• fatty
  • There, they perform FAE hydrolysis, the final step in the signaling cascade for pain and inflammation, yielding an ethanolamine and a fatty acid. (wikipedia.org)
  • membrane
  • Endogenously produced cannabinoids are hydrophobic molecules derived from hydrolysis of membrane phospholipids. (nih.gov)
  • The catalytic efficiency (i.e., the ratio between maximal velocity and Michaelis-Menten constant) of the AEA membrane transporter (AMT) is almost doubled compared with control cells, demonstrate that, among the proteins of the "endocannabinoid system," only CB1 and AMT critically depend on membrane cholesterol content, an observation that may have important implications for the role of CB1 in protecting nerve cells against (endo)cannabinoid-induced apoptosis. (wikipedia.org)
  • NAEs
  • For example, a proposed biosynthetic pathway for the N-acyl ethanolamines (NAEs) has been the hydrolysis of an unusual phospholipid precursor, N-acyl-phosphatidylethanolamine (NAPE), by a phospholipase D activity to liberate NAE and, as a byproduct, phosphatidic acid. (wikipedia.org)
  • lipids
  • However, there were no significant effects of either time (pre- vs. post-treatment measures) as main effect or the interaction time x treatment for the plasma levels of the endocannabinoids anandamide and 2-arachidonoylglycerol or for eight other related lipids. (biomedcentral.com)
  • vivo
  • We determined that blocking endocannabinoid signaling, which increases spontaneous glutamatergic release, increased spontaneous network activity in vitro and in vivo . (jneurosci.org)
  • Blocking endocannabinoid signaling in vivo , and thus increasing SNA, triggered compensatory decreases of both AMPA and GABA mPSC amplitudes. (jneurosci.org)
  • rats
  • Levels of the endocannabinoids 2-AG and anadamide were increased in the jejunum (the middle part of the small intestine) of rats fed the corn oil or mixed liquid diet, but not in rats fed the protein or sugar solutions. (blogspot.com)
  • Unlike
  • Unlike AC, NAAA does not form a heterodimer through disulfide bonds, but rather remains active as two separate cleaved peptides following hydrolysis. (wikipedia.org)
  • Unlike many previous studies, endocannabinoid signaling was not found to influence evoked transmitter release. (jneurosci.org)
  • catalyze
  • A distinct circulating enzyme, peptidase M20 domain containing 1 (PM20D1), can catalyze the bidirectional the condensation and hydrolysis of a variety of N-acyl amino acids in vitro. (wikipedia.org)
  • cell
  • The inference of the endocannabinoid program in cell expansion, difference and success is good recognized today. (bostonscienceandengineeringlectures.com)
  • Therefore, we looked into whether raising endocannabinoid amounts, either by immediate administration or by reducing their enzymatic destruction, or both, offers an effect on the development of an intense pores and skin cancers cell range. (bostonscienceandengineeringlectures.com)
  • The ultimate effect on the endocannabinoid-releasing cell depends on the nature of the conventional transmitter being controlled. (diff.org)
  • For instance, when the release of the inhibitory transmitter GABA is reduced, the net effect is an increase in the excitability of the endocannabinoid-releasing cell. (diff.org)
  • On the converse, when release of the excitatory neurotransmitter glutamate is reduced, the net effect is a decrease in the excitability of the endocannabinoid-releasing cell. (diff.org)
  • levels
  • In a recent study, it was reported that short-term changes in mood produced by a pleasant ambience were correlated with changes in the levels of plasma endocannabinoids and related N -acylethanolamines (Schrieks et al. (biomedcentral.com)
  • In the present study, we investigated whether stress reduction by touch massage (TM) affects blood plasma levels of endocannabinoids and related N -acylethanolamines. (biomedcentral.com)
  • It is concluded that in the participants studied here, there are no overt effects of TM upon plasma endocannabinoid levels. (biomedcentral.com)
  • variety
  • Synthetic cannabinoids encompass a variety of distinct chemical classes: the classical cannabinoids structurally related to THC, the nonclassical cannabinoids (cannabimimetics) including the aminoalkylindoles, 1,5-diarylpyrazoles, quinolines, and arylsulfonamides as well as eicosanoids related to endocannabinoids. (wikipedia.org)
  • important
  • The bingeing literature may not have the same focus and may not be as important to the overall state of obesity as the straight-up obesity literature - but with respect to "munchies" and endocannabinoids, I think it is a fair backdrop. (blogspot.com)