Organ transplantationMurineKidneyRenal transplantationOrthotopicHematopoieticCorneal TransplantationCardiac transplantationAllograftsMiceRejectionGraftsExperimentalHeartAllogeneicOrgansSyngeneicDonorAorticBone marrowStrainsLungLiverPancreasInnateCellular and humoral componentsTissueSurvivalClinicalSignificantlyHumoralCellsToleranceTherapeutic optionChronicSpecificityKidneysBody's
Organ transplantation9
- London, Canada -Antibody-mediated acute vascular rejection (AVR) is a major problem in organ transplantation. (stemcellpatents.com)
- According to the most current report from the United Network for Organ Sharing (UNOS), more than 107,241 Americans were waiting for organ transplantation as of May 2010. (medscape.com)
- Additionally, organs from animal sources could be transplanted into patients currently excluded from the human organ transplantation list. (medscape.com)
- Alexis Carrel is known as the founding father of experimental organ transplantation because of his pioneering work with vascular techniques. (medscape.com)
- Organ transplantation is a life-saving surgery that replaces the diseased organ with a healthy organ from a living or deceased person. (manipalhospitals.com)
- The organ transplantation unit at Manipal Hospitals is equipped with ultra-modern facilities and expert care to perform transplant surgeries with the utmost care. (manipalhospitals.com)
- Liver Transplantation Liver transplantation is the 2nd most common type of solid organ transplantation. (msdmanuals.com)
- Over the past half-century, organ transplantation has become a successful and evolving practice which provides benefit to over 100,000 individuals yearly worldwide. (lecturio.com)
- From 1968 to 1983, Chris Barnard and his team continued to make significant contributions to organ transplantation, notably the development of heterotopic heart transplants. (medicalartsshop.com)
Murine3
- Syngeneic transplantation of murine aorta segments with advanced atherosclerotic lesions in defined recipients is a valuable model for regression studies. (degruyter.com)
- Antigen sampling on the Peyer's patches in a murine small bowel transplantation model. (shengsci.com)
- Infusion of isolated mitochondria into heart donors leads to significant increase in allograft rejection in a murine heterotopic heart transplantation model. (duke.edu)
Kidney8
- One hundred kidney transplant recipients were evaluated on the first and fifth days after transplantation by Tc-99m mononuclear cell scintigraphy. (shengsci.com)
- They developed the buttonhole technique for anastomosis of donor and recipient vessels in kidney transplantation to prevent thrombus formation. (medscape.com)
- The first pancreas transplantation was performed in 1966 by the team of Dr. Kelly, Dr. Lillehei, Dr.Merkel, Dr.Idezuki Y, & Dr. Goetz, three years after the first kidney transplantation . (findmeacure.com)
- A pancreas along with kidney and duodenum was transplanted into a 28-year-old woman and her blood sugar levels decreased immediately after transplantation, but eventually she died three months later from pulmonary embolism. (findmeacure.com)
- Kidney transplantation is a save and well established technique to compensate loss of renal function in humans. (phenos.com)
- The first in the world to perform an innovative approach to kidney transplant without a lifelong regimen of immune-suppressing drugs. (stanfordchildrens.org)
- The first ever randomized study, in children or adults, for treating highly sensitized recipients for kidney transplantation. (stanfordchildrens.org)
- Some research is ongoing in transplantation of non-human organs, such as heart, kidney and liver transplantation. (msdmanuals.com)
Renal transplantation3
- Global cardiovascular risk under early corticosteroid cessation decreases progressively in the first year following renal transplantation. (shengsci.com)
- BACKGROUND: The role of angiotensin II type 1 receptor antibodies (AT1R-Ab) in pediatric renal transplantation is unclear. (bvsalud.org)
- Bβ(15-42) attenuates the effect of ischemia-reperfusion injury in renal transplantation. (phenos.com)
Orthotopic4
- Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model? (stanfordhealthcare.org)
- Here we describe the techniques of heterotopic and orthotopic tracheal transplantations in the rat, comparing the kinetics of systemic host immune response and of histopathologic OAD development.Heterotopic and orthotopic tracheal transplantations were performed in both allogeneic (Brown Norway-to-Lewis) and syngeneic (Lewis-to-Lewis) models. (stanfordhealthcare.org)
- As with immunocompetent animal models, these mice can also be used for both heterotopic and orthotopic tumor models. (uclahealth.org)
- These particles induce innate and adaptive host immune responses to preexisting tumors in both orthotopic and genetically engineered models of basal-like TNBC. (jci.org)
Hematopoietic5
- Striking progress has been observed in the number of volunteer donors for hematopoietic stem cell transplantation in the last years in Brazil. (shengsci.com)
- Secondary failure of platelet recovery (SFPR) is a life-threatening complication that may affect up to 20% of patients after allogeneic hematopoietic stem cell transplantation (HSCT). (bvsalud.org)
- Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. (hindawi.com)
- Hematopoietic Stem Cell Transplantation Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers ( leukemias, lymphomas, myeloma) and other hematologic disorders. (msdmanuals.com)
- Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. (bvsalud.org)
Corneal Transplantation1
- Corneal Transplantation Corneal transplantations are done for several reasons: To reconstruct the cornea (eg, replacing a perforated cornea) To relieve intractable pain (eg, severe foreign body sensation due to recurrent. (msdmanuals.com)
Cardiac transplantation2
- Implantable mechanical devices have been explored in the field of cardiac transplantation. (medscape.com)
- A novel and knotless technique for heterotopic cardiac transplantation in mice. (phenos.com)
Allografts1
- In heterotopic allografts, airway epithelium was rapidly destroyed and OAD progressed with complete luminal occlusion by 30 days. (stanfordhealthcare.org)
Mice3
- Aorta transplantation in young apolipoprotein E-deficient mice: Possible model for studies on regression of atherosclerotic lesions? (degruyter.com)
- The aim of this study was to evaluate a microsurgical technique of syngeneic heterotopic transplantation of the thoracic aorta of young apolipoprotein E-deficient (ApoE-/-) mice to the abdominal aorta of wild-type recipients. (degruyter.com)
- We carry over 140 strains of immune competent, immune deficient, and transgenic mice. (uclahealth.org)
Rejection11
- On 3 December 1967, Barnard transplanted the heart of accident victim Denise Darvall into the chest of 54-year-old Louis Washkansky, with Washkansky regaining full consciousness and being able to talk easily with his wife, before dying eighteen days later of pneumonia, largely brought on by the anti-rejection drugs that suppressed his immune system. (wikipedia.org)
- These include, but are not limited to, (1) preventing hyperacute rejection, (2) preventing acute vascular rejection, (3) facilitating immune accommodation, (4) inducing immune tolerance, (5) preventing the transmission of viruses from xenografts into humans, and (6) addressing the ethical issues surrounding animal sources for xenografts and the appropriate selection of recipients (given that xenotransplantation remains experimental). (medscape.com)
- Thus, to prevent rejection, organ transplant patients must take drugs (such as cyclosporine and corticosteroids) that suppress the immune response of the body. (findmeacure.com)
- The innate immune system is a critical regulator of the adaptive immune responses that lead to allograft rejection. (duke.edu)
- Short-term survival following heart transplantation has improved with the evolution of transplant immunology & immunosuppressive therapy, advances in organ preservation & surgical techniques, as well as diagnosis & management of acute rejection. (lidsen.com)
- Immunosuppressive therapy has improved during the last decade but still acute and chronic rejection are important complications after transplantation. (phenos.com)
- CCL19-IgG prevents allograft rejection by impairment of immune cell trafficking. (phenos.com)
- Heart transplantation is a well established technique to study mechanisms and therapeutic approaches to prevent solid organ transplant rejection. (phenos.com)
- T2 Mapping for Noninvasive Assessment of Interstitial Edema in Acute Cardiac Allograft Rejection in a Mouse Model of Heterotopic Heart Transplantation. (phenos.com)
- It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)
- Author Correction: Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. (ucsf.edu)
Grafts4
- When recipients are given a course of the conventionally used immune suppressant agent cyclosporin A, grafts survive 15 days. (stemcellpatents.com)
- Grafts were quickly rejected, however, because of unknown forces later identified as immune responses. (medscape.com)
- Skin grafts Many different types of tissues can be transplanted, including skin, bone, cartilage, adrenal tissue, fetal thymus, corneas, and composite transplantation of tissues to restore the face or extremities. (msdmanuals.com)
- Recipients of grafts containing immune cells (particularly bone marrow, intestine, and liver) are at risk of graft-vs-host disease, in which the donor immune cells attack recipient tissue. (msdmanuals.com)
Experimental2
- They also performed heterotopic experimental transplantation. (medscape.com)
- Areas related to clinical and experimental transplantation are also of interest. (lidsen.com)
Heart18
- This protocol describes a simple and efficient method for the transplantation of aortic valve leaflets under the renal capsule to allow for the study of alloreactivity of heart valves. (jove.com)
- Heart valve transplantation is proposed as a new type of transplant with the potential to deliver durable heart valves, capable of somatic growth with no requirement for anticoagulation. (jove.com)
- In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients' survival rate. (researchsquare.com)
- After heart transplantation, the donor heart preservation with normoxic CM was associated with shorter re-beating time, histopathological scores, and left ventricular systolic diameter, higher ejection fraction, and fractional shortening of transplanted hearts. (researchsquare.com)
- Heart transplantation remains a well-established therapy of choice for patients with refractory heart failure(1). (researchsquare.com)
- Despite the increasing population of heart failure patients, the number of heart transplantation has not increased proportionally over the past 2 decades due to the shortage of donor hearts(2). (researchsquare.com)
- Additionally, 5% to 10% of recipients have suffered from primary graft dysfunction (PGD) after heart transplantation(3). (researchsquare.com)
- The C3H to BALB/c heterotopic (second heart) cardiac transplant model resembles the human condition of AVR. (stemcellpatents.com)
- Significant progress has been achieved in improving one-year mortality after heart transplantation. (lidsen.com)
- Heterotopic vascularized heart transplantation is carried out according to the method of Corry et al. (phenos.com)
- The first pediatric heterotopic heart transplant in California. (stanfordchildrens.org)
- So, What is heart transplantation? (medicalartsshop.com)
- When was heart transplantation invented? (medicalartsshop.com)
- to generate guarded optimism that heart transplantation would eventually become a viable therapeutic option. (medicalartsshop.com)
- Today, heart transplantation has become a relatively routine and commonplace procedure. (medicalartsshop.com)
- How long does a heart transplantation surgery take? (medicalartsshop.com)
- With improvements in medications suppressing the immune system and preventing all kinds of infection, the survival rate among heart transplant patients has increased. (medicalartsshop.com)
- A cardiologist, cardiothoracic surgeon, trained nursing staff, and pharmacist well trained with titration and side effects of immunosuppressants can significantly improve heart transplantation outcomes. (medicalartsshop.com)
Allogeneic1
- An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)
Organs4
- Xenotransplantation involves the transplantation of nonhuman tissues or organs into human recipients. (medscape.com)
- In light of the lack of supply of human organs for transplantation, several alternatives have been investigated and debated. (medscape.com)
- Finally, most patients perceive xenotransplantation as an acceptable bridge to transplantation of human organs in life-threatening situations. (medscape.com)
- A shift in the nature of complications from early to late graft dysfunction has been similarly observed after transplantation of other solid organs 2 . (ersjournals.com)
Syngeneic1
- We have numerous syngeneic and xenogeneic tumor models, immunological models, and radiobiological partial and whole body, transplantation and tumor models. (uclahealth.org)
Donor1
- An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
Aortic1
- Stereological quantification methods were tested in order to assess changes in structure and volume of the aortic wall including the involvement of immune cells in changes of the atherosclerotic lesions. (degruyter.com)
Bone marrow3
- Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. (stemcellpatents.com)
- investigated that music therapy mitigated pain and nausea, the two most common side effects of transplantation, in patients undergoing bone marrow transplantation. (e-lub.net)
- Reconstitution of the peripheral T-cell compartment is a critical aspect for the success of bone marrow transplantation and is also dependent on the reestablishment of normal thymic structure and function. (ox.ac.uk)
Strains2
- Many immune competent mouse strains are bred in the vivarium under gnotobiotic conditions and are available for purchase at low cost. (uclahealth.org)
- Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
Lung3
- Lung conditions such as acute respiratory distress syndrome have no cure with exception of transplantation, which is limited to a small number of patients. (stemcellpatents.com)
- Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have made intermediate-term survival after lung transplantation an achievable goal. (ersjournals.com)
- Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have contributed to increase the 1‐yr patient survival after lung transplantation (LTx) to 70-80% 1 . (ersjournals.com)
Liver2
- Liver transplantation restores a better quality of life and helps patients in living healthy. (manipalhospitals.com)
- Indications for liver transplantation include Cirrhosis (70% of transplantations. (msdmanuals.com)
Pancreas1
- In 1979 the first living-related partial pancreas transplantation was done. (findmeacure.com)
Innate3
- Mitochondria, ancestrally related to bacteria, possess an array of endogenous innate immune-activating molecules. (duke.edu)
- Several lines of evidence suggest that dynamic interactions between the host's enteric microbiota and innate immune system modulate the intestinal response to radiation. (uclahealth.org)
- Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity. (ucsf.edu)
Cellular and humoral components1
- The FcgammaRIIa receptors, which provide a crucial link between cellular and humoral components of the immune response, display allelic polymorphism. (shengsci.com)
Tissue3
- The motivation for using animal sources for organ or tissue transplantation is driven by supply and demand. (medscape.com)
- Following a stroke, immune responses and neuroinflammation persist throughout all phases of injury, from early tissue damage to late brain tissue remodeling [ 3 , 4 ]. (explorationpub.com)
- Transplantation is a procedure that involves the removal of an organ or living tissue and placing it into a different part of the body or into a different person. (lecturio.com)
Survival2
- Almost always, transplantation is done to replace or restore the function of an end-stage diseased organ, thereby restoring an essential function and improving patient survival. (msdmanuals.com)
- However, some procedures (eg, hand, larynx, tongue, uterus, facial transplantation) enhance the quality of life but do not improve survival and have significant risks related to surgery and immunosuppression. (msdmanuals.com)
Clinical2
- Baboons were followed by clinical/laboratory monitoring of immune/coagulation parameters. (unict.it)
- Clinical Transplantation. (elsevierpure.com)
Significantly1
- The numbers of circulating CD4+CXCR5+, CD4+CXCR5+ICOS+, CD4+CXCR5+PD-1+, CD4+CXCR5+IL-21+ TFH, CD19+CD86+, and CD19 +CD86+CD38+ B cells as well as the level of serum IL-21 in the AMR, AR, and CR groups at post-transplantation were significantly higher than those at pre-transplantation. (bvsalud.org)
Humoral1
- It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. (lecturio.com)
Cells8
- At the same time, a subpopulation of highly tumorigenic glioma stem cells (GSCs) with high plasticity and self-renewal properties contribute to tumor malignancy through their sustained proliferation, invasion, stimulation of angiogenesis, suppression of anti-tumor immune responses and chemo-resistance ( 12 ). (frontiersin.org)
- The T regulatory cells is a specific component of the immune system that is activated by mesenchymal stem cells and has been associated with suppression of autoimmunity. (stemcellpatents.com)
- Also this stem cell population has been proposed, along with adipose stem cells , to have immune modulatory. (stemcellpatents.com)
- Moreover, the numbers of circulating CD4+CXCR5+IL-21+ TFH cells, CD19+CD86+CD38+ B cells as well as the level of serum IL-21 were positive related to the level of serum Cr while showing negative correlated with the values of eGFR in the AMR groups at post-transplantation for 4 and 12 weeks. (bvsalud.org)
- Tolerance Tolerance Pharmacokinetics and Pharmacodynamics of the transplanted organ by the immune system Immune system The body's defense mechanism against foreign organisms or substances and deviant native cells. (lecturio.com)
- Immunotherapy - uses substances made by the body or in a laboratory to boost the immune system and help the body find and destroy cancer cells. (animalresearch.info)
- utilize multiplex fluorescent immunohistochemistry to provide a comprehensive characterization of the metastatic colorectal cancer immune microenvironment, revealing an important role for PD-L1+ antigen presenting cells in immune suppression. (jci.org)
- These findings suggested that thymic atrophy in acute GVHD is effected by impaired cellular proliferation of immature host thymocytes and that the failure of these cells to enter the cell cycle is dependent on an interferon (IFN)-gamma-driven immune response. (ox.ac.uk)
Tolerance1
- Further research is warranted to fill these gaps, develop diagnostic modalities to facilitate early detection of CAV, and management strategies to Improve graft tolerance and immune modulation. (lidsen.com)
Therapeutic option1
- Organ transplantations have become the therapeutic option of choice for many individuals with end-stage organ failure. (lecturio.com)
Chronic1
- F(1 )transplantation models of acute and chronic GVHD, respectively, were studied. (ox.ac.uk)
Specificity1
- Polyclonal CTLs, in contrast, respond to either the native nonapeptide or any of the substituted variants that were tested, which suggests a certain degree of degeneracy in the specificity of the physiologic immune response. (shengsci.com)
Kidneys1
- Successful transplantation of adult-size kidneys into small children. (stanfordchildrens.org)
Body's1
- The body's immune system considers the transplanted organ foreign, and fights it accordingly. (findmeacure.com)