Hydrolysis inositol 1 4 5 trisphosphate. Medical search. Frequent questions

First hydrolysis of PIP2 molecules by activated phospholipase C leads to formation of diacylglycerol and inositol trisphosphate. (wikipedia.org)
evokes Ca 2+ -dependent hydrolysis of PIP 2 and generates two second messengers, inositol 1,4,5-trisphosphate (IP 3 ) and diacylglycerol (DAG) ( Rhee and Choi, 1992 ). (jneurosci.org)
This signalling system liberates two key second messengers, namely, IP 3 (inositol 1,4,5-trisphosphate) and DAG (diacylglycerol). (shawprize.org)
Both effects of endothelin-1 were blocked by an antagonist of phospholipase C, suggesting that Ins(1,4,5) P 3 and/or diacylglycerol production was necessary. (biologists.com)
Scheme of the principal mGluR1 and mGluR5 signaling pathways, showing that G q/11 -dependent activation of phospholipase C β (PLCβ) mediates phosphatidylinositol hydrolysis with the generation of diacylglycerol (DAG) (that activates protein kinase C, PKC) and inositol-1,4,5-trisphosphate (IP 3 ) (that fosters Ca 2+ intracellular release from internal stores by acting on IP 3 R receptors on the endoplasmic reticulum). (encyclopedia.pub)
Ca2+ launch from internal stores in neurons is definitely controlled via the activation of phospholipase C (PLC), hydrolysis of phosphatidylinositol IMD 0354 tyrosianse inhibitor 4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and activation of IP3 receptors located in the endoplasmic reticulum (ER), which leads to the launch of Ca2+ from your ER5. (bioinbrief.com)
PLC catalyzes the hydrolysis of PI 4, 5 P 2 to generate the second messengers inositol 1, 4, 5-trisphosphate bloodhunt wh 1, 4, 5 P 3 and diacylglycerol. (publiguia.net)
1,3-Didecanoylglycerol is a saturated diacylglycerol with decanoic acid (Item No. 20838) at the sn-1 and sn-3 positions. (medkoo.com)
Stretch of neonatal cardiomyocytes activates phospholipase C with production of inositol trisphosphate and diacylglycerol in part by formation of angiotensin II (Ang II). (wustl.edu)
DG(24:0/18:1(9Z)/0:0) is a diglyceride, or a diacylglycerol (DAG). (hmdb.ca)
It catalyzes the cleavage of phosphatidylinositol(4,5)bisphosphate (PtdIns(4,5)P 2) into two initial second messengers, myo-inositol-1,4,5-trisphosphate (InsP 3) and diacylglycerol (DAG). (rochfortgeneconsulting.com)

The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)
The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP 2 ) by phospholipase C yields the second messengers inositol 1,4,5-trisphosphate (InsP 3 ) and 1,2-diacyglycerol. (elsevierpure.com)
abstract = "The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C yields the second messengers inositol 1,4,5-trisphosphate (InsP3) and 1,2-diacyglycerol. (elsevierpure.com)
The effects of propofol on the endothelin-1-induced activation of phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D were evaluated by measuring the formation of inositol phosphates and choline, respectively. (silverchair.com)
Canonical mGluRI signaling is driven by the G q /G 11 -dependent activation of phospholipase C β (PLCβ), inducing the hydrolysis of phosphoinositides and generation of inositol 1,4,5-trisphosphate (IP 3 ) and diacyl-glycerol (DAG). (encyclopedia.pub)
Globally, mGluRI can activate a multifaceted list of effectors, including phospholipase D (PLD), protein kinases pathways such as mitogen-activated protein kinase/extracellular receptor kinase (MAPK/ERK), the mammalian target of rapamycin (mTOR)/p70S6 kinase pathway, casein kinase 1, cyclin-dependent protein kinase 5, and Jun kinase (JUNK) [ 1 ] [ 2 ] ( Figure 1 ). (encyclopedia.pub)
We conclude that in the adult heart, LV dilatation produced stretch-mediated activation of phospholipase C, which resulted in PI hydrolysis and PKCε activation in part by stimulation of the local renin angiotensin system. (wustl.edu)
theβ-myosin heavy chain(β-MHC)and atrial natriuretic factor (ANF), which are recognized as a marker of cardiac hypertrophy, were determined by Real-time quantitative PCR (qRT-PCR), then another gene phospholipase C (PLC), inositol triphosphate (IP 3 ), which associated with RAS were determined by Western blot(WB). (researchsquare.com)
Activation of mAChRs is relatively slow (milliseconds to seconds) and, depending on the subtypes present (M1-M5), they directly alter cellular homeostasis of phospholipase C, inositol trisphosphate, cAMP, and free calcium. (genome.jp)

The endothelin-1-stimulated formation of inositol phosphates was significantly suppressed by propofol. (silverchair.com)
However, propofol had no effect on the formation of inositol phosphates induced by NaF, an activator of heterotrimeric guanosine triphosphate (GTP)-binding proteins. (silverchair.com)
Pretreatment of stretched hearts with the specific angiotensin (AT 1 ) receptor antagonist losartan abolished stretch-mediated accumulation of inositol phosphates. (wustl.edu)
Current synthetic strategies require inositol compounds to be protected (often with more than one group), resolved, phosphorylated and deprotected to produce the desired optically active myo-inositol phosphates. (aston.ac.uk)
PGE1 increased intracellular levels of total inositol phosphates (IP), cyclic GMP, cyclic AMP, and calcium ([Ca2+]i). (shengsci.com)
Specific for lipid substrates, inactive towards water soluble inositol phosphates. (smpdb.ca)

This was studied in SK-N-SH neuroblastoma cells, which possess a muscarinic receptor-regulated PLCβ 1 -signaling pathway. (jneurosci.org)
The effect of propofol on endothelin-1 binding to its receptor was determined by an [125I] endothelin-1-binding assay. (silverchair.com)
Propofol had no effect on the binding of endothelin-1 to its receptor. (silverchair.com)
The inhibitory effect of propofol might be exerted at a point between the endothelin-1 receptor and its GTP-binding protein. (silverchair.com)
The mGluRI distinction from other mGluR groups (group II, including mGluR2 and mGluR3, and group III, comprising mGluR4, mGluR6, mGluR7, mGluR8) is based on amino-acid homology, agonist binding, and signaling pathways downstream to receptor activation [ 1 ] . (encyclopedia.pub)
mGluR1/5, through G q/11 -dependent mechanisms, also modulates ion channels, such as transient receptor potential channels (TRPCs), voltage-gated Ca 2+ channels (VGCC), and different types of K + channels (K v or SK), thus affecting neuronal excitability. (encyclopedia.pub)
In contrast to stretch-mediated inositol phosphate accumulation, PKCε translocation is not prevented by AT 1 receptor blockade, indicating that this PKC isoform can be activated in response to mechanical deformation by an Ang II-independent mechanism in the adult myocardium. (wustl.edu)
Mechanistic investigations revealed that through increasing the levels of intracellular reactive oxygen species (ROS), Gyp-L triggered protein ubiquitination and endoplasm reticulum (ER) stress response, leading to Ca 2+ release from ER inositol trisphosphate receptor (IP 3 R)-operated stores and finally cell death. (oncotarget.com)
This study demonstrated that the Receptor for Activated C-Kinase 1 (RACK1) is important in SC function. (sdbonline.org)
2003). FGF molecules bind to a family of receptor molecules consisting of 4 members (FGFR1, FGFR2, FGFR3, and FGFR4). (beauty104.com.tw)
angiotensin II (Ang II), angiotensin II type 1 receptor (AT 1 R) were determined by ELISA, WB and qRT-PCR methods. (researchsquare.com)
Ang II acts on angiotensin Ⅱ type 1 receptor (AT 1 R)[10,11]. (researchsquare.com)
AT 1 R is a member of the 7-fold transmembrane G-protein-coupled receptor (GPCR) family[12,13], mainly exists in the myocardial membrane and can mediate cardiac hypertrophy induced by pressure overload and mechanical stimulation after activation [14]. (researchsquare.com)
The TEC kinases are the second largest sub-family of non-receptor tyrosine kinases in the human genome after the SRC family [ 1 - 3 ]. (elifesciences.org)
Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a member of the TRAF family and an important multifunctional intracellular adaptin of the tumor necrosis factor superfamily and toll/IL-1 receptor (TIR) superfamily. (shengsci.com)
An inside job: Annexin 1A-Inositol 1,4,5-trisphosphate receptor interaction conveys endoplasmic reticulum luminal Ca sensitivity. (rochester.edu)
Pivotal role of type-1 inositol 1,4,5-trisphosphate receptor for glucagon-induced gluconeogenesis. (rochester.edu)
It has recently been demonstrated that prenatal exposure to the cannabinoid receptor 1 agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone (WIN 55,212-2) produces memory deficit in adulthood, an effect associated with a reduced functionality of the glutamatergic system. (researchgate.net)
Furthermore, both robust phosphorylation of Homer3 and its dissociation from metabotropic glutamate receptor 1α (mGluR1α) were triggered by depolarization in primary cultured Purkinje cells, and these events were inhibited by CaMKII inhibitor. (jneurosci.org)
Human platelets express 2 thrombin receptors: protease-activated receptor (PAR)-1 and PAR4. (ashpublications.org)

Although ventricular cardiomyocytes express inositol 1,4,5-trisphosphate [Ins(1,4,5) P 3 ] receptors, it is unclear how these Ca 2+ channels contribute to the effects of Gq-coupled agonists. (biologists.com)
The endothelin-1-mediated spontaneous Ca 2+ transients were abolished by application of 2-aminoethoxydiphenyl borate (2-APB), an antagonist of Ins(1,4,5) P 3 receptors. (biologists.com)
For example, metabotropic mGluRs assemble into a macromolecular complex with IP3 receptors via the scaffolding protein Homer and co-purify with protein phosphatases and protein kinase A (PKA)1,4. (bioinbrief.com)
These organelles are defined by the expression of receptors for the second messenger Inositol 1,4,5-trisphosphate. (rochester.edu)
Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors. (jefferson.edu)

A cyclase enzyme (lyase) catalyzes the formation of the cyclic nucleotide from its nucleotide triphosphate precursor ( Figure 1 ). (pancreapedia.org)
Cyclic nucleotides form when the phosphate group of the molecule of nucleotide triphosphate (ATP or GTP) is attacked by the 3' hydroxyl group of the ribose, forming a cyclic 3',5'-phosphate ester with release of pyrophosphate. (pancreapedia.org)
Compared with the Ala120 variant, Thr120 was more common in black subjects than in white subjects (63% vs 19%), was associated with higher PAR4-induced human platelet aggregation and Ca 2+ flux, and generated greater inositol 1,4,5-triphosphate in transfected cells. (ashpublications.org)
A second, less frequent F2RL3 variant, Phe296Val, was only observed in blacks and abolished the enhanced PAR4-induced platelet aggregation and 1,4,5-triphosphate generation associated with PAR4-Thr120. (ashpublications.org)

7. Phosphate, but not inositol, is an inhibitor competitive with substrate. (port.ac.uk)
This breakthrough may have scientific relevance, considering that pharmacological inhibitors of endocannabinoid hydrolysis (for instance, the FAAH inhibitor URB597) are being examined for healing potential in pet models of irritation and discomfort. (healthcarecoremeasures.com)
Similarly, inhibition of the PI3K-mTOR pathway by addition of the PI3K inhibitor 2-[4-morpholinyl]-8-phenyl-4H-1-benzopyran-4-one (LY294002) or the mTOR inhibitor rapamycin, although reducing several parameters of transformation, also failed to block transformation. (embl.de)

In addition, mGluRI can activate several other pathways, and also G protein-independent mechanisms, by means of the interaction with specific adaptor proteins that recruit distinct signaling components [ 1 ] . (encyclopedia.pub)
Additional G protein-independent mechanisms involve the recruitment of β-arrestin or other scaffolding/adaptor proteins such as Homer long isoforms, that provide mGluRI coupling with other effectors, thus fostering activation of signaling pathways, such as the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K-Akt-mTOR) kinase pathway, or MEK1/2-ERK 1/2 pathway, both involved in mechanisms promoting protein synthesis. (encyclopedia.pub)
These observations claim that modifications in 5-HT2A-R trafficking and G proteins signaling donate to the advancement and manifestation of neuropsychiatric disorders. (bioinbrief.com)
Levels of proteins, including Cyt C, Bcl-2/BAX, and Nrf2 /HO-1-associated proteins, were determined by western blotting and immunofluorescence. (sdbonline.org)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
Cation-transporting proteins that utilize the energy of ATP hydrolysis for the transport of CALCIUM. (jefferson.edu)

1. An inositol monophosphatase was purified to homogeneity from bovine brain. (port.ac.uk)
A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. (rhea-db.org)
myo-Inositol monophosphatase is a key enzyme in recycling myo-inositol from its monophosphates in the brain and its inhibition is implicated in lithium's antimanic properties. (aston.ac.uk)
This strategy also allows the possible introduction of labels of oxygen and sulphur to give a thiophosphate of known stereochemistry at phosphorus which would be useful for the analysis of the stereochemical course of phosphate hydrolysis catalysed by inositol monophosphatase. (aston.ac.uk)

This pathway leads to the Ca 2+ intracellular mobilization from internal stores and activation of protein kinase C (PKC) [ 1 ] . (encyclopedia.pub)
The PX domain of Vam7p selectively binds PtdIns-3-P, while the PX domain of the CPK PI-3 kinase selectively binds PtdIns-4,5-P(2). (embl.de)
We report here that Sac1p has a specific role in secretion and acts as an antagonist of the phosphatidylinositol 4-kinase Pik1p in Golgi trafficking. (embl.de)
Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230. (embl.de)
The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. (embl.de)
Thus, in isovolumic perfused guinea pig hearts, we characterized stretch-mediated phosphatidylinositol (PI) hydrolysis and protein kinase C (PKC) isoform translocation using elevated diastolic pressure. (wustl.edu)
Structures of the autoinhibited SRC family kinases were solved in 1997 revealing, for the first time, the compact arrangement of the SH3 and SH2 domains assembled onto the distal side of the catalytic kinase domain [ 4 ]. (elifesciences.org)
In 2015 the BTK SH3-SH2-Kinase fragment was crystallized [ 5 ]. (elifesciences.org)
5 ]. The three domains (SH3, SH2, kinase), the SH2-kinase linker, the activation loop and the active site are labeled. (elifesciences.org)
A protein kinase C activator, 4 beta-phorbol 12 beta-myristate 13 alpha-acetate, had opposite effects on PGE1-mediated IP release and cyclic GMP formation (inhibitory) and cyclic AMP formation (stimulatory). (shengsci.com)
For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)

The effect of propofol on the endothelin-1-induced Ca2+ influx into A10 cells was evaluated by measuring intracellular 45Ca2+. (silverchair.com)

in another window Amount 1 The endocannabinoids 2-AG and anandamide serve as substrates for fat burning capacity by a PLA2G10 organic selection of enzymes. (healthcarecoremeasures.com)
Members of a subfamily of these enzymes share a specific domain that was first identified in the yeast Sac1 protein [1]. (embl.de)
The enzyme is a member of the succinate dehydrogenase/fumarate-reductase family of enzymes [5]. (enzyme-database.org)

These results suggest that propofol inhibits endothelin-1-induced intracellular signaling in vascular smooth muscle cells. (silverchair.com)
8. Li+ inhibits hydrolysis of inositol 1-phosphate and inositol 4-phosphate uncompetitively with different apparent Ki values (1.0 mM and 0.26 mM respectively). (port.ac.uk)

The effects of endothelin-1 were compared with two other stimuli, isoproterenol and digoxin, which are known to induce inotropy and spontaneous Ca 2+ transients by overloading intracellular Ca 2+ stores. (biologists.com)
The effects of propofol on endothelin-1-induced intracellular signaling in an aortic smooth muscle cell line, A10 cells, were examined. (silverchair.com)
The various isoforms, arising by alternative splicing, mainly differ in the C-terminal intracellular tail [ 1 ] . (encyclopedia.pub)

4. Several non-inositol-containing monophosphates are also substrates. (port.ac.uk)

Taken together, these findings provide strong evidence that the generation of PtdIns(4)P is sufficient to trigger forward transport from the Golgi to the plasma membrane and that Sac1p is critically required for the termination of this signal. (embl.de)

Berridge's major achievement was to discover one such pathway that is linked to the hydrolysis of inositol lipids. (shawprize.org)

The PI(4,5)P2 cycle or simply PIP2 cycle (also known as PI cycle in past) is one of the important signalling cascades underlying many cellular functions including GPCR signaling, cytokinesis, endocytosis, and apoptosis. (wikipedia.org)
The inositol-1,4,5-trisphosphate (IP3) which regulates free Ca2+ levels in the cytoplasm is derived from hydrolysis of phosphotidylinositol-4,5-bisphosphate (PIP2). (grantome.com)
We have proposed that an increase in the rate of phosphorylation of PI to phosphatidylinositol-4-phosphate (PIP) and to phosphatidylinositol-4,5-bisphosphate (PIP2) could enhance responses to hormones by providing additional substrate for production of the second messengers. (grantome.com)

abstract = "1. (port.ac.uk)
2. {Advantage} of early selection through shortening the breeding cycle}, volume = {48}, issn = {0037-5349}, abstract = {Three main advantages from early selection in tree breeding have been recognized: 1. (upsc.se)

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (smpdb.ca)

The eff ect of IP6 (1-500 μM) on autooxidation and Fe(II)/ascorbate-induced lipid peroxidation in micelles of linoleic acid after 24 h incubation was investigated using a reverse-phase high-performance liquid chromatography (RP-HPLC) with UV detection. (edu.pl)
Comporti M. Lipid peroxidation and biogenic aldehydes: from the identifi cation of 4-hydroxynonenal to further achievements in biopathology. (edu.pl)

Iron binding studies of myo-inositol 1,2,3-trisphosphate demonstrated that phosphate groups with the equatorial-axial-equatorial conformation are required for complete inhibition of hydroxyl radical formation. (aston.ac.uk)
Vucenik I., Shamsuddin A.M. Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from labolatory to clinic. (edu.pl)

13(1): 6316, 2023 04 18. (bvsalud.org)

Belongs to the class of organic compounds known as 1,2-diacylglycerols. (hmdb.ca)

[1-6] The depressor effects of propofol have been ascribed to a decrease in systemic vascular resistance, cardiac output, or both in humans. (silverchair.com)

Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). (smpdb.ca)

5-HTRs coupling to the Gq/11 pathway such as 5-HT2A/C-Rs are abundantly indicated in the brain and are molecular focuses on for atypical antipsychotic medicines and most hallucinogens7. (bioinbrief.com)
In addition, depending on the cell-type and agonist 5-HT2A-Rs not merely stimulate the NOS3 Gq-PLC pathway, but various other pathways like the G12/13-PLA2 and Gi/o-Src pathway16C18 also. (bioinbrief.com)

Ang II binds to AT 1 R, which can induce vasoconstriction, increase blood pressure, and further induce cardiac hypertrophy and proliferation of fibroblasts [15]. (researchsquare.com)
and it may be related to the activation of PLC-IP3, PKC, JAK-STAT, MAPK, Ca/CaMK/CaN signaling pathways after Ang II binds to AT 1 R on the myocardium membrane. (researchsquare.com)

5-HT2A-Rs colocalize with PSD95 and MUPP1 (multi-PDZ website protein 1) in apical dendrites, dendritic shafts and spines8. (bioinbrief.com)
Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1). (embl.de)
decrease the expression of β-MHC, ANF, Ang II, AT 1 R, c-fos and c-myc mRNA and the protein levels of PLC, IP 3 , AngII and AT 1 R in left ventricular myocardium, in addition, the content of Ca 2+ also decrease. (researchsquare.com)

Incubation of electrically-paced ventricular myocytes with a membrane-permeant Ins(1,4,5) P 3 ester provoked the occurrence of spontaneous diastolic Ca 2+ transients with the same characteristics and sensitivity to 2-APB as the events stimulated by endothelin-1. (biologists.com)
It has been suggested that improved activity of 5-HT2A-Rs might be responsible for some of the psychotic symptoms in schizophrenia14 and that atypical antipsychotic providers may antagonize the hyperactivity and membrane focusing on of 5-HT2A-Rs15. (bioinbrief.com)
1) membrane-bound organelles (included are double-membraned and single-membraned cytoplasmic structures). (biologyonline.com)
In a left lung hilar-ligation model of IRI in mice, we found that lung IRI increased the efflux of ATP through pannexin 1 (Panx1) channels at the endothelial cell (EC) membrane. (bvsalud.org)

MGL catalyzes the hydrolysis of 2-AG into arachidonic acidity (AA) and glycerol, whereas FAAH catalyzes hydrolysis of anandamide into arachidonic acidity and Panobinostat ethanolamine. (healthcarecoremeasures.com)

In addition to evoking spontaneous Ca 2+ transients, stimulation of ventricular myocytes with the Ins(1,4,5) P 3 ester caused a positive inotropic effect. (biologists.com)
A zinc finger motif near the amino terminus of the ARF1 GAP was required for stimulation of GTP hydrolysis. (embl.de)

The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs. (embl.de)

1,3-Didecanoate-Glycerol. (medkoo.com)
Since diacylglycerols are synthesized via phosphatidic acid, they will usually contain a saturated fatty acid at the C-1 position on the glycerol moiety and an unsaturated fatty acid at the C-2 position. (hmdb.ca)
These are diacylglycerols containing a glycerol acylated at positions 1 and 2. (hmdb.ca)

The stereoselective addition of the chiral phosphorylating agent (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one to a protected inositol intermediate allowed separation of diastereoisomers and easy deprotection to myo-inositol 3-phosphate. (aston.ac.uk)
The enzyme is highly regioselective for the reduction of the endocyclic 1,2-double bond, and is stereoselective, producing only the 1 R -configured product. (enzyme-database.org)

The first synthesis of myo-inositol 1,2,3-trisphosphate has been completed, along with its X-ray structure determination and that of key synthetic intermediates. (aston.ac.uk)
Here, the synthesis of myo-inositol 3-phosphate has been achieved in only 4 steps from myo-inositol. (aston.ac.uk)
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. (smpdb.ca)

The time course of this event was concordant both with transactivation of Gαq by the direct transfer of [ 32 P]P 3 (4-azidoanilido)-P 1 -5′-GTP from tubulin as well as with the activation of PLCβ 1 . (jneurosci.org)
Activation of 5-HT2A has been associated with changes in spine and dendritic morphology8, changes in BDNF levels in the hippocampus and neocortex11 and normally results in an improved neuronal activity12,13. (bioinbrief.com)
A common feature of neurodegenerative and neuroinflammatory diseases is the activation of CNS resident cells ( 2 - 4 ). (frontiersin.org)
These findings indicate that GSOs protect against GLU-induced neuronal oxidative damage through Nrf2/HO-1 activation. (sdbonline.org)

During the last decade, a massive amount of a new type of characteristics, that are exclusively genomic in nature, became available that allows us to analyze the inherited whole-genome demographics of extant human, especially in the fields such as human genetics, health sciences and medical practices (e.g., 1,2,3), where such health-related characteristics can be related to whole-genome-based categorization. (bvsalud.org)

The antioxidant property of myo-inositol hexakisphosphate is important in the prevention of hydroxyl radical formation which may allow it to act as a 'safe' carrier of iron within the cell. (aston.ac.uk)

There was more than a 10-fold difference between the ED50 for PGE1 at cyclic AMP formation (70 nM) and its ED50 values at IP accumulation (1 microM), cyclic GMP formation (2 microM), and [Ca2+]i increase (5 microM). (shengsci.com)

Esophageal cancer is the fifth leading cause of cancer death for male and eighth for female in developing countries [ 1 ]. (oncotarget.com)

Phytic acid (myo-inositol hexaphosphate, IP6) is a naturally occurring carbohydrate widely found in fi berrich foods and also contained in almost all mammalian cells. (edu.pl)

3. The enzyme hydrolyses both enantiomers of myo-inositol 1-phosphate and both enantiomers of myo-inositol 4-phosphate, but has no activity towards inositol bisphosphates, inositol trisphosphates or inositol 1,3,4,5-tetrakisphosphate. (port.ac.uk)
5. The enzyme requires Mg2+ for activity, and Zn2+ supports activity to a small extent. (port.ac.uk)
1: Sánchez DA, Tonetto GM, Ferreira ML. Screening of Lipases with Unusual High Activity in the sn-2 Esterification of 1,3-Dicaprin under Mild Operating Conditions. (medkoo.com)
Using ARD1 truncations, it appears that amino acids 101-190 are critical for GAP activity, whereas residues 190-333 are involved in physical interaction between the two domains of ARD1 and are required for GTP hydrolysis. (embl.de)
Here, the hypothesis that the recently discovered natural product, myo-inositol 1,2,3-trisphosphate represents the simplest structure to mimic phytate's antioxidant activity has been tested. (aston.ac.uk)
The antioxidant properties of the IP6 at various concentrations (1-500 μM) have been evaluated by using the assays based on hydrogen peroxide scavenging and ferrous metal ions chelating activity determination. (edu.pl)

The two well-established cyclic nucleotides are adenosine-3',5'-cyclic monophosphate (cyclic AMP) and guanine-3',5'-cyclic monophosphate (cyclic GMP). (pancreapedia.org)
The non-canonical cyclic nucleotides include the purines inosine-3',5'-cyclic monophosphate (cyclic IMP), xanthosine-3',5'-cyclic monophosphate (cyclic XMP) and the pyrimidines cytidine-3',5'-cyclic monophosphate (cyclic cCMP), uridine-3',5'-cyclic monophosphate (cyclic UMP), and thymidine-3',5'-cyclic monophosphate (cTMP) (145). (pancreapedia.org)

Anatomy24

Organisms14

Chemicals and Drugs154

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes39

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care1

Diacylglycerol11

Phospholipase9

Phosphates6

Receptor20

Receptors5

Triphosphate4

Inhibitor3

Proteins6

Monophosphatase4

Kinase11

Evaluated by measuring int1

Enzymes3

Inhibits2

Intracellular3

Substrates1

PtdIns1

Lipids1

PIP23

Abstract2

Synaptic1

Lipid2

Inhibition2

20231

Compounds1

Humans1

Isoform1

Pathway2

Binds2

Protein3

Membrane4

Catalyzes1

Stimulation2

Stimulates1

Glycerol3

Stereoselective2

Synthesis3

Activation4

Genetics1

Hydroxyl1

Accumulation1

Cancer1

Carbohydrate1

Activity6

Cyclic2