• complement
  • Evaluation of Pasteurella multocida serotype B:2 resistance to immune serum and complement system', Veterinary Research Forum , 8(3), pp. 179-184. (iranjournals.ir)
  • In the present study, the possible bactericidal activity of immune calf sera in the presence and absence of complement system was investigated. (iranjournals.ir)
  • The results showed that P. multocida B:2 is highly resistant to positive serum, containing high levels of IgG and IgM obtained from calves after vaccination, and complement activity in normal fresh calf serum. (iranjournals.ir)
  • As a control test an E. coli strain was subjected to the same experiment and found completely sensitive to the bactericidal activity of complement in calf and guinea pig fresh sera. (iranjournals.ir)
  • Results were indicative of the presence of inhibitory mechanism(s) in P. multocida B:2 against bactericidal activity of immune calf serum and complement system. (iranjournals.ir)
  • The destructive effects of fresh serum on gram-negative bacteria is assumed to be one of the consequences of the activity of host complement system. (iranjournals.ir)
  • 13 These polysaccharidic components are widely used for bacterial classification, responsible for non-immunological and immunological interactions of bacteria with hosts and also involved in the avoidance of host innate immune mechanisms-such as resistance to phagocytosis, complement-mediated killing, and the bactericidal activity of antimicrobial peptides. (iranjournals.ir)
  • In 1895 Bordet made his discovery that the bacteriolytic effect of acquired specific antibody is significantly enhanced in vivo by the presence of innate serum components which he termed alexine (but which are now known as complement). (wikipedia.org)
  • Four years later, in 1899, he described a similar destructive process involving complement, "hemolysis", in which foreign red blood cells are ruptured or "lysed" following exposure to immune serum. (wikipedia.org)
  • innate immune
  • Compromises to innate immune cell functioning can interfere with, or reflect, adaptive processes and translate into shifts in cytokine patterns that are either pro- or anti-inflammatory [ 11 ]. (medsci.org)
  • In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. (wikipedia.org)
  • Vaccine
  • Severe dengue disease is associated with sub-protective levels of antibody, which exacerbate disease upon re-infection.A dengue vaccine should generate protective immunity without increasing severity of disease.This study explores the immunological basis of protection induced by a dengue vaccine and suggests that a safe and efficient vaccine against dengue should trigger both arms of the immune system. (nih.gov)
  • Vaccine-induced humoral responses had the potential to either protect from or exacerbate dengue disease upon challenge, whereas cellular immune responses were beneficial. (nih.gov)
  • This study explores the immunological basis of protection induced by a dengue vaccine and suggests that a safe and efficient vaccine against dengue should trigger both arms of the immune system. (nih.gov)
  • Cytokine
  • CONCLUSIONS: Our study indicates that swimming in a chlorinated pool induces perturbations of the immune response through acute alterations of patterns of cytokine and chemokine secretion. (uu.nl)
  • guinea pig
  • In comparative tests, furthermore, the anti-lymphoma serums acted more powerfully upon the lymphoma cells in vivo than did such chemotherapeutic agents as amethopterin, azaguanine, ethionine, azaserine, and 6-mercaptopurine, given singly or in various combinations in maximal tolerated amounts, though their effects were not so powerful as those exerted by normal guinea pig serum on lymphoma cells of two types that are susceptible to its action in vivo . (rupress.org)
  • mice
  • In seven separate experiments, nude (nu/nu) mice carrying established murine sarcoma virus (MSV) tumours were reconstituted with syngeneic (+/+) immune splenic T cells. (springer.com)
  • These immune protected mice were randomly divided to provide smaller groups for serial exsanguination. (springer.com)
  • Control sera were obtained from nu/nu and adult +/+ mice inoculated with tumour cells only, and from nu/nu mice protected with normal +/+ spleen cells. (springer.com)
  • On the other hand, in immune protected mice considered alone or together with the control groups, CIC and time after tumour cell inoculation, but not tumour size, were significantly correlated. (springer.com)
  • A significant relationship between blocking and tumour size was also established, although this only applied to immune protected mice. (springer.com)
  • However, analysis of the combined data from sequentially bled immune protected mice in relation to different phases of tumour behaviour, did not support the notion that blocking, and more particularly the persistence of CIC, contribute to tumour regrowth and dissemination. (springer.com)
  • A) 50, 200 or 500 µl DENV2 E85-VRP-immune serum (from AG129 mice immunized i.p. 14 and 5 days prior to serum collection) were transferred i.v. into naïve AG129 recipient mice one day prior to challenge with 5×108 GE DENV. (nih.gov)
  • To assess whether the protective effect of the DENV2 E85-VRP immunization was mediated by serum, 50 µl, 200 µl or 500 µl of serum from AG129 mice immunized 14 and 5 days earlier with 1×106 IU of DENV2 E85-VRP were injected i.v. into naïve AG129 recipient mice one day prior to challenge with 5×108 GE DENV. (nih.gov)
  • As transfer of naïve serum had no effect on the viral load, we concluded that Ab present in the serum of immunized mice had caused ADE. (nih.gov)
  • but these immune serums, when given intraperitoneally in large amounts to susceptible mice that had been implanted subcutaneously with lymphoma cells of one or another of several types, failed entirely to inhibit growth of the lymphoma cells in vivo . (rupress.org)
  • adult
  • however, their presence in the bloodstream causes little to no immune response until death or degradation of the microfilariae or adult worms. (wikipedia.org)
  • cellular
  • Hellstrom, I. , and Hellstrom, K. E. , 1969, Studies on cellular immunity and its serum-mediated inhibition in Moloney virus-induced mouse sarcomas. (springer.com)
  • The company states on its scientific studies page that it's proprietary complex Alasta (made from the aloe vera plant rind) activates NF-Kappa B , which they say stimulates the immune system on a cellular level. (truthinaging.com)
  • chicken
  • 9 However, lesions have also been reported in chickens infected by serum-sensitive strains 10 and the relationship between virulence and serum resistance is complicated in the chicken. (iranjournals.ir)
  • strain
  • 6 In P. multocida serotype A, the causative agent of fowl cholera, it has been shown that a virulent strain was resistant to turkey serum while an avirulent strain was serum-susceptible. (iranjournals.ir)
  • snake
  • He also developed the first antivenom for snake venom, the Calmette's serum. (wikipedia.org)
  • In 1894, he came back to France again and develop the first antivenoms for snake bites using immune sera from vaccinated horses (Calmette's serum). (wikipedia.org)
  • system
  • We hypothesized a potential pathway involving modulation of the immune system. (uu.nl)
  • This is done so that the fetal rhesus D positive erythrocytes are destroyed before the immune system of the mother can discover them and become sensitized. (wikipedia.org)
  • Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. (wikipedia.org)
  • recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. (wikipedia.org)
  • Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. (wikipedia.org)
  • As a result, they designed the "Lymphochip" cDNA microarray, which contained 13,000 genes and was enriched for genes of importance to the immune system. (wikipedia.org)
  • reaction
  • It would be unlikely that the antibody would be reacting specifically with the plate and any non-specific reaction should be happening with your negative sera too. (protocol-online.org)
  • serum sickness syndrome a serum sickness-like hypersensitivity reaction occurring after the administration of certain drugs. (thefreedictionary.com)
  • presence
  • One control group received 1.5 ml naïve serum (500 µl 3, 2 and 1 day prior to challenge), another control group received no serum and was infected in the presence of anti-DENV Ab (ADE) and the last control group received no serum and was infected in the presence of an isotype control Ab of irrelevant specificity (baseline). (nih.gov)
  • As controls, one group received 1500 µl naïve serum (500 µl on day -3, -2, -1) and two groups received no serum and were challenged either in the absence or presence of exogenous anti-DENV Ab (baseline and ADE groups). (nih.gov)
  • cDNA
  • were some of the first to recognize the potential of cDNA microarrays to define gene expression of immune cells. (wikipedia.org)
  • levels
  • Viral RNA levels in the liver were significantly higher in all groups that had received DENV2 E85-VRP-immune serum compared to the baseline group. (nih.gov)
  • significantly
  • Serum IL-7 and IL-8 were significantly higher in the severe CFS/ME group compared with healthy controls and moderate CFS/ME patients. (medsci.org)
  • processes
  • The serum-induced genes have been associated with processes relevant to wound healing, including genes directly involved in remodeling the clot and extracellular matrix, as well as genes encoding signal proteins for inflammation, the development of new blood vessels, and regrowth of epithelial tissue. (wikipedia.org)
  • patients
  • Hardcastle SL, Brenu EW, Johnston S, Nguyen T, Huth T, Ramos S, Staines D, Marshall-Gradisnik S. Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients. (medsci.org)
  • Consecutive serum samples were obtained from patients with syphilis before and on three occasions after treatment. (bmj.com)
  • patterns
  • Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. (wikipedia.org)
  • For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions. (wikipedia.org)
  • results
  • 7,8 Similar results have been reported by other studies and serum resistance has been considered as a tool to assess the virulence in FC-associated strains. (iranjournals.ir)
  • Study
  • He also took part in the development in the first immune serum against the bubonic plague (black pest), in collaboration with the discoverer of its pathogenic agent, Yersinia pestis, by Alexandre Yersin (1863-1943), and went to Portugal to study and to help fight an epidemic at Oporto. (wikipedia.org)
  • role
  • Although not intending to address any aspect of immunity at the start of their experiment, these researchers observed that the expression profiles of serum-stimulated fibroblasts were far richer than anticipated and suggested an important physiological role for fibroblasts in healing wounds. (wikipedia.org)
  • blood cells
  • The term usually refers to blood serum, the clear, straw-colored, liquid portion of the plasma that does not contain fibrinogen or blood cells, and remains fluid after clotting of blood. (thefreedictionary.com)
  • five
  • I was chosen as one of ten reviewers for the Dare To Try It and one of five that received the serum and cream for Sustainable Youth's all-natural and brand new line (the other half received the cream and supplements). (truthinaging.com)
  • growth
  • Usually, the starting point is a crude, heterogeneous group of molecules in a whole cell extract, such as a cell lysate, growth medium or blood serum. (wikipedia.org)