Chemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHealth Care
ParoxetineAntidepressive Agents, Second-GenerationFluvoxamineAntidepressive AgentsTrazodoneGuanidineCytochrome P-450 CYP2D6Serotonin Plasma Membrane Transport ProteinsAntidepressive Agents, TricyclicTrimethylsilyl CompoundsCyclohexanolsSertralineCitalopram1-NaphthylamineSerotoninDouble-Blind MethodImipramineNordefrinAmitriptylineSerotonin AntagonistsDrug InteractionsGuanidinesClomipramineAgoraphobiaPanic DisorderDepressive DisorderNortriptylineDesipramineDelayed-Action PreparationsReceptors, Serotonin, 5-HT2
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Hemihydrate10
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Antidepressant6
  • Loxamine (Paroxetine Hydrochloride) is similar to other antidepressant medicine in that it may increase the risk of suicidal thoughts in some patients. (unitedpharmacies.com)
  • The 2008 meta-analysis combined 35 clinical trials submitted to the Food and Drug Administration (FDA) before licensing of four newer antidepressants (including the SSRIs paroxetine and fluoxetine, the non-SSRI antidepressant nefazodone, and the serotonin and norepinephrine reuptake inhibitor (SNRI) venlafaxine). (wikipedia.org)
  • Paroxetine hydrochloride (PHH) is the most potent antidepressant used for MDD treatment. (cupdf.com)
  • Paroxetin Hydrochloride is a selective serotonin reuptake inhibitor antidepressant. (fujifilm.com)
  • Talk to your child's doctor about these risks and whether your child should take an antidepressant, Children younger than 18 years of age should not normally take paroxetine, but in some cases, a doctor may decide that paroxetine is the best medication to treat a child's condition. (pharmstore.com)
  • Paroxetine (Paxil) is a widely used selective serotonin reuptake inhibitor antidepressant that is indicated for the treatment of major depressive disorder, obsessive compulsive disorder, panic disorder, generalized anxiety disorder, social anxiety disorder, and post-traumatic stress disorder. (aspetjournals.org)
Ligne paroxetine2
Viagra14
Tablets USP7
  • Paroxetine tablets, USP are an orally administered psychotropic drug. (prescriptiondrugs.com)
  • Paroxetine tablets, USP are indicated for the treatment of social anxiety disorder, also known as social phobia, as defined in DSM-IV (300.23). (prescriptiondrugs.com)
  • Lesser degrees of performance anxiety or shyness generally do not require psychopharmacological treatment.The efficacy of paroxetine tablets, USP were established in three 12-week trials in adult patients with social anxiety disorder (DSM-IV). (prescriptiondrugs.com)
  • Paroxetine tablets, USP have not been studied in children or adolescents with social phobia (see CLINICAL PHARMACOLOGY - Clinical Trials). (prescriptiondrugs.com)
  • The effectiveness of paroxetine tablets, USP in long-term treatment of social anxiety disorder, i.e., for more than 12 weeks, has not been systematically evaluated in adequate and well-controlled trials. (prescriptiondrugs.com)
  • Therefore, the physician who elects to prescribe paroxetine tablets, USP for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient (see DOSAGE AND ADMINISTRATION). (prescriptiondrugs.com)
  • Tramadol hydrochloride tablets, USP are an opioid agonist. (nih.gov)
SSRI2
  • Loxamine (Paroxetine Hydrochloride) is classified as a selective serotonin reuptake inhibitor (SSRI). (unitedpharmacies.com)
  • One SSRI, paroxetine, has recently been approved by the US Food and Drug Administration (FDA) for the treatment of vasomotor menopausal symptoms (VMS), including hot flashes and night sweats that occur during the menopausal transition, at about one-third of the dose used to treat most psychiatric disorders. (bmj.com)
Antidepressants2
  • A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as paroxetine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). (pharmstore.com)
  • You should know that your mental health may change in unexpected ways when you take paroxetine or other antidepressants to treat depression or other mental illness even if you are an adult over 24 years of age. (pharmstore.com)
Paxil CR2
  • Paxil CR or the generic Paroxetine Controlled-Release is not a cure for depression or panic disorder, but it can help you to enjoy doing the things you used to do, like return to work/school, and attend family and social events. (discountdrugsfromcanada.com)
  • GlaxoSmithKline announced today the availability of Paxil CR (paroxetine hydrochloride controlled release) tablets in pharmacies across the United States. (news-medical.net)
Sertraline1
  • Paroxetine was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder, sertraline and fluvoxamine were later approved for it, too, escitalopram and citalopram are used off label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder. (wikipedia.org)
Crystalline1
  • Paroxetine hydrochloride, USP is an odorless, white to off-white crystalline powder, having a melting point range of 120° to 138°C. It is freely soluble in methanol, soluble in ethanol, sparingly soluble in dichloromethane and slightly soluble in water. (prescriptiondrugs.com)
Pharmacies4
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Pharmacy4
Depression9
  • Paroxetine hydrochloride is the active ingredient of Paxil, a prescription drug used to treat panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, posttraumatic stress disorder, renal-hepatic impairment, and depression (1). (chromatographyonline.com)
  • Paroxetine is used to treat depression, panic attacks, obsessive-compulsive disorder (OCD), anxiety disorders, and post-traumatic stress disorder. (tajgenerics.com)
  • Paroxetine-DP corrects the chemical imbalance and so helps to relieve the symptoms of depression. (mydr.com.au)
  • Paxil is the trade name of the medication paroxetine, which is prescribed to treat major depression and social anxiety , among other disorders. (drugwatch.com)
  • The phase IV clinical study analyzes which people take Paroxetine and have Depression. (ehealthme.com)
  • Do you take Paroxetine and have Depression? (ehealthme.com)
  • 6 Paroxetine is currently the only FDA-approved, non-hormonal treatment for VMS, although other SSRIs have also shown efficacy for this indication at standard doses used to treat depression. (bmj.com)
  • Morrow GR Hickok JT Roscoe JA Raubertas RF Andres PL Flynn PJ Hynes HE Banerjee TK Kirshner JJ King DK Differential effects of paroxetine on fatigue and depression: a randomized , double-blind trial from the University of Rochester Cancer Center Community Clinical Oncology Program J Clin Oncol 21: 4635-4641, 2003. (pharmacology2000.com)
  • You may also experience changes in your mental health if you are a woman taking a low dose of paroxetine to treat hot flashes and you have never had depression or another mental illness. (pharmstore.com)
Selective1
Synthroid1
Medication1
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Equivalent1
  • Equivalent or greater resolution of related compounds B, D, F, and G from paroxetine was achieved in a single chromatographic run in less than 5 min using an UHPLC system and a 50 mm × 2.1 mm,1.7-μm column. (chromatographyonline.com)
Active Ingredients2
Venta1
Clinical1
  • Saturation of this enzyme at clinical doses appears to account for the nonlinearity of paroxetine kinetics with increasing dose and increasing duration of treatment. (prescriptiondrugs.com)
Methyl1
  • The chemical name for tramadol hydrochloride is (±) cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride. (nih.gov)
Ingredients1
  • You have ever had an allergy to any medicine containing paroxetine hydrochloride or to any of the ingredients listed at the end of this leaflet (see Ingredients). (mydr.com.au)
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Kinetics2
  • We have predicted the pharmacokinetic consequences of CYP2D6 inactivation by paroxetine from in vitro inactivation kinetics ( k inact 0.17 min -1 , unbound K I 0.315 μM), in vivo inhibitor concentrations, and an estimated CYP2D6 degradation half-life of 51 h, using a mathematical model of mechanism-based inhibition. (aspetjournals.org)
  • The model-predicted accumulation ratio of paroxetine was 5 times that expected from single-dose kinetics and in excellent agreement with the observed 5- to 6-fold greater accumulation. (aspetjournals.org)
Prescription1
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Compound2
  • Approximately 64% of a 30-mg oral solution dose of paroxetine was excreted in the urine with 2% as the parent compound and 62% as metabolites over a 10-day post-dosing period. (prescriptiondrugs.com)
  • USP reference standards: USP Paroxetine Hydrochloride RS, USP Paroxetine System Suitability Mixture A RS, USP Paroxetine Related Compound B RS, USP Paroxetine Related Compound C RS, USP Paroxetine Related Compound E Mixture RS, USP Paroxetine Related Compound F RS, USP Related Compound G RS were all purchased from the United States Pharmacopeia (Rockville, Maryland). (chromatographyonline.com)
PRECAUTIONS1
  • The role of this enzyme in paroxetine metabolism also suggests potential drug-drug interactions (see PRECAUTIONS: Drugs Metabolized by CYP2D6). (prescriptiondrugs.com)
CYP2D66
  • The metabolism of paroxetine is accomplished in part by CYP2D6. (prescriptiondrugs.com)
  • Recent data have provided evidence for mechanism-based inactivation of CYP2D6 by paroxetine. (aspetjournals.org)
  • Magnitudes of interactions produced by paroxetine (20-30 mg/day) with desipramine, risperidone, perphenazine, atomoxetine, ( S )-metoprolol, and ( R )-metoprolol were predicted, considering the contribution of CYP2D6 to their oral clearance. (aspetjournals.org)
  • In summary, the scaling model for mechanism-based inactivation successfully predicted the pharmacokinetic consequences of CYP2D6 inactivation by paroxetine from in vitro data. (aspetjournals.org)
  • Paroxetine is an established perpetrator of drug-drug interactions (DDIs) when coadministered with agents whose clearance is largely dependent on the activity of cytochrome P450 2D6 (CYP2D6). (aspetjournals.org)
  • Paroxetine produced a concentration- and time-dependent inhibition of human liver microsomal CYP2D6 activity in vitro, as measured by dextromethorphan O -demethylation rate. (aspetjournals.org)
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Drug-drug interactions1
  • Attempts at predicting drug-drug interactions perpetrated by paroxetine from in vitro data have utilized reversible enzyme inhibition models and have been unsuccessful to date, grossly underpredicting interaction magnitude. (aspetjournals.org)
Side Effects5
Drugstore1
Prix1
Drugs3
  • You must not take Paroxetine-DP until 2 weeks after stopping monoamine oxidase inhibitor drugs (MAOIs). (mydr.com.au)
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  • Pharmaceutical interventions may consist of a regimen of modafinil, paroxetine hydrochloride, or dexamphetamine, among several other drugs. (ajmc.com)
Brand name4
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Indicated for the treatment1
Treatment3
  • If you become pregnant or intend to become pregnant while taking paroxetine, you should make an appointment to see your doctor and have your treatment reviewed. (mydr.com.au)
  • Your healthcare provider will want to see you often while you are taking paroxetine, especially at the beginning of your treatment. (pharmstore.com)
  • Diltiazem hydrochloride (DLH) is a calcium channel blocker useful for the treatment of angina pectoris, arrhythmia, and hypertension. (bvsalud.org)
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