• claim
  • 25. The method of claim 21, further comprising treating, ameliorating or preventing a CB1 receptor inverse-agonist mediated appetite related, obesity related or metabolism related syndrome, disorder or disease in a subject in need thereof comprising the step of administering to the subject an effective amount of a CB1 inverse-agonist compound of Formula I. (patentsencyclopedia.com)
  • 27. The method of claim 21, further comprising the step of administering to the subject a combination product and/or therapy comprising an effective amount of a compound of Formula I and a therapeutic agent. (patentsencyclopedia.com)
  • 32. Use of the compound of claim 21 in the manufacture of a medicament for treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease. (patentsencyclopedia.com)
  • quaternary
  • Likewise, a tetravalent neutral silicon or positively charged quaternary nitrogen atom (ammonium cation) can be the spiro center in these compounds, and many of these have been prepared and described. (wikipedia.org)
  • The washcoat comprises at least one quaternary ammonium salt including at least one hydroxyl functional group, and a compound containing at least two epoxide moieties. (patentgenius.com)
  • and (c) a washcoat layer positioned over the surface of said protective layer which is remote from said support, said washcoat layer comprising: a compound containing at least two epoxide moieties and at least one quaternary ammonium salt includingat least one hydroxyl functional group. (patentgenius.com)
  • hydrocarbon
  • The invention consists in organometallic compounds comprising a hydrocarbon moiety composed of at least one cyclic component having available 11F-electrons and being connected to at least one oletinic chain component having at least two conjugated double bonds, and a transition-metal carbonyl moiety connected by a ir-bond to either the cyclic nucleus -or the side chain. (google.es)
  • Moreover
  • Moreover, dicyclopentadienyl iron compounds are known (usually referred to as ferfocenes) in which an iron, cobalt, nickel or ruthenium atom is bound by fr-bonds to two cyclopentadiene radicals. (google.es)
  • Moreover, the relatively great migration velocity of the compounds known from the state of the art results in a short lifetime of the dyed plastic objects. (google.com)
  • Synthesis
  • citation needed] In both cases, the presence of the spiro center, often with four distinct groups attached, and with its unique aspects of chirality, adds unique challenges to the chemical synthesis of each compound type. (wikipedia.org)
  • The object of the present invention is to provide substances, which dye photochromically well at room temperature, lighten up quickly enough for ophthalmic lenses, possess sufficient longevity and due to their spatial structure have less tendency to migrate than the compounds known from the state of the art, and to describe the synthesis of these substances. (google.com)
  • hydroxyl
  • An acid addition salt may be converted into the free compound by treatment with a base, e.g. a metal hydroxide, ammonia or a hydroxyl ion exchange preparation. (patentgenius.com)
  • Uses
  • It is found that the more new kinds of such organometallic compounds are added to the list of those already known, the wider becomes the field of technical uses of these compounds, and the better are they suited to their different applications. (google.es)
  • effective
  • Such conjugates and/or cytotoxic compounds may be effective for treating a range of diseases, such as cancer, with a relatively high activity at a relatively low, non-toxic dose. (patents.com)
  • preparation
  • Thus, a resulting basic compound can be converted into a corresponding acid addition salt, for example by reacting it with an inorganic or organic acid, such as therapeutically useful acid, or with a corresponding anion exchange preparation, andisolating the desired salt. (patentgenius.com)
  • found
  • The result are, comparable to the procedures in chromatography, layers in which the different pyran compounds are found in above average concentrations. (google.com)
  • image
  • for instance, a spiro compound with a pair of three-membered cyclopropene rings connected in spiro fashion (image below) has been given the popular misnomer of being a bow tie structure, when it is not flat or planar like a bow tie. (wikipedia.org)
  • agents
  • Spiro compounds are present throughout the natural world, some cases of which have been exploited to provide tool compounds for biomedical study and to serve as scaffolds for the design of therapeutic agents with novel shapes. (wikipedia.org)
  • surface
  • In particular, the material specific varying migration of the individual pyran compounds leads to inadequate dyeing results in surface coloring if these pyran compounds are utilized in mixtures, which are needed to obtain a desired mixed tone, because each individual compound penetrates to a different depth into the to-be-dyed material depending on the specific migration velocity. (google.com)
  • case
  • Hence, in the third case, the lack of planarity described above gives rise to what is termed axial chirality in otherwise identical isomeric pair of spiro compounds, because they differ only in the right- versus left-handed "twist" of structurally identical rings (as seen in allenes, sterically hindered biaryls, and alkylidenecycloalkanes as well). (wikipedia.org)