Mounting evidence has demonstrated the role of hypohalous acids as hypochlorous acid (HOCl) and hypobromous acid (HOBr) as agents involved in biomolecules degradation. (fapesp.br)
Hypochlorous acid HOCl and hypothiocyanous acid HOSCN synthesized through the enzyme myeloperoxidase MPO, which catalyzes the reaction between H 2 O 2 and Cl − or SCN − , are important inorganic bactericidal molecules, effective against a wide range of microbes. (encyclopedia.pub)
In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. (lu.se)
Biotinylated Myeloperoxidase Antibody is a high quality research product used as biotin-labelled antibody specific to human Myeloperoxidase, a peroxidase enzyme mostly expressed in neutrophils, which produces hypohalous acids known for their antimicrobial activities. (moleculardepot.com)
Myeloperoxidase (MPO) belong to the family of heme containing peroxidases, produced mostly from polymorphonuclear neutrophils. (preprints.org)
Myeloperoxidase (MPO) is a leukocyte-derived redox enzyme whose peroxidase enzymatic activity generates hypohalous acids that constitute the major component responsible for neutrophil antimicrobial activity, and as such MPO participates in the innate immune defense mechanism. (guidetoimmunopharmacology.org)
Enzyme3
Eosinophil peroxidase is an enzyme found within the eosinophil granulocytes, innate immune cells of humans and mammals. (wikipedia.org)
The fold of the enzyme is known as the heme peroxidase fold, conserved among all members of this gene family. (wikipedia.org)
Heme peroxidases1
The overall structure of the four mammalian heme peroxidases (MPO, LPO, EPO and TPO) is almost identical. (wikipedia.org)
H2O22
For example: H2O2 + Br− → HOBr + H2O Hypohalous acids formed from halides or pseudohalides are potent oxidizing agents. (wikipedia.org)
MPO is the only type of peroxidase using H2O2 to oxidize several halides and pseudohalides to form different hypohalous acids. (preprints.org)
Uric acid2
Total oxidant capacity and oxidative damage to lipids and proteins were higher in the parotid gland, while total antioxidant capacity and uric acid levels were reduced in the submandibular gland of the LEV100 group compared to Control. (bvsalud.org)
On the other hand, total oxidant capacity, oxidative damage to lipids and proteins, total antioxidant capacity, and uric acid levels were lower in both salivary glands of the LEV300 group compared to Control. (bvsalud.org)
Activities2
Eosinophil peroxidase is a heme peroxidase, its activities including the oxidation of halide ions to bacteriocidal reactive oxygen species, the cationic disruption of bacterial cell walls, and the post-translational modification of protein amino acid residues. (wikipedia.org)
Superoxide dismutase and glutathione peroxidase activities were lower in the salivary glands of treated animals compared to Control. (bvsalud.org)
Methods: Fusion proteins incorporating human Cu-Zn-SOD (hSOD1), with (pep1-hSOD1-his) and without (hSOD1-his) a fused hyaluronic acid-binding peptide, were expressed in E. coli. (bvsalud.org)
Role1
However, the role of eosinophilic peroxidase seems to be to generate hyphalous acids largely from bromide and iodide rather than chloride, since the former are favored greatly over the latter. (wikipedia.org)
The major function of eosinophil peroxidase is to catalyze the formation of hypohalous acids from hydrogen peroxide and halide ions in solution. (wikipedia.org)
In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. (abcam.com)
We also investigated how the cellular effects of BT were modified by hydrogen peroxide (H 2 O 2 ) scavenger catalase, hypochlorous acid (HOCl) scavenger methionine, and 4-aminobenzoic acid hydrazide (ABAH), a myeloperoxidase (MPO)-specific inhibitor. (nih.gov)
Amylin was exposed in vitro to hypochlorous acid, hydrogen peroxide and peroxynitrous acid/peroxynitrite to investigate the formation of post-translational oxidative modifications (oxPTMs, via mass spectrometry) and fibril formation (via transmission electron microscopy). (bvsalud.org)
Hydrogen peroxide1
The major function of eosinophil peroxidase is to catalyze the formation of hypohalous acids from hydrogen peroxide and halide ions in solution. (wikipedia.org)
Eosinophil peroxidase is a heme peroxidase, its activities including the oxidation of halide ions to bacteriocidal reactive oxygen species, the cationic disruption of bacterial cell walls, and the post-translational modification of protein amino acid residues. (wikipedia.org)
One of the first aspects known of eosinophil peroxidase was that it was highly cationic, as indicated by its high isoelectric point (see Protein). (wikipedia.org)
Oxidative1
Iodoacetic acid toxicity was mitigated by antioxidants, suggesting the involvement of oxidative stress. (nih.gov)
Light1
and carboxylic acid groups, one of which comes from the light polypeptide chain. (wikipedia.org)