLA an association was found between HL A1,B8 in allergic disease, these are found to link to extended HLA A1-B8 region. (wikipedia.org)
An association between A1 and cold sores was also described. (wikipedia.org)
Association of HLA-DQ Heterodimer Residues -18β and β57 With Progression From Islet Autoimmunity to Diabetes in the Diabetes Prevention Trial-Type 1. (nih.gov)
Chain1
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. (nih.gov)
Include2
The associations rapidly expanded to include 'HL-A8' HLA-B8, as the HLA A1 and B8 were found to be commonly linked. (wikipedia.org)
These concomitant immune defects may include deficiencies of certain IgG subclasses or of mannose-binding lectin (MBL). (medscape.com)
Present1
The present invention is drawn to a next generation nano vaccine platform by using structure- based design to utilize the conserved or less variable or highly immunogenic domains or epitopes and displaying it in a nano cage and produces it in as nanoparticle protein in prokaryotic expression system. (sumobrain.com)
Result2
With rubella, A1-B8 was more frequently found in people infected as a result of maternal transference. (wikipedia.org)
of foreign tissue is the result of an immune response to cell-surface molecules. (slideshare.net)
Central1
Cryptococcal meningitis (CM) is the leading cause of central nervous system (CNS) fungal infections in humans, with the majority of cases reported from the African continent. (frontiersin.org)
Patients1
AB - One hospital's personalized admitting system is staffed by business representatives who perform a variety of liaison activities to ease patients' nonmedical experience in the hospital. (nih.gov)