• Deposited immune complexes can activate complement and effector cells. (hindawi.com)
  • b) Pathogenic effects of deposited immune complexes. (hindawi.com)
  • The Fc portion of antibodies in immune complexes can be bound by C1q of the classical complement pathway, which eventually leads to the release of C5a and C3a. (hindawi.com)
  • Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
  • The hyperactivated leukocytes as well as the pathogenic autoantibodies and immune complexes resulting from the systemic disease ultimately play an important role in local autoimmunity and end organ disease within target organs like the kidneys. (biomedcentral.com)
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
  • Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated. (hindawi.com)
  • Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)
  • An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
  • Dr. Allison is a leader in the field of immunology, particularly in developing ways to help the immune system recognize and destroy cancer cells. (euroacadti.eu)
  • Mads Hald Andersen is vice-director at the Center for Cancer Immune Therapy at Copenhagen University Hospital at Herlev as well as professor at the Department of Immunology and Microbiology at Copenhagen University. (euroacadti.eu)
  • His research is focused on the mechanisms that regulate the immunological response of T lymphocytes, especially strategies to manipulate those responses in clinically relevant areas, including autoimmunity, allergies, vaccinations, and tumor therapy. (euroacadti.eu)
  • Myasthenia gravis (MG) is a relatively rare acquired, autoimmune disorder caused by an antibody-mediated blockade of neuromuscular transmission resulting in skeletal muscle weakness and rapid muscle fatigue. (medscape.com)
  • However the improved understanding of the complexity of the immune system has significantly influenced the way we view autoimmune diseases and their pathogeneses. (hindawi.com)
  • however, it needs to be emphasized that most autoimmune diseases are driven by a dysfunction in the immune network consisting of B cells, T cells, and other immune cells. (hindawi.com)
  • Myasthenia gravis (MG) is a relatively rare autoimmune disorder in which antibodies form against acetylcholine nicotinic postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
  • Cormane RH, Husz S, Hamerlinck F, Immunoglobulin and complement bearing Lymphocytes in contact dermatitis and atopic dermatitis. (voetzorgplus.com)
  • This results both in enhanced vaccine responses and, at times, down-regulation of other immune reactivities, such as transplant rejection and the risk of developing certain immunologic diseases, such as type I diabetes. (unu.edu)
  • In the proper concentration, antiidiotypes can enhance immune responses [5]. (unu.edu)
  • Reciprocal roles of T-cell help for B cells during adaptive immune responses and B-cell help in CD4+ T-cell activation are being increasingly recognized. (hindawi.com)
  • His research has been focusing on the characterization of the natural immune responses towards malignant cells. (euroacadti.eu)
  • The goal of this review is to discuss the systemic and local immune responses - as learned from the studies employing various mouse model systems - that lead to the development of lupus. (biomedcentral.com)
  • They can also be targeted to improve immune responses against cancer. (ircm.qc.ca)
  • Further study is needed of the roles of idiotypic and anti-idiotypic antibodies, growth factors, cytokines, and various anti-inflammatory factors in the maternal milk in the infant's host defence. (unu.edu)
  • Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
  • Different subpopulations of immune cells interplay to directly or indirectly regulate other subpopulations by releasing different cytokines and other mediators of inflammation, thereby contributing to the progression of the systemic disease. (biomedcentral.com)
  • Agents that suppress immune function by one of several mechanisms of action. (lookformedical.com)
  • Adhesion receptors in the interactions between lymphocytes and stromal cells from murine spleen. (anid.cl)
  • By discovering that the CD4 and CD8 T cell co-receptors associate with the protein tyrosine kinase Lck, Dr. Veillette was one of the founders of the field of immune cell activation over 30 years ago. (ircm.qc.ca)
  • One critical mechanism in CLE is the chronic reactivation of innate and adaptive immune pathways. (frontiersin.org)
  • Aberrations in the innate as well as adaptive arms of the immune system both play an important role in the genesis and progression of lupus. (biomedcentral.com)
  • B cells have antibody-dependent and antibody-independent pathogenic functions. (hindawi.com)
  • A significantly higher salivary SlgA antibody response was obtained in breastfed than in nonbreastfed Italian infants after parenteral vaccination with diphtheria and tetanus toxoids and after oral poliovirus vaccination [2]. (unu.edu)
  • Between the ages of 21 and 40 months, serum IgG antibodies to diphtheria toxoid and neutralizing serum antibodies to poliovirus were also significantly increased among the breastfed group compared with the formula-fed controls. (unu.edu)
  • Here, we will review the present understanding - as garnered from studying mouse models - about the roles of various immune cells in lupus pathogenesis. (biomedcentral.com)
  • It is clear that human milk can affect the immune system of the breasfed infant. (unu.edu)
  • Knowledge is continually increasing about the effects of breastfeeding on the infant, including a number of direct and indirect effects on the immune system. (unu.edu)
  • Book translation: Your amazing immune system, (Ed. Masayuki Miyasaka) 2011 Tvoj Ĩudesni imunosni sustav, ISBN: 978-953-7941-09-3, M. Antica (Ed. (irb.hr)
  • However, research using various mouse strains of spontaneous and inducible lupus in the last two decades has provided insights into the role of the immune system in the pathogenesis of this disease. (biomedcentral.com)
  • Although these studies warrant independent confirmation, they support the notion that apoptotic cells could harbor the immunogens responsible for antinuclear antibody formation. (biomedcentral.com)
  • Breastfeeding presumably gives the infant the possibility for an optimal immune response by providing good nutrition, including a decreased risk of vitamin A deficiency. (unu.edu)
  • The control of the intestinal flora and the anti-inflammatory effects of maternal milk also increase the possibilities for an adequate immune response in the infant. (unu.edu)
  • Stool SlgA antibodies could not be used to measure the antibody response because of the presence of milk SlgA antibodies in the stool of breastfed infants. (unu.edu)
  • These observations are in agreement with another study that determined the serum antibody response to the Haemophilus influenzae type b (Hib) polysaccharide capsule in breastfed and nonbreastled children who were vaccinated parenterally with an Hib protein conjugate vaccine [3]. (unu.edu)
  • Thus, maternal milk contains nucleotides that might affect the infant's immune response by stimulating lymphocytes]. (unu.edu)
  • An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)
  • When an isoantigen is encountered by species members who lack it, an immune response is induced. (lookformedical.com)
  • Deliberate prevention or diminution of the host's immune response. (lookformedical.com)
  • Chief Laboratory Technician, Research laboratory Immune dermatology, department of dermatology, University of Amsterdam 1972-1979 the Netherlands. (voetzorgplus.com)
  • We favour the hypothesis that at least some of the enhancing effect could be due to the anti-idiotypic antibodies (anti-antibodies) in human milk. (unu.edu)
  • Data from the recent conferences of the American Society of Clinical Oncology ( ASCO ) clearly show that in solid tumours monoclonal antibodies allow an average increase in survival of around two months, and only in rare cases, with or without associated chemotherapy, does this figure rise to or exceed four months. (beatingcancercenter.com)
  • He obtained his DScTech in 2006, the same year as he co-founded the Center for Cancer Immune Therapy. (euroacadti.eu)
  • Immune checkpoint inhibitors used in treatment of advanced cancers are emerging as one of the important causes for worsening or de novo presentation of MG often associated with myositis and myocarditis and may carry grave prognosis. (medscape.com)
  • 2017-2021 COST Action (The European Cooperation in Science and Technology ) CA16223: LEukaemia GENe Discovery by data sharing, mining and collaboration (LEGEND) M.Antica is representative and Management Committee member for Croatia, Funded by the Horizon 2020 Framework Programme of the European Union. (irb.hr)