GenesDevelopmentalVertebratesSignaling pathwayKinasesChromosomeEncodesMediateAminoWnt10bProto-oncogenePathwaysSerumRegulatePhospholipaseTranscriptionBindSpeciesTissuePhenotypesSignalAntibodyZebrafishOrthologsELISAEmbryoMemberExhibitMutationsSignificantlyControlCellCellsMolecularFoundImportantFUNCTIONPrimaryMembersImportanceDomainGrowthPresent
Genes4
- The WNT gene family consists of structurally related genes that encode secreted signaling proteins. (wikipedia.org)
- Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
- The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
- The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. (antibodies-online.com)
Developmental4
- These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. (wikipedia.org)
- WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. (utsouthwestern.edu)
- Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
- Wnt proteins regulate developmental processes, tissue regeneration and stem cell maintenance. (exeter.ac.uk)
Vertebrates2
- More recently, we have taken advantage of our experience in studying these mechanisms to extend our work to vertebrates, using primarily the mouse. (stanford.edu)
- We identified a novel way of spreading Wnt proteins in vertebrates: Wnt molecules are mobilized on specific cell protrusions known as cytonemes. (exeter.ac.uk)
Signaling pathway3
- This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. (utsouthwestern.edu)
- This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. (utsouthwestern.edu)
- Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
Kinases2
- We demonstrate here that the kinases Gsk3β and cAMP-dependent protein kinase A (PKA) are novel determinants of IZ formation and cooperate with E(Spl) activity in a dose-dependent manner. (biologists.com)
- Among the main element downstream targets of the systems are NF-B, mitogen-activated proteins kinases, and people from the IRF family members (5). (cancer-ecosystem.com)
Chromosome1
- This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. (wikipedia.org)
Encodes1
- It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. (antibodies-online.com)
Mediate2
- Wnt proteins constitute a family of secreted glyocoproteins that activate signal transduction pathways to mediate tissue homeostasis, cell fate, cell proliferation, and self-renewal. (thermofisher.com)
- Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)
Amino4
- This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. (wikipedia.org)
- The human WNT10B sequence is 88% and 95% identical to the mouse gene at nucleotide and amino acid levels, respectively. (abbkine.com)
- At the amino acid level, mature human Wnt-1 is approximately 99% identical to mature mouse Wnt-1. (thermofisher.com)
- Based on the amino acid sequence homology and biological activity in macrophages, Shimamoto et al ( 15 ) identified that HLP was identical to MSP ( 15 ). (spandidos-publications.com)
Wnt10b2
- Protein Wnt-10b (formerly Wnt12) is a protein that in humans is encoded by the WNT10B gene. (wikipedia.org)
- Gain-of-function of Wnt10b in mouse hearts has shown to improve cardiac tissue repair after myocardial injury, by promoting coronary vessel formation and attenuating pathological fibrosis. (wikipedia.org)
Proto-oncogene1
- Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
Pathways1
- These survival mechanisms include accumulation of organic osmolytes and increased expression of heat shock proteins through numerous pathways, resulting in osmotolerance. (biomedcentral.com)
Serum2
- Macrophage stimulating protein (MSP) was discovered as a serum protein that promoted mouse macrophage motility ( 13 ), and was later purified to homogeneity from human plasma ( 14 ). (spandidos-publications.com)
- The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
Regulate1
- Using mouse genetic models, the authors show that Schwann cells regulate vascularization of the sciatic nerve and are required for a decrease in vascular density postnatally. (elifesciences.org)
Phospholipase1
- Next, we delineated the molecular mechanism underlying CXCL1-promoted COX-II expression and noted that CXC chemokine receptor 2 (CXCR2), phospholipase C (PLC), and protein kinase C (PKC) signal transduction were responsible for COX-II expression after CXCL1 incubation for RASFs. (bvsalud.org)
Transcription1
- Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
Bind2
- These pericryptal myofibroblasts produce the Wnt signalling ligands which bind to Frizzled receptors as well as morphogenetic protein (BMP) antagonists gremlin 1(GREM1), gremlin 2 (GREM2) on basal epithelial stem cells and also can modulate notch signaling. (biomedcentral.com)
- Proteins which bind to DNA. (lookformedical.com)
Species3
- Proteins that originate from insect species belonging to the genus DROSOPHILA. (lookformedical.com)
- The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (lookformedical.com)
- Find WNT8B Antibodies for a variety of species such as anti-Human WNT8B, anti-Mouse WNT8B, anti-Rat WNT8B. (antibodies-online.com)
Tissue1
- The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration-dependent manner. (exeter.ac.uk)
Phenotypes1
- In the present review, the phenotypes of Met gene‑modified mice are summarized. (spandidos-publications.com)
Signal2
- Description: The G8.8 monoclonal antibody reacts with the 40 kDa mouse EpCAM (epithelial cellular adhesion molecule), also known as EGP40 (epithelial glycoprotein 40), 17-1A antigen, TACSTD1 (tumor-associated calcium signal transducer 1), and CD326. (thermofisher.com)
- These specialized signalling filopodia transmit signal proteins between communicating cells and allow a high degree of control of propagation speed, direction and concentration of the transmitted ligand. (exeter.ac.uk)
Antibody1
- Immunostaining with an affinity-purified mouse antibody reveals that Eph is highly targeted to axons and growth cones of developing neurons within the VNC. (sdbonline.org)
Zebrafish1
- In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)
Orthologs1
- The p.Asn173His mutation affects a residue in the forkhead domain that is 100% conserved among vertebrate orthologs and is predicted to participate in protein-protein interactions. (molvis.org)
ELISA3
- This Human Protein Wnt-10a (WNT10A) ELISA Kit employs a two-site sandwich ELISA to quantitate WNT10A in samples. (abbkine.com)
- Human Protein Wnt-10a (WNT10A) ELISA Kit has high sensitivity and excellent specificity for detection of Human WNT10A. (abbkine.com)
- Abbkine ELISA kit is series of sandwich ELISA to quantitate specific protein in samples. (abbkine.com)
Embryo1
- Sonic hedgehog (SHH) is a secreted morphogen that regulates the patterning and growth of many tissues in the developing mouse embryo, including the central nervous system (CNS). (silverchair.com)
Member1
- We show that a member of the FK506-binding protein family, FKBP8, is an essential antagonist of SHH signaling in CNS development. (silverchair.com)
Exhibit1
- Both exhibit almost identical biological activity and are not known to possess differing biological activities. (fujifilm.com)
Mutations1
- Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
Significantly1
- The xenograft growth rates were significantly inhibited in mice GSK1292263 given doxycycline, whereas the control group showed rapid tumor growth (Number 6B). (tech-strategy.org)
Control2
- Staining of the TE-71 cell line with 0.06 µg of Rat IgG2a K Isotype Control APC (Product # 17-4321-81) (blue histogram) or 0.06 µg of Anti-Mouse CD326 (EpCAM) APC (purple histogram). (thermofisher.com)
- This result shows that doxycycline-induced ATP1B2 silencing suppressed the tumor volume by 10-collapse versus that of the control mice (Number 6C and ?and6D),6D), and clearly inhibited tumor growth was confirmed using immunohistochemical analysis (Number 6E). (tech-strategy.org)
Cell4
- HGF was cloned as a growth factor for hepatocytes ( 1 , 2 ), is identical to scatter factor (SF) and was originally discovered as a fibroblast-derived cell motility factor for epithelial cells ( 3 ). (spandidos-publications.com)
- Proteins found in the nucleus of a cell. (lookformedical.com)
- To determine the effects of osmolarity/tonicity changes, Wnt/β-catenin and TLR-4 activation on Lcn2-R and Lcn2 expression and cell viability in rat primary IMCD and mouse (m)IMCD3 cells. (biomedcentral.com)
- Furthermore, inducible ATP1B2 knockdown considerably inhibit tumor development tumor development in mice xenografted using the extremely tumorigenic U87 GBM cell series stably expressing doxycycline-inducible shATP1B2-1#. (tech-strategy.org)
Cells1
- Tumors of doxycycline-treated mice showed fewer neoplastic cells in the H&E staining (Number 6F). (tech-strategy.org)
Molecular1
- It may be involved in breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs adipogenesis. (wikipedia.org)
Found1
- We found, in mice, that the sciatic nerve invasion by blood vessels begins around embryonic day 16 and continues until birth. (elifesciences.org)
Important1
- In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. (iiab.me)
FUNCTION1
- FUNCTION: [Summary is not available for the mouse gene. (utsouthwestern.edu)
Primary1
- This is referred to as the primary structure of proteins. (lookformedical.com)
Members1
- The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)
Importance1
- It is of fundamental importance in determining PROTEIN CONFORMATION. (lookformedical.com)
Domain3
- The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. (utsouthwestern.edu)
- HGF forms a family with HGF-like protein (HLP), a unique protein with a domain structure similar to that of HGF ( 12 ). (spandidos-publications.com)
- Substitution of a valine for a glutamic acid in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (iiab.me)
Growth1
- On day time 45, the mice were euthanized and tumor volume measurement strikingly exposed that tumor growth in the doxycycline-treated organizations was minor. (tech-strategy.org)
Present1
- Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)