DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHumanitiesHealth Care
Hypersomnolence, IdiopathicCataplexyNarcolepsyDisorders of Excessive SomnolencePemolineHLA-DQ beta-ChainsHLA-DQ AntigensPolysomnographyKleine-Levin SyndromeSleep ParalysisNeuropeptidesSleep, REMSodium OxybateCase-Control StudiesSleep StagesWakefulnessIntracellular Signaling Peptides and ProteinsWit and Humor as TopicCentral Nervous System StimulantsSleepIdiopathic Pulmonary Fibrosis
Primary hypersomniaDiagnosis of idiopathicHypersomnolenceDisorders such as idiopathic hypersomniaMuscle weaknessHypnagogic hallucinationsPerson with idiopathic hypersomniaNarcolepsy with and without cataplexyWeekly number of cataplexy attacksAdultsPatientsNeurologicalSodiumCause of idiopathicXywavCharacterized by excessive daytime slSymptoms of hypersomniaSecondaryXyremHypocretinWakefulnessSevereMedicationsNocturnalPoorly understoodTreatmentSleepiness duringDaytimeModafinil2022DiagnosticEtiologyChronic sleep disorderResearchersAbsenceFall asleepMSLTSymptomType
Primary hypersomnia8
  • Idiopathic hypersomnia may also be referred to as IH, IHS, or primary hypersomnia and belongs to a group of sleeping disorders known as central hypersomnias, central disorders of hypersomnolence, or hypersomnia of brain origin. (wikipedia.org)
  • Primary hypersomnia, idiopathic hypersomnia (ICSD-3), and hypersomnolence disorder ( DSM-5 ) refer to a central disorder of hypersomnia. (medscape.com)
  • Narcolepsy is considered a primary hypersomnia (excessive sleepiness) condition. (adam.com)
  • To complicate matters further, patients with primary hypersomnia are at increased risk of developing a major depressive disorder. (medscape.com)
  • Unlike primary hypersomnia, secondary hypersomnia results from other underlying medical conditions or medication side effects. (gwinnettsleep.com)
  • Primary hypersomnia is exceedingly rare, affecting fewer than 1% of people. (nestmaven.com)
  • Disorders that fall under the banner of primary hypersomnia include narcolepsy and Kleine-Levin syndrome. (nestmaven.com)
  • For this reason, they fall under the category of primary hypersomnia - although you will typically simply hear them referred to by name. (nestmaven.com)
Diagnosis of idiopathic2
  • Alternatives to the multiple sleep latency test are needed for accurate diagnosis of idiopathic hypersomnia. (clevelandclinic.org)
  • The nocturnal sleep duration should be qualified as adequate before a diagnosis of idiopathic hypersomnia is made. (medscape.com)
Hypersomnolence11
  • Severe idiopathic hypersomnolence is a disabling problem that often leads to permanent unemployment and responds poorly to medical treatment. (medscape.com)
  • Therapy for idiopathic hypersomnolence involves maintaining the patient on daytime stimulants. (medscape.com)
  • Modafinil, a 1:1 racemic mixture of (R)-(-) and (S)-(-) enantiomers, and armodafinil, the isolated (R)-(-) enantiomer, have proved clinically useful in the treatment of narcolepsy and other causes of excessive daytime sleepiness, such as idiopathic hypersomnolence. (medscape.com)
  • Similarities from all, however, include daily periods of irresistible sleep or daytime lapses into sleep, absence of cataplexy, and that the hypersomnolence is not better accounted for by either insufficient sleep or by another sleep disorder. (medscape.com)
  • *This post was originally shared on Hypersomnolence Australia website in 2015 I have since written a thorough review of the historical and current diagnostic conundrum of Idiopathic Hypersomnia and narcolepsy. (hypersomnolenceaustralia.org.au)
  • A validated pediatric hypersomnolence survey for pediatric narcolepsy and idiopathic hypersomnia with high sensitivity, specificity, and interrater reliability is now available. (bvsalud.org)
  • Posttraumatic hypersomnia may mimic hypersomnolence. (medscape.com)
  • This article focuses on the clinical presentation, pathophysiology, diagnosis, differential diagnosis, and management of narcolepsy type 1 and narcolepsy type 2, idiopathic hypersomnia, Kleine-Levin syndrome, and other central disorders of hypersomnolence, as defined in the International Classification of Sleep Disorders, Third Edition (ICSD-3). (flutrackers.com)
  • In ICSD-3, the names of some central disorders of hypersomnolence have been changed: narcolepsy with cataplexy and narcolepsy without cataplexy have been renamed narcolepsy type 1 and narcolepsy type 2, respectively. (flutrackers.com)
  • Central Disorders of Hypersomnolence encompass conditions including Narcolepsy and Idiopathic Hypersomnia - at here at the best Adelaide Sleep clinic in Adelaide, we manage all these conditions. (adelaidesleep.com.au)
  • Hypersomnia (also known as hypersomnolence) directly translates to "excessive sleepiness. (nestmaven.com)
Disorders such as idiopathic hypersomnia2
  • This form of hypersomnia encompasses disorders such as idiopathic hypersomnia and narcolepsy, both of which stem from issues within the central nervous system. (gwinnettsleep.com)
  • The Company's lead product candidate, Quilience®, is a proprietary extended-release formulation of Mazindol (Mazindol ER) and is being developed for the treatment of narcolepsy, and potentially other sleep-wake disorders such as idiopathic hypersomnia (IH), for which NLS recently obtained Orphan Disease Designation (ODD) from the European Medicines Agency (EMA). (newjerseytelegraph.com)
Muscle weakness7
  • Calcium, magnesium, potassium, and sodium oxybate is used to treat attacks of cataplexy (episodes of muscle weakness that begin suddenly and last for a short time) and excessive daytime sleepiness in adults and children 7 years of age and older who have narcolepsy (a sleep disorder that may cause extreme sleepiness, sudden uncontrollable urge to sleep during daily activities, and cataplexy). (medlineplus.gov)
  • Besides EDS, people with narcolepsy type 1 also have cataplexy, which is a sudden but temporary muscle weakness, sometimes brought on by laughter or other emotions. (adam.com)
  • Temporary and sudden muscle weakness without loss of consciousness (called cataplexy ), usually brought on by sudden or strong emotions. (adam.com)
  • Cataplexy, a muscle weakness in various parts of the body, is often present in classic cases of narcolepsy. (dallas-sleep.com)
  • Have received an NT1 diagnosis within the past 10 years or are experiencing NT1 symptoms (characterized by cataplexy, or the sudden loss of muscle control and muscle weakness due to strong emotions or actions, like anger or laughter, while remaining conscious). (hypersomniafoundation.org)
  • Narcolepsy, on the other hand, is a neurological disorder that can cause abrupt sleep attacks, sleep paralysis, and even episodes of cataplexy (sudden muscle weakness). (gwinnettsleep.com)
  • Cataplexy is episodes of muscle weakness triggered by strong, generally positive emotions, and Dr. Scammell's group has found that the amygdala is a key brain region for cataplexy. (wakeupnarcolepsy.org)
Hypnagogic hallucinations4
Person with idiopathic hypersomnia2
  • Therefore, the person with idiopathic hypersomnia who has access to PBS listed modafinil or armodafinil, a) has narcolepsy recorded as their medical diagnosis for the purpose of the PBS application for modafinil/armodafinil, and b) has a medical or mental reason* that makes taking dexamphetamine unsuitable. (hypersomnolenceaustralia.org.au)
  • Similarly, when a person with idiopathic hypersomnia takes naps, they are long and non-refreshing. (polysleep.ca)
Narcolepsy with and without cataplexy2
  • Narcolepsy type 1 (NT1) and type 2 (NT2), also known as narcolepsy with and without cataplexy, are sleep disorders that benefited from major scientific advances over the last two decades. (bvsalud.org)
  • Correlation between HLA-DQB1*06:02 and narcolepsy with and without cataplexy: approving a safe and sensitive genetic test in four major ethnic groups. (cdc.gov)
Weekly number of cataplexy attacks2
  • The primary endpoint was the change in the weekly number of cataplexy attacks, and the key secondary endpoint was the change in the Epworth Sleepiness Scale (ESS) score with JZP-258 compared to placebo. (wakeupnarcolepsy.org)
  • The primary endpoint of the trial is the change from baseline in EDS as measured by the Epworth Sleepiness Scale (ESS), and a key secondary endpoint is the change from baseline in mean weekly number of cataplexy attacks in the subset of patients with cataplexy. (newjerseytelegraph.com)
Adults7
  • The FDA approved calcium/magnesium/potassium/sodium oxybates (Xywav) for adults with idiopathic hypersomnia in August 2021. (medscape.com)
  • idiopathic hypersomnia (IH) in adults. (xywav.com)
  • 2. Jazz Pharmaceuticals Announces U.S. FDA Approval of Xywav® (calcium, magnesium, potassium, and sodium oxybates) Oral Solution for Idiopathic Hypersomnia in Adults. (neurologylive.com)
  • WAKIX® is used to treat excessive daytime sleepiness (EDS) or cataplexy in adults with Narcolepsy. (pwsausa.org)
  • DUBLIN, SEPTEMBER 25, 2019 - Jazz Pharmaceuticals plc (Nasdaq: JAZZ) announced today that positive data from the Phase 3 study of its investigational medicine, JZP-258, for the treatment of cataplexy and excessive daytime sleepiness (EDS) in adults with narcolepsy were presented at World Sleep 2019 in Vancouver, Canada. (wakeupnarcolepsy.org)
  • The Phase 3 study of JZP-258 was a global, double-blind, placebo-controlled, randomized-withdrawal, multicenter study evaluating the efficacy and safety of JZP-258 in the treatment of cataplexy and EDS in adults with narcolepsy. (wakeupnarcolepsy.org)
  • The US Food and Drug Administration (FDA) approved Dublin-based Jazz Pharmaceuticals' Xywav (calcium, magnesium, potassium, and sodium oxybates) oral solution for the treatment of idiopathic hypersomnia in adults. (medium.com)
Patients21
  • Researchers have recently found an abnormal hypersensitivity to GABA (the major brain chemical responsible for sedation) in a subset of patients with central hypersomnia i.e. (wikipedia.org)
  • [ 84 ] Another study from a single sleep center reported subjective improvement in EDS in 53 idiopathic hypersomnia (IH) patients that were refractory to traditional psychostimulants, who were given clarithromycin, an antibiotic that has GABA A inhibitory properties. (medscape.com)
  • The trial showed that patients randomized to switch from the drug to placebo experienced worsening on measures of sleepiness and idiopathic hypersomnia symptoms, compared with patients who continued treatment. (medpagetoday.com)
  • The drug should be available to patients with idiopathic hypersomnia later this year following REMS implementation, the drugmaker said. (medpagetoday.com)
  • Typically, patients with idiopathic hypersomnia have difficulty waking up, and when they awaken, they experience a period of sleep inertia characterized by drowsiness, decreased cognition, and motor impairment. (merckmanuals.com)
  • These patients do not have a positive family or viral infection history, and the cause of the disorder truly is idiopathic. (medscape.com)
  • Around 90% of patients with narcolepsy type 1 (narcolepsy with cataplexy) and half of patients with narcolepsy type 2 (narcolepsy without cataplexy) carry a specific genetic variation, called a haplotype, in an immune system gene (HLA-DQB1*06:02). (adam.com)
  • Dr. Foldvary-Schaefer has been speaking at medical meetings to raise awareness of the shortcomings of the MSLT for idiopathic hypersomnia and to make the case for wider U.S. acceptance of alternate diagnostic modalities, including an extended polysomnography protocol, for select patients. (clevelandclinic.org)
  • This review is also relevant if you are treating patients with Narcolepsy Type 2 (without cataplexy) or are a patient yourself. (hypersomnolenceaustralia.org.au)
  • A low-sodium oxybate formulation was approved in July 2020 in the United States to treat cataplexy and excessive daytime sleepiness in patients 7 years old and older with narcolepsy. (bvsalud.org)
  • Therefore, all patients with hypersomnia should receive a careful mental status and psychiatric evaluation for depression. (medscape.com)
  • 2 Made up of a formulation of calcium, magnesium, potassium, and sodium oxybates, JZP-258 was originally approved for the treatment of cataplexy in patients 7 years of age or older with narcolepsy, in July 2020. (neurologylive.com)
  • Impairment in functioning and quality of life in patients with idiopathic hypersomnia: the real-world idiopathic hypersomnia outcomes study (ARISE). (neurologylive.com)
  • Biotrial is honored to work on a new study expected to promote wakefulness and ameliorate cataplexy in patients diagnosed with narcolepsy or idiopathic hypersomnia. (biotrial.us)
  • Although far less common than many other sleep disorders, central hypersomnias are among the most severe and disabling diseases in the field of sleep medicine, and their early recognition is of major importance for patients, especially children, to maximize their quality of life and functioning in activities of daily living. (flutrackers.com)
  • In recent years, we have seen remarkable advances in the field of sleep medicine, and the future looks promising for hypersomnia patients. (gwinnettsleep.com)
  • By directly addressing the neurotransmitter deficiency in disorders like narcolepsy, orexin receptor agonists could offer a more targeted and effective treatment option for hypersomnia patients. (gwinnettsleep.com)
  • Patients who were switched from Xywav to a placebo experienced worsening sleepiness and symptoms of idiopathic hypersomnia compared with those who continued taking the drug, according to the FDA. (medium.com)
  • Xywav received approval in July 2020 for the treatment of cataplexy or excessive daytime sleepiness in patients seven years of age and older with narcolepsy. (medium.com)
  • Jazz Pharmaceuticals is planning to make Xywav available to patients with idiopathic hypersomnia later this year following Risk Evaluation and Mitigation Strategies (REMS) implementation. (medium.com)
  • Decades ago, the first published neuroimaging paper reported an abnormality of the pontine reticular formation, where REM sleep is generated, in the brain MRIs of three idiopathic tic patients [ 6 ]. (pfmjournal.org)
Neurological6
  • Idiopathic hypersomnia (IH) is a neurological disorder which is characterized primarily by excessive sleep and excessive daytime sleepiness (EDS). (wikipedia.org)
  • Idiopathic hypersomnia is a neurological disorder which has for main characteristic excessive daytime sleepiness (EDS), which can cause a person to frequently fall asleep. (polysleep.ca)
  • The Hypersomnia Foundation congratulates Dr. David Rye and the team at Emory University on their receipt of a 4-year award for nearly $3 million in total costs from the National Institute of Neurological Disorders and Stroke to study the biologic basis of. (hypersomniafoundation.org)
  • Idiopathic hypersomnia is a debilitating neurological sleep disorder characterized by chronic excessive daytime sleepiness, explained Pharma Times . (medium.com)
  • Narcolepsy is a chronic neurological disorder associated with abnormal regulation of the sleep-wake cycle, resulting in excessive daytime sleepiness, disturbed nocturnal sleep, and rapid eye movement (REM) sleep phenomena including cataplexy. (pfmjournal.org)
  • Narcolepsy is a chronic neurological disorder characterized by excessive daytime sleepiness, disruption of sleep-wake behavior, cataplexy, and other rapid eye movement (REM) sleep phenomena, such as sleep paralysis and hypnagogic hallucination [ 1 ]. (pfmjournal.org)
Sodium10
  • A calcium, magnesium, potassium, and sodium oxybate oral solution (Xywav) gained a new indication and became the first drug approved to treat adult idiopathic hypersomnia , the FDA said Thursday. (medpagetoday.com)
  • The effectiveness of the lower sodium oxybate drug in idiopathic hypersomnia was evaluated in a phase III, placebo-controlled, double-blind, randomized withdrawal study . (medpagetoday.com)
  • Sodium oxybate (Xyrem, generic) for cataplexy as well as for EDS. (adam.com)
  • Sodium oxybate (Xyrem) works well to control cataplexy. (nih.gov)
  • In 2021, lower-sodium oxybate became the first FDA-approved treatment for idiopathic hypersomnia. (clevelandclinic.org)
  • Several newer wake-promoting agents and psychostimulants have also been developed, including sodium oxybate, which has a role in the treatment of cataplexy and as an adjunctive wake-promoting agent, and pitolisant, a selective histamine H3 receptor inverse agonist that is currently only available in Europe. (flutrackers.com)
  • As expected, initial cataplexy rates differed based on prior therapy at study entry, with participants taking sodium oxybate only or sodium oxybate and an antidepressant/anticataplectic reporting the least cataplexy at study entry. (wakeupnarcolepsy.org)
  • In participants taking sodium oxybate only at study entry, cataplexy was stable with JZP-258 treatment across the open-label treatment titration and optimization period and the stable dose period (SDP). (wakeupnarcolepsy.org)
  • In those taking sodium oxybate and an antidepressant/anticataplectic at study entry, cataplexy was stable during initial titration of JZP-258, increased during taper and discontinuation of the other anticataplectic, and stabilized during SDP. (wakeupnarcolepsy.org)
  • The clinical program for Xywav has demonstrated that this lower-sodium oxybate is an effective therapy for the treatment of idiopathic hypersomnia," explained Yves Dauvilliers, M.D., director of the Sleep Disorders Centre at the Gui de Chauliac Hospital in Montpellier, France, and lead investigator of the Phase III study. (medium.com)
Cause of idiopathic1
  • While the precise cause of idiopathic hypersomnia remains uncertain, evidence suggests it may be due to an overproduction of an extremely small natural bioactive substance which acts similarly to a sleeping pill. (nestmaven.com)
Xywav7
  • A novel indication for Xywav is significant as the FDA has never granted an approval for idiopathic hypersomnia," Eric Bastings, MD, deputy director of the Office of Neuroscience at FDA's Center for Drug Evaluation and Research, said in a statement. (medpagetoday.com)
  • Idiopathic hypersomnia is a life-long condition, and the approval of Xywav will be instrumental in providing treatment for symptoms such as excessive sleepiness and difficulty waking, and in effectively managing this debilitating disorder. (medpagetoday.com)
  • Today's FDA approval is a major milestone for the entire idiopathic hypersomnia community as Xywav becomes the first medicine approved to manage this chronic sleep disorder. (medium.com)
  • Idiopathic hypersomnia is a lifelong condition, and the approval of Xywav will be instrumental in providing treatment for symptoms such as excessive sleepiness and difficulty waking, and in effectively managing this debilitating disorder," added Eric Bastings, M.D., deputy director of the Office of Neuroscience in the FDA Center for Drug Evaluation and Research. (medium.com)
  • Xywav demonstrated statistically significant and clinically meaningful differences in the primary endpoint of Epworth Sleepiness Scale and secondary endpoints of Patient Global Impression of Change and the Idiopathic Hypersomnia Severity Scale. (medium.com)
  • Xywav is the first drug to be approved by the FDA for idiopathic hypersomnia. (medium.com)
  • FDA gave Xywav Fast Track designation in September 2020 for the treatment of idiopathic hypersomnia and Priority Review designation as part of the supplemental New Drug Application (sNDA) acceptance in April 2021. (medium.com)
Characterized by excessive daytime sl2
  • Idiopathic hypersomnia is characterized by excessive daytime sleepiness, prolonged nighttime sleep, and sleep inertia. (medpagetoday.com)
  • Idiopathic hypersomnia, as the name suggests, has no identifiable cause and is characterized by excessive daytime sleepiness and extended nighttime sleep. (gwinnettsleep.com)
Symptoms of hypersomnia2
  • The main symptoms of hypersomnia are excessive nighttime sleep, sleepiness during the day, difficult wakening in the morning. (differencebetween.net)
  • What Are The Symptoms Of Hypersomnia? (nestmaven.com)
Secondary10
  • It occurs in the absence of medical problems or sleep disruptions, such as sleep apnea, that can cause secondary hypersomnia. (wikipedia.org)
  • ICSD-3 classifies "Central disorders of hypersomolence" into 'primary' and 'secondary' groupings, with narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), idiopathic hypersomnia (IH), and Kline-Levin syndrome (KLS) making up the primary disorders. (medscape.com)
  • The secondary disorders include hypersomnia due to a medical or psychiatric disorder, due to a drug or substance, and lastly, insufficient sleep syndrome (ISS). (medscape.com)
  • In an interview with Neurologia, Karel Šonka said that the ICSD3 new combined Idiopathic Hypersomnia 'seems to be defined negatively against narcolepsy and secondary and comorbid hypersomnias and encompasses perhaps a variety of different diseases. (hypersomnolenceaustralia.org.au)
  • This should be diagnosed if hypersomnia is secondary to the use or abuse of prescription medications, over-the-counter drugs, or illicit drugs. (medscape.com)
  • In the hospital, especially in intensive care units, hypersomnia may also be secondary to a disruption of the sleep-wake cycle or, in severe cases, may reflect an underlying delirium due to a general medical condition. (medscape.com)
  • Hypersomnia , a complex sleep disorder, can be broadly categorized into two main types: primary and secondary hypersomnia. (gwinnettsleep.com)
  • They may not address the root cause of hypersomnia, especially in cases of secondary hypersomnia. (gwinnettsleep.com)
  • Secondary hypersomnia can result from a variety of conditions which will be discussed in detail below. (nestmaven.com)
  • As we touched on earlier, there are many conditions that can result in secondary hypersomnia. (nestmaven.com)
Xyrem1
  • It could include stimulant medicines like Modalert 200 or Modvigil 200 and cataplexy-inhibiting drugs such as Xyrem. (sarose.com.np)
Hypocretin5
  • Unlike narcolepsy with cataplexy, which has a known cause (autoimmune destruction of hypocretin-producing neurons), the cause of IH is largely unknown. (wikipedia.org)
  • Type 1 narcolepsy (narcolepsy with cataplexy), the most common form of the condition, is caused by a deficiency in the neurotransmitter hypocretin (orexin). (adam.com)
  • On the horizon are experimental drugs designed to more precisely target the neuropeptide deficiency in people with classic narcolepsy type 1 (for narcolepsy with cataplexy: hypocretin/orexin agonists). (emoryhealthsciblog.com)
  • Studies in animal models have shown that deficient hypocretin transmission causes narcolepsy with cataplexy [ 4 ], and lower cerebrospinal fluid hypocretin levels have been observed in those with narcolepsy with cataplexy [ 5 ]. (pfmjournal.org)
  • Narcolepsy type 1 is distinguished by sleepiness plus cataplexy and a positive MSLT result or sleepiness plus hypocretin deficiency. (medscape.com)
Wakefulness1
  • People with idiopathic hypersomnia have altered hormones responsible for promoting wakefulness. (thesbb.com)
Severe4
  • 2. Does falling asleep quickly mean your idiopathic hypersomnia is severe (or worse than someone else with IH who had a longer sleep latency)? (hypersomnolenceaustralia.org.au)
  • Real-world results from the ARISE study showed that idiopathic hypersomnia (IH), an uncommon sleep disorder that causes excessive daytime sleepiness, is associated with a moderate to severe effect on quality of life (QoL), as demonstrated by responses on patient-reported outcomes. (neurologylive.com)
  • Cataplexy also has a severe emotional impact on narcoleptics, as it can cause extreme anxiety, fear, and avoidance of people or situations that might elicit an attack. (sleepdisordersresource.com)
  • In severe cases, cataplexy may cause a person to collapse to the ground and stay paralyzed for as long as several minutes. (narcolepsynotalone.com)
Medications4
  • Hypersomnia is determined to be idiopathic if it cannot be associated with a medical condition, medications, insufficient sleep or a psychiatric disorder and if narcolepsy has been excluded. (clevelandclinic.org)
  • There are currently no medications on the PBS for idiopathic hypersomnia. (hypersomnolenceaustralia.org.au)
  • As the use of medications can result in hypersomnia, a careful history and chronology of the symptoms are necessary to clarify the underlying cause. (medscape.com)
  • As it stands, the treatment of hypersomnia involves a multifaceted approach, which includes medications, lifestyle modifications, and cognitive-behavioral therapy. (gwinnettsleep.com)
Nocturnal3
  • Orexin-deficiency is responsible for the main NT1 symptoms: sleepiness, cataplexy, disrupted nocturnal sleep, sleep-related hallucinations, and sleep paralysis. (bvsalud.org)
  • In the absence of a lumbar puncture, the diagnosis is based on neurophysiological tests (nocturnal and diurnal) and the presence of the pathognomonic symptom cataplexy. (bvsalud.org)
  • A nocturnal SOREMP is very specific but not sensitive enough, and the diagnosis of cataplexy is usually based on clinical interview. (bvsalud.org)
Poorly understood2
  • The factors causing idiopathic hypersomnia are still poorly understood. (polysleep.ca)
  • At the recommendation of a neurologist in Iceland, Sigurjon's family sought out David Rye, who is known internationally for his research on idiopathic hypersomnia, a poorly understood sleep disorder. (emoryhealthsciblog.com)
Treatment12
  • The American Academy of Sleep Medicine practice parameters state that successful treatment of hypersomnia of central origin requires an accurate diagnosis, individual tailoring of therapy to produce maximum possible return of function, and regular follow-up to monitor response to therapy. (medscape.com)
  • Treatment Narcolepsy is characterized by chronic excessive daytime sleepiness, often with sudden loss of muscle tone (cataplexy). (merckmanuals.com)
  • In these cases, hypersomnia symptoms arise because of the primary issue, and addressing the root cause is crucial for effective treatment. (gwinnettsleep.com)
  • Stimulants like modafinil and armodafinil are often the first line of treatment for combating excessive daytime sleepiness associated with hypersomnia. (gwinnettsleep.com)
  • As our understanding of hypersomnia and its underlying mechanisms continues to evolve, researchers are delving into innovative treatment approaches to address this sleep disorder more effectively. (gwinnettsleep.com)
  • We are pleased with the positive results from the Phase 3 study of JZP-258, which demonstrate the efficacy of JZP-258 for the treatment of cataplexy and excessive daytime sleepiness in narcolepsy," said Jed Black, M.D., senior vice president, Sleep and Neuroscience at Jazz Pharmaceuticals and adjunct professor, Stanford University Medical Center, Stanford Center for Sleep Sciences and Medicine. (wakeupnarcolepsy.org)
  • In cataplexy treatment-naïve participants, cataplexy decreased consistently from week one of JZP-258 titration through the end of SDP. (wakeupnarcolepsy.org)
  • In order to undertake adequate treatment of hypersomnia, it is important to determine the causes of the condition and to eliminate them. (differencebetween.net)
  • By Treatment, the narcolepsy with cataplexy segment had the highest market share of 37% in 2022. (precedenceresearch.com)
  • By Treatment, the narcolepsy without cataplexy segment is anticipated to grow at a notable CAGR of 9.7% during the projected period. (precedenceresearch.com)
  • While the reason for Idiopathic Hypersomnia (IH) is not known, The treatment for IH is similar to that for narcolepsy. (sarose.com.np)
  • NLS-1021 is a multi-center, randomized, prospective Phase 2a clinical trial evaluating Quilience® (mazindol extended release or 'ER') as a once-daily monotherapy for the treatment of EDS and cataplexy, the primary symptoms of narcolepsy. (newjerseytelegraph.com)
Sleepiness during1
  • Hypersomnia, a sleep disorder characterized by excessive sleepiness during the day, can significantly impact an individual's quality of life. (gwinnettsleep.com)
Daytime5
  • The drug was first approved in 2020 for both cataplexy and excessive daytime sleepiness in people 7 years and older living with narcolepsy. (medpagetoday.com)
  • Excessive daytime hypersomnia also may occur from frequent chronic pain or from repeated awakenings because of an underlying medical disorder. (medscape.com)
  • The INTUNE study is being conducted by Harmony Biosciences to evaluate the safety and efficacy of pitolisant, an investigational medication for treating excessive daytime sleepiness (EDS) in people with idiopathic hypersomnia age 18 years or older. (hypersomniafoundation.org)
  • While these changes can help improve sleep quality and reduce daytime sleepiness, they may not be sufficient to fully address the underlying cause of hypersomnia, causing further intervention. (gwinnettsleep.com)
  • While it's normal for someone suffering from sleep deprivation to experience some level of excessive daytime sleepiness, those with hypersomnia typically get above average amounts of sleep yet still have trouble staying awake during the day. (nestmaven.com)
Modafinil3
  • 4. Why do some people with idiopathic hypersomnia have access to modafinil and armodafinil on the PBS whereas others don't? (hypersomnolenceaustralia.org.au)
  • The only way someone with idiopathic hypersomnia (or any other medical condition that causes EDS) can access affordable (via the PBS) modafinil/armodafinil is if their doctor submits the PBS application form as if they have narcolepsy. (hypersomnolenceaustralia.org.au)
  • 5. I have idiopathic hypersomnia and I am prescribed modafinil/armodafinil on the PBS and I don't have any of those contraindications. (hypersomnolenceaustralia.org.au)
20221
  • A 2022 study further corroborates these findings, suggesting that extended sleep time, circadian delay and teleworking decreased symptoms of central hypersomnias. (medicalnewstoday.com)
Diagnostic1
  • Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) defines idiopathic hypersomnia as EDS without narcolepsy or the associated features of other sleep disorders. (wikipedia.org)
Etiology1
Chronic sleep disorder1
  • Idiopathic Hypersomnia (IH) is a chronic sleep disorder involving persistent sleepiness lasting more than 3 months without abnormal tendencies to enter REM sleep. (narcolepsynotalone.com)
Researchers6
  • Your participation in research studies helps researchers to better understand Narcolepsy Type 1 & 2, and Idiopathic Hypersomnia and to test investigational drugs. (narcolepsynetwork.org)
  • The research also showed, which has been the long-held belief of many researchers, that the clinical features of Monosymptomatic Hypersomnia are more closely related to those found in Narcolepsy without cataplexy (Type 2 Narcolepsy) and that those two disorders should be merged into one single condition. (hypersomnolenceaustralia.org.au)
  • Drawn from 54 references, including over 40 peer-reviewed papers and book chapters on Idiopathic Hypersomnia and Narcolepsy that span more than 6 decades as well as numerous personal conversations with the world's leading Idiopathic Hypersomnia researchers. (hypersomnolenceaustralia.org.au)
  • In cases where hypersomnia is linked to an autoimmune response, researchers are investigating the potential of immunotherapy to counteract the detrimental effects on the nervous system. (gwinnettsleep.com)
  • Researchers have provided more evidence that narcolepsy without cataplexy (Nw/oC ) and idiopathic hypersomnia (IH) without long sleep time (LST) look more alike on testing than do narcolepsy with cataplexy (NwC) and Nw/oC. (hypersomniafoundation.org)
  • Ultimately, a better understanding of these brain mechanisms will enable researchers and doctors to develop new methods to improve sleepiness, cataplexy, and other symptoms of narcolepsy. (wakeupnarcolepsy.org)
Absence2
  • The biggest distinguishing characteristics include differences in REM (rapid eye movement) sleep, the absence of cataplexy (a sudden weakness in the muscles while fully co. (icliniq.com)
  • When a patient presents with hypersomnia in the absence of these disorders and with no other known cause it's called idiopathic hypersomnia. (nestmaven.com)
Fall asleep3
  • Her time to fall asleep on the MSLT ranged from 13 to 17 minutes ― significantly longer than the 8-minute or less criterion for idiopathic hypersomnia ― although she reported that the testing environment made her anxious. (clevelandclinic.org)
  • No. While people with idiopathic hypersomnia do tend to fall asleep quicker than healthy people falling asleep quickly is not a typical trait of idiopathic hypersomnia. (hypersomnolenceaustralia.org.au)
  • Consistent research has shown that people with idiopathic hypersomnia do not necessarily fall asleep quickly. (hypersomnolenceaustralia.org.au)
MSLT4
Symptom3
  • Anyone can experience the symptom of hypersomnia from time to time. (nestmaven.com)
  • In these cases hypersomnia is caused by a disruption to your sleep or energy levels and is considered a symptom rather than a disorder unto itself. (nestmaven.com)
  • Narcolepsy and Kleine-Levin syndrome are sleep disorders that both have hypersomnia as their predominant symptom. (nestmaven.com)
Type5