• lymphocytes
  • Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof. (wikipedia.org)
  • These cells include T lymphocytes (T cells), that primarily mediate the immune system, B lymphocytes (B cells) and Natural Killer cells. (wikipedia.org)
  • Abnormal neutrophil chemotaxis due to decreased production of interferon gamma by T lymphocytes is thought to cause the disease. (wikipedia.org)
  • deficiency
  • In 2017 the FDA approved it for any unresectable or metastatic solid tumor with certain genetic anomalies (mismatch repair deficiency or microsatellite instability). (wikipedia.org)
  • Genetic testing is available for STAT3 (Job's Syndrome), DOCK8 (DOCK8 Immunodeficiency or DIDS), PGM3 (PGM3 deficiency), SPINK5 (Netherton Syndrome - NTS), and TYK2 genetic defects. (wikipedia.org)
  • system
  • The plethora of inbred mouse strains, including genetically modified animals, and the depth of knowledge of the murine immune system have made studies of the mouse particularly valuable. (asmscience.org)
  • Her findings have not only deepened our understanding of how the brain works, but have spurred entirely original fields of inquiry-including a new way of looking at how the immune system communicates with the nervous system, and how this web of interactions gets disrupted in disease. (the-scientist.com)
  • MHC class I molecules are used by the immune system to present antigens for recognition by T cells. (the-scientist.com)
  • Once thought only to attack neurons, immune cells turn out to be vital for central nervous system function. (the-scientist.com)
  • Summary: Researchers link obsessive behaviors in frontotemporal dementia to immune pathways and suggest targeting the immune system could be a new strategy for the treatment of FTD. (neurosciencenews.com)
  • They linked these behaviors to immune pathways, implicating that targeting key components of the immune system could be a new therapeutic strategy for FTD. (neurosciencenews.com)
  • From these key pieces of information, the Gan team wondered how the immune system, and TNF in particular, might be involved in FTD. (neurosciencenews.com)
  • Third, keep in mind that true allergies typically cause immediate reactions, involving the immune system as a whole and occur within a few minutes to a few hours of vaccination. (healthcanal.com)
  • IFNs belonging to all three classes are important for fighting viral infections and for the regulation of the immune system. (wikipedia.org)
  • It blocks a protective mechanism of cancer cells, and allows the immune system to destroy those cancer cells. (wikipedia.org)
  • this same mechanism also allows the immune system to attack the body itself, and checkpoint inhibitors like pembrolizumab have immune-dysfunction side effects as a result. (wikipedia.org)
  • pembrolizumab appears to facilitate clearance of any such tumor by the immune system, by preventing the self-checkpoint system from blocking the clearance. (wikipedia.org)
  • Plasma cells are key effector elements of the adaptive immune system. (wikipedia.org)
  • The immune system consists of specialized cells that work together to fight off bacteria, fungi and viruses. (wikipedia.org)
  • A weakened immune system leaves patients susceptible to different kinds of infection. (wikipedia.org)
  • Hematopoietic Stem Cell Transplantation (HSCT) involves intravenous infusion of stem cells to those who have either a damaged bone marrow or defective immune system. (wikipedia.org)
  • Neuroimmunology is a field combining neuroscience, the study of the nervous system, and immunology, the study of the immune system. (wikipedia.org)
  • From the US National Institute of Health: "Despite the brain's status as an immune privileged site, an extensive bi-directional communication takes place between the nervous and the immune system in both health and disease. (wikipedia.org)
  • Finally, interactions of immune molecules with the hypothalamic-pituitary-gonadal system indicate that sex differences are a significant factor determining the impact of neuroimmune influences on brain function and behavior. (wikipedia.org)
  • While some disorders may affect the nervous and immune systems independently of one another, it is impossible to truly understand neuroimmnulogical science without a complex understanding of how each system works independently and also how they work together. (wikipedia.org)
  • infection
  • Late infection, or stage 3 (persistent or progressive infection), usually begins months to years after the disease onset, sometimes following long periods of latent infection. (asmscience.org)
  • The classic sign of early local infection with Lyme disease is a circular, outwardly expanding rash called erythema chronicum migrans (EM), which occurs at the site of the tick bite three to 32 days after the tick bite. (wikipedia.org)
  • In addition to yield, BPMV can reduce grain quality through protein and oil content, reduced seed quality and performance (discolored appearance, low germination and seedling vigor), delayed plant maturation, and the predisposition to other stresses and diseases (such as infection of Phomopsis fungus decreasing germination of seed and seedling vigor). (wikipedia.org)
  • Some scientists have proposed that some of the genetic variation in human G6PD resulted from generations of adaptation to malarial infection. (wikipedia.org)
  • strains
  • Genetic analysis of 117 albino rat strains collected from all parts of the world carried out by a team led by Takashi Kuramoto at Kyoto University in 2012, showed that the albino rats descended from hooded rats and all the albino rats descended from a single ancestor. (wikipedia.org)
  • In the acute form of the disease caused by highly virulent strains, pigs may develop a high fever, but show no other noticeable symptoms for the first few days. (wikipedia.org)
  • disorders
  • Oesophageal diseases include a spectrum of disorders affecting the oesophagus. (wikipedia.org)
  • Chronic diseases might include congenital diseases such as Zenker's diverticulum and esophageal webbing, and oesophageal motility disorders including the nutcracker oesophagus, achalasia, diffuse oesophageal spasm, and oesophageal stricture. (wikipedia.org)
  • Congenital disorders of the stomach include pernicious anaemia, in which a targeted immune response against parietal cells results in an inability to absorb vitamin B12. (wikipedia.org)
  • Many types of interactions involve both the nervous and immune systems including the physiological functioning of the two systems in health and disease, malfunction of either and or both systems that leads to disorders, and the physical, chemical, and environmental stressors that affect the two systems on a daily basis. (wikipedia.org)
  • viral
  • Second, the only way to help prevent the spread of viral disease amongst cats is to know the viral status of individuals. (sandcreekanimalhospital.com)
  • Newer polymerase chain reaction (PCR) diagnostic tests that detect viral genetic material have been developed to confirm FeLV infections. (sandcreekanimalhospital.com)
  • Viral tropism for the decidua and placenta is then dependent on viral entry receptor expression in these tissues as well as on the maternal immune response to the virus. (jci.org)
  • Expression of type I and III IFNs can be induced in virtually all cell types upon recognition of viral components, especially nucleic acids, by cytoplasmic and endosomal receptors, whereas type II interferon is induced by cytokines such as IL-12, and its expression is restricted to immune cells such as T cells and NK cells. (wikipedia.org)
  • Bean pod mottle virus Table of Contents Description and Importance Symptoms Disease Cycle and Pathogenesis Agronomic Impact Management Strategies Genetic Resistance Cultural Tactics Chemical Tactics Description and Importance BPMV is the viral pathogen that causes the disease Bean Pod Mottle in soybeans and other legumes such as snap peas. (wikipedia.org)
  • 2016
  • University of Minnesota Extension, 2016) Disease Cycle and Pathogenesis BPMV can be transferred via insect vector such as the bean leaf beetle or from infected seed which is a low occurrence (Michigan State University Field Crop Pathology), although it is still not fully understood how the virus gets from one host from another host, if not bean leaf beetles. (wikipedia.org)
  • Pathology
  • A long-term goal of this rapidly developing research area is to further develop our understanding of the pathology of certain neurological diseases, some of which have no clear etiology. (wikipedia.org)
  • molecules
  • Immunological, physiological and psychological stressors engage cytokines and other immune molecules as mediators of interactions with neuroendocrine, neuropeptide, and neurotransmitter systems. (wikipedia.org)
  • embryonic
  • Senescent cells affect tumour suppression, wound healing and possibly embryonic/placental development and a pathological role in age-related diseases. (wikipedia.org)
  • This was the first in a series of development that have begun to make rats tractable as genetic research subjects, although they still lag behind mice, which lend themselves better to the embryonic stem cell techniques typically used for genetic manipulation. (wikipedia.org)
  • senescence
  • Although senescent cells can no longer replicate, they remain metabolically active and commonly adopt an immunogenic phenotype consisting of a pro-inflammatory secretome, the up-regulation of immune ligands, a pro-survival response, promiscuous gene expression (pGE) and stain positive for senescence-associated β-galactosidase activity. (wikipedia.org)
  • This new branch has already provided unique insights into the mechanisms underlying brain development, evolution, neuronal and network plasticity and homeostasis, senescence, the etiology of diverse neurological diseases and neural regenerative processes. (wikipedia.org)
  • acute
  • Acute disease might include infections such as oesophagitis, trauma caused ingestion of corrosive substances, or rupture of veins such as oesophageal varices, Boerhaave syndrome or Mallory-Weiss tears. (wikipedia.org)
  • Chronic or congenital diseases might be investigated using barium swallows, endoscopy and biopsy, whereas acute diseases such as reflux may be investigated and diagnosed based on symptoms and a medical history alone. (wikipedia.org)
  • symptoms
  • There is no cure for FTD, but by better understanding what underlies the symptoms of the disease, researchers believe that they will move closer to a cure. (neurosciencenews.com)
  • Other common symptoms that stomach disease might cause include indigestion or dyspepsia, vomiting, and in chronic disease, digestive problems leading to forms of malnutrition. (wikipedia.org)
  • chronic
  • The most common condition of the oesophagus in Western countries is gastroesophageal reflux disease, which in chronic forms is thought to result in changes to the epithelium of the oesophagus, known as Barrett's oesophagus. (wikipedia.org)
  • When gastritis persists in a chronic state, it is associated with several diseases, including atrophic gastritis, pyloric stenosis, and gastric cancer. (wikipedia.org)
  • advances
  • The findings are possible because of advances in machines that sequence genetic information made by companies such as Illumina and Roche. (health24.com)
  • Advances in genetic testing and more widespread use of Array Comparative Genomic Hybridization has led to increased diagnosis of MECP2 duplication syndrome. (wikipedia.org)
  • endemic
  • While plague is found in several countries, there is little risk to United States travelers within endemic areas (limited locales where a disease is known to be present) if they restrict their travel to urban areas with modern hotel accommodations. (encyclopedia.com)
  • infections
  • Human infections of hantaviruses have almost entirely been linked to human contact with rodent excrement, but recent human-to-human transmission has been reported with the Andes virus in South America. (wikipedia.org)
  • replication
  • Together, the results of this study lay the groundwork for future studies to explore the role of DNA replication in immune cell generation and function. (jci.org)
  • response
  • Since some cats are able to subsequently mount an appropriate immune response and eliminate the virus from their bodies, this viremia (literally virus in the blood) may not be permanent. (sandcreekanimalhospital.com)
  • In general, type I and II interferons are responsible for regulating and activating the immune response. (wikipedia.org)
  • cause
  • What diseases do these viruses cause? (sandcreekanimalhospital.com)
  • Some diseases which involve other parts of the GI tract can manifest in the mouth, alone or in combination, including: Gastroesophageal reflux disease can cause acid erosion of the teeth and halitosis. (wikipedia.org)
  • Several GI diseases, especially those associated with malabsorption, can cause recurrent mouth ulcers, atrophic glossitis, and angular cheilitis (e.g. (wikipedia.org)
  • Diseases of the intestine may cause vomiting, diarrhoea or constipation, and altered stool, such as with blood in stool. (wikipedia.org)
  • mice
  • In mice and flies, the Arc protein forms capsids and carries genetic information. (the-scientist.com)
  • They began their study by using genetic methods to delete the gene for TNF in mice that lacked progranulin. (neurosciencenews.com)
  • The experimental elimination of senescent cells from transgenic progeroid mice and non-progeroid, naturally-aged mice led to greater resistance against aging-associated diseases. (wikipedia.org)
  • ticks
  • The virus causes a haemorrhagic fever with high mortality rates in pigs, but persistently infects its natural hosts, warthogs, bushpigs, and soft ticks of the Ornithodoros genus, with no disease signs. (wikipedia.org)
  • affects
  • This disease disproportionally affects black patients, with higher incidence rates, more advanced stage at diagnosis and decreased survival rates compared to other ethnic groups. (healthcanal.com)
  • health and dis
  • The cardiac extracellular matrix (ECM) not only provides mechanical support, but also transduces essential molecular signals in health and disease. (jci.org)
  • deaths
  • 50% of those affected do not live beyond 25 years of age, with deaths attributed to the impaired immune function. (wikipedia.org)
  • gene expression
  • Many of the immediate gaps in knowledge are attributed to basic lack of understanding of gene expression and regulation and are thus the limiting factors for creating advanced treatments or cures to many diseases. (wikipedia.org)
  • To better understand these processes, neuroimmunological experiments are being created and tested to once and for all amass a more complete anthology of knowledge pertaining to the complex interactions between the nervous and immune systems along with that of gene expression. (wikipedia.org)
  • found
  • It was found that people adjusted to their respective ailments or diseases and gained a resiliency which allowed them to function in productive ways. (wikipedia.org)
  • human disease
  • Early data from the 1,000 Genomes Project is already offering new clues about human disease, including why some people are more severely affected by disease than others. (health24.com)
  • Early data from the 1,000 Genomes Project, an international effort to build a detailed map of human genetic variation, is already offering new clues about human disease, including why some people are more severely affected by disease than others. (health24.com)
  • I believe this is where we will make huge inroads in understanding the genetic basis of human disease,' Eichler said. (health24.com)