• wound hyperalgesia
  • Prolonged Differential Wound Hyperalgesia After an Interval. (lww.com)
  • We assessed postoperative pain at rest and with movement along with wound hyperalgesia in a patient who had undergone lower abdominal surgery under general anesthesia with a unilateral epidural block that persisted throughout surgery and in whom the epidural catheter was replaced immediately afterward. (lww.com)
  • Pain and wound hyperalgesia were consistently greater on the "unblocked" side for the 3-wk period of observation. (lww.com)
  • Neuropathic Pain
  • Hyperalgesia is similar to other sorts of pain associated with nerve irritation or damage such as allodynia and neuropathic pain, and consequently may respond to standard treatment for these conditions, using various drugs such as SSRI or tricyclic antidepressants, Nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, gabapentin or pregabalin, NMDA antagonists, or atypical opioids such as tramadol. (wikipedia.org)
  • 11,14 Furthermore, depletion of monocytes/macrophages ameliorates hyperalgesia in chemically induced peritonitis (acid-induced writhing) 15 and in neuropathic pain models. (asahq.org)
  • receptors
  • One possible strategy for treating hyperalgesia involves blocking activation of these receptors with NMDAR antagonists such as ketamine, dextromethorphan, or methadone (which has NMDAR antagonist properties in addition to being an opioid analgesic). (wikipedia.org)
  • Nav1.8
  • Here we compared visceral pain and referred hyperalgesia in Nav1.8-null mice and their wild-type littermates in five tests that differ in the degree to which behavior depends on spontaneous, ongoing firing in sensitized nociceptors. (jneurosci.org)
  • Nav1.8-null mice also showed blunted pain and hyperalgesia to intracolonic mustard oil, which sensitizes nociceptors but also provokes tissue damage. (jneurosci.org)
  • lidocaine
  • In this multicenter, randomised, placebo-controlled, double-blind trial, hyperalgesia area around the scarce following colorectal laparoscopic surgery (piece removal) will be assessed in 3 groups of patients : group 1: continuous ropivacaine preperitoneal infusion, group 2 : intravenous lidocaine infusion, or group 3 : control group without local anesthetics. (clinicaltrials.gov)
  • Dysfunction
  • However, as with other forms of nerve dysfunction associated pain, treatment of hyperalgesia can be clinically challenging, and finding a suitable drug or drug combination that is effective for a particular patient may require trial and error. (wikipedia.org)
  • placebo
  • Moreover, a significant negative correlation was found between the magnitude of mPFC (but not posterior cingulate) BOLD response and the size of secondary hyperalgesia response under placebo. (jneurosci.org)
  • The investigators want to test the influence of remifentanil, an ultra-short acting opioid, on hyperalgesia observed after UV-B irradiation in human volunteers in a double blind cross-over prospective active placebo controlled clinical trial. (clinicaltrials.gov)
  • chronic
  • Various studies of humans and animals have demonstrated that primary or secondary hyperalgesia can develop in response to both chronic and acute exposure to opioids. (wikipedia.org)
  • Long-term opioid (e.g. heroin, morphine) users and those on high-dose opioid medications for the treatment of chronic pain, may experience hyperalgesia and experience pain out of proportion to physical findings, which is a common cause for loss of efficacy of these medications over time. (wikipedia.org)
  • Where hyperalgesia has been produced by chronic high doses of opioids, reducing the dose may result in improved pain management. (wikipedia.org)
  • morphine
  • Besides hyperalgesia assessment, immediate postoperative and long-term pain, morphine consumption, and endocrin-metabolic response will be evaluated in this study. (clinicaltrials.gov)
  • area
  • That is, individuals with high levels of mPFC during periods of evoked secondary hyperalgesia pain had a smaller surface area of uninjured responsive skin during psychophysical testing and individuals with low levels of mPFC activity had a larger area of responsive skin. (jneurosci.org)
  • The region of hyperalgesia will be established with a 5.18 von Frey hair, and the area of allodynia with a foam brush gently stroked on the skin. (clinicaltrials.gov)
  • second full-length studio album
  • Hyperalgesia is the second full-length studio album by American alternative rock band Victorian Halls from Chicago, Illinois, United States. (wikipedia.org)
  • Their second full-length studio album, "Hyperalgesia" was recorded in Gossip Studios, Chicago and released in May 2015 with help of prolific music producer and mixer Joe Chiccarelli, who has in the past produced dozens of albums for well-known acts and singers (The Strokes, The Killers, U2, Jason Mraz). (wikipedia.org)