• receptors
  • One possible strategy for treating hyperalgesia involves blocking activation of these receptors with NMDAR antagonists such as ketamine, dextromethorphan, or methadone (which has NMDAR antagonist properties in addition to being an opioid analgesic). (wikipedia.org)
  • mice
  • Here we compared visceral pain and referred hyperalgesia in Nav1.8-null mice and their wild-type littermates in five tests that differ in the degree to which behavior depends on spontaneous, ongoing firing in sensitized nociceptors. (jneurosci.org)
  • Nav1.8-null mice also showed blunted pain and hyperalgesia to intracolonic mustard oil, which sensitizes nociceptors but also provokes tissue damage. (jneurosci.org)
  • Furthermore, analyses of mice lacking VR1 have shown that VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia ( 20 , 21 ). (pnas.org)
  • somatic
  • Furthermore, varenicline (0.1 and 0.5 mg/kg) reversed nicotine withdrawal signs such as hyperalgesia and somatic signs and withdrawal-induced aversion in a dose-related manner. (rti.org)
  • analgesic
  • The authors of this study used a balanced design that used electrical stimulation to induce trauma, normally benign pin pricks to assess hyperalgesia, and subsequent intravenous application of lidocaine, a potent analgesic, to block perception of secondary hyperalgesia in normal participants undergoing fMRI scanning. (jneurosci.org)
  • II-Prostaglandins hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. (wikipedia.org)
  • lidocaine
  • In this multicenter, randomised, placebo-controlled, double-blind trial, hyperalgesia area around the scarce following colorectal laparoscopic surgery (piece removal) will be assessed in 3 groups of patients : group 1: continuous ropivacaine preperitoneal infusion, group 2 : intravenous lidocaine infusion, or group 3 : control group without local anesthetics. (clinicaltrials.gov)
  • Dysfunction
  • However, as with other forms of nerve dysfunction associated pain, treatment of hyperalgesia can be clinically challenging, and finding a suitable drug or drug combination that is effective for a particular patient may require trial and error. (wikipedia.org)
  • stimulation
  • The use of a transcutaneous electrical nerve stimulation device has been shown to alleviate hyperalgesia. (wikipedia.org)
  • Under these conditions, the mPFC (as well as the posterior cingulate, another major hub of the DMN) showed a robust response during the perception of secondary hyperalgesia but not primary hyperalgesia (i.e., no mPFC responses were detected during pin-prick stimulation at the site of the electrical trauma). (jneurosci.org)
  • Functional magnetic resonance imaging (fMRI) was used to tease out the cortical regions associated with the processing of ET-1-induced punctate hyperalgesia, as compared to a nonnoxious mechanical stimulation of the contralateral arm. (hindawi.com)
  • placebo
  • Moreover, a significant negative correlation was found between the magnitude of mPFC (but not posterior cingulate) BOLD response and the size of secondary hyperalgesia response under placebo. (jneurosci.org)
  • The investigators want to test the influence of remifentanil, an ultra-short acting opioid, on hyperalgesia observed after UV-B irradiation in human volunteers in a double blind cross-over prospective active placebo controlled clinical trial. (clinicaltrials.gov)
  • chronic
  • Various studies of humans and animals have demonstrated that primary or secondary hyperalgesia can develop in response to both chronic and acute exposure to opioids. (wikipedia.org)
  • Long-term opioid (e.g. heroin, morphine) users and those on high-dose opioid medications for the treatment of chronic pain, may experience hyperalgesia and experience pain out of proportion to physical findings, which is a common cause for loss of efficacy of these medications over time. (wikipedia.org)
  • Where hyperalgesia has been produced by chronic high doses of opioids, reducing the dose may result in improved pain management. (wikipedia.org)
  • area
  • That is, individuals with high levels of mPFC during periods of evoked secondary hyperalgesia pain had a smaller surface area of uninjured responsive skin during psychophysical testing and individuals with low levels of mPFC activity had a larger area of responsive skin. (jneurosci.org)
  • The region of hyperalgesia will be established with a 5.18 von Frey hair, and the area of allodynia with a foam brush gently stroked on the skin. (clinicaltrials.gov)
  • injection
  • Our findings suggest that injection of ET-1 leads to a state of punctate hyperalgesia, which in turn causes the activation of multiple brain regions. (hindawi.com)