AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
IbuprofenIndomethacinAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase InhibitorsProstaglandinsAnalgesics, Non-NarcoticDuctus Arteriosus, PatentAcetaminophenDinoprostoneDiclofenacProstaglandin-Endoperoxide SynthasesNaproxenProstaglandins ECyclooxygenase 2 InhibitorsCyclooxygenase 1Prostaglandin AntagonistsKetoprofenAspirinAntipyreticsStomach UlcerThromboxane B24,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amineArachidonic Acids6-Ketoprostaglandin F1 alphaDose-Response Relationship, DrugCyclooxygenase 2SulfonesArachidonic AcidEpoprostenolMasoprocolLactonesFlurbiprofenGastric MucosaThromboxanesDrug InteractionsLipoxygenase InhibitorsDipyroneTherapeutic EquivalencyFeverAcupuncture TherapyAcupunctureLow Back PainAcupuncture PointsEmergency Service, HospitalAcupuncture AnalgesiaTreatment Outcome
NSAIDsKetoprofenMotrinAspirinPremature infantsCyclo-oxygenaseProstaglandinEnterocolitisPreterm infantsIntravenousInfantsClosureFurosemidePatentNSAIDInhibitsConclusionsDoseInhibitorKidneysBody'sPlaceboComplicationsCapsuleAntiinflammatoryGastrointestinalLithiumSuspensionMedicationTreatGroupDrugProducts
NSAIDs12
  • Many NSAIDs, but particularly indometacin, cause lithium retention by reducing its excretion by the kidneys. (wikipedia.org)
  • All NSAIDs, including indometacin, also increase plasma renin activity and aldosterone levels, and increase sodium and potassium retention. (wikipedia.org)
  • Its treatment and prevention is joint replacement, NSAIDs like Ibuprofen, and exercises, as well as physical therapy. (checkbiotech.org)
  • People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as indomethacin may have a higher risk of having a heart attack or a stroke than people who do not take these medications. (medlineplus.gov)
  • NSAIDs such as indomethacin may cause ulcers, bleeding, or holes in the stomach or intestine. (medlineplus.gov)
  • The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while taking indomethacin. (medlineplus.gov)
  • Indomethacin is in a class of medications called NSAIDs. (medlineplus.gov)
  • Common NSAIDs include: ibuprofen (Motrin, Nuprin or Advil), naproxen (Naprosyn, Aleve) and indomethacin (Indocin). (encyclopedia.com)
  • Several medications can help treat gout flare-ups, including NSAIDs (ibuprofen) and colchicine. (healthline.com)
  • Take nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or indomethacin when symptoms begin. (medlineplus.gov)
  • Experimental studies have reported a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, against mammary carcinogenesis ( 1 - 3 ), and accumulating evidence from both case-control and cohort studies suggests that use of NSAIDs may be associated with a modest decreased risk of breast cancer in women ( 4 - 10 ). (aacrjournals.org)
  • Fenoprofen (fen" oh proe' fen) belongs to the propionic derivative class of NSAIDs similar to naproxen, ketoprofen, flurbiprofen and ibuprofen. (nih.gov)
Ketoprofen3
Motrin2
Aspirin2
Premature infants4
  • To date there is no firm conclusion as to the efficacy and safety of ibuprofen compared with indometacin for patent ductus arteriosus (PDA) closure in extremely premature infants. (bmj.com)
  • Ibuprofen is as effective as indometacin for the early-targeted PDA treatment in extremely premature infants, without increasing the incidence of complications. (bmj.com)
  • Products containing indometacin or ibuprofen, which are only used for closing the ductus arteriosus in premature infants, are classified here. (whocc.no)
  • ABSTRACT Although intravenous indomethacin and ibuprofen are widely used for closure of patent ductus arteriosus in premature infants, these formulations are unavailable in the Islamic Republic of Iran. (who.int)
Cyclo-oxygenase2
  • The drugs used to treat the patent ductus arteriosus are ibuprofen and indomethacin which are potent non-selective inhibitors of cyclo-oxygenase (COX) and therefore inhibit prostaglandin E2 synthesis. (scielo.br)
  • Administration of a cyclo-oxygenase inhibitor ( ibuprofen lysine or indomethacin ) with or without fluid restriction may be tried in preterm infants with a significant shunt, but this therapy is not effective in term infants or older children with PDA. (msdmanuals.com)
Prostaglandin2
  • Indomethacin inhibits prostaglandin synthesis. (medscape.com)
  • Intravenous ibuprofen and indomethacin inhibit prostaglandin E2 synthesis and thereby close the patent ductus arteriosus with similar efficacy. (scielo.br)
Enterocolitis1
  • Ibuprofen reduces the risk of necrotizing enterocolitis and transient renal insufficiency and it is the drug of choice for closing the patent ductus arteriosus. (scielo.br)
Preterm infants2
  • Randomized clinical trials that enrolled preterm infants with a gestational age younger than 37 weeks treated with intravenous or oral indomethacin, ibuprofen, or acetaminophen vs each other, placebo, or no treatment for a clinically or echocardiographically diagnosed hemodynamically significant PDA. (mcmaster.ca)
  • In this study of the therapeutic effects of oral treatments, 20 preterm infants were randomized to oral ibuprofen (1 × 10 mg/kg, then 2 × 5 mg/kg at 24-hour intervals) or oral indomethacin (3 × 0.2 mg/kg at 24-hour intervals). (who.int)
Intravenous2
Infants3
  • The PDA closure rate and the doses of drug (mean (SD)) were similar in both groups: 53/60 (88.3%) and 1.9 (1.5) mg/kg in infants given ibuprofen, and 52/59 (88.1%) and 1.9 (1.7) mg/kg in infants given indometacin. (bmj.com)
  • RESULTS: In 68 randomized clinical trials of 4802 infants, 14 different variations of indomethacin, ibuprofen, or acetaminophen were used as treatment modalities. (mcmaster.ca)
  • There is a significant increase in serum creatinine after indomethacin administration but not after ibuprofen and infants treated with ibuprofen have higher creatinine clearance. (scielo.br)
Closure2
  • Complete ductal closure was seen in 7/10 of the indomethacin and 8/10 of the ibuprofen group. (who.int)
  • Iran, and a comparative study was therefore mg in 5 mL (Hakim Pharmaceutical Com- conducted to evaluate the therapeutic ef- pany, 75-HM-30) was given as an initial fects of oral administration of indomethacin dose of 10 mg/kg, followed by 2 further capsules or ibuprofen suspension on closure doses of 5 mg/kg at 24-hour intervals [ 8 ]. (who.int)
Furosemide1
Patent1
  • Polymorphisms in CYP2C9 are associated with response to indomethacin among neonates with patent ductus arteriosus. (cdc.gov)
NSAID5
  • Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. (wikipedia.org)
  • Indometacin, a non-steroidal anti-inflammatory drug (NSAID), has similar mode of action when compared to other drugs in this group. (wikipedia.org)
  • Acemetacin, a compound of indomethacin , is a nonsteroidal anti-inflammatory drug (NSAID). (e-lactancia.org)
  • Do not take an NSAID such as indomethacin if you have recently had a heart attack, unless directed to do so by your doctor. (medlineplus.gov)
  • Vicoprofen contains the same dose of ibuprofen as over-the-counter (OTC) NSAID, and is usually used for less than 10 days to treat pain. (nih.gov)
Inhibits1
  • For instance, indometacin inhibits both cyclooxygenase-1 and cyclooxygenase-2, which then inhibits the production of prostaglandins in the stomach and intestines responsible for maintaining the mucous lining of the gastrointestinal tract. (wikipedia.org)
Conclusions1
  • No difference were detected either between those treated with indomethacin or ibuprofen.Conclusions: The results show that in absence of other clinical complication, medical treatment of sPDA with indomethacin or ibuprofen, do not increase the risk of serious digestive or renal disorders. (uchile.cl)
Dose1
Inhibitor1
  • This is particularly important if Indometacin is given together with an ACE inhibitor or with potassium-sparing diuretics, because these combinations can lead to hyperkalemia and/or serious kidney failure. (wikipedia.org)
Kidneys1
  • Indomethacin reduces the blood flow velocity in kidneys, intestine and brain. (scielo.br)
Body's1
  • Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to indomethacin. (medlineplus.gov)
Placebo1
Complications1
  • Indomethacin or ibuprofen are used for this purpose with its associated risks.Objective: Characterize digestive and renal complications in EPI who received indomethacin or ibuprofen as sPDA treatment.Patients and Method: Retrospective study on EPI between January-2004 and December-2013. (uchile.cl)
Capsule1
  • Indomethacin comes as a capsule, an extended-release (long-acting) capsule, and a suspension to take by mouth. (medlineplus.gov)
Antiinflammatory1
  • Indometacin used as an antiinflammatory agent is classified in M01AB01 or S01BC01. (whocc.no)
Gastrointestinal1
  • Other common gastrointestinal complaints, including dyspepsia, heartburn and mild diarrhea are less serious and rarely require discontinuation of indometacin. (wikipedia.org)
Lithium1
  • Thus indometacin users have an elevated risk of lithium toxicity. (wikipedia.org)
Suspension1
  • Indomethacin immediate-release capsules and suspension (liquid) are also used to treat acute gouty arthritis (attacks of severe joint pain and swelling caused by a build-up of certain substances in the joints). (medlineplus.gov)
Medication2
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with indomethacin and each time you refill your prescription. (medlineplus.gov)
  • However, for both the household youth and adult questionnaires if a particular medication reported in the prescription medication section of the questionnaire was available in both prescription and non-prescription strengths (e.g., ibuprofen), the staff assumed it was a prescription medication and left it in this section. (cdc.gov)
Treat1
  • Indomethacin is also used to treat pain in the shoulder caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint) and tendinitis (inflammation of the tissue that connects muscle to bone). (medlineplus.gov)
Group1
Drug2
  • The frequency and severity of side effects and the availability of better tolerated alternatives make indometacin today a drug of second choice. (wikipedia.org)
  • Ibuprofen is usually the drug of choice for mild to moderate pain, if no contraindications exist. (medscape.com)
Products1
  • Talk to your doctor before taking other medicines, including aspirins and ibuprofen containing products. (cigna.com)