• perfusion
  • The effect of suxamethonium on intracranial pressure and cerebral perfusion in patients with severe head injuries following blunt trauma. (slideplayer.com)
  • ICP, blood pressure, and cerebral perfusion pressure (CPP) were monitored over 4 hours. (ahajournals.org)
  • Attempts to establish reliable diagnostic tools to identify patients at particular risk of malignant MCA infarction have included determinations of diffusion- and perfusion-weighted MRI parameters, 6,7 of a critical lesion volume on computed tomography (CT), 8,9 of cerebral blood flow by means of single-photon emission CT, 10 or of metabolic measures using positron emission tomography (PET) and microdialysis. (ahajournals.org)
  • 14 15 These accidents were attributed to regional cerebral perfusion changes due to intracranial vascular "steal" phenomenon caused by its vasodilator action. (ahajournals.org)
  • 20 On the other hand, single-photon emission computed tomography (SPECT) with 99m Tc-hexamethylpropyleneamine oxime ( 99m Tc-HMPAO) could demonstrate increased side-to-side asymmetry in occlusive carotid artery disease after intravenous dipyridamole or adenosine administration, claiming the usefulness of intravenous infusion of dipyridamole or adenosine for estimation of cerebral perfusion reserve. (ahajournals.org)
  • The pressure-volume relationship between ICP, volume of CSF, blood, and brain tissue, and cerebral perfusion pressure (CPP) is known as the Monro-Kellie doctrine or the Monro-Kellie hypothesis. (wikipedia.org)
  • Only when ICP exceeds 40-50 mmHg do CPP and cerebral perfusion decrease to a level that results in loss of consciousness. (wikipedia.org)
  • hypoxia
  • 2. The term shallow water blackout has also been used in the scientific literature over many years to refer to loss of consciousness caused by cerebral hypoxia at the end of a deep breath-hold dive during the latter part of the ascent or immediately after surfacing due to lowered oxygen partial pressure caused by reduction in ambient pressure. (wikipedia.org)
  • There are two main mechanisms behind many variations of this practice, both resulting in cerebral hypoxia (oxygen deprivation to the brain). (wikipedia.org)
  • metabolic
  • 1985). Reports suggesting that cerebral metabolic effects of isoflurane differ from halothane are based on observations in animals (Cucchiara et al. (springer.com)
  • Afferent neurons from the peripheral chemoreceptors are via the glossopharyngeal nerve (CN IX) and the vagus nerve (CN X). Levels of CO2 rise in the blood when the metabolic use of O2,and the production of CO2 is increased during, for example, exercise. (wikipedia.org)
  • blackout
  • Hyperventilation-induced blackout This is a recommended term for cases where hyperventilation is known or suspected to have been a contributing factor in either shallow water blackout or deep water blackout. (wikipedia.org)
  • This alone is enough to cause a blackout, but it is widely believed that the effect is enhanced if lung air pressure is increased by holding the breath "hard" or "bearing down" (tightening the diaphragm as in a forced exhalation while allowing no air to escape or having an assistant apply a bear-hug). (wikipedia.org)
  • intravenous
  • 16 No increase in global CBF as measured by positron emission tomography (PET) was observed after intravenous adenosine in a limited number of human subjects. (ahajournals.org)
  • vessels
  • To clarify whether these findings can be transferred to the clinical situation and have beneficial effects in patients, we studied the effects of l -arginine on CO 2 reactivity of the cerebral vessels in patients with impaired vasomotor reactivity (VMR) and compared them with patients with normal VMR. (ahajournals.org)
  • Conclusions- Our data support the hypothesis that in humans l -arginine is able to improve impaired CO 2 reactivity of the cerebral vessels. (ahajournals.org)
  • These results support the hypothesis that circulating adenosine is largely prevented from binding to adenosine receptors of cerebral vessels by the blood-brain barrier. (ahajournals.org)
  • worsen
  • Because other medical conditions can be confused with hyperventilation, namely asthma and heart attacks, most medical studies advise against using a paper bag since these conditions worsen when CO2 levels increase. (wikipedia.org)
  • mmHg
  • The so-called lower level of cerebral Auto-regulation manifests at a blood pressure of approximately 80 mmHg when the lowering of blood pressure is a result of a reduction of the central blood volume. (rigshospitalet.dk)
  • mortality
  • 11 PARALYTIC AGENT: Scoline - agent of choice May transiently increase ICP - no clinical evidence that that this increases mortality/morbidity. (slideplayer.com)
  • There is some suggestion of increased mortality with prehospital intubation in retrospective reviews of trauma patients with moderate-to-severe head injury compared with patients intubated in the ED. Bag-valve-mask ventilation with good technique may be of more benefit to brain injured patients than prehospital intubation. (medscape.com)
  • vasodilation
  • Background and Purpose -Dipyridamole increases the concentration of circulating adenosine, which is a potent vasodilator, by inhibition of uptake of adenosine into the erythrocytes, and hence produces coronary vasodilation. (ahajournals.org)
  • brain
  • an open, internet based trans-national collaborative infrastructure for supporting assessment of health care technologies in brain-injured patients, developing and testing an improved coordination structure/grant no. (springer.com)
  • Bourgoin A, Albanese J, Leone M, Sampol-Manos E, Viiand X, Martin C. Effects of sufentanil or ketamine administered in targetcontrolled infusion on the cerebral hemodynamics of severely brain-inured patients. (slideplayer.com)
  • partial
  • Metabolically active gases have a greater effect in proportion to their concentration, which is proportional to their partial pressure, which for contaminants is increased in proportion to absolute ambient pressure. (wikipedia.org)
  • occurs
  • Biot's respiration, in which breathing is rapid for a period and then absent for a period, occurs because of injury to the cerebral hemispheres or diencephalon. (wikipedia.org)
  • patients
  • Oertel M, Kelly DF, Lee JH, Glenn TC, Vespa PM, Martin NA (2002) Can hyperventilation improve cerebral microcirculation in patients with high ICP? (springer.com)
  • In the 22 patients with reduced VMR in the first examination (42±8%), VMR increased significantly after infusion of l -arginine (52±14%, P =0.005). (ahajournals.org)
  • 3,4 In humans, CO 2 reactivity is known to be depressed in patients with lacunar syndromes and cerebral small-vessel disease. (ahajournals.org)
  • 8 In patients, improvement in cerebral vasomotor reactivity (VMR) was found after intake of pravastatin, an HMG CoA inhibitor leading to upregulation of endothelial NO synthase. (ahajournals.org)
  • Similarly in the study, the legs were the most common affected part of the body and the attacks were reported as stiffening and cramps by those affected.During an episode of PED patients find walking nearly impossible.Cerebral spinal fluid (CSF) analysis showed a two-fold increase of homovanillic acid and 5-hydroxyindoleacetic acid immediately following exercise compared to normal levels. (wikipedia.org)