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  • cell
  • The commonly used imatinib-sensitive cell lines GIST882 and GIST-T1 were shown to harbor defective p53 and therefore failed to respond to nutlin-3 treatment. (plos.org)
  • One other possible mechanism is the effect of ergoloid mesylates on neuronal cell metabolism, resulting in improved oxygen uptake and cerebral metabolism, thereby normalizing depressed neurotransmitter levels. (drugbank.ca)
  • 2017
  • The research report studies the global Global imatinib mesylate market research report 2017 market on the basis of several criteria, including type, application, and geography to provide a better understanding to the readers. (qyresearchreports.com)
  • The report also sheds light on the current trends related to the demand, supply, and sales of Global imatinib mesylate market research report 2017, along with the recent developments in the field. (qyresearchreports.com)
  • The research report takes into consideration the drivers, restraints, trends, and opportunities of the global Global imatinib mesylate market research report 2017 market in order to identify the future of the market. (qyresearchreports.com)
  • The report also provides an estimation of the overall market size in terms of both value and volume and offers qualitative and quantitative insights into the key segments and the geographical subdivisions of the Global imatinib mesylate market research report 2017 market. (qyresearchreports.com)
  • According to the report, equipment and raw material are two primary components of the manufacturing process of Global imatinib mesylate market research report 2017. (qyresearchreports.com)
  • Therefore, the report provides a 360-degree view of the global Global imatinib mesylate market research report 2017 market. (qyresearchreports.com)
  • The report also performs a methodical examination of the vendor landscape of the global Global imatinib mesylate market research report 2017 market by analyzing the company profiles of prominent companies operating in the market. (qyresearchreports.com)
  • It also pays attention to the hierarchy of the global Global imatinib mesylate market research report 2017 market by evaluating the current developments and future prospects of market participants. (qyresearchreports.com)
  • Newly Diagnosed
  • This randomized phase III trial studies how well imatinib mesylate and combination chemotherapy work in treating patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukemia. (cancer.gov)
  • This phase II trial studies how well dasatinib, nilotinib, and imatinib mesylate works in treating patients with newly diagnosed, previously untreated chronic myeloid leukemia in which fewer than 10% of the cells in the blood and bone marrow are blast cells (immature blood cells) (chronic phase). (cancer.gov)
  • India
  • In 1993, during the time India did not allow patents on products, Novartis had patented imatinib, with salts vaguely specified, in many countries but could not patent it in India. (wikipedia.org)
  • Leukemia
  • Giving imatinib mesylate and combination chemotherapy may work better in treating patients with Philadelphia chromosome positive acute lymphoblastic leukemia. (cancer.gov)
  • By inhibiting bcr-abl kinase activity, Imatinib Mesylate would induce cytogenetic remissions in the majority of chronic myeloid leukemia patients. (creative-enzymes.com)
  • Due in part to the development of imatinib and related drugs, the five year survival rate for people with chronic myeloid leukemia increased from 31% in 1993 to 59% in 2003 to 2009. (wikipedia.org)
  • growth
  • If imatinib is used in prepubescent children, it can delay normal growth, although a proportion will experience catch-up growth during puberty. (wikipedia.org)
  • Imatinib is specific for the TK domain in abl (the Abelson proto-oncogene), c-kit and PDGF-R (platelet-derived growth factor receptor). (wikipedia.org)
  • surgical
  • On 1 February 2012, imatinib was approved for use after the surgical removal of KIT-positive tumors to help prevent recurrence. (wikipedia.org)
  • cell
  • The commonly used imatinib-sensitive cell lines GIST882 and GIST-T1 were shown to harbor defective p53 and therefore failed to respond to nutlin-3 treatment. (plos.org)
  • One other possible mechanism is the effect of ergoloid mesylates on neuronal cell metabolism, resulting in improved oxygen uptake and cerebral metabolism, thereby normalizing depressed neurotransmitter levels. (drugbank.ca)
  • GIST
  • On February 25, 2013, the FDA approved regorafenib in a second indication to treat patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate. (wikipedia.org)
  • side
  • Severe congestive cardiac failure is an uncommon but recognized side effect of imatinib and mice treated with large doses of imatinib show toxic damage to their myocardium. (wikipedia.org)
  • Share
  • Mesylate esters are a group of organic compounds that share a common functional group with the general structure CH3SO2O-R, abbreviated MsO-R, where R is an organic substituent. (wikipedia.org)