SynthesisDerivativesAcyl hydrazonesHybridsMolecularAntimicrobialComplexesAgonistsPyridineHydrazinesCompoundsAcidStructurePresenceTitleGive hydrazonesDerivatives bearingPyrazolinesPotentCompoundsDerivativeHeterocyclicThiazoleChalconeArylLigandsCoumarinSynthesis of newIonsInhibitorsAldehydesAnti-inflammatoryReactionHydrazineYieldBiological evaluationActivitiesActivityFormMethodsStudyEvaluationRangeMetal
Synthesis9
- Bingul, The design of novel 4,6-dimethoxyindole based hydrazide-hydrazones: Molecular modeling, synthesis and anticholinesterase activity, J. Mol. (dntb.gov.ua)
- Rohane, Synthesis and in vitro antimycobacterial potential of novel hydrazones of eugenol, Arab. (dntb.gov.ua)
- Al-Sodies, Microwave and conventional synthesis of ester based dicationic pyridinium ionic liquids carrying hydrazone linkage: DNA binding, anticancer and docking studies, J. Mol. (dntb.gov.ua)
- Xavier, Synthesis and spectral characterisation of hydrazone based 14-membered octaaza macrocyclic Ni (II) complexes, J. Chem. (dntb.gov.ua)
- Zheng, Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells, Bioorg. (dntb.gov.ua)
- The present work involves the design and synthesis of some novel acyl hydrazone based molecular hybrids of 1,4-dihydropyridine and pyrazole ( 5a - g ). (biomedcentral.com)
- Electrophilic cyclizations of alpha,beta-alkynic hydrazones by molecular iodine were investigated for the synthesis of 4-iodopyrazoles. (metu.edu.tr)
- Synthesis and biological evaluation of 1, 3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. (ufv.br)
- Synthesis, characterization, anti-ulcer action and molecular docking evaluation of novel benzimidazole-pyrazole hybrids. (ufv.br)
Derivatives3
- The 1H-pyrazole-3-carboxylic acid 2, obtained from the furan-2,3-dione 1 and N-Benzylidene-N'-(3-nitrophenyl) hydrazine, was converted via reactions of its acid chloride 3 with various alcohols or N-nucleophiles into the corresponding ester or amide derivatives 4 or 5, respectively. (yyu.edu.tr)
- Nitrile 6 and anilino-pyrazole acid 7 derivatives of 2 were also obtained by dehydration of 5a in a mixture of SOCl2 with DMF and reduction of 2 with sodium polysulphide, respectively. (yyu.edu.tr)
- The treatment of benzylidenemalononitriles with phenylhydrazines in refluxing ethanol did not provide pyrazole derivatives, but instead furnished hydrazones. (bvsalud.org)
Acyl hydrazones2
- Acyl hydrazones are an important class of heterocyclic compounds promising pharmacological characteristics. (biomedcentral.com)
- Title: Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. (aablocks.com)
Hybrids3
- Coumarin pyrazole hybrids have been synthesized from hydrazones, carbazones and thiocarbazones via Vilsmeier Haack formylation reaction. (wikipedia.org)
- These molecular hybrids were synthesised by condensation of 1,4-dihydropyridin-4-yl-phenoxyacetohydrazides with differently substituted pyrazole carbaldehyde. (biomedcentral.com)
- Therefore here in this study, we have decided to construct the molecular hybrids based on 1,4-DHP and pyrazole moieties using acyl hydrazone linkage which may possibly circumvent the antiplasmodial drug resistance (Fig. 1 ). (biomedcentral.com)
Molecular1
- When treated with molecular iodine in the presence of sodium bicarbonate, alpha,beta-alkynic hydrazones underwent electrophilic cyclization to afford 4-iodopyrazoles in good to high yields. (metu.edu.tr)
Antimicrobial1
- There has been considerable interest in the development of novel compounds with antimicrobial, anti-mycobacterial, and antiviral activities etc. keeping Hydrazones as a centre attraction this review has been carried forward. (ajrconline.org)
Complexes1
- Title: Spectroscopic, and thermal studies of some new binuclear transition metal(II) complexes with hydrazone ligands containing acetoacetanilide and isoxazole. (aablocks.com)
Agonists1
- Pyrazoles act as agonists, which were re-examined using the ER-LBD-DES (agonist) structure. (researchbib.com)
Pyridine1
- The reaction of 2 with 2-hydrazino-pyridine provided hydrazono-pyrazole acid derivative 10, which was decarboxylated to give hydrazono-pyrazole derivative 11. (yyu.edu.tr)
Hydrazines1
- alpha,beta-Alkynic hydrazones were readily prepared by the reactions of hydrazines with propargyl aldehydes and ketones. (metu.edu.tr)
Compounds1
- Hydrazone possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. (ajrconline.org)
Acid1
- In this method, hydrazones are formed as intermediates, which can be subsequently cyclized to 2-Pyrazolines in the presence of a suitable cyclizing reagent like acetic acid. (researchbib.com)
Structure1
- The structure of hydrazones was secured by X-ray analysis. (bvsalud.org)
Presence1
- Iodocyclization was general for a wide range of alpha,beta-alkynic hydrazones and tolerated the presence of aliphatic, aromatic, heteroaromatic, and ferrocenyl moieties with electron-withdrawing and electron-donating substituents. (metu.edu.tr)
Title1
- Title: The ligational behavior of an isatinic quinolyl hydrazone towards copper(II)- ions. (aablocks.com)
Give hydrazones1
- Hydrazine, organohydrazines, and 1,1-diorganohydrazines react with aldehydes and ketones to give hydrazones. (wikipedia.org)
Derivatives bearing1
- 3. Design, synthesis and antitumor activity of Novel Sorafenib derivatives bearing pyrazole scaffold. (nih.gov)
Pyrazolines2
Potent6
- Our group has disclosed that pyrazole benzamides display potent antibacterial and anti-tubercular activities. (nih.gov)
- 23. Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors. (nih.gov)
- 2. Design, Synthesis, and Biological Evaluation of Novel Thiazolyl Substituted Bis-pyrazole Oxime Derivatives with Potent Antitumor Activities by Selectively Inducing Apoptosis and ROS in Cancer Cells. (nih.gov)
- 5. Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents. (nih.gov)
- 16. Design and synthesis of new potent anticancer pyrazoles with high FLT3 kinase inhibitory selectivity. (nih.gov)
- To the best of our knowledge, BPR1P0034 is the first pyrazole-based anti-influenza compound ever identified and characterized from high throughput screening to show potent (sub-μM) antiviral activity. (biomedcentral.com)
Compounds10
- Hydrazones are a class of organic compounds with the structure R1R2C=N−NH2. (wikipedia.org)
- Hydrazones are reactants in hydrazone iodination, the Shapiro reaction, and the Bamford-Stevens reaction to vinyl compounds. (wikipedia.org)
- 28. Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies. (nih.gov)
- 3- Cyano pyridone derivatives were synthesized by treating 1-(4-bromophenyl)-3-(4-(dimethyl amino) phenyl) prop-2-en-1-one with compounds containing active methylene group in the presence of ammonium acetate. (tsijournals.com)
- Therefore,a series of novel myrtenal-based thiazole-hydrazone bioactive compounds can be synthesized by incorporating both thiazole and hydrazone active blocks into the myrtenal skeleton with an attempt to provide a new pathway for the modification and high-value utilization of α-pinene which is a natural and preponderant forest resource in China. (linyekexue.net)
- Then, myrtenal-based thiosemicarbazone was prepared by the condensation reaction of myrtenal with thiosemicarbazide, followed by the reaction of myrtenal-based thiosemicarbazone with a series of substituted α-bromoacetophenones to yield sixteen myrtenal-based thiazole-hydrazone compounds 4a-4p which have not been reported in the literature. (linyekexue.net)
- Result] Sixteen novel myrtenal-based thiazole-hydrazone target compounds were synthesized.At 50 mg·L -1 , the antifungal activity test showed that all the target compounds exhibited to certain degree antifungal activity against Rhizoctonia solani,Fusarium oxysporum f. sp. (linyekexue.net)
- Conclusion] A series of novel myrtenal-based thiazole-hydrazone compounds were synthesized. (linyekexue.net)
- Synthesis and Antifungal Activity of Novel Myrtenal-Based Thiazole-hydrazone Compounds[J]. Scientia Silvae Sinicae, 2017, 53(12): 93-101. (linyekexue.net)
- Ten pharmacologically and synthetically important ( E )-3-(dimethylamino)-1-arylprop-2-en-1-ones (enaminones 4a-j ) were chosen as model compounds for this study. (hindawi.com)
Derivative3
- This compound than resulted in hydrazine derivative and finally converted into aromatic hydrazones. (nih.gov)
- 2. A process for the synthesis of a pyrazole derivative: Inventor- Avijit Kumar Paul , Nikhil Kumar and Shubhangi. (nitkkr.ac.in)
- Periodate-oxidized antibody was treated with PDPH to yield a hydrazone derivative. (bocsci.com)
Heterocyclic1
- 4. Uses of cyanoacetylhydrazine in heterocyclic synthesis: novel synthesis of pyrazole derivatives with anti-tumor activities. (nih.gov)
Thiazole1
- 10. Reaction of pregnenolone with cyanoacetylhydrazine: novel synthesis of hydrazide-hydrazone, pyrazole, pyridine, thiazole, thiophene derivatives and their cytotoxicity evaluations. (nih.gov)
Chalcone1
- Also some pyrazole derivatives have been synthesized via the interaction of the chalcone with hydrazine hydrate. (tsijournals.com)
Aryl1
- Hydrazones can also be synthesized by the Japp-Klingemann reaction via β-keto-acids or β-keto-esters and aryl diazonium salts. (wikipedia.org)
Ligands1
- A enneanuclear nanocage, [Ni 9 (HL) 6 (Pz) 6 ](PzH) 3 (ClO 4 ) 3 (H 2 O) 24 ( 1 ), has been synthesized by coordination-driven face-directed self-assembly of octahedral Ni(II) ions and asymmetric hydrazone ligands with addition of pyrazole in ethanol solution. (figshare.com)
Coumarin3
- 36. Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX. (nih.gov)
- The synthesis of coumarin derivatives containing pyrazole, pyrazolone, thiazolidin-4-one, 5-carboxymethyl-4-thiazolidinone and 3-acetyl-1,3,4-oxadiazole ring is reported. (sagepub.com)
- Keywords: pyrazole, pyrazolone, thiazolidin-4-one, oxadiazole, antioxidant activity Acceptrd April 3, 2009 Coumarin derivatives possess a wide spectrum of biological activities (1-3). (sagepub.com)
Synthesis of new2
Ions1
- Effect of temperature on formation constants of 2 acetylpyridine(N benzoyl)glycine hydrazone with lanthanide(III) ions at different ionic strengths are reported. (researchgate.net)
Inhibitors1
- 21. Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study. (nih.gov)
Aldehydes2
- Hydrazones are the basis for various analyses of ketones and aldehydes. (wikipedia.org)
- First of all, condensation reactions of acetohydrazide with different aldehydes were carried out, 7 hydrazones were obtained. (ktu.lt)
Anti-inflammatory2
- 30. New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies. (nih.gov)
- 33. Non-acidic 1,3,4-trisubstituted-pyrazole derivatives as lonazolac analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile. (nih.gov)
Reaction1
- Hydrazones are converted to azines when used in the preparation of 3,5-disubstituted 1H-pyrazoles, a reaction also well known using hydrazine hydrate. (wikipedia.org)
Hydrazine1
- When derived from hydrazine itself, hydrazones condense with a second equivalent of a carbonyl to give azines: R2C=N−NH2 + R2C=O → R2C=N−N=CR2 + H2O Hydrazones are intermediates in the Wolff-Kishner reduction. (wikipedia.org)
Yield1
- Hydrazones were obtained in 76-78% yield via condensation of (2S,5R)-2-isopropyl-5-methylcyclohexanone with 4-R-phenoxyacetic acid hydrazides in the presence of a catalytic amount of glacial acetic acid. (hacettepe.edu.tr)
Biological evaluation2
- 22. Design, synthesis, cyclooxygenase inhibition and biological evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing amino/methanesulfonyl pharmacophore. (nih.gov)
- 15. Design, synthesis and biological evaluation of 1,3-diphenyl-1H-pyrazole derivatives containing benzimidazole skeleton as potential anticancer and apoptosis inducing agents. (nih.gov)
Activities2
- Pyrazole derivatives have been reported to possess numerous pharmacological activities viz. (nih.gov)
- 2. Reddy, K.K., S. Rao, and B.S. Rao (2015), Synthesis and characterization and biological activities of hydrazones. (ajrconline.org)
Activity1
- Also, it is well documented that pyrazoles, pyrazolin-5-ones, 4-thiazolidinones and 1,3,4-oxadiazoles display pronounced antioxidant (4-6) and antineoplastic activity (7-10). (sagepub.com)
Form2
- Phenylhydrazine reacts with reducing sugars to form hydrazones known as osazones, which was developed by German chemist Emil Fischer as a test to differentiate monosaccharides. (wikipedia.org)
- 4-Methylcoumarinyl-7-oxyacetic acid hydrazide (1) reacted with arylazopropanes or hydrazono-3-oxobutyrate derivatives to form pyrazole (3a-c) and pyrazolone derivatives (5a-c). (sagepub.com)
Methods1
- Hydrazone-based coupling methods are used in medical biotechnology to couple drugs to targeted antibodies (see ADC), e.g. antibodies against a certain type of cancer cell. (wikipedia.org)
Study1
- Ten substituted ( E )-3-(dimethylamino)-1-arylprop-2-en-1-ones (enaminones) were selected for this comparative study. (hindawi.com)
Evaluation1
- 18. Some pyrazole and pyrazolo[3,4-d]pyrimidine derivatives: synthesis and anticancer evaluation. (nih.gov)
Range1
- Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straight-forward synthetic route has been developed for a range of pyrazole fused gamma-pyrone derivatives. (hacettepe.edu.tr)
Metal1
- With a transition metal catalyst, hydrazones can serve as organometallic reagent surrogates to react with various electrophiles. (wikipedia.org)