• lymphocytes
  • Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof. (wikipedia.org)
  • These cells include T lymphocytes (T cells), that primarily mediate the immune system, B lymphocytes (B cells) and Natural Killer cells. (wikipedia.org)
  • Abnormal neutrophil chemotaxis due to decreased production of interferon gamma by T lymphocytes is thought to cause the disease. (wikipedia.org)
  • strains
  • The plethora of inbred mouse strains, including genetically modified animals, and the depth of knowledge of the murine immune system have made studies of the mouse particularly valuable. (asmscience.org)
  • Genetic analysis of 117 albino rat strains collected from all parts of the world carried out by a team led by Takashi Kuramoto at Kyoto University in 2012, showed that the albino rats descended from hooded rats and all the albino rats descended from a single ancestor. (wikipedia.org)
  • In the acute form of the disease caused by highly virulent strains, pigs may develop a high fever, but show no other noticeable symptoms for the first few days. (wikipedia.org)
  • disorders
  • Oesophageal diseases include a spectrum of disorders affecting the oesophagus. (wikipedia.org)
  • Chronic diseases might include congenital diseases such as Zenker's diverticulum and esophageal webbing, and oesophageal motility disorders including the nutcracker oesophagus, achalasia, diffuse oesophageal spasm, and oesophageal stricture. (wikipedia.org)
  • Congenital disorders of the stomach include pernicious anaemia, in which a targeted immune response against parietal cells results in an inability to absorb vitamin B12. (wikipedia.org)
  • Many types of interactions involve both the nervous and immune systems including the physiological functioning of the two systems in health and disease, malfunction of either and or both systems that leads to disorders, and the physical, chemical, and environmental stressors that affect the two systems on a daily basis. (wikipedia.org)
  • While some disorders may affect the nervous and immune systems independently of one another, it is impossible to truly understand neuroimmnulogical science without a complex understanding of how each system works independently and also how they work together. (wikipedia.org)
  • viral
  • Second, the only way to help prevent the spread of viral disease amongst cats is to know the viral status of individuals. (sandcreekanimalhospital.com)
  • Newer polymerase chain reaction (PCR) diagnostic tests that detect viral genetic material have been developed to confirm FeLV infections. (sandcreekanimalhospital.com)
  • Viral tropism for the decidua and placenta is then dependent on viral entry receptor expression in these tissues as well as on the maternal immune response to the virus. (jci.org)
  • IFNs belonging to all three classes are important for fighting viral infections and for the regulation of the immune system. (wikipedia.org)
  • Expression of type I and III IFNs can be induced in virtually all cell types upon recognition of viral components, especially nucleic acids, by cytoplasmic and endosomal receptors, whereas type II interferon is induced by cytokines such as IL-12, and its expression is restricted to immune cells such as T cells and NK cells. (wikipedia.org)
  • Bean pod mottle virus Table of Contents Description and Importance Symptoms Disease Cycle and Pathogenesis Agronomic Impact Management Strategies Genetic Resistance Cultural Tactics Chemical Tactics Description and Importance BPMV is the viral pathogen that causes the disease Bean Pod Mottle in soybeans and other legumes such as snap peas. (wikipedia.org)
  • Mediators
  • Immunological, physiological and psychological stressors engage cytokines and other immune molecules as mediators of interactions with neuroendocrine, neuropeptide, and neurotransmitter systems. (wikipedia.org)
  • embryonic
  • Senescent cells affect tumour suppression, wound healing and possibly embryonic/placental development and a pathological role in age-related diseases. (wikipedia.org)
  • This was the first in a series of development that have begun to make rats tractable as genetic research subjects, although they still lag behind mice, which lend themselves better to the embryonic stem cell techniques typically used for genetic manipulation. (wikipedia.org)
  • senescence
  • The discovery, in 1934, that calorie restriction can extend lifespan by 50% in rats, and the existence of species having negligible senescence and potentially immortal species such as Hydra, have motivated research into delaying and preventing senescence and thus age-related diseases. (wikipedia.org)
  • This new branch has already provided unique insights into the mechanisms underlying brain development, evolution, neuronal and network plasticity and homeostasis, senescence, the etiology of diverse neurological diseases and neural regenerative processes. (wikipedia.org)
  • infections
  • Human infections of hantaviruses have almost entirely been linked to human contact with rodent excrement, but recent human-to-human transmission has been reported with the Andes virus in South America. (wikipedia.org)
  • ischemic
  • There are four categories of people who are considered to be at higher risk, hence strongly advised to be immunised - pregnant women, young children below the age of 5 years, elderly people, and those whose immunity is compromised because of factors such as asthma, diabetes, ischemic heart disease to name a few. (medindia.net)
  • occur
  • Third, keep in mind that true allergies typically cause immediate reactions, involving the immune system as a whole and occur within a few minutes to a few hours of vaccination. (healthcanal.com)
  • 1775
  • The first cause of cancer was identified by British surgeon Percivall Pott, who discovered in 1775 that cancer of the scrotum was a common disease among chimney sweeps. (wikipedia.org)
  • 2016
  • University of Minnesota Extension, 2016) Disease Cycle and Pathogenesis BPMV can be transferred via insect vector such as the bean leaf beetle or from infected seed which is a low occurrence (Michigan State University Field Crop Pathology), although it is still not fully understood how the virus gets from one host from another host, if not bean leaf beetles. (wikipedia.org)
  • recessive
  • Reticular dysgenesis (RD) is a rare, inherited autosomal recessive disease that results in immunodeficiency. (wikipedia.org)
  • This therapy is currently undergoing clinical trial and has cured a small number of children suffering from X-linked SCID and recessive allele SCID. (wikipedia.org)
  • chronic
  • The most common condition of the oesophagus in Western countries is gastroesophageal reflux disease, which in chronic forms is thought to result in changes to the epithelium of the oesophagus, known as Barrett's oesophagus. (wikipedia.org)
  • When gastritis persists in a chronic state, it is associated with several diseases, including atrophic gastritis, pyloric stenosis, and gastric cancer. (wikipedia.org)
  • cause
  • What diseases do these viruses cause? (sandcreekanimalhospital.com)
  • Some diseases which involve other parts of the GI tract can manifest in the mouth, alone or in combination, including: Gastroesophageal reflux disease can cause acid erosion of the teeth and halitosis. (wikipedia.org)
  • Several GI diseases, especially those associated with malabsorption, can cause recurrent mouth ulcers, atrophic glossitis, and angular cheilitis (e.g. (wikipedia.org)
  • Diseases of the intestine may cause vomiting, diarrhoea or constipation, and altered stool, such as with blood in stool. (wikipedia.org)
  • They normally infect rodents and do not cause disease in these hosts. (wikipedia.org)
  • The Dutch professor Francois de la Boe Sylvius, a follower of Descartes, believed that all disease was the outcome of chemical processes, and that acidic lymph fluid was the cause of cancer. (wikipedia.org)
  • replication
  • Together, the results of this study lay the groundwork for future studies to explore the role of DNA replication in immune cell generation and function. (jci.org)
  • response
  • Since some cats are able to subsequently mount an appropriate immune response and eliminate the virus from their bodies, this viremia (literally virus in the blood) may not be permanent. (sandcreekanimalhospital.com)
  • An alternative to the IFA test is to repeat the ELISA test in the clinical setting in one month, thus allowing the cat time to mount an appropriate immune response and potentially eliminate the FeLV virus. (sandcreekanimalhospital.com)
  • In general, type I and II interferons are responsible for regulating and activating the immune response. (wikipedia.org)
  • ticks
  • The virus causes a haemorrhagic fever with high mortality rates in pigs, but persistently infects its natural hosts, warthogs, bushpigs, and soft ticks of the Ornithodoros genus, with no disease signs. (wikipedia.org)
  • mechanisms
  • is that the virus strain originated at Fort Riley, Kansas, by two genetic mechanisms - genetic drift and antigenic shift - in viruses in poultry and swine which the fort bred for local consumption. (wikipedia.org)
  • affects
  • This disease disproportionally affects black patients, with higher incidence rates, more advanced stage at diagnosis and decreased survival rates compared to other ethnic groups. (healthcanal.com)
  • human
  • This year's awards showcase achievements in cardiovascular disease, cancer, immunotherapy and human parasitic diseases. (ucsd.edu)
  • In the two crystal structures of normal human G6P, Pro172 is seen exclusively in the cis confirmation, while in the crystal structure of one disease causing mutant (variant Canton R459L), Pro172 is seen almost exclusively in the trans confirmation. (wikipedia.org)
  • health and dis
  • The cardiac extracellular matrix (ECM) not only provides mechanical support, but also transduces essential molecular signals in health and disease. (jci.org)
  • From the US National Institute of Health: "Despite the brain's status as an immune privileged site, an extensive bi-directional communication takes place between the nervous and the immune system in both health and disease. (wikipedia.org)
  • known
  • I. Sandoval, N. Áñez, E. Villegas, and J. V. Scorza, "Persistent transmission of Chagas disease in controlled venezuelan localities in absence of known domestic vectors," Revista de la Sociedad Venezolana de Microbiología , vol. 23, no. 2, pp. 166-168, 2003. (hindawi.com)
  • We have now identified three cases: the Brevig Mission case and two archival cases that represent the only known sources of genetic material of the 1918 influenza virus", said Taubenberger, chief of AFIP's molecular pathology division and principal investigator on the project. (wikipedia.org)
  • deaths
  • 50% of those affected do not live beyond 25 years of age, with deaths attributed to the impaired immune function. (wikipedia.org)
  • gene expression
  • Many of the immediate gaps in knowledge are attributed to basic lack of understanding of gene expression and regulation and are thus the limiting factors for creating advanced treatments or cures to many diseases. (wikipedia.org)
  • To better understand these processes, neuroimmunological experiments are being created and tested to once and for all amass a more complete anthology of knowledge pertaining to the complex interactions between the nervous and immune systems along with that of gene expression. (wikipedia.org)
  • differences
  • and/or race-based differences in disease biology. (healthcanal.com)
  • Finally, interactions of immune molecules with the hypothalamic-pituitary-gonadal system indicate that sex differences are a significant factor determining the impact of neuroimmune influences on brain function and behavior. (wikipedia.org)
  • certain
  • A long-term goal of this rapidly developing research area is to further develop our understanding of the pathology of certain neurological diseases, some of which have no clear etiology. (wikipedia.org)
  • virus
  • It was originally called "Four Corners disease," but the name was changed to "Sin Nombre virus" after complaints by Native Americans that the name "Four Corners" stigmatized the region. (wikipedia.org)
  • The virus causes a lethal haemorraghic disease in domestic pigs. (wikipedia.org)
  • One of the four recovered samples contained viable genetic material of the virus. (wikipedia.org)