Impaired fastingSensitivityCompensatory hyperinsulinemiaHyperglycemiaType 2 diabetIncreased insulin secretionObeseMetabolic syndromeDevelopment of insulin resistanceLead to hyperinsulinemiaPathogenesisIncrease insulinPostprandialAdipose tissueReceptor substrateReceptorsFattyEffect of insulinActions of insulinObesity-relatedPolycysticStimulatesSecretion of insulinPancreasInduceNormal glucoseHormoneCause insulin resistanceClinicalFasting insulin levelsOxidative stressHigher insulin levelsGlucose uptakeAbstractDiabetes mellitusAtherosclerosisAmount of insulinChronicallyLipid storagePCOSHypertriglyceridemiaInducesConcentration of insulinDietaryEffects of insulinMuscle insulinReduce insulinGlycogenConcentrationsAcuteImpairsPlasma insulinImprove insulinRegulateDiabetic2001LiverExcessHepaticBasalSteatosis
Impaired fasting1
Sensitivity22
- High-fat diet-induced hyperinsulinemia, as a result of potentiated insulin secretion, coupled with selective insulin sensitivity in adipose tissue of Cry1/2-/-mice, correlates with increased lipid uptake. (eur.nl)
- Many studies have confirmed the effectiveness of lower-carb eating plans for lowering insulin levels and increasing insulin sensitivity, especially when compared with other diets. (healthline.com)
- While carbohydrates are typically an important part of a balanced diet, lower-carb diets have been shown to increase insulin sensitivity and reduce insulin levels in people living with obesity, diabetes, metabolic syndrome, and PCOS. (healthline.com)
- Consuming fewer calories has consistently been shown to increase insulin sensitivity and decrease insulin levels in people living with excess weight and obesity, regardless of the type of diet they consume ( 17 , 18 , 19 , 20 ). (healthline.com)
- Improvements in insulin sensitivity in women with PCOS, either through lifestyle changes or through pharmaceutical intervention, have consistently resulted in a marked improvement in the reproductive and metabolic abnormalities in PCOS. (knowcancer.com)
- Secondary objective is to improve circulating hyperandrogenemia and insulin sensitivity then single agent therapy. (knowcancer.com)
- Secondary objective is to improve ovulatory frequency and insulin sensitivity than just the use of a single agent therapy. (knowcancer.com)
- The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and cardiovascular health in pre-eclamptic patients. (who.int)
- Studies have consistently shown that there is a link between insulin resistance and circadian rhythm, with insulin sensitivity being higher in the morning and lower in the evening. (wikipedia.org)
- The Homeostasis Model for Assessment [HOMA= fasting insulin (mUI/ml) * fasting glucose (mmol/L) / 22.5] has proved useful in the measurement of insulin sensitivity in euglycemic patients. (isciii.es)
- Thus, insulin resistance depends on insulin secretion and insulin sensitivity. (isciii.es)
- Insulin secretion increases when insulin sensitivity decreases. (isciii.es)
- At a certain level, increasing insulin secretion does no longer improve insulin sensitivity. (isciii.es)
- The best method to measure insulin sensitivity is the hyperinsulinemic euglycemic clamp. (isciii.es)
- This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
- Conclusions Our findings suggest that DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake. (researchgate.net)
- DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
- In general the masters athlete should seek to maximize insulin sensitivity, as studies show that taking in carbohydrates in an insulin-resistant state can impede muscle growth. (ironmanmagazine.com)
- Below are three dietary interventions for increasing insulin sensitivity and anabolism. (ironmanmagazine.com)
- Research from Gabriel's lab at the University of Illinois, however, has demonstrated that lowering it to 1.5 grams of carb results in improved insulin sensitivity, fat loss and greater increases in muscle during training.9,10 Thus, we recommend eating no more than one to 1 1/2 grams of carbohydrates per gram of protein at a meal. (ironmanmagazine.com)
- Exercise further increases insulin sensitivity, accelerates weight loss and induces other changes within the cardiovascular system to lower blood pressure. (massagetoday.com)
- Insulin resistance and metabolic syndrome also play an important role in the obesity epidemic because excess body fat impairs insulin sensitivity. (vitalitymagazine.com)
Compensatory hyperinsulinemia4
- In the first phase of insulin resistance a compensatory hyperinsulinemia develops. (benthamscience.com)
- It is known that the normal response to insulin resistance is compensatory hyperinsulinemia, which may prevent diabetes. (psychiatrist.com)
- Insulin resistance and compensatory hyperinsulinemia are present in 44%-70% of women with PCOS, suggesting that they are more likely to develop type 2 diabetes, according to the researchers led by Milena Cioana, BHSc, with the department of pediatrics, McMaster University, Hamilton, Ont. (medscape.com)
- This may be because compensatory hyperinsulinemia is a fast inescapable defense of the organism against insulin resistance and hyperinsulinemia is rapidly compensated for by insulin resistance for the sake of maintaining fuel for the brain and glucose homeostasis. (diabetesjournals.org)
Hyperglycemia6
- however, only in the early stages of impaired insulin metabolism do hyperglycemia and hyperinsulinemia appear to be significant contributors to the presence of hypertension. (medscape.com)
- When insulin is unable to induce glucose uptake, pancreatic beta-cells increase insulin production and the hyperinsulinemic state prevents hyperglycemia. (isciii.es)
- Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. (researchgate.net)
- Moreover, I3C exerts anti-obesity effects by reducing body weight and fat accumulation in epididymal adipose tissue in HFD-induced obese mice and thereby improves hyperglycemia and hyperinsulinemia [126]. (researchgate.net)
- Development of advanced glycation end products (AGEs), i.e. the cross-linking of proteins and glucose caused by chronically elevated levels of glucose and insulin in the blood causing hyperglycemia and hyperinsulinemia. (vitalitymagazine.com)
- Commonly consumed berries, especially cranberries, blueberries, raspberries and strawberries, ameliorate postprandial hyperglycemia and hyperinsulinemia in overweight or obese adults with insulin resistance, and in adults with the metabolic syndrome (MetS). (rsc.org)
Type 2 diabet13
- Clinical studies suggest that type 2 diabetes mellitus (T2DM) is a risk factor for cognitive decline and dementia, and have found evidence that insulin resistance (IR) occurs in the brain of patients with T2DM and Alzheimer disease (AD). (nature.com)
- Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of the mechanisms underlying this relationship. (nature.com)
- Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. (cambridge.org)
- Photobiomodulation therapy decreases free fatty acid generation and release in adipocytes to ameliorate insulin resistance in type 2 diabetes. (google.com)
- PCOS entails diseases such as type 2 diabetes, hypertension, cardiovascular disease, and endometrial cancer ( 3 , 4 ), and insulin resistance (IR) and hyperandrogenemia might be closely associated with the pathogenesis of PCOS ( 5 ). (frontiersin.org)
- Children and adolescents in the study who had normal insulin levels also had testicular volumes that were 1.5-2 times higher compared to those with higher insulin levels in their blood, a condition known as hyperinsulinemia and which is often associated with type 2 diabetes. (thedoctorwillseeyounow.com)
- Thus, insulin concentrations are usually high early in type-2 diabetes, but have also been seen in many subjects who are not obese or diabetic, but who have other metabolic syndrome components such as hypertriglyceridemia or arterial hypertension (1). (isciii.es)
- Metabolic Syndrome (MetS) and Type 2 diabetes (T2D) are clinical conditions involving the impaired uptake and utilization of glucose, altered lipid metabolism, and the disruption of the metabolic signaling pathways that regulate insulin secretion from pancreas ( 1 ). (frontiersin.org)
- Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
- It is characterized by a cluster of risk factors of atherosclerosis including insulin resistance, hyperinsulinemia, impaired glucose tolerance or type 2 diabetes, hypertension, dyslipidemia, and coagulation abnormalities. (erudit.org)
- Insulin resistance, metabolic syndrome, and type 2 diabetes are all conditions that may be curable or at least reversible in some people using specific diet and lifestyle changes. (vitalitymagazine.com)
- The traditional view of the pathogenesis of type 2 diabetes is that hyperinsulinemia occurs as a consequence of insulin resistance ( 1 ). (diabetesjournals.org)
- Recent epidemiological studies indicate bisphenol-A (BPA), an estrogenic chemical used in production of epoxy, polycarbonate and plastic may increase risk of insulin resistance and type 2 diabetes. (cdc.gov)
Increased insulin secretion2
- Collectively, these data indicate that Cry deficiency results in an increased vulnerability to high-fat diet-induced obesity that might be mediated by increased insulin secretion and lipid storage in adipose tissues. (eur.nl)
- thus, insulin resistance results in increased insulin secretion to maintain normal glucose and lipid homeostasis. (medscape.com)
Obese8
- There are a number of risk factors for insulin resistance, including being overweight or obese or having a sedentary lifestyle . (wikipedia.org)
- In obese subjects, adipokines and miokines interact to promote reticulum stress, insulin resistance, metabolic inflexibility and endothelial dysfunction. (benthamscience.com)
- When investigators collected data on them - age, body mass index, testicular volume and insulin resistance - they noticed that boys with normal weight had a 1.5 times higher testicular volume compared to those who were overweight or obese before hitting puberty. (thedoctorwillseeyounow.com)
- Overweight or obese boys with hyperinsulinemia or insulin resistance had lower testicular volume than their healthy peers. (thedoctorwillseeyounow.com)
- It has been found that an increase in diacylglycerol species in insulin resistant obese and T2D subjects stimulates the secretion of insulin by the pancreas to maintain a normal glucose level ( 6 ). (frontiersin.org)
- IR-A is often aberrantly expressed in cancer cells, thus increasing their responsiveness to IGF-II and to insulin and explaining the cancer-promoting effect of hyperinsulinemia observed in obese and type 2 diabetic patients. (scienceopen.com)
- Metabolically, obese women have increased insulin resistance in early pregnancy, which becomes manifest clinically in late gestation as glucose intolerance and fetal overgrowth. (bmj.com)
- As senior investigator Dr. Noyan Gokce told Reuters Health, "Our data demonstrate that obese subjects exhibit varying degrees of inflammation in their fat tissue, and increased inflammatory activity in fat was associated with systemic metabolic abnormalities including insulin resistance. (massagemag.com)
Metabolic syndrome9
- The syndromes of insulin resistance actually make up a broad clinical spectrum, which includes obesity, glucose intolerance, diabetes, and the metabolic syndrome, as well as an extreme insulin-resistant state. (medscape.com)
- People living with health conditions characterized by insulin resistance, such as metabolic syndrome and polycystic ovary syndrome (PCOS) , may experience a dramatic lowering of insulin with carb restriction ( 6 , 7 , 8 ). (healthline.com)
- Insulin resistance is considered a component of the metabolic syndrome . (wikipedia.org)
- Non-alcoholic fatty liver disease is associated with obesity, non-insulin dependent diabetes, and hypertriglyceridemia and represents the hepatic manifestation of the metabolic syndrome[ 4 ]. (wjgnet.com)
- Hyperinsulinemia: the key feature of a cardiovascular and metabolic syndrome. (mja.com.au)
- Insulin resistance is a major feature of the metabolic syndrome. (isciii.es)
- Metabolic Syndrome Metabolic syndrome is characterized by a large waist circumference (due to excess abdominal fat), hypertension, abnormal fasting plasma glucose or insulin resistance, and dyslipidemia. (merckmanuals.com)
- These clinical markers for insulin resistance, leading to metabolic syndrome and obesity, are the precursors for Type II diabetes. (vitalitymagazine.com)
- The sum of inflammatory signals and deranged substrate handling induce most of the metabolic syndrome traits: insulin resistance, obesity, diabetes, liver steatosis, hyperlipidemia and their compounded combined effects. (medscape.com)
Development of insulin resistance3
- Sedentary lifestyle increases the likelihood of development of insulin resistance. (wikipedia.org)
- Several reports support the notion that an increase in plasma free fatty acids (FFAs) is key in the development of insulin resistance and T2D ( 2 - 4 ). (frontiersin.org)
- Hyperinsulinemia is a major complication associated with the development of insulin resistance. (scienceopen.com)
Lead to hyperinsulinemia2
- Your pancreas releases different amounts of insulin depending on the type of food you eat, but eating a large amount of foods that cause your body to produce extra insulin can eventually lead to hyperinsulinemia. (healthline.com)
- PCOS can also be accompanied by obesity because central obesity could exaggerate IR and lead to hyperinsulinemia ( 7 ). (frontiersin.org)
Pathogenesis3
- It remains to be examined whether failure of adequate pancreatic b-cell compensation for insulin resistance plays a central role in the pathogenesis of diabetes associated with this class of drugs. (psychiatrist.com)
- Taken together, these studies confirm that muscle insulin resistance represents a major factor in the pathogenesis of T2D. (frontiersin.org)
- The authors wrote: "Although earlier studies suggested that obesity-related insulin resistance and hyperinsulinemia can contribute to PCOS pathogenesis, insulin resistance in patients with PCOS may be present independently of [body mass index]. (medscape.com)
Increase insulin1
- A mismatch between the circadian rhythm and the meals schedule, such as in circadian rhythm disorders , may increase insulin resistance. (wikipedia.org)
Postprandial1
- Thus, moderate weight loss helps to reverse insulin resistance, lowering basal and postprandial insulin blood levels. (massagetoday.com)
Adipose tissue8
- Transcript analysis of white adipose tissue reveals upregulated expression of lipogenic genes, many of which are insulin targets. (eur.nl)
- Lipodystrophy, lack of adipose tissue, is also associated with insulin resistance. (cambridge.org)
- Any plausible explanation for the link between excess adipose tissue and insulin resistance needs to be able to account for this observation. (cambridge.org)
- Adipose tissue in obesity becomes refractory to suppression of fat mobilization by insulin, and also to the normal acute stimulatory effect of insulin on activation of lipoprotein lipase (involved in fat storage). (cambridge.org)
- This view of the link between adipose tissue and insulin resistance emphasises the important role of adipose tissue in 'buffering' the daily influx of dietary fat entering the circulation and preventing excessive exposure of other tissues to this influx. (cambridge.org)
- Visceral adipose tissue mass secretes a number of proinflammatory cytokines, adipokines and growth factors leading to low grade inflammatory process and insulin resistance. (benthamscience.com)
- Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). (mdpi.com)
- Its pathophysiology is likely to involve insulin resistance at the level of both skeletal muscle and visceral adipose tissue and altered fluxes of metabolic substrates between these tissues that in turn impair liver metabolism. (erudit.org)
Receptor substrate4
- As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. (nature.com)
- Insulin receptor substrate (IRS) proteins play essential roles in mediating insulin/IGF signaling by recruiting a series of downstream effectors 23 . (nature.com)
- Insulin is known to regulate pancreatic β-cell function through the activation of cell surface insulin receptors, phosphorylation of insulin receptor substrate (IRS)-1 and -2, and activation of phosphatidylinositol (PI) 3-kinase. (diabetesjournals.org)
- This was associated with DIM‐enhanced phosphorylation of the signaling intermediates Akt, insulin receptor substrate‐1, and insulin receptor early in differentiation. (researchgate.net)
Receptors4
- Insulin resistance ( IR ) is a pathological condition in which cells either fail to respond normally to the hormone insulin or downregulate insulin receptors in response to hyperinsulinemia . (wikipedia.org)
- [3] It is hypothesized that increasing cell membrane fluidity by increasing PUFA concentration might result in an enhanced number of insulin receptors, an increased affinity of insulin to its receptors, and reduced insulin resistance. (wikipedia.org)
- These nuclear hormone receptors impact on hepatic triglyceride accumulation and insulin resistance. (wjgnet.com)
- Fat cells secrete inflammatory proteins that interfere with insulin receptors, exacerbating insulin resistance. (vitalitymagazine.com)
Fatty6
- Björntorp , P ( 1994 ) Fatty acids, hyperinsulinemia, and insulin resistance: which comes first? (cambridge.org)
- The percentage of polyunsaturated fatty acids (PUFAs) is inversely correlated with insulin resistance. (wikipedia.org)
- Polycystic ovary syndrome (PCOS) is strongly associated with abdominal obesity and insulin resistance and effective approaches to nutrition (e.g., omega-3 fatty acids intake) might improve the cardiometabolic risk profile. (frontiersin.org)
- This study aimed to examine the associations of dietary and serum omega-3 fatty acids with insulin resistance (IR) and body composition among PCOS patients. (frontiersin.org)
- The multivariable linear regression model was applied to analyze the associations of dietary and serum omega-3 fatty acids with the levels of Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and body composition parameters among PCOS patients. (frontiersin.org)
- In contrast, others have favored the concept that exaggerated insulin secretion will cause insulin resistance ( 3 , 4 ), possibly via fatty acid-mediated impairment of insulin action ( 5 - 7 ). (diabetesjournals.org)
Effect of insulin1
- However, an acute effect of insulin in modulating β-cell electrical activity and its underlying ionic currents has not been reported. (diabetesjournals.org)
Actions of insulin3
- cellular actions of insulin involve a wide variety of effects on postreceptor signaling pathways within target cells. (medscape.com)
- the kinase activity autophosphorylates and mediates multiple actions of insulin. (medscape.com)
- Further research is needed to fully dissect the molecular mechanisms underlying the biological actions of insulin in PCa. (scienceopen.com)
Obesity-related2
- Obesity is associated with insulin resistance and hyperinsulinemia, which is considered to be a core component in the pathophysiology of obesity-related comorbidities. (tum.de)
- In addition, obesity-related comorbidities, such as hyperinsulinemia and insulin resistance, have been found to influence testicular volume in pre- and post-puberty. (thedoctorwillseeyounow.com)
Polycystic2
- [1] Various genetic factors can increase risk, such as a family history of diabetes, and there are some specific medical conditions associated with insulin resistance, such as polycystic ovary syndrome . (wikipedia.org)
- Although current evidence suggests increased risk of obesity, insulin resistance, and metabolic alterations in patients with polycystic ovary syndrome (PCOS), especially of a hyperandrogenic phenotype, the impact of each one of these variables on muscle mass remains uncertain. (bvsalud.org)
Stimulates2
- GLP-1 is an incretin hormone that stimulates insulin secretion, causes B-cell mitosis while inhibiting apoptosis, inhibits glucagon secretion, and delays gastric emptying with overall antidiabetic effects. (medscape.com)
- That's how insulin works: It stimulates capillaries to produce more NO and thus trigger vasodilation and amino acid-rich blood flow delivery to muscles. (ironmanmagazine.com)
Secretion of insulin1
- In response, beta cells in the pancreas step up the secretion of insulin to deal with the blood sugar spike, facilitating glucose transport through cell membranes and lowering blood sugar. (vitalitymagazine.com)
Pancreas5
- Insulin is an extremely important hormone that's produced by your pancreas. (healthline.com)
- This condition, known as insulin resistance, leads your pancreas to produce even more insulin, creating a precarious cycle ( 4 ). (healthline.com)
- Insulin is released by the pancreas in response to carbohydrates consumed in the diet. (wikipedia.org)
- That doesn't happen, though, unless insulin is released from the pancreas, binds to the muscle and signals it to increase the uptake of glucose. (ironmanmagazine.com)
- But when blood sugar levels are chronically elevated, the pancreas becomes stressed and progressively more dysfunctional, unable to produce enough insulin to deal with the spikes. (vitalitymagazine.com)
Induce5
- Many hormones can induce insulin resistance including cortisol , [14] growth hormone , and human placental lactogen . (wikipedia.org)
- In transgenic mice models the HCV core protein has been found to induce insulin resistance via TNF production. (isciii.es)
- Resistance emerges as a consequence of the inability of insulin to induce its effect on glucose metabolism. (isciii.es)
- Besides, virus C infection may induce insulin resistance by blocking intracellular signaling, and lastly, insulin resistance has been associated with a decreased rate of sustained response to peginterferon alpha plus ribavirin in patients with chronic hepatitis C. (isciii.es)
- The aims of this study were to investigate whether insulin can directly induce mitogenic activities in PCa-derived cell lines and to examine the mechanisms responsible for these actions. (scienceopen.com)
Normal glucose2
- Although young PTG heterozygous mice initially demonstrate normal glucose tolerance, progressive glucose intolerance, hyperinsulinemia, and insulin resistance develop with aging. (jci.org)
- Under chronic hyperinsulinemia, FA oxidation progressively decreases with a consequent alteration in glucose transport, and/or phosphorylation pathways associated with normal glucose uptake ( 5 ). (frontiersin.org)
Hormone7
- Someone pointed you to some blog where someone was saying that insulin was a satiety hormone (made animals stop eating). (robbwolf.com)
- The chronically high levels of insulin that result interfere with the satiety hormone leptin, which makes the body think it is starving and causes the animal to eat more. (robbwolf.com)
- Insulin is a hormone that facilitates the transport of glucose from blood into cells, thereby reducing blood glucose (blood sugar). (wikipedia.org)
- An additional factor is the release of the hormone insulin. (ironmanmagazine.com)
- Insulin is the hormone that regulates cellular nourishment by aiding in the absorption and metabolism of nutrients from the blood. (vitalitymagazine.com)
- Nonetheless, what has recently emerged is that insulin resistance alone (in the non-β-cell target tissues of the hormone) cannot cause diabetes without β-cell failure ( 10 ). (diabetesjournals.org)
- STAT5B acts as a part of the growth hormone signalling pathway leading to stimulation of insulin-like growth factor I (IGF-I) gene transcription [Woelfle et al. (lu.se)
Cause insulin resistance1
- Being exposed to light during sleep has been shown to cause insulin resistance and increase heart rate. (wikipedia.org)
Clinical3
- In clinical practice, no single laboratory test is used to diagnose insulin resistance syndrome. (medscape.com)
- In insulin resistance, various clinical entities of this state are evident. (medscape.com)
- There are multiple ways to measure insulin resistance such as fasting insulin levels or glucose tolerance tests, but these are not often used in clinical practice. (wikipedia.org)
Fasting insulin levels1
- However, ACV did not seem to affect fasting insulin levels or insulin resistance ( 14 ). (healthline.com)
Oxidative stress1
- Although there is no unifying mechanism responsible for the adverse perinatal outcomes associated with maternal obesity, on the basis of the available data, increased prepregnancy maternal insulin resistance and accompanying hyperinsulinemia, inflammation, and oxidative stress seem to contribute to early placental and fetal dysfunction. (bmj.com)
Higher insulin levels1
- Despite significantly higher insulin levels, the rate of intravenous glucose required to maintain the defined elevation of glucose levels was either identical (1.38 mmol/l) or even significantly lower (2.75 mmol/l) following weight gain. (tum.de)
Glucose uptake2
- Insulin, after binding its receptor, induces the phosphorylation of receptor substrates in the liver and muscles, and induces several steps toward the transactivation of GLUT-4, which increases glucose uptake by cells and its storage as glycogen, and inhibits the net production of glucose by the liver, thus blocking glycogenolysis and neoglycogenesis. (isciii.es)
- 3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
Abstract1
- ABSTRACT Adiponectin has profound insulin-sensitizing, anti-inflammatory and anti-atherogenic effects. (who.int)
Diabetes mellitus3
- Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
- Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
- By studying diabetic dyslipid- in diabetes mellitus because insulin resist- aemia among a group of our patients we ance or deficiency affects key enzymes hoped to draw attention of the medical com- and pathways in lipid metabolism [ 1 ]. (who.int)
Atherosclerosis1
Amount of insulin2
- In states of insulin resistance, the same amount of insulin does not have the same effect on glucose transport and blood sugar levels. (wikipedia.org)
- Thus, an abnormally large amount of insulin is required to achieve a biological response. (isciii.es)
Chronically1
- However, living with chronically high levels of insulin, also known as hyperinsulinemia , can lead to excessive weight gain and serious health problems like heart disease and cancer ( 1 , 2 , 3 ). (healthline.com)
PCOS5
- In another small study from 2013, when people with PCOS ate a lower-carb diet containing enough calories to maintain their weight, they experienced greater reductions in insulin levels than when they ate a higher-carb diet ( 10 ). (healthline.com)
- PCOS is also characterized by insulin resistance and hyperinsulinemia. (knowcancer.com)
- Excessive insulin level is not only a potential cause of hyperandrogenemia but also one of the high-risk factors leading to metabolic syndromes among those with PCOS ( 6 ). (frontiersin.org)
- Seventy percentage of overweight PCOS patients were accompanied by IR, with the majority of overweight PCOS patients also being accompanied by hyperinsulinemia ( 8 ), suggesting potential relationships between body fat with PCOS. (frontiersin.org)
- Elevated levels of male sex hormones and hyperinsulinemia are typical laboratory findings in PCOS patients. (pronatal.cz)
Hypertriglyceridemia1
- Fructose feeding induces a rise in blood pressure in normal rats and is associated with insulin resistance, hyperinsulinemia, and hypertriglyceridemia. (nih.gov)
Induces2
- In summary, hepatitis C promotes insulin resistance and insulin resistance induces steatosis, fibrosis, and interferon resistance. (isciii.es)
- Our results indicated that insulin induces cell proliferation in a dose-dependent fashion in the LNCaP, C4-2, and P69 cell lines. (scienceopen.com)
Concentration of insulin2
- Insulin resistance is a state in which a given concentration of insulin produces a less-than-expected biological effect. (medscape.com)
- Methods 3T3‐L1 preadipocytes were differentiated by using a mixture of adipogenic inducers, including a suboptimal concentration of insulin. (researchgate.net)
Dietary4
- You may be able to help reduce high insulin levels by making dietary changes and increasing your physical activity. (healthline.com)
- Insulin resistance can be improved or reversed with lifestyle approaches, such as exercise and dietary changes. (wikipedia.org)
- Dietary factors are likely to contribute to insulin resistance. (wikipedia.org)
- The objective of this review is to summarize and discuss the role of dietary berries (taken as fresh, frozen, or other processed forms) on insulin resistance and biomarkers of T2D in human feeding studies. (rsc.org)
Effects of insulin2
- The effects of insulin were reversed by tolbutamide, which decreased cell conductance to 0.5 ± 0.1 nS and shifted the current reversal potential to −25.2 ± 2.3 mV. (diabetesjournals.org)
- Conversely, IR-B is predominantly expressed in adult, well-differentiated tissues, including the liver, where it enhances the metabolic effects of insulin. (scienceopen.com)
Muscle insulin1
- Indeed, although targeted disruption of the muscle insulin receptor causes a marked defect of insulin action in this tissue, the phenotype of such animals is modest with a lack of diabetes ( 11 ). (diabetesjournals.org)
Reduce insulin2
- Treatment involves pharmacologic therapy to reduce insulin resistance, along with surgical management of underlying causes if appropriate. (medscape.com)
- Medications that reduce insulin resistance (insulin-sensitizing and antihyperglycemic effects) include metformin and the thiazolidinediones. (medscape.com)
Glycogen1
- During calorific restriction or extremely low-carbohydrate diets, insulin production by pancreatic β-cells is reduced, lipogenesis is decreased and glycogen stores are depleted. (karger.com)
Concentrations3
- Baseline insulin, C-peptide, and glucose concentrations were significantly higher after weight gain from 21.8 to 23.8 kg/m(2) BMI within 4(1/2) mo. (tum.de)
- Following oral or intravenous stimulation insulin concentrations were significantly higher post-weight gain during all three test conditions, whereas C-peptide and glucose levels did not differ. (tum.de)
- Calculations of insulin secretion and clearance demonstrated that higher stimulated insulin concentrations are entirely due to clearance but not secretion. (tum.de)
Acute1
- Acute exposure of the brain to insulin blunts hunger because it clears dopamine from the brain, which signals the end of a meal. (robbwolf.com)
Impairs1
- The fact that insulin impairs protein synthesis in older muscles has spurred scientists to suggest that aging people need a higher protein-to-carbohydrate ratio. (ironmanmagazine.com)
Plasma insulin1
- A recent study in pregnant mice, administered BPA sc on days 9-16 of gestation demonstrated an association between BPA exposure, glucose intolerance and increased plasma insulin during pregnancy and 4 months postpartum. (cdc.gov)
Improve insulin1
- In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. (researchgate.net)
Regulate1
- Ambient insulin levels, various physiologic and disease states, and drugs regulate insulin receptor concentration or affinity. (medscape.com)
Diabetic3
- The current results indicated that PBMT inhibited FFA generation and release in insulin-resistant adipocytes and reduced plasma FFA levels in diabetic db/db mice and HFD-fed mice. (google.com)
- Therefore, PBMT might ameliorate whole-body insulin resistance in diabetic mice. (google.com)
- Thus, hyperinsulinemia is regarded as a potentially important cancer risk factor among diabetic patients. (scienceopen.com)
20011
- As JD McGarry stated in his 2001 Banting lecture, "…the hyperinsulinemia turns the liver into a 'fat-producing factory' with all of its negative downstream effects. (vitalitymagazine.com)
Liver2
- Accumulation of triacylglycerol in skeletal muscles and in liver is associated with insulin resistance. (cambridge.org)
- Insulin resistance is more often seen in hepatitis C than in other liver diseases, including non-alcoholic steatohepatitis. (isciii.es)
Excess2
- First, high risk diets result in the consumption of excess calories, and the development of hyperinsulinemia and insulin resistance. (utoronto.ca)
- The glucose excess elicits hyperinsulinemia, which may derive, in the end, into insulin resistance. (medscape.com)
Hepatic1
- Cortisol counteracts insulin and can lead to increased hepatic gluconeogenesis , reduced peripheral utilization of glucose, and increased insulin resistance. (wikipedia.org)
Basal2
- Calculations of insulin secretion and clearance indicate that reduced insulin clearance contributes more to post-weight gain basal hyperinsulinemia than insulin secretion. (tum.de)
- The associated basal and stimulated hyperinsulinemia is the result of differentiated changes of insulin secretion and clearance, respectively. (tum.de)
Steatosis1
- Insulin resistance has been associated with steatosis development and fibrosis progression in a genotype-dependent manner. (isciii.es)