Immune response humans murine acquired immunodeficiency syndrome. Medical search. Frequent questions

Necrotizing Tenon's capsule infection in a lymphopenic Down syndrome patient following strabismus surgery. (ucla.edu)
A hyperinflammatory 'cytokine storm' state termed macrophage activation syndrome (MAS), culminating from a complex interplay of genetics, immunodeficiency, infectious triggers and dominant innate immune effector responses, can develop across disparate entities including systemic juvenile idiopathic arthritis (sJIA) and its counterpart adult-onset Still disease (AOSD), connective tissue diseases, sepsis, infection, cancers and cancer immunotherapy. (nature.com)
Many scenarios, including infection, aberrant immunity, cancer and cancer immunotherapy, are associated with cytokine storm, also known as cytokine release syndrome (CRS) or hypercytokinaemia. (nature.com)
Due to high zoonotic potential and the risk of infection via shared marine food resources, these findings may also indicate potential health threats for other animals and humans. (frontiersin.org)
In intermediate hosts, T. gondii tachyzoites spread systemically, often causing subclinical infection in healthy animals and humans. (frontiersin.org)
For individuals surviving initial infection, T. gondii tachyzoites respond to the host immune response by converting to bradyzoite-filled tissue cysts in the central nervous system, muscles, and other tissues. (frontiersin.org)
People commonly use L. acidophilus for diarrhea from antibiotics, as well as irritable bowel syndrome (IBS), overgrowth of bacteria in the vagina, and an infection caused by the bacteria Helicobacter pylori (H. pylori). (medlineplus.gov)
These recommendations update the interim guidelines (1) developed by the U.S. Public Health Service for the use of zidovudine (ZDV) to reduce the risk for perinatal transmission of human immunodeficiency virus (HIV) infection. (cdc.gov)
Acquired Immunodeficiency Syndrome ( AIDS ) is a deficiency of cellular immunity brought on by infection with the human immunodeficiency virus (HIV-1) and characterized by a range of opportunistic diseases and infections. (mpkb.org)
Such opportunistic infection proliferate in the absence of a robust immune response. (mpkb.org)
HIV is a viral infection, and AIDS is the syndrome, which results - according to the Marshall Pathogenesis - in a dysregulated vitamin D metabolism. (mpkb.org)
However, certain populations are at an increased risk of severe shigellosis infection, including children in daycare, incarcerated persons, international travelers, homosexual men, people infected with human immunodeficiency virus (HIV), and those who live in crowded, unsanitary conditions. (medscape.com)
Infectious causes of glomerulonephritis included streptococcal infections, human immunodeficiency virus (HIV) infection, and hepatitis viral infections, both hepatitis C (HCV) and hepatitis B (HBV). (medscape.com)
Vaccine strategies that concentrate on stimulating T cell immunity will at best generate reactive and persisting T cell responses that can suppress virus without preventing infection, limiting or preventing the damage the virus cause. (scielo.br)
The rapid destruction of these cells due to HIV-1 infection makes the infected individual immune-compromised and prone to several opportunistic infections. (openaccesspub.org)
The primary immunologic abnormality resulting from infection by human immunodeficiency virus (HIV) is the progressive depletion and functional impairment of T lymphocytes expressing the CD4 cell surface glycoprotein. (justia.com)
The immune system could play a crucial role in virus infection. (medsci.org)
The successful development and implementation to intervene prevention and treatment of virus infection over the past hundred years have had great advances on human and animal health. (medsci.org)
The critical role of the immune system has been found in the discovery that there are reported high morbidity and mortality rates of human CoV infection in immunocompromised host as well as patients with comorbidities [ 3 - 6 ]. (medsci.org)
Human Immunodeficiency Virus Type I (HIV-1) infection is associated with a high incidence of B-cell lymphomas. (biomedcentral.com)
Human Immunodeficiency Virus Type I (HIV-1) infection is associated with an elevated incidence of B-cell non-Hodgkin's lymphoma (NHL) and in recent years also with Hodgkin's lymphoma [ 1 ]. (biomedcentral.com)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour. (bioseek.eu)
The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
Infection with human immunodeficiency virus (HIV) commonly results in neurologic disease called the AIDS dementia complex. (ox.ac.uk)
The simian immunodeficiency virus (SIV)-infected macaque is an excellent animal model for HIV infection, but neuronal loss has not been demonstrated. (ox.ac.uk)
As opposed to almost every other lentiviruses, such as for example human immunodeficiency trojan (HIV)-1, simian immunodeficiency trojan (SIV) and feline immunodeficiency trojan (FIV), which need co-receptors for effective an infection, EIAV seems to depend just on an operating ELR1 for the invasion of focus on cells. (angiogenesis-blog.com)

Here, we describe HIV-1 Env Fab-dimerized glycan (FDG)-reactive bnAbs without VH-swapped domains from simian-human immunodeficiency virus (SHIV)-infected macaques. (bvsalud.org)
1H magnetic resonance spectroscopy reveals neuronal injury in a simian immunodeficiency virus macaque model. (ox.ac.uk)

Zidovudine (AZT), the most popular of the AIDS medications, was originally developed for chemotherapy in cancer, but due to its toxicity it was never approved for human use (3). (robertogiraldo.com)
As a result, en end-stage AIDS patients levels of 1,25-D approach zero. (mpkb.org)
It is the etiologic agent of the acquired immunodeficiency syndrome (AIDS) that targets the CD4 + T-lymphocyte cells of the human immune system 1 . (openaccesspub.org)
The loss of CD4 helper/inducer T cell function probably underlies the profound defects in cellular and humoral immunity leading to the opportunistic infections and malignancies characteristic of the acquired immunodeficiency syndrome (AIDS) (Lane et al. (justia.com)
The attributed higher incidence is primarily due to an increase in the acquired immunodeficiency syndrome (AIDS) population, cancer, and diabetic patients. (encyclopedia.pub)
Murine models for human AIDS-related B cell lymphomas have been lacking. (biomedcentral.com)
1. AIDS: Acquired immune deficiency syndrome Acquired immunodeficiency syndrome 2. (cdc.gov)
AIDS-like syndrome: AIDS-like disease (illness) (syndrome) ARC AIDS-related complex Pre-AIDS AIDS-related conditions Prodromal-AIDS 3. (cdc.gov)

On June 6, 1994, the U.S. Public Health Service convened a workshop in Bethesda, Maryland, to develop recommendations for the use of zidovudine to reduce the risk for perinatal transmission of human immunodeficiency virus (HIV). (cdc.gov)
Worldwide, perinatal (i.e., mother-to-infant) transmission accounts for most human immunodeficiency virus (HIV) infections among children. (cdc.gov)
External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. (lookformedical.com)
Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. (lookformedical.com)
Viral co-infections (including Epstein-Barr virus, Human Herpes Virus 6, etc.) are found in all the diseases the Marshall Protocol treats, but the viruses are not believed to bethe proximate cause of disease. (mpkb.org)
Anti-HIV-1 T cell responses are evaded by continuous mutation of the virus. (scielo.br)
Human Immunodeficiency Virus Type-1 (HIV-1) belongs to the retroviridae family and to the Lentivirus genus. (openaccesspub.org)
This relates to the field of human immunodeficiency virus (HIV), specifically to the use of α4 integrin antagonists for the treatment of HIV infections. (justia.com)
Cellular factors regulate transactivation of human immunodeficiency virus type 1. (microbiologyresearch.org)
Cytotoxic effect on lymphocytes of Tat from human immunodeficiency virus (HIV-1). (microbiologyresearch.org)
Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines. (microbiologyresearch.org)
Human immunodeficiency virus Vpr product is a virion-associated regulatory protein. (microbiologyresearch.org)
Natural HIV-1 Nef accelerates virus replication in primary human lymphocytes. (microbiologyresearch.org)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
For this reason, the infect humans, this virus can infect cordance between humans and ex- question about tumour site concor- several other species - including perimental animals. (who.int)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)
These in vitro, and their expression in these human tumour virus. (who.int)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
These vectors contained strong enhancers as part of the long terminal repeat (LTR) of the Moloney murine leukemia virus (MLV) retroviral backbone. (europeanhealthjournal.com)

Chediak-Higashi syndrome (CHS) is a rare, autosomal recessive congenital immunodeficiency caused by mutations in CHS1 , a gene encoding a putative lysosomal trafficking protein. (biomedcentral.com)
Animal models of human BTK mutations are confined to mice at this time. (medscape.com)
Murine gene mutations in human counterparts may be associated with a clinical illness different from the illness seen in mice. (medscape.com)

Human monoclonal antibodies are characterized to study the humoral immune response in these disorders. (umassmed.edu)
The effect of graded amounts of dietary lactalbumin (L) and casein (C) hydrolyzates on the immune responsiveness of C3H/HeN and DBA/2 strain mice has been investigated by measuring both the specific humoral immune response to sheep red blood cells (SRBC) and the nonspecific splenic cell responsiveness to phytohemagglutinin, concanavalin A and Escherichia coli lipopolysaccharide after stimulation with Mycobacteriurn bovis, strain BCG. (immunehealthscience.com)
In the C-fed mice, a comparable enhancement of mitogen responsiveness with increasing amino acid level of diet was seen, but there was no change in the humoral immune response. (immunehealthscience.com)
The humoral immune response of mice fed C, S, and W diets was substantially lower than that of mice fed stock diet, whereas that of mice fed L diet was higher. (immunehealthscience.com)
The effect of 20 g/100 g diet of lactalbumin (L), casein (C), soy (S) and wheat (W) protein on the immune responsiveness of C3H/HeN mice has been investigated by measuring the humoral immune response to the T cell-independent antigen, TNP-Ficoll. (immunehealthscience.com)
The humoral immune response of mice fed the L diet was found to be higher than that of mice fed the C, S and W diets. (immunehealthscience.com)

TYK2 deficiency has more dramatic effects in human cells than in mouse cells. (wikipedia.org)
Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene therapy. (europeanhealthjournal.com)

T cells play essential effectors and regulatory roles in adaptive immune responses to tumors, viruses, bacteria, parasites, transplanted tissues, allergens and even to self antigens. (bcm.edu)
Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). (lookformedical.com)
Proteins synthesized by HUMAN IMMUNODEFICIENCY VIRUSES such as the HIV-1 and HIV-2 . (lookformedical.com)
These results show that LMP1 , mour viruses classified by IARC in EBV-specific T-cell response. (who.int)

Some probiotics have caused blood infections in a small number of people with weakened immune systems. (medlineplus.gov)
Panax ginseng is also used for depression , anxiety , general fatigue and chronic fatigue syndrome (CFS), multiple sclerosis , for boosting the immune system, and for fighting particular infections in a lung disease called cystic fibrosis. (emedicinehealth.com)
We collaborate with Drs. Greiner, Brehm and Luban here at UMMS and Dr. Leonard Schultz at Jackson Laboratories on humanized mouse models for the generation of human monoclonal antibodies and as models for passive immunotherapy for bacterial or viral infections. (umassmed.edu)
The laboratory has also been involved in pharmacokinetic and pharmacodynamic studies of IgG and IgA human monoclonal antibodies, in several bacterial and viral infections. (umassmed.edu)
When activation of the peripheral immune system continues unabated, such as during systemic infections, cancer or autoimmune diseases, the ensuing immune signalling to the brain can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals. (bioseek.eu)
Analysis of microbial populations showed the effects of immune reconstitution, including normalization of gut microbiota and clearance of viral infections. (europeanhealthjournal.com)
[ 1 ] Such infections that begin in male infants as maternal IgG antibodies, acquired transplacentally, are lost. (medscape.com)
Chlamydia are bacteria that cause disease in humans, including sexually transmitted infections (STIs), and infections of the eyes and respiratory tract. (msdmanuals.com)

Classifying MAS using the immunological disease continuum model, with strict boundaries that define the limits of innate and adaptive immunity, at one boundary is MAS with loss of immune function, as occurs in the 'perforinopathies' and some cases of sJIA-AOSD. (nature.com)
Considering the boundaries of immunodeficiency and immune hypersensitivity in MAS related to systemic juvenile idiopathic arthritis and adult-onset Still disease, and the role of lymphoid cells, severe COVID-19 is generally a distinctive lung-specific immunopathology. (nature.com)
Many cutaneous disorders experienced by patients undergoing dialysis have little to do with the uremic syndrome and are related to the same underlying pathologic process that caused the renal disease. (medscape.com)
The distinction between acquired and inherited disease may present a clinical challenge, but more than 80% of cases are acquired. (medscape.com)
It is an immune-mediated disease characterized by the presence of recurrent fever (of unknown origin) and other autoinflammatory features such as mouth ulcers and headaches [ 10 ]. (biomedcentral.com)
Not only do we generate new human monoclonal antibodies for our studies, but also for a large number of laboratories throughout the world for research on infectious diseases, cancer and autoimmune disease. (umassmed.edu)
the disease caused by the cognate cel s from human cord blood. (who.int)
Non-human primates (NHPs) can sustain viral replication in relevant cell types and develop a robust immune response, but they do not develop overt disease. (mdpi.com)
In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
Humanized mouse models can sustain DENV replication and show some signs of disease, but further development is needed to validate the immune response. (mdpi.com)
Note that some writers refer to the typhoid and paratyphoid fever as distinct syndromes caused by the typhi versus paratyphi serovars, while others use the term typhoid fever for a disease caused by either one. (medscape.com)
May be seen in more serious systemic and local illnesses together with SuttonвЂ™s illness, BechetвЂ™ s disease, ReiterвЂ™s syndrome, leukopenias, CrohnвЂ™s disease and ulcerative colitis (see index). (ehd.org)
Ataxia telangiectasia (AT) is a rare autosomal recessive disease, characterised by cerebella ataxia, immunodeficiency, increased sensitivity to ionising radiation, and a predisposition to malignancies, especially lymphoid neoplasms. (bmj.com)
Type 1 diabetes is an autoimmune disease characterized by T cell-dependent and -mediated chronic inflammatory response that destroys pancreatic insulin-producing beta cells resulting with hyperglycemia and metabolic disturbances. (magnusgroup.org)
Bruton agammaglobulinemia (see the image below) was the first primary immunodeficiency disease to be described. (medscape.com)
Mouse models have milder disease than humans. (medscape.com)

that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
Moreover, the brain contains immune cells, such as macrophages and dendritic cells, which are present in the choroid plexus and meninges. (bioseek.eu)

DHEA and DHEAS (an active, sulfated form of DHEA), are endogenous hormones secreted by the adrenal cortex in primates and a few non-primate species in response to ACTH. (medilabcompounding.com)

The antibody response to HIV-1 in vivo is direct against several viral proteins. (scielo.br)
The expertise at MassBiologics, particularly in the areas of Discovery and Process Development, has allowed rapid production of SARS CoV-2 proteins (including several spike proteins and N protein) and human antibodies and nanobodies , contributing to the evaluation and development of therapeutics and diagnostics. (umassmed.edu)
The above-described immune effect of all tested proteins was obtained at 20 g/100 g concentration with no further increments with 30- and 40 g/100 g protein in the diet. (immunehealthscience.com)
8 , 9 The protein is a member of a novel family of large proteins, which show sequence homology to the catalytic domain of phosphatidylinositol 3 kinase, 3 and are implicated in cell cycle regulation, signal transduction, and the response to DNA damage. (bmj.com)

Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. (wikipedia.org)
A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES), a primary immunodeficiency characterized by elevated serum immunoglobulin E. TYK2 appears to play a central role in the inflammatory cascade responses in the pathogenesis of immune-mediated inflammatory diseases such as psoriasis. (wikipedia.org)
SCID-X1 gene therapy results in reconstitution of the previously lacking T cell compartment, allowing analysis of the roles of T cell immunity in humans by comparing before and after gene correction. (europeanhealthjournal.com)
SCID-X1 gene therapy thus provides a unique opportunity to study the consequences of T cell function in previously deficient human subjects. (europeanhealthjournal.com)
The human gene, CHS1 , was originally called LYST for lysosomal trafficking regulator gene ( LYST , OMIM #606897). (biomedcentral.com)

Thereafter, some patients progressing on ipilimumab showed systemic responses only upon receiving radiation to one lesion, confirming clinically the proimmunogenic effects of radiation. (aacrjournals.org)

Abstract: Escherichia coli are remarkably versatile microorganisms and important members of the normal intestinal microbiota of humans and animals. (preprints.org)

One of the key mechanisms that HIV fosters immune dysfunction is through completely taking over the VDR and interfering with D-binding protein. (mpkb.org)
Full length human recombinant protein of human SAMHD1(NP_056289) produced in HEK293T cell. (novusbio.com)
The era of immune checkpoint blockers (ICB), which started in 2011 with the approval of an antibody targeting cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells (namely, ipilimumab) for the treatment of metastatic melanoma ( 1 ), has brought a new paradigm to cancer therapy whereby the immune system is being harnessed to cure the cancer. (aacrjournals.org)
In contrast, classical immune (type I/ II) cytokine receptors do not have intrinsic protein kinase activity but associate with the Janus family of kinases (JAKs). (openrheumatologyjournal.com)
Our data indicate that it was possible to increase the level of this type of protein in the diet above the minimum requirement (12% LAH) and thus produce augmented humoral immune responsiveness and resistance to salmonellosis. (immunehealthscience.com)
The enhancement of immune responsiveness observed in mice fed the 28% L diet was moderately reduced by the addition of phenylalanine to the diet, indicating that the lower level of this amino acid in the L protein may be of some significance. (immunehealthscience.com)
Little difference in immune responses was noted among mice fed C, S or W protein diets. (immunehealthscience.com)
The principal factor responsible for the observed immune effect does not appear to be the availability or concentration of single essential amino acids but rather the composite effect of the specific amino acid distribution in the protein. (immunehealthscience.com)

In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)

FDG Abs also recognized cell-surface glycans on diverse pathogens, including yeast and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike. (bvsalud.org)
Pneumonia caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is spreading globally. (medsci.org)
In the past dozen years, the outbreak of the novel coronavirus is the third on record spillover of an animal coronavirus to humans after occurring of severe acute respiratory syndrome (SARS) started in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2014, which is resulting in a pandemic in global. (medsci.org)
A minority of these cases progress to clinical forms which is with one or more severe complications, such as acute respiratory distress syndrome (ARDS) that is potentially fatal [ 1 , 2 ]. (medsci.org)

However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)

Although TYK2−/− mice are phenotypically normal, they exhibit abnormal responses to inflammatory challenges in a variety of cells isolated from TYK2−/− mice. (wikipedia.org)
Although NK precursors and immature NK cells have been identified in mice and humans, the precise sites where NK cell maturation take place are not yet fully defined. (scielo.br)
In the present study we investigated the effect of four weeks of treatment with a diet containing lactalbumin hydrolysate (LAH: Nestlé, Vevey, Switzerland) on the immune response of C3H/HeN mice. (immunehealthscience.com)
The immune responses of mice fed the L diets were found to be significantly greater than those of mice fed the corresponding C diets, especially at the 28% level. (immunehealthscience.com)
Furthermore in the mice fed L diet, increasing the concentration of amino acid in the diet from 12 to 28% greatly enhanced immune responsiveness by both parameters measured. (immunehealthscience.com)
The immune response of mice fed the L diets, was found to be almost five times higher than that of mice fed the corresponding C diets. (immunehealthscience.com)

Also, we show that our patient had a good response after 1 year of treatment with low doses of intravenous immunoglobulin and colchicine. (biomedcentral.com)

Lactobacillus acidophilus (L. acidophilus) is a type of probiotic ("good" bacteria) found in the human gut, mouth, and vagina, and also in certain foods. (medlineplus.gov)

NK cells coordinate tumor immunosurveillance and the immune response against pathogens. (scielo.br)

Under physiological conditions, immune cells are, in general, regulated by the action of many cytokines and it has become clear that cross-talk between different cytokine-signalling pathways is involved in the regulation of the JAK-STAT pathway. (wikipedia.org)
Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. (mdpi.com)
Insights into how this effector-immunity pairing alters the physiological responses of the recipient organism might provide opportunities relating to the T6SS agricultural and biotherapeutic applications. (preprints.org)

In humans, AZT magnifies the risk of lymphomas by 50 (17). (robertogiraldo.com)
Similar to human HAL, Tg lymphomas are preceded by diffuse lymphadenopathy and increased pro-inflammatory serum cytokines. (biomedcentral.com)

To the best of our knowledge, there are no previous reports of acute disseminated encephalomyelitis and optic neuritis preceded by autoinflammation, triggered by periodic fever syndrome. (biomedcentral.com)
We report on a case of acute disseminated encephalomyelitis with optic neuritis and periodic fever syndrome in a 12-year-old Ecuadorian Hispanic boy with several relapses over the past 10 years, always preceded by autoinflammatory manifestations and without evidence of infectious processes. (biomedcentral.com)
Comparison of Acute and Chronic Toxicity Laboratory Bioassay Endpoints with Benthic Community Responses in Field-Exposed Contaminated Sediments. (yale.edu)

This loss and gain of function MAS model offers immune cartography for a novel mechanistic classification of MAS with therapeutic implications. (nature.com)
Possible additive effects of herb and drug allow sparing of drug, reduction of drug side effects, and enhanced therapeutic responses. (interactionsguide.com)
This therapeutic strategy has benefited many patients and in addition provides a unique window to study mechanisms associated with immune reconstitution. (europeanhealthjournal.com)

T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human leukocyte antigens) in humans. (bcm.edu)
Cytokines play pivotal roles in immunity and inflammation by regulating the survival, proliferation, differentiation, and function of immune cells, as well as cells from other organ systems. (wikipedia.org)
We studied the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated HIV-1 envelope (Env) as a model antigen. (bvsalud.org)
AZT is highly toxic to human cells, including T4 lymphocytes, at the "antiretroviral" dosage recommended by the manufacturer (12). (robertogiraldo.com)
There are also very well documented investigations showing that AZT has carcinogenic properties with respect to fast growing human and animal immune and other cells (12). (robertogiraldo.com)
Although macrophage activation syndrome (MAS) is often termed autoinflammatory in both loss and gain of function phenotypes, adaptive lineage cells, especially T cells, are clearly important in both settings. (nature.com)
We also analyzed CD38 expression on the surface of memory CD8+ T cells as a robust marker of immune activation. (mpkb.org)
However, clear evidence for functional NK cell subsets exists in humans and the presence of NK cells in the thymus and immature NK cells in the liver suggests specific functions for NK cells in the tissues. (scielo.br)
In an excellent issue, J.P. Di SANTO focuses on murine NK cells, although parallels to human NK cell biology are also made. (scielo.br)
1 In humans, glucocorticoid receptors have been shown in many different cells, including those of the granulocyte-macrophage lineage and lympho cytes. (bmj.com)

It might make auto-immune diseases worse. (webmd.com)
This harmless commensal organism can acquire a mixture of comprehensive mobile genetic elements that contain genes encoding viru-lence factors, becoming an emerging human pathogen capable of causing a broad spectrum of intestinal and extraintestinal diseases. (preprints.org)
This review summarizes new de-velopments in our understanding of diverse virulence factors associated encoding genes used by different pathotypes of enteric pathogenic E. coli to cause intestinal and extraintestinal diseases in humans. (preprints.org)

Neurotrophins and immune mediators in the human brain. (neurotree.org)

The proposed model for MAS immune heterogeneity and cellular topography can be applied to understanding other hyper-inflammatory conditions. (nature.com)
Moreover, vitamin D increase upon supplementation was associated with a reduction in cellular immune activation levels (Fig. 1c). (mpkb.org)
We also found that serum levels of vitamin D and the expression of the cellular immune activation markers were inversely correlated in this longitudinal setting (Fig. 1d). (mpkb.org)
Vitamin D status appears therefore to impact on cellular immune activation levels. (mpkb.org)
The molecular links between the cellular response to radiotherapy and type I IFN secretion are just being uncovered. (aacrjournals.org)

Here, we describe a patient diagnosed as having ADEM-ON who also presented with familial cold autoinflammatory syndrome (FCAS) for whom we used whole exome sequencing (WES) to dissect possible variants in a non-HLA set of genes that could explain the patient's clinical features (immunological and neurological). (biomedcentral.com)

If you have a weakened immune system, talk with your healthcare provider before taking probiotics, including L. acidophilus. (medlineplus.gov)
Panax ginseng seems to increase the activity of the immune system . (webmd.com)
Dendritic cell as sentinel of the immune system plays an irreplaceable role. (medsci.org)
From inflammation to sickness and depression: when the immune system subjugates the brain. (bioseek.eu)
The brain and the immune system communicate through different pathways. (bioseek.eu)
The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins. (mdpi.com)
Ear drops?AutoPap: Computer-assisted cytology interpretation system?AV: Aortic valve?AV: Atrioventricular?A-V: Arteriovenous?AVERT: Atorvastatin Versus Revascularization treatment?AVID: ?AVM: Arteriovenous Malformation?AVNRT: AV nodal reentry tachycardia?AVP: Arginine vasopressin?AVR: Aortic valve replacement?AVR: Augmented V lead, right arm (ECG)?AVRT: ?AVS: Arteriovenous shunt?AWS: Alcohol withdrawal syndrome?AXR: Abdominal X ray?AZF: Azoospermia factor genes?AZT: Azidothymidine (zidovudine)?B & O: Belladonna and opium?B Bx. (kuwaitpharmacy.com)

However, a significant contributing factor is the deceptively poor inflammatory response seen in the absence of antibodies. (medscape.com)

Capsule?CAPD: Continuous ambulatory peritoneal dialysis?Caps: Capsules?CAPS: Cryopyrin-Associated Periodic Syndromes disorders?CAPTIA Syph G: ?CAPTIA Syph M: ?CAST: Cardiac arrhythmia suppression trials?CAT: Computerized axial tomography?Cataplasm. (kuwaitpharmacy.com)

In this study, we used several high throughput sequence-based methods to analyze samples from the SCID-X1 trials, with the goal of probing immune mechanisms and the resulting effects on microbial communities. (europeanhealthjournal.com)

Response likely to depend on multiple factors, including diet and patient characteristics. (interactionsguide.com)

Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia (see the image below). (medscape.com)

Increasing response to sexual stimuli in healthy people. (webmd.com)
By using a combination of optogenetics, in vivo electrophysiology, and machine learning analysis, we find that a subset of neurons in the ACC receives S1 inputs, and activation of the S1 axon terminals increases the response to noxious stimuli in ACC neurons. (iasp-pain.org)

Pathologic Study of Supernumerary Orbital Band in Type I Duane Syndrome. (ucla.edu)

Nowadays the MHC Tetramer technique has become a "gold standard" for the quantification of T cell immune responses. (bcm.edu)
Conversely, at the other boundary, immune hypersensitivity with gain of immune function in MHC class II-associated sJIA-AOSD and with chimeric antigen receptor (CAR) T cell therapy also triggers MAS. (nature.com)
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) (also known as CD152) is a major negative regulator of T cell responses which interacts with the B7-1 (CD80) / B7-2 (CD86) ligands on the surface of an antigen-presenting cell. (scielo.br)

Anatomy26

Organisms28

Diseases47

Chemicals and Drugs77

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Psychiatry and Psychology4

Phenomena and Processes46

Information Science6

Named Groups1

Health Care12

Geographicals1

Infection27

Simian2

AIDS8

Virus20

Mutations3

Humoral immune r6

Deficiency2

Viruses4

Infections8

Disease16

Macrophages2

PRIMATE1

Proteins4

Gene5

Systemic1

Abstract1

Protein8

Species1

Severe4

Transgenic1

Mice6

Immunoglobulin1

Bacteria1

Pathogens1

Physiological3

Lymphomas2

Acute3

Therapeutic3

Cells10

Diseases3

Mediators1

Cellular5

Autoinflammatory1

System7

Inflammatory1

Disorders1

Mechanisms1

Factors1

Peripheral1

Stimuli2

Type1

Cell3