MyopathyMyopathiesJuvenile idiopathiSystemicMyositisLupusPolymyositis and dermatomyositisMortality in patients with polymyositisAmyopathicCase of DermatomyositisTreatment of dermatomyositisAutoantibodiesInterstitial pneumoniaManifestationsPulmonaryChronicAntisynthetase syndromeSymptomsDiseasesInflammatory diseaseAdultCutaneousCharacteristicClinical featuresPatients with juvenileMuscleMusclesPediatricAntibodiesChildren with juvenileOccurAdultsRarePatientSkin
Myopathy14
- Juvenile dermatomyositis (JDM) is an idiopathic inflammatory myopathy (IMM) of presumed autoimmune dysfunction resulting in muscle weakness among other complications. (wikipedia.org)
- Juvenile dermatomyositis (JDM) is the main cause of chronic idiopathic inflammatory myopathy of autoimmune origin in children. (nih.gov)
- Dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous findings that occur in children and adults (see the image below). (medscape.com)
- It is also known as idiopathic inflammatory myopathy. (medlineplus.gov)
- The idiopathic inflammatory myopathies (IIM) encompass eight categories: 1) dermatomyositis (DM) in adults, 2) juvenile dermatomyositis, 3) amyopathic DM, 4) cancer-associated DM, 5) polymyositis, 6) immune-mediated necrotizing myopathy, 7) inclusion body myositis, and 8) overlap myositis.1 These categories help classify the myopathies based on clinical and histologic features. (the-rheumatologist.org)
- Clinically similar to polymyositis, dermatomyositis is an idiopathic, inflammatory myopathy associated with characteristic dermatologic manifestations. (medscape.com)
- [ 1 ] Inclusion body myositis is a slowly progressive, idiopathic, inflammatory myopathy with characteristic pathologic findings that is generally found in older males. (medscape.com)
- Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy (IIM) associated with an increased risk for malignancy. (bvsalud.org)
- Dermatomyositis (DM) is an idiopathic inflammatory myopathy. (bvsalud.org)
- It is an idiopathic myopathy that also affects the skin. (marham.pk)
- Muscle biopsy indicative of active idiopathic inflammatory myopathy (IIM) in the past 3 months e. (who.int)
- Receiving a permitted background treatment for idiopathic inflammatory myopathy. (who.int)
- Autoimmune myositis is characterized by inflammatory and degenerative changes in the muscles (polymyositis, necrotizing immune-mediated myopathy) or in the skin and muscles (dermatomyositis). (msdmanuals.com)
- Human leukocyte antigen in Japanese patients with idiopathic inflammatory myopathy. (cdc.gov)
Myopathies11
- Ernste FC, Reed AM. Idiopathic inflammatory myopathies: current trends in pathogenesis, clinical features, and up-to-date treatment recommendations. (epnet.com)
- IDIOPATHIC INFLAMMATORY MYOPATHIES - The idiopathic inflammatory myopathies are a group of diseases in which inflammation occurs in muscles and often in organs and tissues other than muscle. (medilib.ir)
- The cause of the idiopathic inflammatory myopathies remains undetermined. (medilib.ir)
- More than 15 autoantibodies have been identified in patients with idiopathic inflammatory myopathies (IIM). (bmj.com)
- Idiopathic inflammatory myopathies often affect extramuscular organs such as the skin, joints, lungs, heart and gastrointestinal tract ( 1 ). (frontiersin.org)
- Some of the chronic forms of myositis are idiopathic inflammatory myopathies, meaning their cause is unknown. (creakyjoints.org)
- Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients. (nih.gov)
- A systematic review of adult-onset clinically amyopathic dermatomyositis (dermatomyositis siné myositis): a missing link within the spectrum of the idiopathic inflammatory myopathies. (nih.gov)
- Data from the literature suggested that TNF-alpha plays an important role in idiopathic inflammatory myopathies. (medscape.com)
- Analysis of anti-melanoma differentiation-associated gene 5 antibody in Hong Kong Chinese patients with idiopathic inflammatory myopathies: diagnostic utility and clinical correlations. (cdc.gov)
- The spectrum and clinical significance of myositis-specific autoantibodies in Chinese patients with idiopathic inflammatory myopathies. (cdc.gov)
Juvenile idiopathi9
- If your child is experiencing pain in their muscles or joints, unexplained fevers or symptoms of an autoimmune or a rheumatic condition, such as juvenile idiopathic arthritis or lupus, our pediatric rheumatology team is here to guide you both through diagnosis and treatment. (geisinger.org)
- The diseases were all fascinating, from the 7 juvenile idiopathic arthritis (JIA) subtypes to systemic lupus erythematosus to juvenile dermatomyositis. (chop.edu)
- I treat patients with Systemic Lupus Erythematosus, Juvenile Idiopathic Arthritis/Juvenile Rheumatoid Arthritis, Juvenile Dermatomyositis, periodic fever syndromes. (mhs.net)
- The most commonly seen condition in our rheumatology clinic is juvenile idiopathic arthritis (JIA) . (shrinerschildrens.org)
- We have reviewed the literature to provide an overview of the respiratory complications of the commonest rheumatological diseases to occur in children (juvenile systemic lupus erythematosus, scleroderma, juvenile dermatomyositis, mixed connective tissue disease, granulomatosis with polyangitis and juvenile idiopathic arthritis). (bmj.com)
- JA is actually an umbrella term for the various autoimmune and inflammatory conditions that affect children 16 years or younger, the most common form being juvenile idiopathic arthritis (JIA), which replaces the term 'juvenile rheumatoid arthritis. (prebiotin.com)
- RNA was separately extracted from peripheral blood neutrophils and mononuclear leukocytes, labeled, and hybridized to genome level microarrays to generate expression profiles of children with polyarticular juvenile idiopathic arthritis, juvenile dermatomyositis relative to childhood controls. (biomedcentral.com)
- Methotrexate (MTX) is the first line of therapy for patients with juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM). (biomedcentral.com)
- The most common childhood rheumatic diseases we treat are systemic lupus erythematosus (juvenile), juvenile dermatomyositis and juvenile idiopathic arthritis (JIA). (hcahealthcare.co.uk)
Systemic4
- I had a long way to go before becoming comfortable recognizing the subtle joint effusions of chronic arthritis, the synechiae of longstanding anterior uveitis, the tortuous nailfold capillaries in dermatomyositis, and the clubbing in systemic JIA lung disease. (chop.edu)
- PAH is a complication of various connective tissue diseases (CTD), including scleroderma (affecting roughly 10% of patients), systemic lupus erythematosus (SLE), mixed CTD, dermatomyositis, Sjogren's syndrome and rheumatoid arthritis.7 Compared with idiopathic pulmonary hypertension patients, these patients are predominantly female, are older at the time of diagnosis of PAH and have shorter survival (the unadjusted risk of death is three times higher than in IPAH). (bjcardio.co.uk)
- Secretion Influences the Development of Dermatomyositis and Systemic Lupus Erythematosus. (cdc.gov)
- XRCC1 variants do not represent a risk for dermatomyositis and systemic lupus erythematosus in Bulgarian patients. (cdc.gov)
Myositis6
- Unclassifiable ILDs, autoimmune ILDs, chronic hypersensitivity pneumonitis, sarcoidosis, myositis, Sjögren syndrome, coal worker pneumoconiosis, and idiopathic forms of interstitial pneumonias (eg, idiopathic nonspecific interstitial pneumonia [NSIP]) are among the diseases that may develop a progressive form of chronic fibrosing ILD. (medscape.com)
- To stratify patients with polymyositis/dermatomyositis-associated interstitial lung disease (ILD) who were initially treated with an intensive regimen consisting of high-dose corticosteroids, a calcineurin inhibitor, and intravenous cyclophosphamide (triple-combo therapy) into subgroups based on mortality outcomes by a cluster analysis using a large-scale multicenter retrospective cohort of Japanese patients with myositis-associated ILD (JAMI). (frontiersin.org)
- These chronic forms affect approximately 1 in 100,000 people, and include polymyositis, dermatomyositis and inclusion body myositis. (creakyjoints.org)
- 2016 American College of Rheumatology/European League against rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: an international myositis assessment and clinical studies group/paediatric rheumatology international trials organisation collaborative initiative. (medlineplus.gov)
- Amyopathic dermatomyositis (dermatomyositis siné myositis). (nih.gov)
- The association of cancer with dermatomyositis (less so with polymyositis) suggests that a tumor may incite myositis as the result of an autoimmune reaction against a common antigen in muscle and tumor. (msdmanuals.com)
Lupus1
- These diseases haves names like juvenile idiopathic ["without clear cause"] arthritis, juvenile dermatomyositis, and juvenile lupus. (prebiotin.com)
Polymyositis and dermatomyositis8
- Though the exact cause is unknown, evidence suggests that polymyositis and dermatomyositis are autoimmune disorders in which the immune system mistakenly attacks tissues in the body. (creakyjoints.org)
- Polymyositis and dermatomyositis are rare inflammatory diseases. (medlineplus.gov)
- Polymyositis and dermatomyositis have many shared clinical features. (medscape.com)
- Studies so far have yielded less favorable results than treatment for polymyositis and dermatomyositis. (medscape.com)
- An autoimmune response to nuclear and cytoplasmic autoantigens is detected in about 60-80% of patients with polymyositis and dermatomyositis. (medscape.com)
- The effect of cigarette smoking on the clinical and serological phenotypes of polymyositis and dermatomyositis. (cdc.gov)
- Meta-Analysis of Polymyositis and Dermatomyositis Microarray Data Reveals Novel Genetic Biomarkers. (cdc.gov)
- Mortality in Patients with Polymyositis and Dermatomyositis in an Israeli Population. (cdc.gov)
Mortality in patients with polymyositis1
- In particular, interstitial lung disease (ILD) is one of the major manifestations associated with poor mortality in patients with polymyositis (PM)/dermatomyositis (DM) ( 2 ). (frontiersin.org)
Amyopathic2
- We developed a cluster model consisting of 6 clusters, which were categorized by age at onset, clinically amyopathic dermatomyositis, CRP, KL-6, requirement of supplemental oxygen, anti-ARS antibody, and anti-MDA5 antibody. (frontiersin.org)
- Amyopathic dermatomyositis: a review. (nih.gov)
Case of Dermatomyositis1
- An elusive case of dermatomyositis. (nih.gov)
Treatment of dermatomyositis2
- To learn more about Octagam 10% for the treatment of dermatomyositis, please click here . (octapharma.com)
- What is the treatment of dermatomyositis? (marham.pk)
Autoantibodies1
- Association of Dermatomyositis Sine Dermatitis With Anti-Nuclear Matrix Protein 2 Autoantibodies. (nih.gov)
Interstitial pneumonia1
- [ 9 ] To address this, the European Respiratory Society and American Thoracic Society released a joint consensus statement in 2015 proposing the term "interstitial pneumonia with autoimmune features" (IPAF) be used for "idiopathic interstitial pneumonia" (IIP) with clinical features that suggest an underlying autoimmune process. (medscape.com)
Manifestations1
- Persons with dermatomyositis often present with skin disease as one of the initial manifestations, and it may be the sole manifestation at onset in perhaps as many as 40% of individuals with this condition. (medscape.com)
Pulmonary1
- Pulmonary hypertension in children is most commonly idiopathic or hereditary PAH or caused by congenital heart disease. (bjcardio.co.uk)
Chronic2
- Chronic inflammatory diseases such as rheumatoid arthritis (RA) and juvenile dermatomyositis (JDM) are examples of human diseases whose etiologies and pathogenic mechanisms remain incompletely understood. (biomedcentral.com)
- OBJECTIVES: Juvenile dermatomyositis (JDM) is a chronic autoimmune disease. (bvsalud.org)
Antisynthetase syndrome1
- Mechanic's hands - People with a type of dermatomyositis called "antisynthetase syndrome" may develop "mechanic's hands," a roughening and cracking of the skin of the tips and sides of the fingers, resulting in irregular, dirty-appearing lines that resemble those of a manual laborer ( picture 5 ). (medilib.ir)
Symptoms2
- What are the symptoms of dermatomyositis? (marham.pk)
- You can also book a video consultation through Marham to discuss your symptoms with the most experienced top skin doctor for dermatomyositis in Pakistan. (marham.pk)
Diseases3
- https://rarediseases.info.nih.gov/diseases/6263/dermatomyositis. (octapharma.com)
- Autoimmune diseases can increase the risk of developing dermatomyositis in both children and adults. (marham.pk)
- The actual cause behind dermatomyositis is unknown but autoimmune diseases are known to increase the increase of developing the disease. (marham.pk)
Inflammatory disease1
- Dermatomyositis is an inflammatory disease that results in skin changes and muscle weakness. (epnet.com)
Adult3
- Octapharma USA today announced the U.S. Food and Drug Administration (FDA) Office of Orphan Products Development (OOPD) has awarded seven years of marketing exclusivity for Octagam ® 10% [Immune Globulin Intravenous (Human)], the first and only intravenous immunoglobulin (IVIg) to be indicated for the treatment of adult dermatomyositis (DM). (octapharma.com)
- The field has moved away from the idea that anti-TNF therapy could be helpful in dermatomyositis, because in adult forms of the disease, study results have been extremely mixed, said Lisa Rider MD, deputy chief, Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland. (medscape.com)
- Serum interleukin-17A level is associated with disease activity of adult patients with dermatomyositis and polymyositis. (cdc.gov)
Cutaneous1
- A rare form of juvenile dermatomyositis that manifests with characteristic cutaneous findings for at least six months in the absence of any detectable muscle involvement. (nih.gov)
Characteristic1
- [ 3 ] Despite these similarities, muscle biopsy findings and characteristic skin findings of dermatomyositis reveal each as a distinct clinical entity. (medscape.com)
Clinical features1
- The clinical features, diagnosis and classification of dermatomyositis. (nih.gov)
Patients with juvenile1
- LONDON - For patients with juvenile dermatomyositis , a rare autoimmune disease that affects children, anti-tumor necrosis factor (TNF) agents appear to be an exciting new treatment option, results from a large observational cohort study suggest. (medscape.com)
Muscle6
- In some cases, the rash of dermatomyositis appears, but muscle weakness never develops. (medilib.ir)
- Polymyositis causes muscle weakness, usually in the muscles of the trunk, while dermatomyositis causes muscle weakness plus a skin rash. (creakyjoints.org)
- Idiopathic inflammatory muscle disease: clinical aspects. (nih.gov)
- Dermatomyositis is a rare systematic disease causing muscle weakness and skin rash. (marham.pk)
- Dermatomyositis is diagnosed using blood tests showing elevated muscle enzymes level. (marham.pk)
- That's a helpful point about this study because the data here are more striking: there is clearly benefit from anti-TNF treatment in this treatment-refractory group of juvenile dermatomyositis patients for both muscle and skin," she told Medscape Medical News . (medscape.com)
Muscles1
- Another explanation developed by scientists, states that the cause behind dermatomyositis is a virus acting on the skeletal muscles. (marham.pk)
Pediatric1
- it is the pediatric counterpart of dermatomyositis. (wikipedia.org)
Antibodies1
- It contains antibodies that can block the unhealthy ones linked to dermatomyositis. (epnet.com)
Children with juvenile1
- More than 500 children with juvenile dermatomyositis are being treated at the Institute of Child Health, despite the fact that the disease occurs annually in only two or three children per million, she reported. (medscape.com)
Occur2
- Scalp - Changes in the scalp resembling psoriasis may occur in people with dermatomyositis. (medilib.ir)
- Idiopathic ischemic dermatosis can occur at any age and any canine breed. (dvm360.com)
Adults1
- The FDA approval is based on the results of ProDERM (ClinicalTrials.gov Identifier: NCT02728752), a pivotal randomized clinical trial and the first study to evaluate the long term efficacy and safety of IVIg for adults with dermatomyositis. (octapharma.com)
Rare1
- Dermatomyositis is a rare idiopathic autoimmune disorder of unknown cause affecting approximately 10 out of every million U.S. residents. (octapharma.com)
Patient1
- Consult the most experienced specialists for Dermatomyositis in Pakistan based on their qualifications, patient reviews, location, and fees. (marham.pk)
Skin4
- Skin changes - People with dermatomyositis often develop a rash or other changes in the skin. (medilib.ir)
- The condition is called dermatomyositis when it involves the skin. (medlineplus.gov)
- The skin rash that appears in dermatomyositis is easily spotted as the physical features are very prominent. (marham.pk)
- Active dermatomyositis (DM) skin rash d. (who.int)