Immune response cell characteristic immunoglobulin idiotypes. Medical search. Frequent questions

In checkpoint therapy, antibodies bind to molecules involved in T-cell regulation to remove inhibitory pathways that block T-cell responses, known as immune checkpoint therapy. (wikipedia.org)
It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)
Based on the above observations, it was postulated that the plasmablasts that produced these broadly neutralizing antibodies were predominantly derived from activated memory B cells specific for epitopes conserved in some influenza strains. (biomedcentral.com)
Antibodies from different classes also differ in where they are released in the body and at what stage of an immune response. (wikipedia.org)
Together with B and T cells , antibodies comprise the most important part of the adaptive immune system . (wikipedia.org)
Initially, all antibodies are of the first form, attached to the surface of a B cell - these are then referred to as B-cell receptors (BCR). (wikipedia.org)
After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
Antibodies are glycoproteins belonging to the immunoglobulin superfamily . (wikipedia.org)
Patients have shown deposition of IgM in the involved tissue, and using anti-idiotype antibodies, IgM monoclonal antibodies were demonstrated to react with epidermal antigens. (medscape.com)
The invention also provides cells producing the antibodies, and methods of making and using the same. (justia.com)
They persist because of the failure of immune surveillance mechanisms to repress these antibodies. (medscape.com)
Chronic lymphocytic leukemia (CLL) usually involves the expansion of a clone of CD5+ B cells synthesizing IgM antibodies. (omicsdi.org)
Polyclonal antibodies are antibodies that are derived from different B- cell lines. (wikidoc.org)
By contrast, monoclonal antibodies are derived from a single cell line. (wikidoc.org)
the necessary characteristics [e.g., class, subclass (isotype), complement fixing nature] of the antibodies to be made. (wikidoc.org)
When HEL was expressed in a soluble form, HEL-specific B cells were not deleted, but became unable to proliferate or secrete HEL-specific antibodies ( 2 ). (silverchair.com)
Antibodies (also known as immunoglobulins [1] ) are proteins that are found in blood or other bodily fluids of vertebrates , and are used by the immune system to identify and neutralize foreign objects, such as bacteria and viruses . (wikidoc.org)
each antibody has two large heavy chains H and two small light chains L . Antibodies are produced by a kind of white blood cell called a B cell . (wikidoc.org)
[3] This huge diversity of antibodies allows the immune system to recognize an equally wide diversity of antigens. (wikidoc.org)
Production of antibodies is the main function of the humoral immune system . (wikidoc.org)
Antibodies occur in two forms: a soluble form secreted into the blood and tissue fluids, and a membrane-bound form attached to the surface of a B cell that is called the B cell receptor (BCR). (wikidoc.org)
[8] Antibodies are, therefore, an essential component of the adaptive immune system that learns, adapts and remembers responses to invading pathogens. (wikidoc.org)
Cytokines binding to antibodies paradoxically have a stronger immune effect than the cytokine alone. (wikidoc.org)

In 2010 administration of lymphocytes genetically engineered to express a chimeric antibody receptor (CAR) against B cell antigen CD19 was shown to mediate regression of an advanced B cell lymphoma. (wikipedia.org)
Cold agglutinin disease usually results from the production of a specific IgM antibody directed against the I/i antigens (precursors of the ABH and Lewis blood group substances) on red blood cells (RBCs). (medscape.com)
Cold agglutinins commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody. (medscape.com)
An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). (wikipedia.org)
To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. (wikipedia.org)
The constant region at the trunk of the antibody includes sites involved in interactions with other components of the immune system. (wikipedia.org)
The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
The complement system consists of more than 20 proteins in serum capable of lysing antibody-coated cells. (jinnah.edu)
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) can acquire phage-encoded immune modulators, such as the immune evasion cluster (IEC), which protects bacteria from components of the human innate immune system, and the enzyme TarP, which protects against antibody-mediated immune recognition. (cdc.gov)
Adjuvants are generally used with soluble protein antigens to increase antibody titers and induce a prolonged response with accompanying memory. (wikidoc.org)
Interleukin-4 is considered one of the critical cytokines in the development of allergies and the production of IgE antibody by the immune system. (wikidoc.org)
However, with the exception of idiotype, few antigen targets have been identified that would facilitate specific immunotherapy of MM. We have previously described a murine monoclonal antibody that recognizes a conformation-dependent epitope on free human kappa light chains and a cell surface antigen, KMA, expressed on kappa MM (MM) plasma cells 1,2. (slideserve.com)
Here we show that the murine antibody, mKap, binds specifically to a range of kappa-type multiple myeloma (MM) cell lines and mediates in vivo anti-tumor activity in a SCID mouse human myeloma xenograft model. (slideserve.com)
Five different antibody isotypes are known in mammals, which perform different roles, and help direct the appropriate immune response for each different type of foreign object they encounter. (wikidoc.org)
Recognition of an antigen by an antibody tags it for attack by other parts of the immune system. (wikidoc.org)
This allows a single antibody to be used by several different parts of the immune system. (wikidoc.org)
[7] Activated B cells differentiate into either antibody generating factories called plasma cells that secrete soluble antibody, or into memory cells that survive in the body for years afterwards to allow the immune system to remember an antigen and respond faster upon future exposures. (wikidoc.org)
The company was founded by a group of scientists with extensive experience in protein expression, antibody development, library construction, stable cell line construction, cell culture, gene editing, and other related services. (alphalifetech.com)

Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
There were compared with epitopes in the Immune Epitope Database (IEDB) which contains experimentally identified epitopes in sH1N1 HA proteins, which may be helpful in design of common antigens of pH1N1 influenza and sH1N1 viruses. (biomedcentral.com)
The goal of the current study was to assess the association of COVID-19 clinical courses controlled by patients' adaptive immune responses without progression to severe disease with patients' Human Leukocyte Antigen (HLA) genetics, AB0 blood group antigens, and the presence or absence of near-loss-of-function delta 32 deletion mutant of the C-C chemokine receptor type 5 (CCR5). (biomedcentral.com)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Adjuvants are used to improve or enhance an immune response to antigens. (wikidoc.org)
Most complex protein antigens induce multiple B-cell clones during the immune response, thus, the response is polyclonal. (wikidoc.org)
Immune responses to non-protein antigens are generally poorly or enhanced by adjuvants and there is no system memory. (wikidoc.org)
Here, we demonstrate that developing self-reactive B cells are not always highly sensitive to the deletion mechanisms imposed by membrane-bound self-antigens. (silverchair.com)
At low amounts, membrane-bound antigens allow survival of B cells bearing a single high affinity self-reactive B cell receptor (BCR). (silverchair.com)
Based on these results, it was postulated that B cell deletion required BCR cross-linking and could only be induced by membrane bound self-antigens. (silverchair.com)
Functions mainly as an antigen receptor on B cells that have not been exposed to antigens. (wikidoc.org)
One class of non-self molecules are called antigens (short for anti body gen erators) and are defined as substances that bind to specific immune receptors and elicit an immune response. (wikidoc.org)

New methods: subunit vaccines, anti-idiotype and DNA vaccines. (jinnah.edu)

Part I contains studies on immunoglobulin genes, messages, and molecules. (elsevier.com)
Part III examines membrane immunoglobulins while Part IV focuses on immunoglobulins as regulatory molecules. (elsevier.com)
Cell surface receptors are able to detect chemical gradients of molecules such as interleukin-8 (IL-8), interferon gamma (IFN-gamma), and C5a which these cells use to direct the path of their migration. (bionity.com)
18:217-242), the β-chemokines regulate the expression of adhesion molecules on endothelial cells and thereby indirectly affect diapedesis and extravasation of immune cells from the circulation into tissues. (justia.com)
They are a mixture of immunoglobulin molecules secreted against a specific antigen , each recognising a different epitope . (wikidoc.org)
Both innate and adaptive immunity depend on the ability of the immune system to distinguish between self and non-self molecules . (wikidoc.org)
In immunology , self molecules are those components of an organism's body that can be distinguished from foreign substances by the immune system. (wikidoc.org)
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)

Description of T cell growth factor interleukin-2 (IL-2) in 1976 allowed T lymphocytes to be grown in vitro, often without loss of effector functions. (wikipedia.org)
1982, studies demonstrated that intravenous immune lymphocytes could treat bulky subcutaneous FBL3 lymphomas. (wikipedia.org)
In 2006 administration of normal circulating lymphocytes transduced with a retrovirus encoding a T-cell receptor (TCR) that recognized the MART-1 melanoma-melanocyte antigen, mediated tumor regression. (wikipedia.org)
With the eosinophil and the basophil , they form the class of polymorphonuclear cells (PMNs), named for the nucleus 's characteristic multilobulated shape (as compared to lymphocytes and monocytes , the other types of white cells). (bionity.com)
The β-chemokines form a gradient that serves as a chemoattractant and potential proliferation signal for immune and other cells such as monocytes, macrophages, basophils, eosinophils, T lymphocytes and fibroblasts. (justia.com)
Human MCP-1, MCP-2 and MCP-3 all have chemotactic activity for a variety of cell types, including T lymphocytes and monocytes (Van Coillie et al. (justia.com)
They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
This induces the B- lymphocytes to produce IgG immunoglobulins specific for the antigen. (wikidoc.org)

The immunoglobulin (Ig) variable region (V) genes expressed by IgM chronic lymphocytic leukemia (CLL) B cells display little or no somatic mutations. (omicsdi.org)
In the IgA/IgG-coexpressing CLL B cells, identical VH-D-JH cDNA sequences were spliced to either C alpha or C gamma genes. (omicsdi.org)
Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis. (omicsdi.org)
The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)

Schnitzler syndrome is an autoinflammatory disease for which the exact pathophysiology remains unclear but seems to involve the innate immune system. (medscape.com)
If a pathogen breaches these barriers, the innate immune system provides an immediate, but non-specific response. (wikidoc.org)
Innate immune systems are found in all plants and animals . (wikidoc.org)
[2] However, if pathogens successfully evade the innate response, vertebrates possess a third layer of protection, the adaptive immune system , which is activated by the innate response. (wikidoc.org)
They are particularly important in both innate and adaptive immune responses. (wikidoc.org)

Part VI examines immunoglobulin idiotypes while Part VII contains papers on the ontogeny of immunoglobulin-synthesizing cells. (elsevier.com)
These findings suggest that IgA- and/or IgG-expressing CLLs represent, in their VH gene structure, transformants of B cells at different stages of ontogeny. (omicsdi.org)
When HEL was expressed in membrane form, HEL-specific B cells were deleted early on ontogeny ( 3 ). (silverchair.com)

The cellular data indicate that B cells with lesser amounts of surface membrane IgD and higher IgM/IgD ratios are more likely to undergo this switching process. (omicsdi.org)
Collectively, these data suggest that not all members of a B-CLL clone are frozen at the surface membrane Ig-expressing stage of B cell maturation, and that some members can switch to the production of non-IgM isotypes. (omicsdi.org)

We will also look at the combination of mAbs with immunostimulants such as GMCSF and IL-2 (fusion proteins) and eventual conjugation of the mAbs with alpha and possibly B -emitters to help in targeting bystander cells. (jcancer.org)
By performing large-scale major histocompatibility complex (MHC) II analyses on HA proteins, the degree of T-cell cross-reactivity between sH1N1 from 1968 to 2009 and pH1N1 strains was investigated. (biomedcentral.com)
In this study, the highly conserved antigenic epitopes sequences and the locations of HA and NA proteins, including B-cell epitopes, MHC I and MHC II epitopes between pH1N1 and sH1N1 viruses, based on immunoinformatics, were analyzed. (biomedcentral.com)
[1] The immune systems of vertebrates such as humans consist of many types of proteins , cells, organs , and tissues, which interact in an elaborate and dynamic network. (wikidoc.org)

They occur in two forms: one that is attached to a B cell , and the other, a soluble form, that is unattached and found in extracellular fluids such as blood plasma . (wikipedia.org)

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
Conventional therapies have limited efficacy, and overall response is still unsatisfactory considering that immune checkpoint inhibitors induce lasting clinical responses only in a low percentage of patients. (bmj.com)
low quantities of self-antigen induce the selection and accumulation of increased numbers of self-reactive B cells with decreased expression of antigen-specific BCRs. (silverchair.com)

In autologous cancer immunotherapy, T cells are extracted from the patient, genetically modified and cultured in vitro and returned to the same patient. (wikipedia.org)
Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study. (nwbio.com)
Thanks to the power of naturally occurring canine tumors as predictive models for cancer immunotherapy response, these data may represent a basis for the translation of this approach to the treatment of human patients with CSPG4-positive melanoma subtypes. (bmj.com)

The association of the immunogenetic background parameters were further related to patients' humoral antiviral immune response patterns by longitudinal observation. (biomedcentral.com)
In the current study, we took the diverging approach of assessing immunogenetic characteristics for their association with COVID-19 clinical courses as well as with adaptive antiviral humoral immune response patterns in patients who mastered the infection without progression to severe manifestations (WHO° 3 or less). (biomedcentral.com)
Lymphoid cells concerned with humoral immunity. (lookformedical.com)
Eliminates pathogens in the early stages of B cell mediated (humoral) immunity before there is sufficient IgG. (wikidoc.org)

The company focuses on immune cell based anticancer therapy using NK cells and T cell receptors, and clinical trials based on independent research infrastructure, enabling patients to receive new drugs for cancer and get cured. (genscriptprobio.com)

Cells grown in vitro from neoplastic tissue. (lookformedical.com)

In 2016, CD19-specific chimeric antigen receptor (CAR)-modified T cells were used to treat patients with relapsed and refractory CD19+ B cell malignancies, including B cell acute lymphoblastic leukemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells. (wikipedia.org)
These isotype-switched CLL B cells expressed surface HLA-DR, CD19, CD23, and CD5, and displayed no alterations of the bcl-1 and bcl-2 oncogenes and the p53 tumor-suppressor gene. (omicsdi.org)
The cDNA VH-D-JH gene sequence was joined with that of the C alpha gene in the B cells of the three IgA CLLs, and with that of the C gamma gene in the IgG CLL B cells. (omicsdi.org)
In all five CLLs, the pattern of C mu DNA probe hybridization to the digested genomic DNAs was consistent with deletion of the C mu exon from the rearranged Ig gene locus, suggesting that these CLL B cells had undergone DNA switch recombination. (omicsdi.org)
They also suggest that Ag may play a role in the clonal selection of some of these isotype-switched leukemic cells, but bcl-1 and bcl-2 oncogene rearrangements and p53 tumor suppressor gene mutation are not associated with the pathogenesis of isotype-switched CLLs. (omicsdi.org)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
AffyXell Therapeutics Co., Ltd. is a joint venture between Daewoong Pharmaceutical and Avacta Group, developing a novel cell & gene therapy to obstacle diseases that come from the imbalance of immune system homeostasis. (genscriptprobio.com)

[ 1 ] Donath-Landsteiner hemolytic anemia is also caused by a cold-reacting immunoglobulin, but most cases are due to polyclonal IgG. (medscape.com)
It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation. (lookformedical.com)

CCR5 is known to play a decisive role as a chemotactic receptor abundantly expressed on monocytes, macrophages and T-cells and its heterozygous mutation-related deficiency implies impaired memory CD4 + T-cell response [ 5 ]. (biomedcentral.com)
MONOCYTES and a variety of other immune cells. (lookformedical.com)

The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)

Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. (nwbio.com)
Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)
Prospective studies in larger patient populations also including novel SARS-CoV-2 variants will be required to assess the impact of HLA genetics on the capacity of mounting protective vaccination responses in the future. (biomedcentral.com)

Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines. (nwbio.com)
PRP vaccines were ineffective in children less than 18 months of age because of the T-cell-independent nature of the immune response to PRP polysaccharide (3). (cdc.gov)
Specific characteristics of the four conjugate vaccines available for infants and children vary (e.g., the type of protein carrier, the size of the polysaccharide, and the chemical linkage between the polysaccharide and carrier) ( Table 1 ). (cdc.gov)

Leprosy offers a broad spectrum of altered immunological sceneries, ranging from strong cell-mediated immune responses seen in tuberculoid leprosy (TT), through borderline leprosy (BB), to the virtual absence of T cell responses characteristic in lepromatous leprosy (LL). (bvsalud.org)
This improved response is then retained after the pathogen has been eliminated, in the form of an immunological memory , and allows the adaptive immune system to mount faster and stronger attacks each time this pathogen is encountered. (wikidoc.org)
Due to their central role in the immune system, cytokines are involved in a variety of immunological, inflammatory and infectious diseases. (wikidoc.org)

Basophils are the least common of the granulocytes , representing about 0.01% to 0.3% of circulating leukocytes (white blood cells). (wikidoc.org)
Recent evidence suggests that basophils are an important source of the cytokine, interleukin-4 , perhaps more important than T cells . (wikidoc.org)
There are other substances that can activate basophils to secrete which suggests that these cells have other roles in inflammation. (wikidoc.org)
Binds to allergens and triggers histamine release from mast cells and basophils , and is involved in allergy . (wikidoc.org)

Being highly motile, neutrophils quickly congregate at a focus of infection , attracted by cytokines expressed by activated endothelium , mast cells and macrophages . (bionity.com)

the IL-17 family - It has yet to be completely characterized, though member cytokines have a specific effect in promoting proliferation of T-cells that cause cytotoxic effects. (wikidoc.org)

Hence, primary hemostatic disorders are characterized by prolonged bleeding time, and the characteristic physical examination findings are petechiae and purpura. (medscape.com)
In comparison, defects in secondary hemostasis result in delayed deep bleeding (eg, into muscles and joints) and the characteristic physical examination finding is hemarthrosis. (medscape.com)

Molecular characterization of IgA- and/or IgG-switched chronic lymphocytic leukemia B cells. (omicsdi.org)

From biological studies using peripheral blood mononuclear cell (PBMC) from human donors not previously exposed to the pandemic virus, pre-existing CD4+ T cells can elicit cross-reactive effector responses against the pandemic H1N1 virus. (biomedcentral.com)
Peripheral blood smears may reveal clumps of red blood cells (RBCs). (medscape.com)
[ 8 ] Hypersensitivity to lipo-polysaccharide IL-1 production has been found in peripheral blood cells, particularly mononuclear cells. (medscape.com)
Furthermore, cKap satisfies the therapeutic criteria of being able to trigger ADCC MMusing human peripheral blood-derived effector cells. (slideserve.com)

It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION. (lookformedical.com)

Attempts to use T cells to treat transplanted murine tumors required cultivating and manipulating T cells in culture. (wikipedia.org)
In 1986, human TILs from resected melanomas were found to contain cells that could recognize autologous tumors. (wikipedia.org)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)

As part of this more complex immune response, the vertebrate system adapts over time to recognize particular pathogens more efficiently. (wikidoc.org)
Here, the immune system adapts its response during an infection to improve its recognition of the pathogen. (wikidoc.org)

[ 21 ] It is found on cold agglutinin-producing malignant lymphoid cells in the bone marrow in persons with lymphoproliferative disorders, on a small proportion of normal lymphoid cells, and in the spleen of a 15-week-old fetus. (medscape.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)

Antigen CD19 appears only on B cells, which go awry in lymphoma and leukemia. (wikipedia.org)
Lymphoma b cell. (lookformedical.com)

Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC, Völler MC, De Weijer K, Mulders PF, Oosterwijk E. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. (nwbio.com)

Chemokines," which take their name from chemotactic cytokines, are small secreted polypeptides that regulate movement of immune cells into tissues (Baggiolini et al. (justia.com)
Other shared functions of MCP-1, MCP-2, and MCP-3 include induction of N-acetyl β-D-glucosaminidase release, gelatinase B release, and granzyme A release which are believed to help the cells digest the extracellular matrix components necessary to enable them to migrate into tissues (Van Coillie et al. (justia.com)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
The mast cell , a cell in tissues , has many similar characteristics. (wikidoc.org)
It detects a wide variety of agents, from viruses to parasitic worms , and needs to distinguish them from the organism's own healthy cells and tissues in order to function properly. (wikidoc.org)
In contrast, autoimmune diseases result from a hyperactive immune system attacking normal tissues as if they were foreign organisms. (wikidoc.org)

Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)

Comparatively, allogeneic therapies involve cells isolated and expanded from a donor separate from the patient receiving the cells. (wikipedia.org)
rarely, it may involve monoclonal immunoglobulin G (IgG), immunoglobulin A (IgA), or λ light chain restriction. (medscape.com)

AffyXell is developing pipelines taking this new therapeutic approach to lead in resolving fundamental causes of intractable diseases like immune rejection and autoimmune diseases. (genscriptprobio.com)

The immune system protects you from dying from infection with layered defenses of increasing specificity. (wikidoc.org)

An immune system is a collection of mechanisms within an organism that protects against disease by identifying and killing pathogens and tumor cells. (wikidoc.org)

Administration of IL-2 after cell transfer enhanced therapeutic potential. (wikipedia.org)
And various studies have secured animal experimental data on the efficacy and safety of the ACT platform, and confirmed the therapeutic characteristics while remaining in the immunosuppressive microenvironment of solid cancer and it complements the shortcomings of the existing second-generation CAR-T. (genscriptprobio.com)

Immune thrombocytopenic purpura (ITP) is one of the most common autoimmune disorders. (medscape.com)
Disorders in the immune system can cause disease. (wikidoc.org)

Cell biology and significance of different pathways for antigen processing and presentation by class I and class II MHC. (jinnah.edu)

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants , fish , reptiles , and insects . (wikidoc.org)

The cells are most commonly derived from the immune system with the goal of improving immune functionality and characteristics. (wikipedia.org)
In vivo, this electrical charge guided the particles towards the patient's dendritic immune cells that specify immune system targets. (wikipedia.org)
The course is intended to cover the knowledge of microbial agents, clinical microbiology, public health and food microbiology and immune system structure and function. (jinnah.edu)
Neutrophil granulocytes , generally referred to as neutrophils , are the most abundant type of white blood cells in humans and form an integral part of the immune system . (bionity.com)
Immunodeficiency diseases occur when the immune system is less active than normal, resulting in recurring and life-threatening infections. (wikidoc.org)
However, not all their functions are limited to the immune system, as they are also involved in several developmental processes during embryogenesis. (wikidoc.org)

Expressed on the surface of B cells and in a secreted form with very high avidity. (wikidoc.org)
Each cytokine binds to a specific cell-surface receptor . (wikidoc.org)

those with an immunoglobulin G (IgG) monoclonal gammopathy are considered to be a distinct group. (medscape.com)

CONCLUSIONS: Intervention response heterogeneity was significant for nonfatal MI. (cdc.gov)

In some patients, the administered antitumor cells represented up to 80% of the CD8+ T cells months after the infusion. (wikipedia.org)

They contain large cytoplasmic granules which obscure the cell nucleus under the microscope . (wikidoc.org)

These B cells appear to be blocked at the antigen receptor-expressing stage of B cell differentiation and are thought not to undergo an isotype class switch to IgG or IgA production. (omicsdi.org)

The molecular data indicate that approximately 50% of B-CLL patients have amplifications of IgM+ B cells that undergo an isotype class switch. (omicsdi.org)
2Department of Cell and Molecular Biology, University of Technology Sydney, Broadway, NSW, 2007, Australia JJN3 MMk cells (IgAk) were incubated with mKap or cKap alone or in the presence of competing free kappa light chains (kBJP). (slideserve.com)

In transgenic mice expressing hen egg lysozyme (HEL) as a neo self-antigen, B cells transgenic for a high affinity B cell receptor (BCR) specific for HEL undergo different fates ( 2 , 3 ). (silverchair.com)
The BCR allows a B cell to detect when a specific antigen is present in the body and triggers B cell activation. (wikidoc.org)
While hormones are released from specific organs into the blood and neurotransmitters are released by nerves, cytokines are released by many types of cells. (wikidoc.org)
The term chemokine refers to a specific class of cytokines that mediates chemoattraction ( chemotaxis ) between cells. (wikidoc.org)

As immunity against influenza viruses involved not only B cell activation, but also T cell recognition and presentation, the T cell subgroups undoubtedly play an important role. (biomedcentral.com)

Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)

Positive preoperative serum TgAb is associated with worse primary tumour characteristics but rarely showed poor prognosis, probably due to more aggressive treatment of these subjects. (cusabio.com)

Anatomy43

Organisms11

Diseases14

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes58

Disciplines and Occupations2

Information Science3

Health Care2

Antibodies23

Antibody19

Antigens13

Anti-idiotype1

Molecules8

Lymphocytes10

Genes5

Innate5

Ontogeny3

Membrane2

Proteins4

Soluble1

Induce3

Cancer immunotherapy3

Humoral4

Receptors1

Vitro1

Gene7

Polyclonal2

Monocytes2

Endothelial cells1

Vaccination6

Vaccines3

Immunological3

Basophils4

Macrophages1

Cytotoxic1

Physical examination2

Characterization1

Peripheral4

Cutaneous1

Tumors5

Adapts2

Malignant4

Lymphoma2

Dendritic cells2

Tissues6

Focuses1

Involve2

Autoimmune diseases1

Specificity1

Tumor Cells1

Therapeutic2

Disorders2

Pathways1

Mechanisms2

System6

Surface2

Distinct1

Conclusions1

Antitumor1

Nucleus1

Antigen receptor1

Molecular2

Specific4

Immunity1

Populations1

Rarely1