Ati IV and/or Ati + Flu IV tended to induce rapid recovery from hyperglycemia and reverse the NEFA decreases. (chula.ac.th)
It was possible to detect the peak of cortisol, glucose, non-esterified fatty acids (NEFA), ß-hydroxibutyrate (BHB), and aspartate aminotransferase (AST) on delivery and week +1. (ufrgs.br)
METHODS: Twenty-two pigs were stratified according to four protocols: low NEFA + low insulin (nicotinic acid), high NEFA + low insulin (fasting) and high insulin + low NEFA ± high glucose (hyperinsulinaemia-hyperglycaemia or hyperinsulinaemia-euglycaemia). (ox.ac.uk)
RESULTS: Myocardial glucose extraction was increased by NEFA suppression and was similar in the hyperinsulinaemia-hypergylcaemia, hyperinsulinaemia-euglycaemia and nicotinic acid groups. (ox.ac.uk)
The observation that hyperinsulinaemia and nicotinic acid led to myocardial fuel deprivation provides a potential explanation for the cardiovascular outcomes reported in recent intensive glucose-lowering and NEFA-lowering clinical trials. (ox.ac.uk)
NEFAs1
Obese and diabetic topics have raised plasma degrees of nonesterified essential fatty acids (NEFAs) and hyperglycemia, that are believed to trigger reduced insulin synthesis and impaired blood sugar responsiveness in pancreatic -cells, termed glucolipotoxicity [2] also, [3]. (cgp60474.com)
Lipids5
Bile acids are derived from cholesterol and serve an important role in emulsifying and digesting lipids. (metabolon.es)
A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids. (lookformedical.com)
A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids. (lookformedical.com)
The situation is further complicated by the fact that carbon from linoleic acid goes into the synthesis of other lipids - including cholesterol and palmitate. (blogspot.com)
Once obese Zucker diabetic fatty rats become diabetic, glucose- stimulated insulin secretion (GSIS) is absent and β-cell GLUT2 reduced. (elsevierpure.com)
Islet GIP-R expression and immunohistochemistry studies were performed in pancreas-specific PPARγ knockout mice (PANC PPARγ −/− ), normoglycemic 60% pancreatectomy rats (Px), normoglycemic and hyperglycemic Zucker fatty (ZF) rats, and mouse islets incubated with troglitazone. (diabetesjournals.org)
Glucagon does not increase plasma free fatty acid and glycerol concentrations in patients with noninsulin-dependent diabetes mellitus. (nhri.edu.tw)
Glucose4
Glucose is then oxidized to pyruvate and under anaerobic conditions is reduced to lactic acid. (wikipedia.org)
These abnormalities, the hyperinsulinemia, the hyperplasia of β-cells, i.e., its in vitro equivalent, enhanced bromodeoxyuridine incorporation, and the increased low K(m) glucose usage can be induced by culturing normal islets with 2 mmol/l free fatty acids (FFAs). (elsevierpure.com)
Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid incretin hormone that binds to a seven-transmembrane G-protein-coupled receptor (GIP-R) that is expressed in numerous tissues including islet β-cells and α-cells ( 1 , 2 ). (diabetesjournals.org)
Hyperglycaemia enhanced myocardial glucose uptake due to a mass action. (ox.ac.uk)
Primary and secondary bile2
The Bile Acids Targeted Panel measures all the major human and rodent primary and secondary bile acids as well as their glycine and taurine conjugates. (metabolon.es)
In addition, C3R inhibited the formation of cholesterol micelles and bound to primary and secondary bile acid. (biomedcentral.com)
Proteins1
Amino acids (AA) are the foundational building blocks for peptides and proteins. (metabolon.es)
Docosahexaenoic Acid3
Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid (PUFA) in the brain and a structural component of neuronal membranes. (koreascience.kr)
This work investigates how docosahexaenoic acid (DHA) modifies the effect of Cholesterol (Chol) on the structural and dynamical properties of dipalmitoylphosphatidylcholine (DPPC) membrane. (nutrition-evidence.com)
Omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), present an anti-inflammatory effect that could ameliorate some patients need for intensive care unit (ICU) admission. (nutrition-evidence.com)
Insulin secretion1
Diabetes mellitus , which is a metabolic disorder is characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. (herbconer.com)
Amino Acids3
Branched chain amino acids play a large role in building muscle tissue and participate in increasing protein synthesis. (metabolon.es)
Amino acids also play a role in cell signaling, gene expression and protein phosphorylation. (metabolon.es)
Maintaining an optimal balance of amino acids is vital to maintaining a stable equilibrium of physiological processes. (metabolon.es)
Rats1
The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue - Evid Based Complement Alternat Med. (qualitycounts.com)
Leptin1
Results demonstrate that the microencapsulated L.f. 11976 formulation greatly reduced the adiposity index (p = 0.0014), serum insulin (p = 0.0042), insulin resistance (p = 0.0096), glycosylated albumin (p = 0.00013), serum leptin (p = 0.048), serum uric acid (p =0.025) serum total cholesterol (p = 0.024), serum esterified cholesterol (p = 0.0328) and free non-esterified fatty acid (p = 0.029) levels in the treated animals. (ku.edu)
Dysfunction2
In particular, IR and beta-cell dysfunction lead to the persistent hyperglycemia which characterizes T2D. (e-apem.org)
Postprandial OBJECTIVE - Diabetes is characterized by marked postprandial endothelial dysfunction induced by hyperglycemia, hypertriglyceridemia, advanced glycation end products (AGEs), and dicarbonyls (e.g., methylglyoxal [MG]). In vitro hyperglycemia-induced MG formation and endothelial dysfunction could be blocked by benfotiamine, but in vivo effects of benfotiamine on and occurs not only in patients with car- postprandial endothelial dysfunction and MG synthesis have not been investigated in humansuntil now. (health-abstracts.com)
Supplementation1
Although the inflammatory resolution improved by EPA and DHA could contribute to the recovery of patients infected with SARS-CoV-2, Omega-3 fatty acids supplementation cannot be recommended before randomized and controlled trials are carried out. (nutrition-evidence.com)
Hepatic4
Non-alcoholic fatty liver disease is associated with obesity, non-insulin dependent diabetes, and hypertriglyceridemia and represents the hepatic manifestation of the metabolic syndrome[ 4 ]. (wjgnet.com)
Non-esterified fatty acid, and hepatic triglyceride levels were also observed to be lowered. (herbconer.com)
In order to test the hypothesis that peroxidized fatty acids, generated by heating of standard cooking oils, trigger hepatic inflammation, Boehm et al. (blogspot.com)
Synthesis1
A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. (lookformedical.com)
Cholesterol1
There is a discrepancy in the regulation of HMG-CoA - reductase and LDL receptor activities in liver from animals fed cholesterol with linoleic acid. (blogspot.com)
Acyl2
We review evidence that increased tissue levels of fatty acyl CoA cause the β-cell abnormalities of nondiabetic obesity and ultimately result in obesity-dependent diabetes. (elsevierpure.com)
Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. (lookformedical.com)
NAFLD2
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and can result in nonalcoholic steatohepatitis (NASH) and progressive liver disease including cirrhosis and hepatocellular carcinoma. (wjgnet.com)
An estimated 30% of adults and 10% of children and adolescents in the United States have nonalcoholic fatty liver disease (NAFLD), defined as liver fat content exceeding 5% (Figure 1 )[ 1 - 3 ]. (wjgnet.com)
Cortisol1
The hyperglycemia concomitant with the peak of cortisol at delivery may be explaining by the activation of the somatotropic axis, due to the stress of calving. (ufrgs.br)
Assay1
The bile acid binding was measured using the colorimetric assay. (biomedcentral.com)
Lipid1
Results obtained in this work shed light on the effect of polyunsaturated fatty acids - particularly DHA - on lipid membranes, with potential preventive applications in many diseases, e.g. neuronal as, Alzheimer's disease, and viral, as Covid-19. (nutrition-evidence.com)
Metabolism1
It is an amino acid derivative and an essential cofactor for fatty acid metabolism. (lookformedical.com)
Ferulic Acid (FA) is a natural phenolic acid produced by a number of lactic acid bacteria. (ku.edu)
Liver1
It is created via a multi-step process involving the break-down of fatty acids into acetyl CoA, conversion to acetoacetate and reduction to β-hydroxybutyrate in the liver. (metabolon.es)
Obesity2
This research indicates that the probiotic L.f. 11976 microencapsulated formulation may significantly delay the onset of insulin resistance, hyperglycemia, hyperinsulinemia, dyslipidemia and obesity, indicating a lower risk of diabetes and cardiovascular disease. (ku.edu)
The study included 56 individuals with obesity, of whom 30 individuals underwent Roux-en-Y gastric bypass surgery (RYGB) and twenty-six underwent sleeve gastrectomy (SG). (biomedcentral.com)
Stable1
The antioxidant activities were evaluated using stable 1,1-diphenyl 2-picrylhydrazyl (DPPH) free radical scavenging method, 2,2´-azinobis (3-ethyl benzo thiazoline-6-sulphonic acid) radical cation (ABTS) and Ferric reducing antioxidant power (FRAP). (bvsalud.org)
Vegetable1
A saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. (lookformedical.com)
Radical1
The addition of an organic acid radical into a molecule. (lookformedical.com)
Process1
The process of converting an acid into an alkyl or aryl derivative. (lookformedical.com)
Vascular1
mice showed intensified vascular calcification, which was alleviated by treatment with the HMGB1 inhibitor glycyrrhizic acid. (omicsdi.org)
Carbon5
Salts and esters of the 16-carbon saturated monocarboxylic acid--palmitic acid. (lookformedical.com)
Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated eight carbon aliphatic structure. (lookformedical.com)
La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)
Role1
A fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis. (lookformedical.com)