• ACTH
  • Glucocorticoids feed back on the hypothalamus and pituitary to dial down production of CRF and ACTH, and also mediate many of the physiological effects of stress, such as raising blood glucose and depressing the immune system. (alzforum.org)
  • This lateral hypothalamic abnormality would be expected to affect the function of most of the pituitary axes (as shown in other neurodegenerative diseases where neuroendocrine alterations occur ), potentially modifying the basal levels of GH, TSH, ACTH, LH, FSH, and prolactin, at least at late in the course of HD. (plos.org)
  • Glucocorticoids in turn act back on the hypothalamus and pituitary (to suppress CRH and ACTH production) in a negative feedback cycle. (wikipedia.org)
  • E/NE will positively feedback to the pituitary and increase the breakdown of POMCs into ACTH and β-endorphins. (wikipedia.org)
  • Its main function is the stimulation of the pituitary synthesis of ACTH, as part of the HPA Axis. (wikipedia.org)
  • In addition to quantifying adrenal insufficiency, the test can distinguish whether the cause is adrenal (low cortisol and aldosterone production) or pituitary (low ACTH production). (wikipedia.org)
  • tumor
  • Ando S, Sarlis NJ, Oldfield EH, Yen PM. Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor. (springer.com)
  • Conversely, acromegaly and gigantism are conditions of GH and IGF-1 excess usually due to a pituitary tumor, and are characterized by overgrowth and tall stature. (wikipedia.org)
  • deficiency
  • Increased CRH production has been observed to be associated with Alzheimer's disease and major depression, and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia. (wikipedia.org)
  • disorder
  • Huntington's disease (HD) is a severe inherited neurodegenerative disorder characterized, in addition to neurological impairment, by weight loss suggesting endocrine disturbances. (plos.org)
  • Huntington's disease (HD) is a rare, autosomal dominant, neurodegenerative disorder resulting from expansion of a CAG repeat within the IT15 huntingtin (htt) gene on chromosome 4p . (plos.org)
  • Hypothalamic disease is a disorder presenting primarily in the hypothalamus, which may be caused by damage resulting from malnutrition, including anorexia and bulimia eating disorders, genetic disorders, radiation, surgery, head trauma, lesion, tumour or other physical injury to the hypothalamus. (wikipedia.org)
  • liver
  • Almost always the endocrine manifestations occur in a patient with widespread disease involving the lungs, skin or liver. (bmj.com)
  • Cirrhosis is most commonly caused by alcohol, hepatitis B, hepatitis C, and non-alcoholic fatty liver disease. (wikipedia.org)
  • Non-alcoholic fatty liver disease has a number of causes, including being overweight, diabetes, high blood fats, and high blood pressure. (wikipedia.org)
  • A separate system of scoring the histological features of nonalcoholic fatty liver disease (NAFLD) called the NAFLD Activity Score (NAS) was used. (clinicaltrials.gov)
  • and either a decrease in the activity score for nonalcoholic fatty liver disease to a score of 3 or less or a decrease in the activity score of at least 2 points, with at least a 1-point decrease in either the lobular inflammation or steatosis score. (clinicaltrials.gov)
  • Evidence of mild or severe liver disease may be found. (wikipedia.org)
  • cortisol
  • The variation in cortisol levels according to disease type and severity, as well as variation within the same patient, hampers the establishment of a clear threshold below which CIRCI occurs. (wikipedia.org)
  • hyperthyroidism
  • Therefore, a correct diagnosis is fundamental in order to prevent dramatic consequences, such as improper thyroidectomy in patients with secondary hyperthyroidism due to TSHoma or unnecessary pituitary surgery in patients with RTH. (springer.com)
  • Virtually all the signs and symptoms of Graves' disease result from the direct and indirect effects of hyperthyroidism, with exceptions being Graves' ophthalmopathy, goitre and pretibial myxedema (which are caused by the autoimmune processes of Graves' disease). (wikipedia.org)
  • patients
  • The somatotropic axis is overactive even in patients with early disease, and could be related to the weight loss seen in HD patients. (plos.org)