• Lung
  • however, the mechanisms connecting hyperoxia and the inflammatory response to lung damage is not clear. (jimmunol.org)
  • This study focuses on the mechanisms of inflammasome activation by hyperoxia and the contributions of inflammasome activation to lung injury and alveolar epithelial permeability. (jimmunol.org)
  • A hyperoxia test is a test that is performed-usually on an infant-to determine whether the patient's cyanosis is due to lung disease or a problem with blood circulation. (wikipedia.org)
  • BMP9 treatment of rat pups with hyperoxia-induced experimental BPD reduced alveolar enlargement, lung septal thickness and fibrosis, and prevented inflammation, but did not attenuate vascular remodeling and RVH. (frontiersin.org)
  • By contrast, KGF neither corrected changes induced by hyperoxia in parameters of lung morphometry that clearly indicated impaired alveolarization nor had any significant effect on tissue or BAL surfactant phospholipids. (physiology.org)
  • Hyperoxia can also indirectly cause carbon dioxide narcosis in patients with lung ailments such as chronic obstructive pulmonary disease or with central respiratory depression. (wikipedia.org)
  • alveolar
  • Hyperoxia decreased by 30% the rate of wound closure of a monolayer of fetal alveolar epithelial cells, due to cell death, which was overcome by recombinant human KGF (100 ng/ml). (physiology.org)
  • cerebral
  • We agree that there are many potential risks associated with hyperoxia, including but not limited to reductions in coronary and cerebral blood flow, decreased cardiac output, increased oxidative stress, delay in recognising a clinical deterioration and rebound hypoxaemia if oxygen therapy is abruptly stopped. (bmj.com)
  • baseline
  • On another day, measurements were repeated at a second baseline (B2) and during hyperoxia (100% oxygen breathing) for 15 normal subjects and 13 glaucoma patients. (bmj.com)
  • Results Of 252 patients, there were no differences in baseline characteristics between the hyperoxia and control group. (bmj.com)
  • inflammation
  • After hyperoxia-induced photoreceptor degeneration had begun, the number of genes that showed significant expression differences between the inferior and superior retina more than quadrupled, with genes related to immune processes, defense processes, and inflammation being numerically dominant. (pubmedcentralcanada.ca)
  • Results
  • These results suggest that hyperoxia induces K + efflux through the P2X7 receptor, leading to inflammasome activation and secretion of proinflammatory cytokines. (jimmunol.org)
  • normal
  • Hyperoxia resulted in reduced PSV and EDV in the ophthalmic arteries of normal subjects only (p = 0.001 and 0.031 respectively). (bmj.com)
  • changes
  • ORi can be trended and has optional alarms to notify clinicians of changes in a patient's oxygen reserve, and may enable proactive interventions to avoid hypoxia and unintended hyperoxia. (wikipedia.org)
  • subjects
  • The hyperoxia-associated microcirculatory dysregulation and impaired tissue oxygenation known to take place in the presence of a physiologic hemoglobin concentration are not encountered in hemodiluted subjects. (uni-muenchen.de)
  • model
  • The 50/10 rat experiments demonstrate that PHDi is also effective in a 24-h alternating hyperoxia/hypoxia model. (arvojournals.org)
  • The rat OIR model further validates the therapeutic value of PHDi to prevent retinopathy of prematurity, because it reduces oxygen-induced vascular obliteration and retinovascular growth attenuation in prolonged and/or alternating hyperoxia. (arvojournals.org)
  • development
  • Hyperoxia was defined as the highest quartile of an area under the curve of PaO 2 , until the development of DCI (PaO 2 ≥173 mm Hg). (bmj.com)