• induces
  • Nevertheless, substantial evidence exists demonstrating that hypercholesterolemia induces oxidative and nitrative stress in the heart and that oxidative/nitrative stress plays a role in several cardiac pathologies. (hindawi.com)
  • PCSK9
  • Alnylam Pharmaceuticals , Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today positive results from its Phase I clinical trial of ALN-PCS, an RNAi therapeutic targeting PCSK9 for the treatment of severe hypercholesterolemia. (news-medical.net)
  • Physical
  • In this review, we discuss the effects of various pharmaceuticals, nutraceuticals, some novel potential pharmacological approaches, and physical exercise on hypercholesterolemia-induced oxidative/nitrative stress and subsequent cardiac dysfunction as well as impaired ischemic stress adaptation of the heart in hypercholesterolemia. (hindawi.com)
  • diagnosis
  • An investigation into the reliability of Chinese medicine diagnosis according to eight guiding principles and Zang-Fu theory in Australians with hypercholesterolemia," Journal of Alternative and Complementary Medicine , vol. 15, no. 3, pp. 259-266, 2009. (hindawi.com)
  • diet
  • Epidemiological considerations indicate that although various strategies exist, the most cost-effective method of reducing the burden of hypercholesterolaemia in New Zealand would be by changing the nations diet as a whole. (biomedsearch.com)
  • known
  • In addition to its well-known proatherogenic effect, hypercholesterolemia may exert direct effects on the myocardium resulting in contractile dysfunction, aggravated ischemia/reperfusion injury, and diminished stress adaptation. (hindawi.com)
  • effect
  • Research on the effect of pu huang and its preparations on hypercholesterolemia and the function of macrophages," Shanghai Zhong Yi Yao Za Zhi , vol. 8, pp. 46-48, 1989. (hindawi.com)