• renal
  • The purpose of the present study was to develop a controllable experimental model in the dog that would consistently and predictably produce a malignant hypertensive crisis, and to determine the sequential changes in renal function, salt and water balance, and hormones that are involved in the transition from benign to accelerated hypertension. (ahajournals.org)
  • At the end of this period of benign hypertension, MAP had risen from a control value of 91 +/- 4 to 132 +/- 8 mm Hg, in association with approximately a 10-fold increase in PRA and a 40% reduction in renal function. (ahajournals.org)
  • 1. The possible contribution of changes in cardiac β-adrenoceptors to alterations in cardiac responses to isoprenaline were investigated in hearts isolated from rats with renovascular hypertension (two-kidney, one-clip Goldblatt), 6, 12 and 18 weeks after renal artery clipping. (clinsci.org)
  • 1 Furthermore, intrarenal renin-angiotensin system constitutes a pivotal determinant of systemic hypertension in renal artery stenosis. (ahajournals.org)
  • Underlying renal disease and renal failure were less common among pill users than among non-users with malignant hypertension who were of similar age. (mysciencework.com)
  • cause
  • Chronic pulmonary thromboembolic disease is an important cause of severe pulmonary hypertension, and as such is associated with significant morbidity and mortality. (bmj.com)
  • CTEPH is the only cause of severe pulmonary hypertension which is potentially curable without the need to resort to lung transplantation. (bmj.com)
  • In four the interval between the start of oral contraception and the diagnosis of malignant hypertension was less than four months, and in eight no other cause for the hypertension was found. (mysciencework.com)
  • These results suggest that oral contraceptives may be a common cause of malignant hypertension in women of child-bearing age. (mysciencework.com)
  • patients
  • Underpinning this is an increasing understanding of the cellular, molecular and genetic mechanisms underlying pulmonary arterial hypertension (PAH), coupled with an increased range of effective treatment (drug) options for patients with this condition. (bmj.com)
  • There is no consensus about the optimal treatment of hepatocellular carcinoma (HCC) with cirrhotic portal hypertension, While this group of patients are classified as hepatectomy contraindication according to guidelines from National Comprehensive Cancer Network (NCCN) and American Association for the Study of Liver Diseases (AASLD). (clinicaltrials.gov)
  • With improvement of surgical technique, preoperative evaluation, and perioperative management,especially the Precise Hepatectomy Technique, more and more studies confirmed the safety of surgical intervention to hepatocellular carcinoma (HCC) patients with cirrhotic portal hypertension.However, most of the previous studies were either retrospective or with small samples. (clinicaltrials.gov)
  • treatment
  • The investigators project is a prospective randomized controlled trial, planning to compare the safety, efficacy and quality of life between precise hepatectomy and combined interventional treatment on hepatocellular carcinoma (HCC) with cirrhotic portal hypertension, to make a further understanding of optimal strategy. (clinicaltrials.gov)