Immune response chimeric vaccines subunit. Medical search. Frequent questions

These findings demonstrate the potential efficacy of fusion protein rGB as a candidate subunit vaccine and showed the development of memory response and functional role of antibodies in protection against Brucella infections. (journalcra.com)
The use of a plant biotechnology-based expression system for vaccine production also represents one part of this international effort, which is to develop plant-based heterologous expression systems, virus-like particles (VLPs)-vaccines, antiviral drugs, and a rapid supply of antigen-antibodies for detecting kits and plant origin bioactive compounds that boost the immunity and provide tolerance to fight against the virus infection. (encyclopedia.pub)
Our results suggest a possible effect of non- env HIV-1 genes on the interaction of Env and neutralizing antibodies and highlight the need to generate a library of IMCs representative of the HIV-1 subtype spectrum to be used as standardized neutralization assay reagents for assessing HIV-1 vaccine efficacy. (plos.org)
2. Tomana M, Novak J, Julian BA, Matousovic K, Konecny K, Mestecky J. Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. (southernbiotech.com)
Evaluation of naturally acquired IgG antibodies to a chimeric and non-chimeric recombinant species of Plasmodium vivax reticulocyte binding protein-1: lack of association with HLA-DRB1*/DQB1* in malaria exposed individuals from the Brazilian Amazon. (southernbiotech.com)
Subunit, DNA and vectored vaccine candidates have been developed using this glycoprotein as the primary antigen, demonstrating that gD has the capacity to induce robust virus neutralizing antibodies and strong cell-mediated immune responses, as well as protection from clinical symptoms, in target species. (biomedcentral.com)
Antiviral activities of antibodies may either be dependent only on interactions between the antibody and cognate antigen, as in binding and neutralization of an infectious virion, or instead may require interactions between antibody-antigen immune complexes and immunoproteins or Fc receptor expressing immune effector cells. (frontiersin.org)
We propose that additional investigation into the role of ADCP in protective viral responses, the specific virus epitopes targeted by ADCP antibodies, and the types of phagocytes and Fc receptors involved in ADCP at sites of virus infection will provide insight into strategies to successfully leverage this important immune response for improved antiviral immunity through rational vaccine design. (frontiersin.org)
Antibodies are a key component of the human adaptive immune system, and the elicitation of antibodies has been correlated with vaccine efficacy in many diseases ( 1 ). (frontiersin.org)
Chimeric antibodies consist of an antibody's original antigen-binding variable domain with the constant domain from a different species. (absoluteantibody.com)
Below are several articles illustrating the use of chimeric rabbit IgG antibodies to expand the usefulness of classic research clones. (absoluteantibody.com)
The laboratory has ongoing collaborations with academic and biopharmaceutic partners to develop vaccines and monoclonal antibodies for human use against COVID-19, Lyme disease, pertussis, tetanus, Salmonella, cholera, and ricin toxin. (wadsworth.org)
Crystal structures of ricin toxin's enzymatic subunit (RTA) in complex with neutralizing and non-neutralizing single-chain antibodies. (wadsworth.org)
The synthesis and applications of the peptides are gaining increasing popularity as a result of the developments in biotechnology and bioengineering areas and for a number of research purposes including cancer diagnosis and treatment, antibiotic drug development, epitope mapping, production of antibodies, and vaccine design. (intechopen.com)
Chimeric, Human and Humanized Anti-CSAP Monoclonal Antibodies - The present invention provides humanized, chimeric and human anti-CSAp antibodies and anti-CSAp antibody fusion proteins that are useful for the treatment and diagnosis of various cancers, including colon cancer. (patentsencyclopedia.com)
Further, in particular embodiments, the chimeric virus has a different immunological profile than one or both of the parent viruses (i.e., is only weakly or not at all recognized by neutralizing antisera or antibodies against the parent virus), thereby allowing for administration to subjects that have antibodies directed against the parent virus or repeat administration following administration of another serotype. (justia.com)
VLPs are highly immunogenic and can induce elevated titers of neutralizing antibodies, even without adjuvants, thanks to the maintenance of the native conformation of viral proteins presenting repetitive epitopes to the host immune system cells. (nature.com)
During this SARS-CoV-2 pandemic, many studies on the development of plant-derived vaccines and antibodies are underway. (nature.com)
This allows the transformation of undifferentiated immune cells into the active B or T cell types that are ready to make antibodies (B-cells) or fight infection (T-cells). (thetenpennyreport.com)

Dengvaxia is a chimeric vaccine made using recombinant DNA technology by replacing the PrM (pre-membrane) and E (envelope) structural genes of the yellow fever attenuated 17D strain vaccine with those from the four dengue serotypes. (wikipedia.org)
Immune reactivity of Brucella melitensis-vaccinated rabbit serum with recombinant Omp31 and DnaK proteins. (ijmedrev.com)
Immunogenic response to a recombinant pseudorabies virus carrying bp26 gene of Brucella melitensis in mice. (ijmedrev.com)
In the present study, a recombinant chimeric protein rGB contriving immunologically active regions of Gapdh and bvrS from B. abortus S19 was constructed, cloned and expressed in E. coli host cell. (journalcra.com)
The VANIR trial is a global, randomized, double-blind Phase 3 trial of the recombinant MVA-BN RSV vaccine in 20,000 adults aged 60 years and older. (pipelinereview.com)

There are other vaccine candidates in development including live attenuated, inactivated, DNA and subunit vaccines. (wikipedia.org)
CYD-TDV, sold under the brand name Dengvaxia and made by Sanofi Pasteur, is a live attenuated tetravalent vaccine that is administered as three separate injections, with the initial dose followed by two additional shots given six and twelve months later. (wikipedia.org)
This vaccine is a live attenuated B. pertussis strain delivered nasally in order to mimic the natural route of infection. (frontiersin.org)
This comprises of inactivated viruses, messenger RNA (mRNA), DNA vaccines, protein subunits, nonreplicating and replicating vector viral-like particles (VLP), and live attenuated vaccines. (springeropen.com)
In this study, the efficacy of inactivated and live-attenuated (2 × 10 3.5 or 2 × 10 4.0 50 % tissue culture infective dose [TCID 50 ] dose) chimeric PCV1-2b vaccines was compared side-by-side in conventional pigs. (biomedcentral.com)
Both inactivated and live-attenuated chimeric PCV1-2b vaccines induced a robust antibody responses, and significantly decreased microscopic lesion and lower viral loads in serum or superficial inguinal lymph nodes (SILN) compared with that in the nonvaccinated challenged group. (biomedcentral.com)
PCV2 antibody titers decreased after 7 days post challenge (DPC) in pigs administered the inactivated PCV1-2b vaccine and they were lower than those in pigs inoculated with live-attenuated PCV1-2b on the day of necropsy. (biomedcentral.com)
Moreover, no viremia was present in pigs inoculated with live-attenuated PCV1-2b vaccine at 21 DPC regardless of the dose difference. (biomedcentral.com)
The results demonstrated that both inactivated and live-attenuated chimeric PCV1-2b vaccines were effective to induce protective immunity against PCV2b infection. (biomedcentral.com)

These protein subunits can assemble into virus particles without viral RNA genome in mammalian cells to study virus-cell entry 2 and to develop vaccines 3 . (nature.com)

However, many challenges remain, including: the emergence of vaccine-resistant mutant viruses, vaccine stability during storage and transport, waning vaccine-induced immunity, and concerns about infrequent adverse events associated with existing vaccines. (bvsalud.org)
FINDINGS: Each formulation of the RBD-Fc vaccines drove strong neutralising antibody (nAb) responses and provided durable and highly protective immunity against lower and upper airway infection in mouse models of COVID-19. (bvsalud.org)
Development of dengue vaccines began in the 1920s, but was hindered by the need to create immunity against all four dengue serotypes. (wikipedia.org)
As these resident memory T cells are long lived, vaccines that are able to induce them should provide long-lasting immunity. (frontiersin.org)
As of today, only one vaccine designed to induce potent mucosal immunity is in clinical development. (frontiersin.org)
Several reasons may account for this resurgence, including faster waning of immunity through acellular compared to whole-cell vaccines and potential strain adaptation to escape vaccine-induced immunity ( 9 ). (frontiersin.org)
Vaccines are critical in boosting immunity, lowering COVID-19-related illnesses, reducing the infectious burden on the healthcare system, and reducing economic loss, according to current data. (springeropen.com)
Protective anti-influenza immunity often correlates with antibody responses to influenza surface glycoproteins, particularly hemagglutinin (HA), the main antigenic determinant on the surface of both influenza virus and infected cells. (researchsquare.com)
In view of its role in the induction of protective immunity, gD has been tested in new vaccine development strategies against both viruses. (biomedcentral.com)
Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice. (wadsworth.org)
The trial included a revaccination of subjects after one year, following which the immune responses were rapidly and significantly increased, notably in subjects with the weakest immunity prior to the booster vaccination 3 . (pipelinereview.com)
Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines. (thetenpennyreport.com)

The role of non-viral antigens in the cotton rat model of respiratory syncytial virus vaccine-enhanced disease. (southernbiotech.com)
The recognition of antigens by immune cells is a crucial step in tumor-specific killing, and neoantigens generated by mutations in cancer cells possess high immunogenicity and are selectively expressed in tumor cells, making them an attractive therapeutic target. (techscience.com)
The mRNA vaccines can encode multiple antigens, strengthening the immune response against pathogens and enabling the targeting of multiple microbial variants [19] . (researchgate.net)
The vaccine incorporates five distinct RSV antigens to stimulate a broad immune response against both RSV subtypes (A and B), thus mimicking the immune response observed following a natural response to an RSV infection. (pipelinereview.com)
Although the assembled VLPs do not have S protein spikes, they could be developed as formulations that can improve the immunogenicity of vaccines including S antigens, and further could be used as platforms that can carry S antigens of concern for various mutations. (nature.com)
Moreover, VLPs offer interesting biotechnological advantages as they can serve as scaffolds for presenting heterologous antigens capable of inducing immune responses against other infectious diseases. (nature.com)

Thus far, there is no experimental or clinical evidence that any vaccine will be able to completely prevent HIV infection. (aerzteblatt.de)
Even if vaccines do not prevent infection, a vaccine strategy that reduces the viral load and thus transmission and slows down the disease process would be epidemiologically useful and probably feasible. (aerzteblatt.de)
In May 2019, Dengvaxia was approved in the United States as the first vaccine approved for the prevention of dengue disease caused by all dengue virus serotypes (1, 2, 3 and 4) in people ages nine through 16 who have laboratory-confirmed previous dengue infection and who live in endemic areas. (wikipedia.org)
In 2017, the manufacturer recommended that the vaccine only be used in people who have previously had a dengue infection, as outcomes may be worsened in those who have not been previously infected. (wikipedia.org)
Bahador A, Esmaeili D, Mansoori N, Mahdavi M. Protection against Brucella abortus 544 Strain Infection in BALB/c Mice by Subcutaneouse Administration of Multicomponent Vaccine of rCagA Conjugated with LPS + CpG. (ijmedrev.com)
Influenza viral vectors expressing the Brucella OMP16 or L7/L12 proteins as vaccines against B. abortus infection. (ijmedrev.com)
Despite of extensive research, till now no licensed vaccines are available against Brucella infection for human application. (journalcra.com)
Epidemiological and experimental evidence has shown that the vaccines fail to prevent B. pertussis infection and transmission, although they are very effective in preventing disease. (frontiersin.org)
In contrast to vaccination, natural infection in humans and experimental infections in animals induce strong secretory IgA responses in the naso-pharynx and in the lungs. (frontiersin.org)
Furthermore, studies in mouse models have revealed that B. pertussis infection, but not immunization with current acellular pertussis vaccines induces resident memory T cells, which may also contribute to protection against colonization by B. pertussis . (frontiersin.org)
In addition, it will allow researchers to have enough time to develop fast testing kits and treatments that limit the infection and the candidate vaccine to immunize the population. (encyclopedia.pub)
Recent advances in the understanding of antimycobacterial immune response have led to descriptions of predisposing conditions to dissemination of nontuberculous mycobacteria (NTM) infection. (cdc.gov)
The recurrent NTM infection led us to investigate her immune status. (cdc.gov)
Immunoglobulin-specific responses to Chlamydia elementary bodies in individuals with and at risk for genital chlamydial infection. (southernbiotech.com)
both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. (nature.com)
Using this approach, we characterized CoV infection mediated by the SHC014 spike protein in primary human airway cells and in vivo , and tested the efficacy of available immune therapeutics against SHC014-CoV. (nature.com)
It is recommended that mRNA COVID-19 vaccines should be offered to individuals 6 months of age and older with previous SARS-CoV-2 infection without contraindications to the vaccine. (canada.ca)
Vaccine-induced antibody and T cell responses correlated with protection against lethal influenza virus infection. (researchsquare.com)
Moreover, antibody responses induced by influenza virus vaccines are usually short-lived and less cross-reactive against antigenically drifted virus variants than those induced by a natural influenza virus infection 1 . (researchsquare.com)
Additionally, vaccine-induced neutralizing antibody titers diminish over time, thereby affecting the extent of protection against infection during an entire influenza season and the subsequent seasons. (researchsquare.com)
DNAM-1 Activating Receptor and Its Ligands: How Do Viruses Affect the NK Cell-Mediated Immune Surveillance during the Various Phases of Infection? (torvergata.it)
VLPs self-assembled into empty shells can be used safely as vaccines without the risk of replication or infection due to the lack of viral nucleic acid. (nature.com)
Vaccines for Human Papillomavirus Infection and Anogenital Disease. (edu.au)

INTERPRETATION: These results demonstrated that an RBD-Fc protein subunit/MF59® adjuvanted vaccine can induce high levels of broadly reactive nAbs, including when used as a booster following prior immunisation of mice with whole ancestral-strain spike vaccines. (bvsalud.org)
Therefore, there is an urgent need for a better cost-effective influenza vaccine which can induce antigenically broader and long-lasting immune response. (researchsquare.com)
This optimism is built on recently published studies demonstrating the efficacy of mRNA vaccines in combatting several types of cancer and infectious pathogens where conventional vaccine platforms may fail to induce protective immune responses. (researchgate.net)

T cell receptors (TCRs) can specifically recognize KRAS mutant neoantigens presented by human lymphocyte antigen (HLA) and mediate T cell responses to eliminate tumor cells. (bvsalud.org)
This study details the benefit of adjuvants that target multiple innate immune receptors to shape the host vaccine response. (researchsquare.com)
IgG2a also engages in high affinity interactions with Fc receptors on immune cells which can result in antibody-dependent cell-mediated cytotoxicity (ADCC) as well as antibody-dependent cellular phagocytosis (ADCP) by phagocytosing cells like macrophages 3-8 . (researchsquare.com)
solid course="kwd-title" Keywords: bispecific T-cell engager (BiTE), chimeric antigen receptors (Vehicles), gene-modified adoptive T-cell transfer, Atractylodin T-cell tumor therapy, tumor-specific epitope Intro Tumor cells communicate different epitopes and proteins on the surface area that differentiate them from healthful cells, either by degrees of manifestation or by uncovering novel epitopes not really seen in regular self. (techieindex.net)

Immune checkpoint therapy, which is based on modulation of T cell reactivity, has achieved breakthrough in clinical treatment of multiple tumors. (bvsalud.org)
Immune therapy has tremendously changed the scenario of clinical tumor treatment and become critical strategies for treating multiple tumors. (bvsalud.org)
This vaccine platform offers a potential approach to augment some of the currently approved vaccines in the face of emerging variants of concern, and it has now entered a phase I clinical trial. (bvsalud.org)
Several vaccine candidates are currently undergoing clinical evaluation. (aerzteblatt.de)
Basic and clinical research institutions in Germany are increasingly involved in HIV vaccine development. (aerzteblatt.de)
The company is involved in approximately 18% of clinical trials related to mRNA vaccines being applied to oncology. (biospace.com)
Currently, 102 candidate vaccines are in clinical trials, and 185 candidate vaccines are in preclinical trials [ 3 ] . (encyclopedia.pub)
Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines. (mdpi.com)
Efficacy data from a Phase III clinical trial conducted across 11 sites in 7 African countries in children (aged 5 to 17 months) and infants (aged 6-12 weeks) revealed that the vaccine conferred moderate protective efficacy against clinical disease and severe malaria which waned over time [ 2 ]. (biomedcentral.com)
The vaccine conferred only 36.3% protection against clinical malaria and 32.2% against severe malaria in children aged 5-17 months who received 3 primary doses of RTS,S with a booster in the 20th month [ 2 ]. (biomedcentral.com)
These clinical considerations provide information to healthcare professionals and public health officials on use of COVID-19 vaccines. (cdc.gov)
COPENHAGEN, Denmark I April 20, 2022 I Bavarian Nordic A/S (OMX: BAVA) announced today the dosing of the first subject in the Phase 3 VANIR clinical trial of its investigational respiratory syncytial virus (RSV) vaccine candidate, MVA-BN ® RSV in older adults. (pipelinereview.com)
Over one hundred vaccines using varied approaches including protein subunit, viral vector, RNA, DNA, inactivated virus, attenuated virus, and virus like particles (VLPs) platforms are in clinical trials. (nature.com)

An authorized viral vector COVID-19 vaccine may be offered to individuals 18 years of age and over, without contraindications to the vaccine, when all other authorized COVID-19 vaccines are contraindicated. (canada.ca)
There is currently no FDA-approved or FDA-authorized COVID-19 vaccine for children younger than age 6 months. (cdc.gov)

Rituximab impairs immunoglobulin (Ig)M and IgG (subclass) responses after influenza vaccination in rheumatoid arthritis patients. (southernbiotech.com)
Influenza vaccine effectiveness could be improved by combination with an adjuvant with the potential to enhance the host-vaccine response both quantitatively and qualitatively. (researchsquare.com)
The goal of this study was to explore a RIG-I agonist (SDI-nanogel) and a TLR7/8 agonist (Imidazoquinoline (IMDQ)‐PEG‐Chol) as adjuvants, when co-administered with a licensed quadrivalent inactivated influenza vaccine (QIV), and to determine the role of these adjuvants in directing helper T (Th) cell responses for their role in the immunoglobulin (Ig) class switching. (researchsquare.com)
Despite several vaccine candidates available on the market, influenza virus is responsible for severe illness in humans, with a substantial global death toll every year (https://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html). (researchsquare.com)
However, due to antigenic drift in influenza viruses, vaccines need to be updated every year to protect against the circulating strains of the virus. (researchsquare.com)
We thank Adimmune Corporation Chairman Dr. Chi-Hsien Chan for his intensive support this research work and lead a team to develop the H7N9 influenza vaccine in Taiwan. (chk1inhibitor.com)
Despite an estimated burden on the healthcare system which is similar to that of influenza, no vaccines are available yet. (pipelinereview.com)

Our findings demonstrate the difference between Mhp field strains could influence the virulence, and we hypothesize that the most frequent genes in Mhp field strains could possibly be used as vaccine candidates. (biomedcentral.com)
However, it has taken over 15 years to finally license a moderately efficacious malaria vaccine for implementation due to extreme levels of antigenic diversity of most vaccine candidates, which reduces their efficacy across a broad range of evolving natural parasite populations. (biomedcentral.com)

While the urgent global need for a COVID-19 vaccine has recently put a spotlight on messenger RNA (mRNA) technology, this platform has long been under investigation by the biopharmaceutical industry for use against another urgent need -fast-acting cancers characteristic of occupational hazards like asbestos and per- and polyfluoroalkyl substances (PFAS). (biospace.com)
A complete primary series with an mRNA COVID-19 vaccine may be offered to children 6 months to less than 5 years of age and should be offered to children 5 to 11 years of age without contraindications to the authorized vaccine, with a dosing interval of at least 8 weeks between the first and second dose. (canada.ca)
A complete primary series, preferentially with an mRNA COVID-19 vaccine, should be offered to individuals 12 years of age and older without contraindications to the vaccine. (canada.ca)
A first booster dose of mRNA COVID-19 vaccine should be offered to adults 18 years of age and older and select children and adolescents 5 to 17 years of age. (canada.ca)
A first booster of mRNA COVID-19 vaccine may also be offered to all other children and adolescents 5 to 17 years of age. (canada.ca)
It is recommended that an authorized protein subunit COVID-19 vaccine (Novavax Nuvaxovid) should be offered to individuals in the authorized age groups without contraindications to the vaccine who are not able or willing to receive an mRNA COVID-19 vaccine. (canada.ca)
Healthcare providers who administer the Moderna COVID-19 Vaccine (2023-2024 Formula) to individuals ages 6 months through 11 years should ensure the correct volume of the vaccine (0.25 mL) is withdrawn from the vial and administered to the recipient. (cdc.gov)
All people ages 65 years and older should receive 1 additional dose of any updated (2023-2024 Formula) COVID-19 vaccine (i.e. (cdc.gov)
Updated information for reporting adverse events to VAERS following administration of a COVID-19 vaccine. (cdc.gov)
These vaccines are hereafter referred to as updated (2023-2024 Formula) Moderna COVID-19 Vaccine. (cdc.gov)
These vaccines are hereafter referred to as updated (2023-2024 Formula) Pfizer-BioNTech COVID-19 Vaccine. (cdc.gov)
Novavax COVID-19 Vaccine, Adjuvanted (hereafter referred to as Novavax COVID-19 Vaccine) is authorized for people ages 12 years and older. (cdc.gov)
COVID-19 vaccine-specific package inserts and EUA fact sheets for healthcare providers (fact sheets) and U.S. COVID-19 Vaccine Product Information can be consulted for a full list of ingredients and information on the conditions of use, storage and handling, preparation, and administration procedures. (cdc.gov)
There is no preferential recommendation for the use of any one COVID-19 vaccine over another when more than one recommended and age-appropriate vaccine is available. (cdc.gov)
See Appendix A for recommendations for people who received COVID-19 vaccine outside the United States. (cdc.gov)

This review summarizes the progress of TCR-based immune therapeutic strategies, including T cell receptor-engineered T cell (TCR-T), TCR-based protein drugs, and other cell therapies based on TCR signaling, providing useful information for future design of immune therapeutics based on TCR. (bvsalud.org)
Due to its high pathogenicity, pandemic potential, and lack of therapeutics or approved vaccines, its study requires biosafety level 4 (BSL4) containment. (cdc.gov)

Instead of the classical types of vaccines such as live and inactivated viruses, several novel immunogens including protein subunit and DNA vaccines as well as viral and bacterial vectors are currently being examined. (aerzteblatt.de)
DIVA vaccines include genetically engineered gene-deleted viruses, for example gE − virus, and subunit or vectored vaccines based on a viral envelope glycoprotein such as gD. (biomedcentral.com)
In particular embodiments, the chimeric viruses of the invention have enhanced transduction capability (e.g., transduction of skeletal muscle, cardiac muscle, glial cells, astrocytes, liver, retina and/or lung, etc.), enhanced levels of transgene expression and/or earlier onset of transgene expression. (justia.com)

It is estimated that whooping cough causes globally around 200,000 deaths per year and more than 24 million new pertussis cases in children younger than 5 years were reported in 2014 ( 5 ), in spite of the wide usage of efficacious pertussis vaccines ( 6 ). (frontiersin.org)

Yet, compared to systemic responses, mucosal immune responses have attracted relatively little attention in the context of pertussis vaccine development. (frontiersin.org)
Bavarian Nordic has also previously reported strong results from a Phase 2 trial of MVA-BN RSV in 421 older adults, demonstrating that the vaccine was well-tolerated and induced both broad and durable antibody and T-cell responses against RSV, as well as mucosal immune responses that may be important for protection against RSV. (pipelinereview.com)

METHODS: We report on a protein subunit vaccine comprising the receptor-binding domain (RBD) of the ancestral SARS-CoV-2 spike protein, dimerised with an immunoglobulin IgG1 Fc domain. (bvsalud.org)
IL-12 p40 subunit plasmatic level was decreased, but the IL-12 receptor was present and functional. (cdc.gov)
These Fc receptor-dependent antibody functions provide a direct link between the innate and adaptive immune systems by combining the potent antiviral activity of innate effector cells with the diversity and specificity of the adaptive humoral response. (frontiersin.org)
The Fc receptor-dependent function of antibody-dependent cellular phagocytosis (ADCP) provides mechanisms for clearance of virus and virus-infected cells, as well as for stimulation of downstream adaptive immune responses by facilitating antigen presentation, or by stimulating the secretion of inflammatory mediators. (frontiersin.org)
Fc receptor-dependent antibody functions are important components of the immune response that provide mechanisms for clearance of infected host cells, immune complexes, or opsonized pathogens. (frontiersin.org)
Fc receptor-dependent antibody functions are also involved in activation of downstream adaptive immune responses by facilitating antigen presentation or by stimulating the secretion of inflammatory mediators ( 12 , 13 ). (frontiersin.org)
Thus, the multispecific antagonist contains at least one binding specificity related to the diseased cell or condition being treated and at least one specificity to a component of the immune system, such as a receptor or antigen of B cells, T cells, neutrophils, monocytes and macrophages, and dendritic cells, a modulator of coagulation, or a proinflammatory cytokine. (patentsencyclopedia.com)

Administration of QIV with the two adjuvants, individually or combined, resulted in enhanced HA-specific serum ELISA IgG titers, serum hemagglutination inhibition (HAI) titers and splenic T cell responses as examined by IFN-γ and IL-4 enzyme-linked immunosorbent spot (ELISPOT) assays, 4-weeks post-prime and post-boost vaccination in BALB/c mice. (researchsquare.com)
Combination of the two adjuvants not only skewed the response completely towards IgG2a, but also resulted in induction of HAI titers that outperformed groups that received single adjuvant. (researchsquare.com)
It gives a full rundown of the current NP-based vaccines, their potential as adjuvants, and the ways they can be delivered to cells. (researchgate.net)

These include messenger ribonucleic acid (mRNA) vaccines, protein subunit and virus-like particle (VLP) vaccines, and non-replicating viral vector vaccines. (canada.ca)
Among these, viral vector and RNA vaccines are currently in use. (nature.com)

These results have implications for the efficacy of the vaccine in Ghana and will inform the choice of alleles to be included in future multivalent or chimeric vaccines. (biomedcentral.com)
The primary objective of the study will assess the efficacy of the vaccine candidate against lower-respiratory tract disease caused by RSV compared to placebo. (pipelinereview.com)

Serum antibody profiling identifies vaccine-induced correlates of protection against aerosolized ricin toxin in rhesus macaques. (wadsworth.org)

BACKGROUND: The SARS-CoV-2 global pandemic has fuelled the generation of vaccines at an unprecedented pace and scale. (bvsalud.org)
An efficient vaccination campaign is projected to increase innate and adaptive immune responses, offering better protection against SARS-CoV-2 variants. (springeropen.com)
The presence of altered SARS-CoV-2 variants circulating around the world puts the effectiveness of vaccines already on the market at risk. (springeropen.com)
As a result of these concerns, new vaccines based on modern technology should be developed to guard against the growing SARS-CoV-2 variations. (springeropen.com)
Currently, seven SARS-CoV-2 vaccine platforms have been developed. (springeropen.com)
This review focuses on the SARS-CoV-2 mutations, variants of concern (VOCs), and advances in vaccine technologies. (springeropen.com)
The rapid emergence of the SARS-CoV-2 virus necessitated the development of vaccines targeting the spike protein in an unprecedented timeframe [ 20 ]. (springeropen.com)
Using the SARS-CoV reverse genetics system 2 , we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone. (nature.com)
Therefore, to examine the emergence potential (that is, the potential to infect humans) of circulating bat CoVs, we built a chimeric virus encoding a novel, zoonotic CoV spike protein-from the RsSHC014-CoV sequence that was isolated from Chinese horseshoe bats 1 -in the context of the SARS-CoV mouse-adapted backbone. (nature.com)
The 2023-2024 formulation for all COVID-19 vaccines licensed or authorized in the United States (Moderna, Novavax, and Pfizer-BioNTech) has been updated to a monovalent vaccine based on the Omicron XBB.1.5 sublineage of SARS-CoV-2. (cdc.gov)
The pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a public health emergency, and research on the development of various types of vaccines is rapidly progressing at an unprecedented development speed internationally. (nature.com)
13 predicted the VLP of HBcAg-exposing epitopes of SARS-CoV-2 by an immunoinformatics approach towards the development of a vaccine against SARS-CoV-2. (nature.com)

Currently, neoantigens find utility in various domains, primarily in the realm of neoantigen vaccines such as DC vaccines, nucleic acid vaccines, and synthetic long peptide vaccines. (techscience.com)

The 'beta variant' RBD vaccine, combined with MF59® adjuvant, induced strong protection in mice against the beta strain as well as the ancestral strain. (bvsalud.org)
Furthermore, when used as a heterologous third dose booster, the RBD-Fc vaccines combined with MF59® increased titres of nAb against other variants including alpha, delta, delta+, gamma, lambda, mu, and omicron BA.1, BA.2 and BA.5. (bvsalud.org)

Dr. Halstead and his colleague Dr. Phillip Russell proposed that the vaccine only be used after antibody testing, to check for prior dengue exposure and avoid vaccination of sero-negative individuals. (wikipedia.org)
While QIV+SDI-nanogel largely induced antigen-specific IgG1 responses, QIV+IMDQ-PEG-Chol predominantly induced IgG2a antibody isotypes post-prime vaccination, suggesting efficient induction of Th2 (IL-4) and Th1 (IFN-γ) responses, respectively. (researchsquare.com)
A booster vaccination with QIV+IMDQ-PEG-Chol resulted in a more balanced IgG1/IgG2a response in animals primed with QIV+IMDQ-PEG-Chol but increased only IgG2a titers in animals that received the combination adjuvant during prime vaccination, suggesting that class switching events in germinal centres during the prime vaccination contribute to the outcome of booster vaccination. (researchsquare.com)

Bavarian Nordic's vaccine candidate, MVA-BN RSV, is being developed for the prevention of respiratory syncytial virus (RSV) in older adults. (pipelinereview.com)

Thirty-one percent of candidate vaccines are based on protein subunit platforms ( Table 1 ). (encyclopedia.pub)
Virus-like particles (VLPs) enable the construction of promising platforms in the field of vaccine development. (nature.com)
VLPs constitute attractive vaccine platforms in view of their safety and ease of production. (nature.com)

In the last few years, mRNA used as a vaccine with rapid, scalable, and cost-effective production during the corona pandemic [2]. (researchgate.net)

Many companies and researchers have developed various types of vaccines that are now being supplied around the world. (nature.com)

The OMPs of Brucella could be used as a suitable vaccine candidate versus brucellosis. (ijmedrev.com)
Siadat SD, Salmani AS, Aghasadeghi MR. Brucellosis vaccines: an overview. (ijmedrev.com)
The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic and oral acquired brucellosis. (ijmedrev.com)

2012) Immunogenicity and Efficacy of Intramuscular Replication-Defective and Subunit Vaccines against Herpes Simplex Virus Type 2 in the Mouse Genital Model. (upb.ro)

Human IgG subclass responses in relation to serum bactericidal and opsonic activities after immunization with three doses of the Norwegian serogroup B meningococcal outer membrane vesicle vaccine. (southernbiotech.com)
No one can tell how much time it takes to reach a new level of perfection, and that the development of vaccines for active immunization is a long process. (pubannotation.org)

The present invention provides chimeric virus vectors that have been designed to exhibit one or more properties of interest (e.g., enhanced tissue tropism). (justia.com)

While UV1 implements specific amino acid chains representative of the human telomerase enzyme's (hTERT) reverse transcriptase subunit to help the native immune response target cancer cells, cancer vaccines that utilize mRNA technology have therapeutic potential in low-treatment option cancers, including many of those linked to occupational hazards. (biospace.com)

The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. (thermofisher.com)

Progress in Brucella vaccine development. (ijmedrev.com)
The in-vitro lymphocyte proliferation assay resulted in a higher splenic lymphocyte response in immunized mice upon antigen stimulation in comparison with control mice implicating the development of elevated immune responses. (journalcra.com)
Humanized mouse models can sustain DENV replication and show some signs of disease, but further development is needed to validate the immune response. (mdpi.com)
The aim of this study was to investigate the genetic profile of Brazilian Mhp field strains in order to help the development of more effective vaccines against Mhp, as well as specific diagnostic tests for Mhp. (biomedcentral.com)
Standardized assays to assess vaccine and antiviral drug efficacy are critical for the development of protective HIV-1 vaccines and drugs. (plos.org)
These immune assays will be advanced by the development of standardized viral stocks, such as HIV-1 infectious molecular clones (IMC), that i) express a reporter gene, ii) are representative of globally diverse subtypes and iii) are engineered to easily exchange envelope (env) genes for expression of sequences of interest. (plos.org)
Thus far, a subtype B IMC backbone expressing Renilla luciferase (LucR), and into which the ectodomain of heterologous env coding sequences can be expressed has been successfully developed but as execution of HIV-1 vaccine efficacy trials shifts increasingly to non-subtype B epidemics (Southern African and Southeast Asia), non-subtype B HIV-1 reagents are needed to support vaccine development. (plos.org)
New strategies for vaccine development against both BoHV-1 and BoHV-5 have been focused on the design of marker vaccines, which differentiate infected from vaccinated animals (also known as DIVA vaccines). (biomedcentral.com)
Dr. Mantis' research focuses on host-pathogen interactions and the development of vaccines for biodefense and emerging infectious diseases (BDEID). (wadsworth.org)

The conserved domain of proteins was obtained and the epitopes of TN-OMPs were capable of inducing both B-cell and T-cell mediated immune responses. (ijmedrev.com)
In contrast, a positive Tajima's D was observed for the Navrongo P. falciparum population, consistent with balancing selection acting on the immuno-dominant TH2R and TH3R vaccine epitopes. (biomedcentral.com)

For example, in early December, Norwegian pharmaceutical company Ultimovacs announced that the U.S. Food and Drug Administration granted its cancer vaccine, UV1, orphan drug designation. (biospace.com)

For example, 'Two mRNA vaccines developed by Pfizer-BioNTech and Moderna are effective against the coronavirus. (researchgate.net)

Stagnation in the decline of malaria over the last 5 years indicates that global malaria elimination targets may not be achieved without the addition of a broadly effective vaccine to complement the panel of available malaria control tools [ 1 ]. (biomedcentral.com)
The initiation of this pivotal trial of our vaccine candidate is a significant contribution to the global efforts to develop a safe and effective vaccine against RSV and represents an important step for Bavarian Nordic towards fulfilling our ambition to become one of the largest pure play vaccine companies," said Paul Chaplin, President and Chief Executive Officer of Bavarian Nordic. (pipelinereview.com)

As of 2023, there are two commercially available vaccines, sold under the brand names Dengvaxia and Qdenga. (wikipedia.org)

Two subunit vaccines are based on capsid protein expressed in the baculovirus system. (biomedcentral.com)

Clin Vaccine Immunol. (wadsworth.org)

Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. (nature.com)

The different targets include (i) proinflammatory effectors of the innate immune system, (ii) coagulation factors, and (iii) targets specifically associated with an inflammatory or immune-dysregulatory disorder, with a pathologic angiogenesis or cancer, or with an infectious disease, wherein the targets included in group (iii) are neither a proinflammatory effector of the immune system nor a coagulation factor. (patentsencyclopedia.com)
The multispecific antagonists are used in the treatment of various diseases that are generated or exacerbated by, or otherwise involve, proinflammatory effectors of the innate immune system or coagulation factors. (patentsencyclopedia.com)
Nanovaccines can improve antigen presentation, targeted delivery, stimulation of the body's innate immune system, and a strong T-cell response without putting people at risk. (researchgate.net)
The modification helps the foreign mRNA bypass part of the body's first line of defense - the innate immune system. (thetenpennyreport.com)

Chimeric plantibody passively protects mice against aerosolized ricin challenge. (wadsworth.org)

METHODS AND COMPOSITIONS FOR IMMUNOTHERAPY AND DETECTION OF INFLAMMATORY AND IMMUNE-DYSREGULATORY DISEASE, INFECTIOUS DISEASE, PATHOLOGIC ANGIOGENESIS AND CANCER - Methods and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases, using multispecific antagonists that target at least two different markers are disclosed. (patentsencyclopedia.com)
When the multispecific antagonist reacts specifically with a target associated with an inflammatory or immune-dysregulatory disorder, with a pathologic angiogenesis or cancer, or with an infectious disease, it also binds specifically with at least one proinflammatory effector of the immune system or at least one coagulation factor. (patentsencyclopedia.com)

The RTS,S vaccine is a malaria subunit vaccine that is formulated from a fragment of the circumsporozoite protein (CSP) of Plasmodium falciparum 3D7 laboratory strain fused with the Hepatitis B surface antigen and the AS01 adjuvant [ 5 ]. (biomedcentral.com)

These vaccines were also tested as a heterologous third dose booster in mice, following priming with whole spike vaccine. (bvsalud.org)
As a result, effective vaccines must target the viral spike glycoprotein. (springeropen.com)
The trimeric, transmembrane spike (S) glycoprotein of the virus, SARS-2-S, includes two main functional subunits: S1 and S2. (pubannotation.org)

T cells play central roles in anti-tumor immune responses. (bvsalud.org)
Role of Fas ligand expression in promoting escape from immune rejection in a spontaneous tumor model. (southernbiotech.com)
Phase I trial of overlapping long peptides from a tumor self-antigen and poly-ICLC shows rapid induction of integrated immune response in ovarian cancer patients. (southernbiotech.com)

However, due to heavy global demand, there are strains in global vaccine production. (encyclopedia.pub)
This work demonstrated the genetic diversity of several Mhp field strains based on 16 selected genes related to virulence and/or immune response in Brazil. (biomedcentral.com)
Therefore, it is important to investigate the genetic diversity and variability of Mhp field strains to improve the vaccines and develop more specific and effective diagnostic methods. (biomedcentral.com)

Non-human primates (NHPs) can sustain viral replication in relevant cell types and develop a robust immune response, but they do not develop overt disease. (mdpi.com)

We analyzed the genetic profile of Mhp field samples using 16 genes that encode proteins involved in the mechanisms of bacterial pathogenesis and/or the immune responses of the host. (biomedcentral.com)

The safety and effectiveness of the vaccine was determined in three randomized, placebo-controlled studies involving approximately 35,000 individuals in dengue-endemic areas, including Puerto Rico, Latin America and the Asia Pacific region. (wikipedia.org)
Previous studies have demonstrated effectiveness of chimeric PCV1-2 vaccines against PCV2b challenge. (biomedcentral.com)

CagA is a cellular immunogenic protein that induces a Th1 response. (ijmedrev.com)

Anatomy25

Organisms21

Diseases7

Chemicals and Drugs124

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes47

Technology, Industry, Agriculture1

Information Science3

Health Care3

Antibodies19

Recombinant5

Live attenuated9

Protein subunits1

Immunity12

Antigens6

Infection23

Induce3

Receptors4

Clinical13

Authorized COVID-192

Influenza7

Candidates2

COVID-19 Vaccine15

Therapeutics2

Viruses3

Efficacious1

Mucosal immune responses2

Receptor7

Adjuvants3

Viral Vector2

Efficacy of the vaccine2

Correlates1

SARS-CoV12

Nucleic acid1

MF592

Vaccination3

Respiratory1

Platforms3

Pandemic1

Types of vaccines1

Brucellosis3

Immunogenicity1

Immunization2

Present invention provides1

Telomerase1

Antigenic1

Development9

Epitopes2

Cancer vaccine1

Pfizer-BioNTech1

Effective vaccine2

Available vaccines1

Capsid1

Immunol1

Additionally1

Innate immune4

Passively1

Infectious disease2

Adjuvant1

Spike3

Tumor3

Strains3

Replication1

Proteins1

Effectiveness2

Induces1