• concentrations
  • We assessed the association between indicators of swimming in a chlorinated pool and changes in serum immune marker concentrations using linear regression with bivariate normal distributions and adjusted for multiple comparisons by applying the Benjamini-Hochberg procedure. (uu.nl)
  • innate
  • In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. (wikipedia.org)
  • In 1895 Bordet made his discovery that the bacteriolytic effect of acquired specific antibody is significantly enhanced in vivo by the presence of innate serum components which he termed alexine (but which are now known as complement). (wikipedia.org)
  • mice
  • In seven separate experiments, nude (nu/nu) mice carrying established murine sarcoma virus (MSV) tumours were reconstituted with syngeneic (+/+) immune splenic T cells. (springer.com)
  • These immune protected mice were randomly divided to provide smaller groups for serial exsanguination. (springer.com)
  • At various time points mice were individually bled and CIC concentration and blocking activity of each individual serum was determined. (springer.com)
  • Control sera were obtained from nu/nu and adult +/+ mice inoculated with tumour cells only, and from nu/nu mice protected with normal +/+ spleen cells. (springer.com)
  • On the other hand, in immune protected mice considered alone or together with the control groups, CIC and time after tumour cell inoculation, but not tumour size, were significantly correlated. (springer.com)
  • A significant relationship between blocking and tumour size was also established, although this only applied to immune protected mice. (springer.com)
  • However, analysis of the combined data from sequentially bled immune protected mice in relation to different phases of tumour behaviour, did not support the notion that blocking, and more particularly the persistence of CIC, contribute to tumour regrowth and dissemination. (springer.com)
  • A) 50, 200 or 500 µl DENV2 E85-VRP-immune serum (from AG129 mice immunized i.p. 14 and 5 days prior to serum collection) were transferred i.v. into naïve AG129 recipient mice one day prior to challenge with 5×108 GE DENV. (nih.gov)
  • To assess whether the protective effect of the DENV2 E85-VRP immunization was mediated by serum, 50 µl, 200 µl or 500 µl of serum from AG129 mice immunized 14 and 5 days earlier with 1×106 IU of DENV2 E85-VRP were injected i.v. into naïve AG129 recipient mice one day prior to challenge with 5×108 GE DENV. (nih.gov)
  • As transfer of naïve serum had no effect on the viral load, we concluded that Ab present in the serum of immunized mice had caused ADE. (nih.gov)
  • but these immune serums, when given intraperitoneally in large amounts to susceptible mice that had been implanted subcutaneously with lymphoma cells of one or another of several types, failed entirely to inhibit growth of the lymphoma cells in vivo . (rupress.org)
  • Statistically significant alterations were observed in protein fractions of sera and peritoneal fluids of Ehrlich ascites tumor-bearing mice and mice immunized to this tumor when they were compared to normal mice. (aacrjournals.org)
  • However, their probable direct participation in the humoral destruction of tumor cells at their growth site in the immune mice is correlated. (aacrjournals.org)
  • Inflammation
  • The serum-induced genes have been associated with processes relevant to wound healing, including genes directly involved in remodeling the clot and extracellular matrix, as well as genes encoding signal proteins for inflammation, the development of new blood vessels, and regrowth of epithelial tissue. (wikipedia.org)
  • Cytokine
  • CONCLUSIONS: Our study indicates that swimming in a chlorinated pool induces perturbations of the immune response through acute alterations of patterns of cytokine and chemokine secretion. (uu.nl)
  • immunity
  • Hellstrom, I. , and Hellstrom, K. E. , 1969, Studies on cellular immunity and its serum-mediated inhibition in Moloney virus-induced mouse sarcomas. (springer.com)
  • Severe dengue disease is associated with sub-protective levels of antibody, which exacerbate disease upon re-infection.A dengue vaccine should generate protective immunity without increasing severity of disease.This study explores the immunological basis of protection induced by a dengue vaccine and suggests that a safe and efficient vaccine against dengue should trigger both arms of the immune system. (nih.gov)
  • Emil von Behring and Kitasato Shibasaburō demonstrate passive immunity, protection of animals from infection by injection of immune serum (1890). (wikipedia.org)
  • Although not intending to address any aspect of immunity at the start of their experiment, these researchers observed that the expression profiles of serum-stimulated fibroblasts were far richer than anticipated and suggested an important physiological role for fibroblasts in healing wounds. (wikipedia.org)
  • patterns
  • Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. (wikipedia.org)
  • For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions. (wikipedia.org)
  • vivo
  • In comparative tests, furthermore, the anti-lymphoma serums acted more powerfully upon the lymphoma cells in vivo than did such chemotherapeutic agents as amethopterin, azaguanine, ethionine, azaserine, and 6-mercaptopurine, given singly or in various combinations in maximal tolerated amounts, though their effects were not so powerful as those exerted by normal guinea pig serum on lymphoma cells of two types that are susceptible to its action in vivo . (rupress.org)
  • fetal
  • Serum α-fetoprotein (AFP) is a fetal glycoprotein produced by the yolk sac and fetal liver 1 that is routinely used as a marker of hepatocellular carcinoma in subjects with chronic liver diseases. (lww.com)
  • This is done so that the fetal rhesus D positive erythrocytes are destroyed before the immune system of the mother can discover them and become sensitized. (wikipedia.org)
  • adult
  • however, their presence in the bloodstream causes little to no immune response until death or degradation of the microfilariae or adult worms. (wikipedia.org)
  • normal
  • Intravenous administration of anti-alpha-rANP antiserum caused an obvious rise of mean blood pressure and cardiac output in both SHR and WKY compared with rats administered with normal rabbit serum. (biomedsearch.com)
  • On the other hand, significant reductions in urine output and urinary sodium and potassium excretion lasted for approximately 20 min after administration of the antiserum in both SHR and WKY compared with rats administered with normal rabbit serum. (biomedsearch.com)
  • reaction
  • It would be unlikely that the antibody would be reacting specifically with the plate and any non-specific reaction should be happening with your negative sera too. (protocol-online.org)
  • serum sickness syndrome a serum sickness-like hypersensitivity reaction occurring after the administration of certain drugs. (thefreedictionary.com)
  • cDNA
  • were some of the first to recognize the potential of cDNA microarrays to define gene expression of immune cells. (wikipedia.org)
  • As a result, they designed the "Lymphochip" cDNA microarray, which contained 13,000 genes and was enriched for genes of importance to the immune system. (wikipedia.org)
  • response
  • Serum α-Fetoprotein Levels Predict Early Virologic Response. (lww.com)
  • 8 To date, no study has evaluated the association between serum AFP levels and early virologic response (EVR) to anti-HCV treatment in the HIV-positive population. (lww.com)
  • Symptoms are caused by the microfilariae and the immune response to infection, rather than the adults themselves. (wikipedia.org)
  • Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. (wikipedia.org)
  • that is, the whole pathogenic peptide sequence is not necessary to initiate an immune response. (wikipedia.org)
  • fraction
  • The sera contained immunosuppresive factors associated with the immunoglobulin fraction, which could depress the natural killer cell activity of healthy controls. (bmj.com)
  • cells
  • The term usually refers to blood serum, the clear, straw-colored, liquid portion of the plasma that does not contain fibrinogen or blood cells, and remains fluid after clotting of blood. (thefreedictionary.com)
  • It has revealed that some of the immune system's most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. (wikipedia.org)
  • Four years later, in 1899, he described a similar destructive process involving complement, "hemolysis", in which foreign red blood cells are ruptured or "lysed" following exposure to immune serum. (wikipedia.org)
  • growth
  • Usually, the starting point is a crude, heterogeneous group of molecules in a whole cell extract, such as a cell lysate, growth medium or blood serum. (wikipedia.org)
  • presence
  • One control group received 1.5 ml naïve serum (500 µl 3, 2 and 1 day prior to challenge), another control group received no serum and was infected in the presence of anti-DENV Ab (ADE) and the last control group received no serum and was infected in the presence of an isotype control Ab of irrelevant specificity (baseline). (nih.gov)
  • As controls, one group received 1500 µl naïve serum (500 µl on day -3, -2, -1) and two groups received no serum and were challenged either in the absence or presence of exogenous anti-DENV Ab (baseline and ADE groups). (nih.gov)
  • system
  • This study explores the immunological basis of protection induced by a dengue vaccine and suggests that a safe and efficient vaccine against dengue should trigger both arms of the immune system. (nih.gov)
  • We hypothesized a potential pathway involving modulation of the immune system. (uu.nl)
  • recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. (wikipedia.org)
  • Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. (wikipedia.org)
  • significantly
  • Serum IL-7 and IL-8 were significantly higher in the severe CFS/ME group compared with healthy controls and moderate CFS/ME patients. (medsci.org)
  • Viral RNA levels in the liver were significantly higher in all groups that had received DENV2 E85-VRP-immune serum compared to the baseline group. (nih.gov)
  • Journal
  • Thought you might appreciate this item(s) I saw at JAIDS Journal of Acquired Immune Deficiency Syndromes. (lww.com)
  • patients
  • Hardcastle SL, Brenu EW, Johnston S, Nguyen T, Huth T, Ramos S, Staines D, Marshall-Gradisnik S. Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients. (medsci.org)
  • Consecutive serum samples were obtained from patients with syphilis before and on three occasions after treatment. (bmj.com)
  • Study
  • He also took part in the development in the first immune serum against the bubonic plague (black pest), in collaboration with the discoverer of its pathogenic agent, Yersinia pestis, by Alexandre Yersin (1863-1943), and went to Portugal to study and to help fight an epidemic at Oporto. (wikipedia.org)
  • cell
  • Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. (wikipedia.org)