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Jejunoileal BypassHyperlipidemiasHypertriglyceridemiaLipidsHyperlipoproteinemia Type IVTriglyceridesLipid MetabolismLipoprotein LipaseApolipoprotein C-IIILipid ALipoproteins, VLDLApolipoproteins CCholesterolLipid BilayersLipoproteinsHypolipidemic AgentsPostprandial PeriodCholesterol, HDLChylomicronsMetabolic Syndrome XHyperlipidemia, Familial CombinedApolipoproteins ALipid PeroxidationLiverApolipoproteins BApolipoproteinsLipaseCholesterol, VLDLBezafibrateCholesterol, LDLHyperlipoproteinemia Type IApolipoprotein C-IIInsulin ResistanceDyslipidemiasHyperlipoproteinemiasBlood GlucoseLipoproteins, HDLObesityLipodystrophyFibric AcidsFenofibrateClofibric Acid
TriglyceridesMetabolismLipoproteinsHypercholesterolemiaTriglyceride levelsPrimary hyperlipidemiaAbnormalitiesFamilial hypertriglyceridemiaDisordersObesityCardiovascular riskPrevalenceTreatment of High CholesterolElevationFatsMetabolicStatinsGlucoseIncreasesType 2 diabetPhenotypeBloodInsulin resistanceAbnormalityTotal cholesterolLevelsSignificant risk factor for cardiovascularAtherosclerosisAbstractDiabetesOccurConcentrationsSimvastatinHypertensionPatientsArteriesAccumulationDensity lipoproteinFoam cellsAdiposeFattyPlasmaDisorderTherapyCoagulationRiskGenetic predispositionDietary
Triglycerides34
Metabolism16
  • Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
  • Overview of Lipid Metabolism Lipids are fats that are either absorbed from food or synthesized by the liver. (msdmanuals.com)
  • An F2 population of the two strong on albuminuria and lipid metabolism contrasting rat strains from 539 animals, was characterized phenotypically and genotypically. (fu-berlin.de)
  • Advances in research on the genetic mechanisms of lipid metabolism disorder provide new ways to control gene expression, that is relevant to the pathogenesis of cardiovascular disease and essential hypertension. (fu-berlin.de)
  • In the present study, we investigated whether a 4 h-delayed feeding promoted high-sucrose diet-induced abnormalities in lipid metabolism, such as fatty liver and obesity in rats. (bvsalud.org)
  • The oscillations of hepatic lipid and glucose metabolism-related gene expression were delayed by almost 2-4 h, and the clock genes were delayed by approximately 2 h. (bvsalud.org)
  • The 4 h-delayed feeding induced weight gain by affecting body temperature, insulin resistance, and circadian oscillation of lipid metabolism-related genes in rats fed a high-sucrose diet, suggesting that a high sucrose intake with breakfast skipping leads to obesity. (bvsalud.org)
  • Chronic high glucose dramatically influences β-cell lipid metabolism via substrate availability, changes in the activity and expression of enzymes of glucose and lipid metabolism, and modifications in the expression level of key transcription factors. (diabetesjournals.org)
  • Favourable changes in the serum lipid profiles, HDL particle subclass distribution and cholesterol metabolism in paediatric patients with NS during remission took place. (biochemia-medica.com)
  • Abstract The present study was performed to investigate the possible effects of wheat germ supplementation on lipid metabolism in humans. (cryonet.org)
  • Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. (biomedcentral.com)
  • Although dysregulated lipid metabolism results in diabetic nephropathy (DN) development in patients with type 2 diabetes mellitus (T2DM), it is not understood whether betatrophin is associated with urinary albumin excretion and renal function. (biomedcentral.com)
  • Abnormal lipid metabolism, primar- ily of LDL cholesterol, contributes to the development of hypercholesterolemia because it's the major risk factor for the development of atherosclerosis. (contemporaryclinic.com)
  • [1-5] It was in this environment, with a high omega-3 intake, where our metabolism was calibrated - so even if the omega-3 levels in our food have gone down with the advent of industrial society and the adoption of the modern diet, our requirement for omega-3 has not. (priceplow.com)
  • By studying diabetic dyslipid- in diabetes mellitus because insulin resist- aemia among a group of our patients we ance or deficiency affects key enzymes hoped to draw attention of the medical com- and pathways in lipid metabolism [ 1 ]. (who.int)
  • Processes involved in atherosclerosis include coagulation, inflammation, lipid metabolism, intimal injury, and smooth muscle cell proliferation (see the image below). (medscape.com)
Lipoproteins4
  • The pathogenetic link between hypertriglyceridemia and atherosclerotic cardiovascular disease is thought to be triglyceride-rich lipoproteins, which are converted to remnant particles and contribute to the development of atherosclerotic plaques ( 2,5 ). (lww.com)
  • Authors Lairon D. Lacombe C. Borel P. Corraze G. Nibbelink M. Chautan M. Chanussot F. Lafont H. Title Beneficial effect of wheat germ on circulating lipoproteins and tissue lipids in rats fed a high fat, cholesterol-containing diet. (cryonet.org)
  • It decreases low density lipoproteins and increases high density lipoproteins. (sdrugs.com)
  • Al lomicrons, low-density lipoproteins (LDL), Muhtaseb's study of Arab women indi- very-low-density lipoproteins (VLDL) and cated an incidence of 50% of lipid disorders high-density lipoproteins (HDL). (who.int)
Hypercholesterolemia19
  • Heterozygous familial hypercholesterolemia: High total cholesterol. (upmc.com)
  • Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. (globalrph.com)
  • Reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia (HoFH) as an adjunct to other lipid-lowering treatments (e.g. (globalrph.com)
  • Hypercholesterolemia and hypertriglyceridemia, as well as hereditary and acquired forms, may be distinguished. (pkheartjournal.com)
  • Some lipid disorders, such as "familial hypercholesterolemia" (FH) , are strictly genetically inherited and have to be diagnosed and treated specifically. (stulnig.at)
  • Hyperlipidemia resulting from single-gene disorders , e.g., familial hypercholesterolemia , can cause severe elevations in lipoprotein levels and early atherosclerotic complications. (amboss.com)
  • Unlike familial hypercholesterolemia, hyperlipidemia appears in only 10 to 20% of patients in childhood, usually in the form of hypertriglyceridemia. (nih.gov)
  • Hyperlipidemia vs. Hypercholesterolemia: What's the Difference? (healthline.com)
  • What's the Difference Between Hyperlipidemia and Hypercholesterolemia? (healthline.com)
  • You may have also heard of hyperlipidemia and hypercholesterolemia and wondered if these conditions are the same and how they relate to your cholesterol or triglyceride levels. (healthline.com)
  • Hypercholesterolemia is a specific type of hyperlipidemia. (healthline.com)
  • With hypercholesterolemia, you either have too much LDL cholesterol or too little high-density lipoprotein (HDL) cholesterol in your blood. (healthline.com)
  • The risk factors, potential causes, and possible health impacts are the same for hypercholesterolemia as they are for hyperlipidemia. (healthline.com)
  • What are the key differences between hypercholesterolemia and hyperlipidemia? (healthline.com)
  • Hypercholesterolemia is a type of hyperlipidemia. (healthline.com)
  • Neither hyperlipidemia nor hypercholesterolemia cause symptoms in most people. (healthline.com)
  • They all presented an hypercholesterolemia (from 6.58 to 9.50 mM), associated in 6 over 10 cases to an hypertriglyceridemia (from 1.70 to 5.00 mM). (cryonet.org)
  • Crestor 10 Mg is used in the treatment of Homozygous Familial Hypercholesterolemia which is a genetic disorder characterized by high cholesterol levels. (welloxpharma.com)
  • Also indicated for homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies or when other such therapies are not available. (illnesshacker.com)
Triglyceride levels8
  • In this multi-institutional cohort study, high triglyceride variability was associated with an increased risk of first attack of acute pancreatitis, independent of baseline and mean triglyceride levels. (lww.com)
  • Myung Soo Park, 2021) A promising option for the treatment of hypertriglyceridemia and reduces triglyceride levels by 25% to 50% below the baseline. (vibcare.co.in)
  • In addition, extremely high triglyceride levels may provoke pancreatitis, which may be life-threatening. (stulnig.at)
  • A serum lipid panel includes total cholesterol , LDL , HDL , and triglyceride levels. (amboss.com)
  • Having high triglyceride levels plus high LDL may increase the risk of plaque buildup in your arteries. (healthline.com)
  • A blood test called a lipid panel , or a lipid profile, can determine your cholesterol and triglyceride levels. (healthline.com)
  • However, middle-grade proteinuria and increased serum triglyceride levels indicative of type V hyperlipidemia developed rapidly thereafter. (biomedcentral.com)
  • I have many patients with something called familial hypertriglyceridemia, a genetic condition that permits triglyceride levels of 500, 1000, even many thousands of mg/dl, levels that, as the anonymous commenter points out, can be dangerous. (undoctored.com)
Primary hyperlipidemia4
  • However, it is not established whether primary hyperlipidemia can predispose to obesity. (biomedcentral.com)
  • However, it is not established whether primary hyperlipidemia can predispose one to obesity. (biomedcentral.com)
  • This type of hyperlipidemia is called primary hyperlipidemia, or familial hyperlipidemia . (healthline.com)
  • Used as an adjunct to dietary therapy to treat primary hyperlipidemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia. (illnesshacker.com)
Abnormalities6
  • A variety of lipid abnormalities may occur in nephrotic syndrome, which can include hypercholesterolaemia and hypertriglyceridaemia. (pulsenotes.com)
  • Although HDL-C levels predict cardiovascular risk in the general population, the increased risk may be caused by other factors, such as accompanying lipid and metabolic abnormalities, such as hypertriglyceridemia, rather than the HDL-C level itself. (msdmanuals.com)
  • This system does not take into account specific lipoprotein abnormalities (eg, low HDL-C or high LDL-C) that may contribute to disease despite normal cholesterol and TG levels. (msdmanuals.com)
  • We discuss here the emerging view that β-cell "glucotoxicity" is in part indirectly caused by "lipotoxicity," and that β-cell abnormalities will become particularly apparent when both glucose and circulating fatty acids are high. (diabetesjournals.org)
  • As part of my cardiology practice, I provide consultation on complex hyperlipidemias , or unusual lipid abnormalities. (undoctored.com)
  • The lipid abnormalities are prevalent dyslipidaemia. (who.int)
Familial hypertriglyceridemia1
  • Mateo-Gallego R, Calmarza P, Jarauta E, Burillo E, Cenarro A and Civeira F (2010) Serum ferritin is a major determinant of lipid phenotype in familial combined hyperlipidemia and familial hypertriglyceridemia. (scielo.br)
Disorders12
  • These lipid disorders may occur in primary (inherited) [ 5 - 7 ] or secondary form [ 8 ]. (hindawi.com)
  • Doctors label lipid disorders based on the type of high cholesterol you have. (upmc.com)
  • For example, high HDL-C levels caused by some genetic disorders may not be associated with a lower risk of cardiovascular disorders, and low HDL-C levels caused by some genetic disorders may not be associated with an increased risk of cardiovascular disorders. (msdmanuals.com)
  • Nutrition is an effective treatment for some but not all lipid disorders. (stulnig.at)
  • Lipid disorders encompass a spectrum of metabolic conditions that affect blood lipid levels. (amboss.com)
  • Lipid disorders are usually detected during laboratory testing as part of an ASCVD risk assessment . (amboss.com)
  • In genetic lipid disorders, symptoms generally occur at an earlier age and are more severe than in acquired lipid disorders. (amboss.com)
  • To clarify whether there is a genetic link between albuminuria and lipid disorders, the two rat strains SHR and SS, marked by an arterial hypertension, were compared. (fu-berlin.de)
  • Various inherited or acquired disorders that cause high lipid levels in the blood fall under this umbrella category. (healthline.com)
  • Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
  • Their prevalence is higher in patients presenting cardiovascular risk factors.This review takes stock of the frequency, the mechanisms, and the implications of major cardiovascular risk factors in patients with serious mental disorders. (bvsalud.org)
  • ABSTRACT This study investigated the patterns and determinants of lipid disorders among a group of 250 type 2 adult diabetic patients and 60 age- and sex-matched healthy controls in Sudan. (who.int)
Obesity13
  • Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
  • Apart from CVD, hyperlipidemia is also closely associated with diabetes, insulin resistance, and obesity [ 10 ]. (hindawi.com)
  • Hypertriglyceridemia is a common type of dyslipidemia found in obesity. (biomedcentral.com)
  • Hypertriglyceridemia is one of the most common types of dyslipidemia found in obesity, together with low HDL levels and the presence of small and dense LDL particles [ 6 ]. (biomedcentral.com)
  • Treatment should not only consider lowering the blood glucose level but also should focus on the correction of any associated CVD risk factors such as smoking, hyperlipidemias, and obesity as well as monitoring of blood pressure and ~treatment of hypertension. (who.int)
  • We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr −/− .Leiden) mice, and studied the morphological structure of the testes and histologically examined the proportion of Sertoli cells, spermatocytes and spermatids in the seminiferous tubules. (nature.com)
  • HFD-induced obesity caused high plasma leptin and abnormal testosterone levels and induced an aberrant intra-tubular organisation (ITO) which is associated with an altered spermatids/spermatocytes ratio (2:1 instead of 3:1). (nature.com)
  • We have previously shown that a combination of glucosyl hesperidin (G-hesperidin) plus caffeine reduces accumulation of body fat, whereas G-hesperidin or caffeine alone shows little effect on high-fat diet-induced obesity in mice. (ironmagazine.com)
  • The aim of this study is to evaluate the anti-obesity effect of G-hesperidin plus caffeine on body fat and serum TG in healthy subjects with moderately high body mass index (BMI) and serum TG. (ironmagazine.com)
  • It is known that visceral fat-type obesity induces type-2 diabetes mellitus, hyperlipidaemia, hypertension and increases the risk of cardiovascular disease [1-3]. (ironmagazine.com)
  • Metabolic Syndrome (MS) is the denomination proposed by the World Health Organization (WHO) 42 , which designates a set of risk factors for cardiovascular diseases (CVDs), such as visceral obesity, dyslipidemia, high hypertension, glucose intolerance and insulin resistance 32 , which frequently are presented together. (bvsalud.org)
  • According to NCEP ATP III, an individual should be considered as having MS when he or she presents at least three of the following factors: visceral obesity, hypertriglyceridemia, HDL (reduced cholesterol), altered hypertension and fasting glycemia 27 . (bvsalud.org)
  • The relatively high prevalence of the metabolic syndrome is a worldwide phenomenon that seems to be increasing in parallel with the obesity prevalence 16 . (bvsalud.org)
Cardiovascular risk4
  • Treatment of high blood lipids depends on your individual cardiovascular risk. (stulnig.at)
  • Cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease CG67. (guiasalud.es)
  • The retail health clinic setting provides a unique opportunity to identify patients with hyperlipidemia and related cardiovascular risk factors. (contemporaryclinic.com)
  • 2018). Blood lipid levels are fundamental measures included in NHANES that can be used for cardiovascular risk assessment. (cdc.gov)
Prevalence2
  • However, despite the high prevalence of diabetes and its complications and the availability of successful prevention strategies, essential health care requirements and facilities for self-care are often inadequate in this Region. (who.int)
  • The goals of NHANES blood lipid measurements include: 1) monitoring the prevalence and trends in major cardiovascular conditions and overall risk factors in the U.S. (cdc.gov)
Treatment of High Cholesterol1
Elevation3
  • ZOCOR has not been studied in conditions where the major abnormality is elevation of chylomicrons (i.e., hyperlipidemia Fredrickson types I and V). (globalrph.com)
  • Hyperlipidemia is an elevation of total cholesterol (TC) or non-high-density-lipoprotein (HDL) cholesterol (TC minus HDL-cholesterol). (contemporaryclinic.com)
  • The genetic basis for elevation in lipid levels is not well understood, but substantial heritability has been demonstrated in twin [ 9 ] and family-based [ 10 - 12 ] studies, which have estimated that approximately 43% to 83% of the variance in blood lipid and lipoprotein levels is attributable to genetic factors. (cdc.gov)
Fats3
  • Abetalipoproteinemia is a congenital lipid disorder in which a deficiency of apolipoproteins (hypolipoproteinemia) leads to impaired intestinal absorption of fats and fat-soluble vitamins . (amboss.com)
  • Hyperlipidemia is a condition where you have a high level of lipids (fats) in your blood. (healthline.com)
  • The closely interwoven lifestyle elements of sedentary behaviors and high dietary intake of saturated or trans fats are the most often seen secondary causes. (contemporaryclinic.com)
Metabolic4
  • A triglyceride level of 150 mg/dL or higher is also a risk factor for metabolic syndrome . (medlineplus.gov)
  • 107730). Patients with FCHL are at increased risk of cardiovascular disease and mortality and have a high frequency of comorbidity with other metabolic conditions such as type 2 diabetes, nonalcoholic fatty liver disease, steatohepatitis, and the metabolic syndrome (summary by Bello-Chavolla et al. (nih.gov)
  • Acute respiratory distress, metabolic acidosis, and death after rapid infusion of intravenous lipid emulsions have been reported. (drugs.com)
  • Many genes involved in metabolic pathways have been found to contribute to lipid level variability [ 14 , 26 , 27 ]. (cdc.gov)
Statins2
  • The main treatment modalities are lifestyle modifications and lipid-lowering agents such as statins . (amboss.com)
  • Rosuvastatin is a member of the drug class of statins, used in combination with exercise, diet, and weight-loss to treat high cholesterol and related conditions and to prevent cardiovascular disease. (illnesshacker.com)
Glucose1
  • Demo- graphic and clinical data, body mass index and waist circumference, and fasting blood samples were taken to estimate the glucose and lipid profile. (who.int)
Increases4
  • Gemfibrozil increases levels of high density lipoprotein (HDL) subfractions HDL2 and HDL3, as well as apolipoproteins AI and AII. (nih.gov)
  • A fall in oncotic pressure increases the rate of lipoprotein synthesis in the liver that results in a high level of cholesterol. (pulsenotes.com)
  • High Triglyceride Variability Increases the Risk of First At. (lww.com)
  • Natarajan Harivenkatesh, 2014) Effectively increases high-density lipoprotein-cholesterol in patients with a wide variety of dyslipidaemias. (vibcare.co.in)
Type 2 diabet1
  • Shows a highly beneficial effect on lipid parameters in type 2 diabetes associated with combined hyperlipidemia. (vibcare.co.in)
Phenotype1
  • By the genetic linkage analysis this study shows that the phenotype hyperlipidemia has possible candidate gene regions on chromosomes 2, 4, 8 and 17. (fu-berlin.de)
Blood16
  • Certain conditions, such as extraordinarily high blood levels of lipid (hyperlipidemia/hypertriglyceridemia) or protein (hyperparaproteinemia), magnify the electrolyte exclusion effect. (wikipedia.org)
  • In 2013, the American Heart Association reported that proportions of American adults aged 20 or above had abnormal blood lipid serum profile (details are shown in Table 1 ) [ 4 ]. (hindawi.com)
  • Average percentage of abnormal blood lipid levels among Americans at age 20 or above [ 4 ]. (hindawi.com)
  • Without a blood test, familial lipid syndrome can be hard to spot. (upmc.com)
  • General supportive measures are required in all patients such as monitoring renal function, lowering blood pressure, treating oedema and high cholesterol and managing thrombotic complications. (pulsenotes.com)
  • Because HDL cholesterol plays an important role in getting rid of LDL, you want higher levels of HDL in your blood. (healthline.com)
  • 10) National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). (guiasalud.es)
  • It is prescribed by a doctor to lower cholesterol in people who have been diagnosed with high cholesterol (high levels of LDL cholesterol in the blood). (medika.life)
  • Doctors diagnose high cholesterol through a simple blood test. (medika.life)
  • Crestor 10 Mg is used to treat Hyperlipidemia, which is a condition characterized by high levels of lipids in the blood. (welloxpharma.com)
  • High cholesterol is significant risk factor for cardiovascular disease, along with high blood pressure and smoking. (contemporaryclinic.com)
  • The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. (cdc.gov)
  • Variants within APOE (rs7412, rs429358), PON1 (rs854560), ITGB3 (rs5918), and NOS3 (rs2070744) were found to be associated with one or more blood lipids in at least one race/ethnic group in crude and adjusted analyses. (cdc.gov)
  • We report the significant associations of blood lipids with variants and haplotypes in APOE , ITGB3, NOS3 , and PON1 in the three main race/ethnic groups in the U.S. population using a large, nationally representative and population-based sample survey. (cdc.gov)
  • Decades of research have demonstrated that serum concentrations of blood lipids are associated with increased risk for cardiovascular disease and mortality [ 1 - 4 ]. (cdc.gov)
  • Recent candidate gene studies [ 13 - 16 ], as well as genome-wide association studies [ 17 - 25 ], have identified polymorphisms that account for a portion of the variation in blood lipid levels. (cdc.gov)
Insulin resistance1
  • Serum insulin concentration during the feeding period was higher than in the control rats, suggesting that slight insulin resistance was induced by the 4 h-delayed feeding. (bvsalud.org)
Abnormality1
Total cholesterol3
  • Familial defective apolipoprotein B-100: High total cholesterol. (upmc.com)
  • Data on total cholesterol are provided in Cholesterol - Total (TCHOL_J) file, and HDL-C data are provided in Cholesterol - High - Density Lipoprotein (HDL_J). (cdc.gov)
  • Previous reports from the Framingham Heart Study suggested a strong positive relationship between coronary heart disease and elevated levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels, in addition to an inverse relationship between the disease and high-density lipoprotein cholesterol (HDL-C) levels [ 5 - 8 ]. (cdc.gov)
Levels7
  • For someone with the disorder, LDL levels are high from birth or childhood. (upmc.com)
  • Without treatment, levels get higher over time. (upmc.com)
  • It's rare, but when both parents pass on the gene to their child, LDL levels are dangerously high. (upmc.com)
  • In this context of hyperandrogenism, the estrogenic pill Dianette is particularly suitable for women who have high progestin levels (a tendency to produce too much androgen). (alfadoc.info)
  • the term is applied to lipid levels for which treatment has proven beneficial. (msdmanuals.com)
  • In the general population, evidence is less strong for a benefit from lowering elevated TG and increasing low high-density lipoprotein cholesterol (HDL-C) levels. (msdmanuals.com)
  • Vasoconstriction, with the high levels of oxidized LDL, lowers the release of vasodilator nitric oxide from damaged endothelial walls and raises platelet aggregation and thromboxane release. (contemporaryclinic.com)
Significant risk factor for cardiovascular1
  • The hyperlipidemia is a significant risk factor for cardiovascular diseases. (fu-berlin.de)
Atherosclerosis2
  • Without cholesterol there can be no atherosclerosis" stated Anitchkov in 1915 and the causal role of lipids in this ubiquitous disorder is now indisputable. (bmj.com)
  • Indication: For the treatment of primary hyperlipidaemia types IIa, IIb, III, IV and V (Fredrickson classification) corresponding to groups I, II and III of the European Atherosclerosis Society guidelines - when diet alone or improvements in lifestyle such as increased exercise or weight reduction do not lead to an adequate response. (sdrugs.com)
Abstract1
  • Abstract Adult male rats were fed for 7 wk either a low fat diet (3% fat) or a high fat-cholesterol diet (20% fat, 0.5% cholesterol) containing 7% wheat germ or not. (cryonet.org)
Diabetes4
  • Three (17%) patients withdrew due to diarrhea, 2 with hyperglycemia at baseline developed diabetes mellitus, 7 (54%) required addition of or increase in lipid-lowering agents, but none had grade 3 or 4 hyperlipidemia. (researchgate.net)
  • Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
  • This risk is especially higher in patients with diabetes mellitus. (welloxpharma.com)
  • Also for the treatment of secondary hyperlipidaemias, e.g. severe hypertriglyceridemias, when sufficient improvement does not occur after correction of the underlying disorder (e.g. diabetes mellitus). (sdrugs.com)
Occur1
  • For example, in familial combined hyperlipidemia, expression may occur only in the presence of significant secondary causes. (msdmanuals.com)
Concentrations2
  • The role of lipids was established by Kannel et al , 1 who demonstrated correlations between the concentrations of serum cholesterol and the major lipoprotein classes at entry to the study and the development of CHD during the subsequent 14 years. (bmj.com)
  • Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations. (cdc.gov)
Simvastatin2
  • ZOCOR (simvastatin) is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. (globalrph.com)
  • High-dose simvastatin for aneurysmal subarachnoid hemorrhage: multicenter randomized controlled double-blinded clinical trial. (druglib.com)
Hypertension2
  • Elevated fibrinogen appears to be an important risk-factor, alongside the lipids, smoking and hypertension, in the development of atheroma. (sdrugs.com)
  • Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)
Patients12
  • In patients with coronary heart disease (CHD) or at high risk of CHD, ZOCOR® can be started simultaneously with diet. (globalrph.com)
  • Reduce elevated TG in patients with hypertriglyceridemia (Fredrickson type lV hyperlipidemia). (globalrph.com)
  • Reduce elevated TG and VLDL-C in patients with primary dysbetalipoproteinemia (Fredrickson type lll hyperlipidemia). (globalrph.com)
  • Current studies suggest that dyslipidemia affects the antiviral efficacy of hepatitis C virus (HCV) therapies, while recent studies suggest that serum lipids influence the response rates of chronic hepatitis B (CHB) patients receiving PEGylated interferon-alpha (Peg IFN-α) treatment. (biomedcentral.com)
  • We identified 98,819 patients who were diagnosed with hyperlipidemia between January 1, 2007, and December 31, 2013, and had at least 1 triglyceride measurement annually for 4 consecutive years from the Chang Gung Research Database in Taiwan. (lww.com)
  • Subgroup analysis showed that this association was more pronounced among the patients with a higher neutrophil-to-lymphocyte ratio ( P for trend = 0.022). (lww.com)
  • An appropriate first-line lipid-lowering therapy in numerous groups of patients at low to high risk of coronary heart disease. (vibcare.co.in)
  • Although optimal treatment strategies for MAS in kidney transplant patients remains unclear, we strengthened lipid-lowering therapy using pemafibrate, without modifying the amount of immunosuppressants. (biomedcentral.com)
  • It is an idiopathic condition in paediatric patients characterized by proteinuria, hypoalbuminemia, oedema and hyperlipidaemia ( 1 ). (biochemia-medica.com)
  • There is lower immediate postoperative mortality, as well as long-term mortality, for patients who undergo surgery in high-volume pancreatic centers. (medscape.com)
  • Intervention1: Pegozafermin: In Double blind randomized period, patients with diagnosis of Severe Hypertriglyceridemia will be randomized 3 3 2, pegozafermin 30 mg, pegozafermin 20 mg, placebo, n equal to 135 in each pegozafermin arm and n equal to 90 in the placebo arm. (who.int)
  • Control Intervention1: Placebo (Tris buffer solution (containing Arginine hydrochloride, and polysorbate 80)): In Double blind randomized period, patients with diagnosis of Severe Hypertriglyceridemia, subjects will be randomized 3 3 2, pegozafermin 30 mg, pegozafermin 20 mg, placebo, n equal to 135 in each pegozafermin arm and n equal to 90 in the placebo arm. (who.int)
Arteries1
  • If you already had a myocardial infarction, stent implantation, stroke, narrowing of arteries or similar, your risk is anyway very high. (stulnig.at)
Accumulation2
  • Glomerular lipidosis is a rare histological feature presenting the extensive glomerular accumulation of lipids with or without histiocytic infiltration, which develops under various conditions. (biomedcentral.com)
  • Crestor 10 Mg is used in the treatment of Type III Hyperlipoproteinemia which is a genetic disorder characterized by the improper breakdown of lipids, causing accumulation of lipids in the body. (welloxpharma.com)
Density lipoprotein5
  • The likelihood of developing its cardiovascular consequences, especially coronary heart disease (CHD), is enhanced by dyslipidaemia, which manifests itself either as an increase in low-density lipoprotein (LDL), resulting in hypercholesterolaemia, or in very-low-density lipoprotein (VLDL), resulting in either hypertriglyceridaemia or, if VLDL remnants accumulate, mixed hyperlipidaemia. (bmj.com)
  • HDL cholesterol , or high-density lipoprotein, is the "good cholesterol" that hunts down and absorbs bad cholesterol. (upmc.com)
  • Moderate reductions in total plasma cholesterol and low density lipoprotein cholesterol were observed for the gemfibrozil treatment group as a whole, but the lipid response was heterogeneous, especially among different Fredrickson types. (nih.gov)
  • High-density lipoprotein (HDL) cholesterol is also known as "good" cholesterol. (healthline.com)
  • Serum low-density lipoprotein particles (LDL) and high-density lipoprotein particles (HDL) were separated using non-denaturing polyacrylamide gradient gel (3-31%) electrophoresis. (biochemia-medica.com)
Foam cells1
  • Histiocytic lesions are characterized by dilated glomerular capillary loops that contain lipid-laden histiocytes (foam cells). (biomedcentral.com)
Adipose3
  • Lipogenesis rates were similar, while exogenous lipid retention was increased in perigonadal (2-fold) and brown adipose tissues (40 %) of apoCIII mice. (biomedcentral.com)
  • Thus, apoCIII overexpression resulted in increased NEFA availability to adipose uptake and decreased adipocyte lipolysis, favoring lipid enlargement of adipose depots. (biomedcentral.com)
  • Thus, in the postprandial period especially, there is an excess flux of circulating lipid metabolites that would normally have been 'absorbed' by adipose tissue. (cambridge.org)
Fatty2
  • The 4 h-delayed feeding rats showed increased body weight gain, although it did not induce fatty liver and hyperlipidemia compared to normal feeding rats. (bvsalud.org)
  • Ghost Fish Oil returns, and on top of its high percentage of omega-3 fatty acids, it uses SmartPrime-Om to enhance your body's uptake of those omega-3 fatty acids! (priceplow.com)
Plasma2
Disorder2
  • About one in every 250 people have the genetic mutation for a familial lipid disorder. (upmc.com)
  • If a family member has a confirmed lipid disorder diagnosis, your doctor might suggest genetic testing to learn if you have it. (upmc.com)
Therapy3
  • The optimal age at which to initiate lipid-lowering therapy to decrease the risk of symptomatic adulthood CAD has not been determined. (globalrph.com)
  • The clinical effects of triglyceride-lowering therapy were limited, suggesting that hypertriglyceridemia was not the cause of but rather may be a consequence of renal-limited MAS. (biomedcentral.com)
  • Lifestyle changes are the first-line therapy for lipid management. (contemporaryclinic.com)
Coagulation1
  • Its is important to check a lipid profile, coagulation, renal function in all cases. (pulsenotes.com)
Risk7
  • In fact, hyperlipidemia is one of the risk factors of CVD [ 11 ], which becomes one of the major killers around the world. (hindawi.com)
  • Epidemiological studies have shown that both low HDL-cholesterol and high LDL-cholesterol are independent risk factors for coronary heart disease. (nih.gov)
  • In addition, hyperlipidaemia, increased risk of venous/arterial thrombosis and higher risk of infection is typical of the syndrome. (pulsenotes.com)
  • Hypertriglyceridemia is associated with an increased risk of both cardiovascular disease ( 1,2 ) and acute pancreatitis ( 3,4 ). (lww.com)
  • A level of 40 mg/dL or lower (for males) and 50 mg/dL or lower (for females) is considered to put you at a higher risk of a heart attack and stroke . (healthline.com)
  • With high risk identified, referral for diagnostic laboratory evaluation is indicated. (contemporaryclinic.com)
  • if there is a combination of high-risk features on imaging, then this is likely to increase the risk of malignancy even further. (medscape.com)
Genetic predisposition2
  • Hyperlipidemias are often caused by a genetic predisposition together with environmental factors. (stulnig.at)
  • Hyperlipidemia is most commonly a result of genetic predisposition in combination with lifestyle factors (e.g., diet, lack of activity, alcohol consumption). (amboss.com)
Dietary2
  • Treatment involves dietary changes, exercise, and lipid-lowering drugs. (msdmanuals.com)
  • Taken as a whole, the present results obtained in humans are very close to those previously obtained in the rat and point out that wheat germ may play a beneficial role in the dietary management of hyperlipidemia. (cryonet.org)