OrganismsDiseasesChemicals and DrugsPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social Phenomena
ImipramineAntidepressive AgentsAntidepressive Agents, TricyclicAntidepressive Agents, Second-GenerationMianserinSwimmingFluoxetineDepressionDepressive DisorderBehavior, AnimalAmitriptylineDesipramineDibenzazepinesMaprotilineChlorpromazineEnuresisClomipramineChlorprothixeneAdrenergic Uptake InhibitorsFluvoxamineNomifensineHypericumTrazodoneMetyraponePromazineNortriptylineSerotoninDoxepinTrimipramineSparteineAstemizoleMephenytoinParoxetine
AntidepressantAntidepressantsAdministration of imipramineNorepinephrine reuptakeMechanism of actToxicityAmineMetaboliteTherapeuticChronicSerumCitalopramMedicinalMiceTreatmentsIncreasesOutcomesDrugTreatmentEffectsStressPatientsActivitiesDesipramineAntidepressant imipramineReuptakeSerotoninPossessesDosesDepressionSerumInhibitorsRatsConclusionBDNFSignificantlyEffectivelyResultsSimilarFoundExpressionStudy
Antidepressant14
  • Imipraminoxide (brand names Imiprex, Elepsin), or imipramine N-oxide, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1960s for the treatment of depression. (wikipedia.org)
  • A 33 year old woman arrives to the emeregency department with suspected tricyclic antidepressant overdose. (bestbets.org)
  • Amre DK A meta-analysis of prognostic indicators to predict seizures, arrhythmias or death after tricyclic antidepressant overdose. (bestbets.org)
  • So, the effects of MnRN lesion on hippocampal neurogenesis in animals chronically stressed and treated or not with Imipramine (a tricyclic antidepressant) will be investigated too. (fapesp.br)
  • Amoxapine, the N -demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). (genelabs.com)
  • Amoxapine is a tricyclic antidepressant of the dibenzoxazepine class, chemically distinct from the dibenzodiazepines, dibenzocycloheptenes, and dibenzoxepines. (genelabs.com)
  • Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, amoxapine, by decreasing its metabolism. (genelabs.com)
  • The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation. (genelabs.com)
  • Imipramine is a tricyclic antidepressant that possesses anti-inflammatory activity and has been reported to inhibit the progression of highly metastatic non-small cell lung cancer. (bvsalud.org)
  • The present study evaluates the possible synergistic antidepressant effect of sub-therapeutic dose of iron co-administered with citalopram or imipramine in female Institute of Cancer Research mice. (bvsalud.org)
  • Iron, citalopram and imipramine, unlike desferrioxamine, reduced immobility score in the TST, FST and OSST without affecting locomotor activity, suggesting antidepressant-like effect. (bvsalud.org)
  • Sub-therapeutic dose of iron in combination with citalopram or imipramine further enhanced the antidepressant-like effect, producing a more rapid effect when compared to the iron, citalopram or imipramine alone. (bvsalud.org)
  • Our study provides experimental evidence that iron has antidepressant-like effect and sub-therapeutic dose of iron combined with citalopram or imipramine produces more rapid antidepressant-like effect. (bvsalud.org)
  • Venlafaxine, an antidepressant agent structurally and pharmacologically unrelated to other antidepressants and agents used to treat generalized anxiety disorder, is used to treat melancholia, generalized anxiety disorder (GAD), panic disorder, post-traumatic stress disorder, and hot flashes in breast cancer survivors. (illumina.com)
Antidepressants11
  • ABSTRACT: Experimental data have suggested that in neuropathic pain, tricyclic antidepressants may work solely through a β2-agonist action. (sdu.dk)
  • β2-agonism seems not to be an important mechanism of action of tricyclic antidepressants in neuropathic pain. (sdu.dk)
  • Although serotoninergic agents such as antidepressants have been shown to increase neurogenesis, the effects of MnRN lesions remain to be elucidated. (fapesp.br)
  • In the following decades, the monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants were introduced. (beatcfsandfms.org)
  • Toxic manifestations of amoxapine overdosage differ significantly from those of other tricyclic antidepressants. (genelabs.com)
  • Barbiturates like butabarbital may increase the metabolism of tricyclic antidepressants like amoxipine. (genelabs.com)
  • Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. (genelabs.com)
  • Barbiturates such as butalbital may increase the metabolism of tricyclic antidepressants amoxapine. (genelabs.com)
  • Treatment options include anticholinergics, antispasmodic agents, and tricyclic antidepressants (TCAs). (medscape.com)
  • Venlafaxine's toxicity appears to be higher than other SSRIs, with a fatal toxic dose closer to that of the tricyclic antidepressants than the SSRIs. (illumina.com)
  • As a nootropic , and for cognitive health, St. John's wort is as effective at relieving mild-to-moderate depression as the most commonly prescribed SSRI and TCA (tricyclic) antidepressants. (nootropicsexpert.com)
Administration of imipramine1
  • Thus basic physiological and behavioral outcomes in naïve mice were significantly altered by the chronic administration of imipramine and, to a lesser extent, citalopram. (ox.ac.uk)
Norepinephrine reuptake1
  • Imipraminoxide's pharmacology has not been well elucidated, but based on its very close relationship with imipramine, it likely acts as a serotonin and norepinephrine reuptake inhibitor and serotonin, adrenenaline, histamine, and muscarinic acetylcholine receptor antagonist, though with weaker antiadrenergic and anticholinergic actions. (wikipedia.org)
Mechanism of act1
  • Although their mechanism of action differs, oxybutynin and imipramine work together to improve urge incontinence. (medscape.com)
Toxicity1
  • A panel convened in November 2010 found that among the currently recommended analgesic products for arthritis-related pain, fixed-low-dose combination products hold promise for pain control because such products allow lower doses of individual agents resulting in decreased toxicity and acceptable efficacy due to synergy between the individual drugs. (openrheumatologyjournal.com)
Amine1
  • They contain a tricyclic ring system with an alkyl amine substituent on the central ring. (genelabs.com)
Metabolite1
Therapeutic2
  • Although single drugs in one or two classes were available for the treatment of depression several decades ago, multiple therapeutic modalities now exist, often with many agents within each class. (beatcfsandfms.org)
  • Mice (n = 8) received iron (0.8-7.2 mg/kg), citalopram (3-30 mg/kg), imipramine (3-30 mg/kg), desferrioxamine (50 mg/kg) or saline in the single treatment phase of each model and subsequently a sub-therapeutic dose of iron co-administered with citalopram or imipramine. (bvsalud.org)
Chronic3
  • Chronic imipramine treatment (16 mg kg(-1) per day for 25 days) prevented both the repeated social defeat-induced alterations of biological and behavioral parameters and the associated increase of cortical CCK release. (nih.gov)
  • The differential effects of chronic imipramine or citalopram administration on physiological and behavioral outcomes in naïve mice. (ox.ac.uk)
  • Managing pain from chronic conditions, such as, but not limited to, osteoarthritis and rheumatoid arthritis, requires the clinician to balance the need for effective analgesia against safety risks associated with analgesic agents. (openrheumatologyjournal.com)
Serum1
  • Iron, citalopram and imipramine or their combinations increased serum BDNF concentration, hippocampal neuronal count and dendritic spine densities. (bvsalud.org)
Citalopram3
  • Using imipramine and citalopram, we sought to assess which drug would be more appropriate as pharmacological reference in paradigms of depression in C57BL6N mice by measuring their effect on liquid consumption, home cage activity, body weight and long-term memory in naïve animals treated with each compound at generally used dose of 15 mg/kg/day. (ox.ac.uk)
  • Imipramine also impaired learning in the object recognition task, but citalopram diminished object exploration sufficiently to invalidate the test. (ox.ac.uk)
  • We further show that iron alone or its combination with citalopram or imipramine attenuates the neuronal loss associated with depressive conditions, increases dendritic spines density and BDNF levels. (bvsalud.org)
Medicinal2
  • These agents represent first-line medicinal therapy in women with urge incontinence. (medscape.com)
  • Antidepressive medicinal products should continue for at least six months following remission. (tajgenerics.com)
Mice1
  • Compared to control, imipramine-treated mice displayed increased sucrose and water intake, as well as enhanced home-cage and novelty exploration activities, and reduced body weight. (ox.ac.uk)
Treatments1
  • More careful assessment of the efficacy of an agent at early and regular intervals, with early revision of the treatment modality if it is not optimal, is an important new guideline that applies not only to somatic treatments, but also to psychotherapeutic approaches and combination psychotherapy-pharmacotherapy when treatment is not proceeding optimally. (beatcfsandfms.org)
Increases1
  • however, imipramine also increases the bladder outlet resistance at the level of the bladder neck. (medscape.com)
Outcomes1
  • Secondary outcomes were also unaltered by terbutaline but improved by imipramine. (sdu.dk)
Drug1
  • When a single drug treatment does not work, a combination therapy such as oxybutynin (Ditropan) and imipramine (Tofranil) may be used. (medscape.com)
Treatment2
  • These agents are beneficial in the treatment of mild to moderately severe stress incontinence in women. (medscape.com)
  • The treatment of MNE can be performed through behavioral therapy, use of alarms or medications such as desmopressin and imipramine. (bvsalud.org)
Effects1
  • Potential adverse effects of all anticholinergic agents include blurred vision, dry mouth, heart palpitations, drowsiness, and facial flushing. (medscape.com)
Stress1
  • Sympathomimetic drugs, estrogen, and tricyclic agents increase bladder outlet resistance to improve symptoms of stress urinary incontinence. (medscape.com)
Patients1
  • The patients received terbutaline (5-15 mg), imipramine (30-150 mg), or placebo in a random order. (sdu.dk)
Activities1
  • Because of the potential for drowsiness-especially when combined with alcohol, sedatives, or hypnotic drugs-these agents may impair the patient's ability to perform hazardous activities, such as driving or operating heavy machinery. (medscape.com)
Desipramine9
  • First, CYP2C19 converts imipramine into the active metabolite desipramine, which is then inactivated by CYP2D6. (nih.gov)
  • This retrospective single center study aimed to prove whether CYP2C19 and ample CYP2D6 genotyping (taking into consideration four null alleles and three decreased-activity alleles) could be used to predict imipramine and desipramine plasma concentrations in depressed patients, and whether genotype-based drug dose recommendations might assist in the early management of imipramine pharmacotherapy. (nih.gov)
  • In 181 subjects with major depressive disorder, drug doses were recorded, imipramine and desipramine plasma concentrations were monitored and CYP2C19 (*2) and CYP2D6 genotype (*3, *4, *5, *6, *9, *10, *41 and gene duplication) were obtained, yielding graded allele-specific CYP2D6 patient groups. (nih.gov)
  • Our protocol for CYP2D6 genotyping will thus importantly aid in the prediction of imipramine metabolism, allowing for the use of an adjusted starting dose and faster achievement of predefined imipramine+desipramine plasma levels in all genetic patient subgroups. (nih.gov)
  • Imipramine is metabolized to desipramine which has antidepressant activity equal to that of imipramine. (nih.gov)
  • Two women who were taking imipramine 50 mg daily for panic disorder had imipramine and desipramine breastmilk levels measured 1 month postpartum (time after dose not stated). (nih.gov)
  • Sixteen days after initiation, milk imipramine plus desipramine levels ranged from 21 to 59 mcg/L at various times while taking a dose of 200 mg daily. (nih.gov)
  • Milk imipramine plus desipramine levels ranged from 48 to 622 mcg/L, with little correlation to dosage. (nih.gov)
  • Two infants had serum level measurements of imipramine plus desipramine while breastfeeding. (nih.gov)
Antidepressant imipramine2
  • The inactivation and clearance of the tricyclic antidepressant imipramine is dependent on CYP2D6 activity. (nih.gov)
  • In addition, combination treatment of mice with risperidone and a monoamine reuptake inhibitor antidepressant imipramine or fluoxetine elicited larger increases in brain phospho-Ser-GSK3 than each agent alone. (researchgate.net)
Reuptake1
  • Imipraminoxide's pharmacology has not been well elucidated, but based on its very close relationship with imipramine, it likely acts as a serotonin and norepinephrine reuptake inhibitor and serotonin, adrenenaline, histamine, and muscarinic acetylcholine receptor antagonist, though with weaker antiadrenergic and anticholinergic actions. (wikipedia.org)
Serotonin1
  • Serotonin has been variously described as a central neurohumoral agent or chemical mediator, as a 'headache substance' acting directly or indirectly to lower pain threshold, as an intrinsic 'motor hormone' of the gastrointestinal tract, and as a 'hormone' involved in connective tissue reparative processes. (drugbank.com)
Possesses2
  • A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. (nih.gov)
  • Imipramine is a tricyclic antidepressant that possesses anti-inflammatory activity and has been reported to inhibit the progression of highly metastatic non-small cell lung cancer. (bvsalud.org)
Doses2
  • 2 ] However, other agents may be preferred when large doses are required or while nursing a newborn or preterm infant. (nih.gov)
  • Four mothers who were taking imipramine in doses of 75 to 150 mg daily had milk samples taken 12 to 15 hours after their daily dose. (nih.gov)
Depression3
Serum2
  • One infant whose mother began imipramine 75 mg daily 2 weeks postpartum and was breastfed for 7 weeks had a serum level of 0.6 mcg/L. Another infant was breastfed for 17 weeks after his mother began imipramine 100 mg daily 8 weeks postpartum and later decreased to 75 mg daily. (nih.gov)
  • Iron, citalopram and imipramine or their combinations increased serum BDNF concentration, hippocampal neuronal count and dendritic spine densities. (bvsalud.org)
Inhibitors1
  • The imipramine-induced BDNF increase was suppressed with inhibitors for protein kinase A (PKA) or MEK/ERK. (elsevierpure.com)
Rats1
  • A possible role of Y1 receptor in anxiety-related behaviours was demonstrated by the observations that transgenic rats overexpressing NPY show less anxiety, and that NPY can mimic the effects of imipramine in the forced swim test. (jpn.ca)
Conclusion1
  • CONCLUSION: Imipramine effectively suppressed TNBC progression by inducing apoptosis and inhibiting metastasis. (bvsalud.org)
BDNF3
  • In the present study, we evaluated the effects of imipramine, a classic tricyclic antidepressant drug, on BDNF expression in cultured rat brain astrocytes. (elsevierpure.com)
  • Imipramine dose-dependently increased BDNF mRNA expression in astrocytes. (elsevierpure.com)
  • These results suggested that imipramine induced BDNF expression through CREB activation via PKA and/or ERK pathways. (elsevierpure.com)
Significantly1
  • The binding of tritiated imipramine was significantly reduced in the hippocampus and occipital cortex from a series of patients with depressive illness compared with age-matched patients with no psychiatric disorder. (cambridge.org)
Effectively1
  • The 2009 American College of Gastroenterologists (ACG) position statement on the management of irritable bowel syndrome noted that the antidiarrheal agent loperamide effectively reduced stool frequency and improved stool consistency, but it did not relieve pain, bloating, or other global irritable bowel syndrome symptoms. (medscape.com)
Results1
  • RESULTS: Imipramine induced caspase-mediated extrinsic and intrinsic apoptosis and was potentially associated with patient overall survival. (bvsalud.org)
Similar1
  • Antidepresivo tricíclico similar en acción y efectos colaterales a la IMIPRAMINA. (bvsalud.org)
Found1
  • In another study, 25 infants whose mothers took a tricyclic antidepressant during pregnancy and lactation were tested formally between 15 to 71 months and found to have normal growth and development. (nih.gov)
Expression1
  • Furthermore, imipramine suppressed the invasion and migration abilities and the expression of metastasis-associated proteins in TNBC cells. (bvsalud.org)
Study1
  • MATERIALS AND METHODS: This study used MTT assay, apoptosis markers flow cytometry analysis, open-source data analysis, NF-B reporter gene assay, and western blotting to elucidate the effect of imipramine on MDA-MB-231 and 4T1 cells. (bvsalud.org)