• TRPML1-mediated lysosomal calcium release can also dephosphorylate TFEB and promote its nuclear translocation and regulate lysosome biogenesis, autophagy, and lipid metabolism. (biomedcentral.com)
  • Lysosome biogenesis in health and disease. (uni-bielefeld.de)
  • Lysosomes function as an intracellular signal transduction platform. (biomedcentral.com)
  • Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
  • 1) Materials can be recycled to the plasma membrane by Rab11-positive recycling endosomes. (biomedcentral.com)
  • 2) The remaining contents will be sequestered in Rab7-positive late endosomes, which can fuse with the plasma membrane to form exosomes. (biomedcentral.com)
  • 5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)
  • Lysosomes in nutrient signalling: A focus on pancreatic β-cells. (uni-bielefeld.de)
  • RESULTS: Pancreatic levels of Rab9 and its membrane-bound (active) form decreased in rodent pancreatitis models and in human disease. (bvsalud.org)
  • Emerging evidence suggests that lysosomes may also be the cellular center for intracellular transport (Fig. 1 ), signaling (Fig. 2 ), and metabolism. (biomedcentral.com)
  • In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
  • Comprehensive proteome analysis of lysosomes reveals the diverse function of macrophages in immune responses. (uni-bielefeld.de)
  • The combination of growth factors and RTKs can activate the PI3K/AKT signaling pathway and negatively regulate TSC1/2, promoting Rheb to become GTP loaded, which can activate mTORC1. (biomedcentral.com)
  • The uncoated transport vesicles can fuse with autophagosome or heterophagosome to form autophagolysosome, heterophagic lysosome or phagolysosome. (biomedcentral.com)
  • It may also function in the protection, maintenance, and adhesion of the lysosome. (wikipedia.org)
  • This suggests that the three glycoproteins are involved in tumor development, specifically in the processes of angiogenesis and tissue remodeling. (wikipedia.org)
  • Therefore, identifying the factors and mechanisms that regulate the functional status and spatial distribution of lysosomes and elucidating the relationship between lysosomes and the development and progression of cancer can provide important information for cancer diagnosis and prognosis prediction and may yield new therapeutic targets. (biomedcentral.com)
  • Lysosomes are cell organelles found in most animal cells. (wikipedia.org)
  • The two LAMP molecules act as ligands for the cell-adhesion molecules. (wikipedia.org)
  • In a study of glial tumors, the cell membranes of glial and endothelial cells were found to contain LAMP1 and LAMP2, while YKL-40 (a different glycoprotein) was found in the cytoplasm. (wikipedia.org)
  • This was caused by ethanol-induced upregulation of ATG4B, a cysteine protease that, cell dependently, regulates the balance between cytosolic LC3-I and membrane-bound LC3-II. (bvsalud.org)
  • This study briefly reviews the above information and explores the potential value of lysosomes in cancer therapy. (biomedcentral.com)
  • 2. Acting Administrator, Animal and Plant Health Inspection Service. (sfroundup.com)
  • These hydrolyses are stored in the lysosomal membrane, which also house lysosomal membrane glycoproteins. (wikipedia.org)
  • LAMP1 and LAMP2 make up about 50% of lysosomal membrane glycoproteins. (wikipedia.org)
  • In each disorder, a deficiency of a lysosomal hydrolase is inherited, which leads to lysosomal accumulation of the enzyme's specific sphingolipid substrate. (medscape.com)
  • Co-localization of conidia expressing green fluorescent protein with proteins present in the early endosomal (CD71) and lysosomal (CD63, LAMP-1) membrane was assessed using confocal microscopy. (silverchair.com)
  • PMID- 5157720 TI - 1-Hydroxy-3-amino-pyrrolidone-2(HA-966): a new GABA-like compound, with potential use in extrapyramidal diseases. (nih.gov)
  • This suggests that the three glycoproteins are involved in tumor development, specifically in the processes of angiogenesis and tissue remodeling. (wikipedia.org)
  • Lysosomes are cell organelles found in most animal cells. (wikipedia.org)
  • They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)
  • In a study of glial tumors, the cell membranes of glial and endothelial cells were found to contain LAMP1 and LAMP2, while YKL-40 (a different glycoprotein) was found in the cytoplasm. (wikipedia.org)
  • In J774 cells, 75% of internalized conidia were found in phagosomes containing LAMP-1 120 minutes post-infection. (silverchair.com)
  • In A549 cells, 55% and 58% of internalized conidia were found to co-localize with LAMP-1 and CD63 by 24 hours. (silverchair.com)