AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Immune SystemImmune ToleranceGuanine Nucleotide Exchange FactorsImmunity, InnateImmune EvasionAntigen-Antibody ComplexImmune SeraImmunity, CellularT-LymphocytesMice, Inbred C57BLImmunityMice, Inbred BALB CCytokinesImmune Complex DiseasesImmune System DiseasesSOXD Transcription FactorsImmunoglobulin GLymphocyte ActivationAntibody FormationLinkage DisequilibriumPolymorphism, Single NucleotideSpleenAptamers, PeptideDendritic CellsInterferon-gammaHaplotypesAdaptive ImmunityCleft LipGenotypeCD4-Positive T-LymphocytesNuclear FamilyCells, CulturedGenetic Predisposition to DiseaseCleft PalateSignal Transductionrac GTP-Binding ProteinsImmunizationImmunity, HumoralAdjuvants, ImmunologicMolecular Sequence DataMacrophagesB-LymphocytesImmune System ProcessesAllelesMice, Knockoutrac1 GTP-Binding ProteinPhosphoproteinsFlow CytometryEnzyme-Linked Immunosorbent AssayLymphocytesAntibodies, ViralInflammationModels, ImmunologicalCell LineAntigensDisease Models, AnimalTh1 CellsProtein-Serine-Threonine KinasesKiller Cells, NaturalImmunity, MucosalToll-Like ReceptorsT-Lymphocytes, RegulatoryGene Expression RegulationImmunoglobulinsVaccinationAmino Acid SequenceHypersensitivity, DelayedGenome-Wide Association StudyCase-Control StudiesAntibodies, BacterialHapMap ProjectModels, GeneticImmunoglobulin ATh2 CellsImmunotherapyImmunoglobulin MT-Lymphocyte SubsetsHopeLipopolysaccharidesLeukocytes, MononuclearGene FrequencyInterleukin-10Antigens, CDVaccines, DNAT-Lymphocytes, CytotoxicLymph Nodesrho GTP-Binding ProteinsHost-Pathogen InteractionsParentsEpitopesAutoimmune DiseasesExomeImmunity, ActiveMice, TransgenicImmunologic MemoryRho Guanine Nucleotide Exchange FactorsImmunization, PassiveAntigens, BacterialInheritance PatternsAntibodies
MicrobiotaMicrobiomeSusceptibilityInnate immune proteinVariantsMutationsProteinStrainsLociDefenseImmunityAcuteExaggerated immune responseInfluenzaLiverGeneticsInflammatoryAntibioticsAdrenalChromosomeEssentialGeneticMiceAllergiesDiseasesBacteriaInflammationSystemMutationCrucialStudiesResponseCellsExpressionDiverseLevelsFunctionPatientsPresentArticlesHostNewsRiskFoundEffect
Microbiota3
  • METHODS: We employed high-throughput 16S rDNA gene sequencing to assess gut microbiota composition in early-life FA children in southern Zhejiang. (bvsalud.org)
  • For the first time, a collection of cultured bacterial strains provides comprehensive information on the mouse gut microbiota: Scientists at the Technical University of Munich were able to isolate, characterize, and archive a hundred strains, including 15 hitherto unknown taxa. (vetscite.org)
  • In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)
Microbiome9
  • Salivary microbiome was analyzed by sequencing the entire 16S rRNA gene. (bvsalud.org)
  • We investigated the relationship of the microbiome with the neuroanatomy and cognitive function of 281 healthy children in a cross-sectional analysis and demonstrated that differences in gut microbial taxa and gene functions are associated with the size of brain regions and with overall cognitive function. (biorxiv.org)
  • COCOA investigates whether the following five environmental variables contribute causally to the development and natural course of allergic diseases: (1) perinatal indoor factors ( i.e. house-dust mite, bacterial endotoxin, tobacco smoking, and particulate matters 2.5 and 10), (2) perinatal outdoor pollutants, (3) maternal prenatal psychosocial stress and the child's neurodevelopment, (4) perinatal nutrition, and (5) perinatal microbiome. (biomedcentral.com)
  • The child's microbiome, genes, epigenetics, plasma cytokine levels, and neuropsychological status, the microbiome of the residence, and the levels of indoor and outdoor pollutants are measured by standard procedures. (biomedcentral.com)
  • And we do media briefings, like this one, where we're going to present you with a trio of experts with some deep knowledge on the topic of the day, the microbiome and its connection to health and, in particular, the gut microbiome. (sciline.org)
  • This review aims to provide an overview of pediatric IBD and discuss the role of the gut microbiome, IL-10/STAT3 pathway, and HO-1 gene in modulating immune homeostasis in IBD pathogenesis. (biomedres.us)
  • That ecosystem-the microorganisms, their genes, and even the surrounding environment 1 - that's your skin microbiome. (gladskin.com)
  • 3 The skin microbiome also has an important role to play in maintaining immune function and mediating inflammation. (gladskin.com)
  • Thomas Clavel from ZIEL and colleagues describe a new resource in "Nature Microbiology" which, for the first time, contains a hundred cultured bacterial strains from the mouse gut microbiome. (vetscite.org)
Susceptibility4
  • We evaluated MBL2 variants known to influence MBL levels with pediatric influenza-related critical illness susceptibility and/or severity including with bacterial co-infections. (escholarship.org)
  • We used a population control of 1,142 healthy children and also analyzed family trios (PBAT/HBAT) to evaluate disease susceptibility, and nested case-control analyses to evaluate severity. (escholarship.org)
  • We found no association between influenza-related critical illness susceptibility and MBL2 variants using family trios (633 biologic parents) or compared to population controls. (escholarship.org)
  • Cord blood and blood samples from the child are used to assess whether the child's genes and epigenetic changes influence allergic-disease susceptibility. (biomedcentral.com)
Innate immune protein2
  • a non-specific immunoglobulin of adaptive immunity) is not quiescent, but plays a crucial role in immediate immune defense by collaborating with ficolin (an innate immune protein). (wikipedia.org)
  • Mannose-binding lectin (MBL) is an innate immune protein with strong biologic plausibility for protecting against influenza virus-related sepsis and bacterial co-infection. (escholarship.org)
Variants3
  • Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness. (escholarship.org)
  • MBL2 variants were not associated with admission illness severity, septic shock, ALI, or bacterial co-infection diagnosis. (escholarship.org)
  • In addition to the genes that directly relate to hormones, the most important genetic variants that can affect hormones and fertility are genes dealing with antioxidant production, phase 1 (CYP genes), and phase 2 (methylation, glucuronidation, sulfonation, glutathione conjugation related genes) liver detoxification. (rebelhealthtribe.com)
Mutations4
  • The in vitro synthesis of proteins in cell-free extracts is an important tool for molecular biologists and has a variety of applications, including the rapid identification of gene products (e.g., proteomics), localization of mutations through synthesis of truncated gene products, protein folding studies, and incorporation of modified or unnatural amino acids for functional studies. (netlify.app)
  • New mutations identified within the IL-10 pathway have been shown to disrupt immune homeostasis and cause gastrointestinal inflammation. (biomedres.us)
  • August 9, 2022 - Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant from Stand Up To Cancer® (SU2C) to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients who currently lack effective treatment options. (mssm.edu)
  • H) 2015 AIP Creating LLC.Goal: Steroidogenic acute regulating (Celebrity) proteins plays a vital role within steroidogenesis, along with mutations from the STAR gene result in genetic lipoid adrenal hyperplasia (CLAH). (micrornainhibitors.com)
Protein7
  • The combination of collagen-like and fibrinogen-like domain allows the protein to form a basic subunit containing a triple helical tail and a trio of globular heads. (wikipedia.org)
  • THESIS FOR DOCTORAL DEGREE av M Selmer · 2002 · Citerat av 2 - In this thesis three different protein components of the bacterial protein synthesis system have been structurally studied. (netlify.app)
  • Contains a trio of protein sources to drip-feed your muscles. (netlify.app)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • One of the few antigens against which mammals develop protective immunity is the highly polymorphic OspC protein, encoded by the ospC gene on the cp26 plasmid. (cdc.gov)
  • By means of DNA sequencing of a large sample collection of the pathogen from across the United States, we studied the gene for the bacterium's highly diverse OspC protein, protective immunity against which develops in animals. (cdc.gov)
Strains1
  • Over time, OspC genes were transferred between strains through recombinations involving the whole or parts of the gene and one or both flanks. (cdc.gov)
Loci1
  • Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)
Defense1
Immunity2
  • By acquisition of the complete part or a large part of a novel ospC gene, an otherwise adapted strain would assume a new serotypic identity, thereby being comparatively fitter in an area with a high prevalence of immunity to existing OspC types. (cdc.gov)
  • Acquisitions of OspC genes that are novel for the region confer to recipients unique identities to host immune systems and, presumably, selective advantage when immunity to existing types is widespread among hosts. (cdc.gov)
Acute2
  • The IL-10/STAT3 pathway is a well-studied gene pathway as is, involved in maintaining immune homeostasis in both acute and chronic inflammation. (biomedres.us)
  • I.V. Vitamin C is indicated for immune support, allergies, wound healing, viral conditions and in some cases acute bacterial infections. (cardeahealthwny.com)
Exaggerated immune response1
  • An allergy is an exaggerated immune response or reaction to substances that are generally not harmful. (flaglerlive.com)
Influenza2
  • In an autopsy cohort of 105 influenza-infected young people, carriage of the deleterious MBL gene MBL2 _Gly54Asp("B") mutation was identified in 5 of 8 individuals that died from influenza-methicillin-resistant Staphylococcus aureus (MRSA) co-infection. (escholarship.org)
  • October 5, 2022 - Researchers have identified the gene TDRD7 as a key regulator against influenza A virus (IAV), which causes respiratory tract infections in 5 to 20 percent of the human population. (mssm.edu)
Liver2
  • The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)
  • Glutathione is a powerful antioxidant which neutralizes free radicals, enhances the immune system, and improves liver detoxification. (cardeahealthwny.com)
Genetics1
  • Genetics and Detoxification: Your genes are key to knowing what detox protocol will best suit your body. (rebelhealthtribe.com)
Inflammatory2
  • Inflammatory bowel disease (IBD) is an auto-immune condition characterized by chronic gastrointestinal inflammation. (biomedres.us)
  • Inflammatory bowel disease (IBD), mostly ulcerative colitis (UC) and Crohn's disease (CD), is a chronic auto-immune condition affecting 0.4% to 0.6% of the North American population [1]. (biomedres.us)
Antibiotics2
  • Before the mercury exposure was disclosed, the siblings were treated with platelet transfusions, intravenous immune globulin (IVIG) for possible immune thrombocytopenic purpura, and antibiotics for possible infectious causes. (cdc.gov)
  • Normally, antibiotics are quite effective for bacterial infection. (jeffreydachmd.com)
Adrenal1
  • The Myers' Cocktail combines magnesium, calcium, B vitamins, and vitamin C. This combination of nutrients is versatile for immune boosting and adrenal support. (cardeahealthwny.com)
Chromosome1
  • Ficolin-1 and ficolin-2 are encoded be a gene localised on chromosome 9 (9q34) and they share approximately 80% identity in amino sequence. (wikipedia.org)
Essential1
  • The TWiPinella solve the case of the Woman from Guinea, and describe the use of CRISPR/Cas9 to identify essential apicomplexan genes. (libsyn.com)
Genetic3
  • They watched for genetic variations between those cells that had high rates of bacterial invasion and those that didn't, and found their answer: a single nucleotide of DNA, in a gene VAC14, was associated with how rapidly the bacteria spread. (ajmc.com)
  • August 5, 2022 - Mount Sinai researchers have achieved an unprecedented understanding of the genetic and molecular machinery in human microglia-immune cells that reside in the brain-that could provide valuable insights into how they contribute to the development and progression of Alzheimer's disease (AD). (mssm.edu)
  • However, there are quite a lot more genes that can affect your hormones, which is why getting a personalized reading of your genetic blueprint can give you so many answers! (rebelhealthtribe.com)
Mice3
  • The effects of Tri-ortho-tolyl Phosphate (TOTP) on the immune system of mice. (cdc.gov)
  • Scientists are still discovering the extent of the relationship between the gut and the skin, but studies in mice and in people show that introducing changes to bacteria in the gut can influence the skin and the immune system. (gladskin.com)
  • The goal of our work was to take a big initial step towards decoding the cultured fraction of gut bacterial communities in mice. (vetscite.org)
Allergies1
Diseases1
  • 8 Babies born via c-section are less likely to receive the same diversity of bacteria, and are at higher risk of developing eczema and other immune-driven diseases. (gladskin.com)
Bacteria2
  • Mary Mallon was a cook who was apparently immune to the bacteria she carried in her gallbladder, but infected more than 50 people in New York City between 1900 and 1915. (ajmc.com)
  • Researchers were able to confirm this by knocking out the gene, and the bacteria invaded even more easily, as seen by the fluorescent marker. (ajmc.com)
Inflammation1
System1
  • It builds healthy cells and repairs ones that are damaged, keeps your immune system in tip-top shape and helps you to feel full and satisfied after a meal, making weight loss easier. (netlify.app)
Mutation1
  • These studies looked into the particular Legend mutation variety and also functionally reviewed a manuscript Legend mutation throughout Mandarin chinese patients immune-mediated adverse event using CLAH. (micrornainhibitors.com)
Crucial1
  • Proteogenomics, which studies the roles of proteins and genes within a cell or organism, is a crucial area of exploration to further our understanding of cancer. (mssm.edu)
Studies2
  • Li Zhao studies the intriguing genes that emerge from previously silent or non-coding stretches of DNA. (rockefeller.edu)
  • We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. (bioseek.eu)
Response2
  • That imbalanced state is called dysbiosis, and it can result in an altered immune response. (gladskin.com)
  • October 25, 2022 - A new approach to cancer immunotherapy that uses one type of immune cell to kill another-rather than directly attacking the cancer-provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York. (mssm.edu)
Cells1
  • The CDC is immune cells and 30s as a immunosurveillance for building guidelines to be the 2008 Physical Activity Guidelines( HHS, 2008). (tassenkuchenblog.de)
Expression1
Diverse1
  • The most diverse bacterial environment on your skin: your forearm. (gladskin.com)
Levels1
  • Low ficolin levels contribute to cirrhosis-associated immune dysfunction. (wikipedia.org)
Function1
Patients2
  • All patients with advanced PC were tested for hot-spot panels using NGS panels including a 50-gene panel, a 409-gene panel if the standard 50-gene panel (Ion Torrent, Life Technology) was negative or a FoundationOne panel. (cancerindex.org)
  • Among the 11 patients, 4 patients had the 50-gene panel only, 6 had 409-gene panel after a negative 50-gene panel and 1 had FoundationOne. (cancerindex.org)
Present1
  • Ficolins are pattern recognition receptors that bind to acetyl groups present in the carbohydrates of bacterial surfaces and mediate activation of the lectin pathway of the complement cascade. (wikipedia.org)
Articles1
  • ont permis la publication de plus de 370 articles et monographies, dont une 44 en 2020. (u-paris.fr)
Host2
  • Various bacterial pathogens release NADase enzymes into the host cell that deplete the host's NAD + pool, thereby causing rapid cell death. (nature.com)
  • Borrelia burgdorferi , an emerging bacterial pathogen, is maintained in nature by transmission from one vertebrate host to another by ticks. (cdc.gov)
News1
  • The news media reported a Nevada women who succumbed to bacterial infection with an antibiotic resistant super bug called CRE, short for carbapenem-resistant Enterobacteriaceae. (jeffreydachmd.com)
Risk1
  • She found that the VAC14 gene variant was associated with a moderate risk of typhoid fever. (ajmc.com)
Found1
  • We found that the distributions and frequencies of types of OspC genes differed between populations of B. burgdorferi in the Northeast, the Midwest, and California. (cdc.gov)
Effect1
  • 1992. Effect of tricresyl phosphate on humoral and cell-mediated immune responses in albino rats. (cdc.gov)