Humans polymerase factor. Medical search. Frequent questions

Depending on the organism, a RNA polymerase can be a protein complex (multi-subunit RNAP) or only consist of one subunit (single-subunit RNAP, ssRNAP), each representing an independent lineage. (wikipedia.org)
RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. (wikipedia.org)
hPaf1/PD2, a subunit of the human PAF-complex, involved in the regulation of transcriptional elongation has oncogenic potential. (nebraska.edu)
Human transcription factor IIIC box B binding subunit. (nih.gov)
Trifunctional enzyme subunit beta, mitochondrial (TP-beta) also known as 3-ketoacyl-CoA thiolase , acetyl-CoA acyltransferase , or beta-ketothiolase is an enzyme that in humans is encoded by the HADHB gene . (wikidoc.org)

Promoter selectivity is mediated by SL1/TIF-IB, a multiprotein complex containing the TATA-binding protein (TBP) and TBP-associated factors (TAFs) which bind to DNA and nucleate the assembly of initiation complexes. (prinsesmaximacentrum.nl)
Core, L. J., Waterfall, J. J. & Lis, J. T. Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. (nature.com)
Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation from RNA polymerase III promoter. (nih.gov)
Therefore, TGF-β2 could be a factor in the initiation of the modification of ECM in the glaucomatous ONH. (arvojournals.org)
GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)

Olaparib is a type of drug called a PARP (poly [adenosine diphosphate-ribose] polymerase) inhibitor. (cancersa.org.au)
Several main apoptotic indicators were found in GS-002-treated cells, such as the cleaved forms of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP). (hindawi.com)

Using a human cell line that expresses epitope-tagged yeast TBP, we have isolated a chimeric complex consisting of yeast TBP and human TAFs which faithfully promotes human rDNA transcription in vitro. (prinsesmaximacentrum.nl)
Various antimicrobial factors present in human milk were tested for in-vitro antiviral activity against three rhinoviruses (two clinical isolates and rhinovirus 2) and an isolate of cytomegalovirus (CMV) from human milk. (microbiologyresearch.org)
We demonstrate that this selective regulation of RNA polymerase II phosphorylation state exists within human cells, consistent with in vitro assays. (rcsb.org)
In this study, we examined the antitumor effects of GS-002 in human hepatoma Hep3B and HepG2 cells in vitro . (hindawi.com)
Its principle is based on the use of DNA polymerase which is an in vitro replication of specific DNA sequences. (intechopen.com)

This TF induction was dependent on signal transducer and activator of transcription-6 signaling and poly ADP ribose polymerase activity. (haematologica.org)

Type-specific polymerase chain reaction (PCR) for HPV types 16 and 18 and general primer PCR (GP5+/6+) was performed on DNA extracted from paraffin-embedded tissue from women with lesions or fresh material from controls. (nih.gov)
Quantitative analysis by the polymerase chain reaction. (jci.org)
To demonstrate the presence of components of local RASs in humans we used the polymerase chain reaction (PCR) after reverse transcription to detect renin- angiotensinogen-, and angiotensin-converting enzyme-mRNA in small quantities of human tissues. (jci.org)
LACDPH concluded that the outbreak was caused by Using multiplex polymerase chain reaction assay (BioFire Diagnostics, LLC). (cdc.gov)
In a Polymerase Chain Reaction (PCR) array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of STAT3. (cdc.gov)
Taniguchi and colleagues reported that while hOvol1 and hOvol2 were detected by reverse transcription-polymerase chain reaction (RT-PCR) in the testes of patients capable of spermatogenesis, they were not detected in those with Sertoli cell-only syndrome. (medscape.com)
The activity of the NLRP3/caspase‑1 inflammasome was assessed via western blot analysis, immunofluorescence, reverse transcription‑quantitative polymerase chain reaction and ELISA. (spandidos-publications.com)
In this study we used real-time reverse transcriptase polymerase chain reaction to evaluate erbB-2 expression in seven canine OSA cell lines and 10 canine OSA tissue samples. (cdc.gov)
Polymerase chain reaction (PCR) was invented by Mullis in 1983 and patented in 1985. (intechopen.com)
It has affinity for viral thymidine kinase, and, once phosphorylated, it causes DNA chain termination when acted on by DNA polymerase. (medscape.com)
METHODS: : The entire CDKN2A coding region and exon 2 of the CDK4 gene of an affected member of each of 52 families from southern Sweden with at least two cases of melanoma in first- or second-degree relatives were screened for mutations by use of polymerase chain reaction-single-strand conformation polymorphism analysis. (lu.se)
Diagnosis is by serologic tests, histopathology, or polymerase chain reaction (PCR). (msdmanuals.com)

However in contrast to genes transcribed by RNA polymerases II and III, ribosomal gene transcription by RNA polymerase I (Pol I) is species-specific. (prinsesmaximacentrum.nl)
Most genes are associated with factors that establish and release paused Pol II and therefore appear to progress through this step, although only a subset of genes appears to be directly regulated by pausing. (nature.com)
Although pausing has been connected to extremely rapid and synchronous activation of genes, pausing is also highly associated with constitutively expressed genes that encode signalling and transcription factors. (nature.com)
Distinct signals that act through diverse targeted transcription factors can regulate different steps in the transcription pathway and provide a highly modulated transcriptional response at individual genes. (nature.com)
Here we review the most recent advancements on C. concisus and other human hosted Campylobacter species including their clinical relevance, transmission, virulence factors, disease associated genes, interactions with the human immune system and pathogenic mechanisms. (frontiersin.org)
Presenting the genes of the human genome in their biological context, Guide to the Human Genome is an extensive online resource (also available in print) that provides easy access to information about human genes and their roles in specific processes. (cshlpress.com)
In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. (cshlpress.com)
The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. (wikidoc.org)
With a kinetic modeling approach we ascribe function to the observed OCT4-SOX2-NANOG network by making plausible assumptions about the interactions between the transcription factors at the gene promoter binding sites and RNA polymerase (RNAP), at each of the three genes as well as the target genes. (lu.se)

RNA polymerase II synthesizes precursors of mRNAs and most sRNA and microRNAs. (wikipedia.org)
Previous studies have demonstrated that microRNAs (miRs) serve important roles in the progression of human cancer types, including pancreatic cancer (PC), a highly lethal malignancy. (spandidos-publications.com)
Yao and colleagues found 174 microRNAs (miRNAs) were differentially expressed in human Sertoli cells in men with SCO syndrome compared with men with obstructive azoospermia, suggesting that these miRNAs may be associated with the pathogenesis of SCO syndrome. (medscape.com)

In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that catalyzes the chemical reactions that synthesize RNA from a DNA template. (wikipedia.org)
After transcription starts, the factor can unbind and let the core enzyme proceed with its work. (wikipedia.org)
Human bocavirus (HBoV) is a recently discovered parvovirus associated with mild to severe lower respiratory tract infections in children, the aim of the work was determination of human bocavirus in nasopharyngeal aspirate (NPA) of infants by qualitative PCR and determination of acute human bocavirus infection by estimation of immunoglobulin M (IgM) antibodies in serum by enzyme linked immunosorbent assay. (scienceopen.com)
Finally, we have studied the effect of a host factor, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), on HIV-1 RT. (umsystem.edu)

Eukaryotes have multiple types of nuclear RNAP, each responsible for synthesis of a distinct subset of RNA: RNA polymerase I synthesizes a pre-rRNA 45S (35S in yeast), which matures and will form the major RNA sections of the ribosome. (wikipedia.org)
Recent years have witnessed a sea change in our understanding of transcription regulation: whereas traditional models focused solely on the events that brought RNA polymerase II (Pol II) to a gene promoter to initiate RNA synthesis, emerging evidence points to the pausing of Pol II during early elongation as a widespread regulatory mechanism in higher eukaryotes. (nature.com)
Transcription in eukaryotes is carried out by three main RNA polymerases: Pol I, II, and III. (mdpi.com)

These molecules inhibit HSV polymerase with 30-50 times the potency of human alpha-DNA polymerase. (medscape.com)

HADHB is a functional molecular target of ERα in the mitochondria, and the interaction may play an important role in the estrogen -mediated lipid metabolism in animals and humans. (wikidoc.org)

The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors. (nih.gov)
We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)

In most prokaryotes, a single RNA polymerase species transcribes all types of RNA. (wikipedia.org)
The nomenclature of different promoter-associated RNA polymerase II (Pol II) species is explicitly defined in an effort to provide consistency in future literature. (nature.com)
the Campylobacter species that cause human acute intestinal disease such as Campylobacter jejuni and Campylobacter coli originate from animals. (frontiersin.org)
Over the past decade, studies on human hosted Campylobacter species strongly suggest that Campylobacter concisus plays a role in the development of inflammatory bowel disease (IBD). (frontiersin.org)
In addition to C. concisus , humans are also colonized by a number of other Campylobacter species, most of which are in the oral cavity. (frontiersin.org)
Some of these animal hosted Campylobacter species, such as Campylobacter jejuni and Campylobacter coli , can cause acute bacterial gastroenteritis in humans through consumption of contaminated food or water ( Galanis, 2007 ). (frontiersin.org)
Several Campylobacter species utilize humans as their natural host and accumulated evidence supports their role in chronic inflammatory diseases of the human intestinal tract. (frontiersin.org)
Most of the studies on the human hosted Campylobacter species in the past decade were on Campylobacter concisus , this bacterium is therefore the focus of this review. (frontiersin.org)
In addition, other human hosted Campylobacter species were also reviewed. (frontiersin.org)
To date, 40 Campylobacter species and subspecies have been isolated from a wide variety of animal or human sources (Figure 1 ). (frontiersin.org)
They survive as commensal bacteria in their hosts, and some species, such as C. jejuni and C. coli , can cause human diseases. (frontiersin.org)
For each protein, basic characteristics about its composition and length, its human relatives and relatedness to proteins in other species, and direct links to resources at NCBI are included. (cshlpress.com)
Additional links to NCBI resources are provided for human noncoding RNAs and repeated DNA elements and for proteins of interest from other species. (cshlpress.com)
The entire text of the Guide is searchable, and tools are available for identifying human protein sequences using those from other species. (cshlpress.com)
Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and fibroblasts. (uib.no)
In addition, the activity of the nuclear factor erythroid 2‑related factor 2 (Nrf2) pathway was detected using western blotting, and the level of reactive oxygen species (ROS) was assessed by 2,7‑dichlorofluorescein fluorescence and flow cytometry. (spandidos-publications.com)

A transcription factor and its associated transcription mediator complex must be attached to a DNA binding site called a promoter region before RNAP can initiate the DNA unwinding at that position. (wikipedia.org)
In Escherichia coli bacteria, more than 100 transcription factors have been identified, which modify the activity of RNAP. (wikipedia.org)

RNA polymerase III synthesizes tRNAs, rRNA 5S and other small RNAs found in the nucleus and cytosol. (wikipedia.org)

Members who choose to subscribe to Human Mutation will receive a substantial discount. (hgvs.org)

In addition, Kayed et al ( 15 ) demonstrated that RUNX2 was overexpressed in PC and could be regulated by certain cytokines, including transforming growth factor β1 and bone morphogenetic protein 2. (spandidos-publications.com)
Phospholipase D activity in human platelets is inhibited by protein kinase A, involving inhibition of phospholipase D1 translocation. (uib.no)
Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription. (rcsb.org)
Only 1.5% of nucleic acids in human genome are used for protein encoding, but other 98.5% of the genome does not encode proteins. (jcancer.org)
E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)

As C. jejuni and C. coli are the main Campylobacter pathogens which cause human acute intestinal disease and they originate from animal sources, Campylobacteriosis has historically been considered to be zoonotic. (frontiersin.org)

For instance, H19 is the first lncRNA transcribed by RNA polymerase II and is expressed mainly in human embryonic cells. (jcancer.org)

The major risk factors include chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, environmental carcinogens such as aflatoxin B1 (AFB1), alcoholic cirrhosis, and inherited genetic disorder such as hemochromatosis, Wilson's disease, and tyrosinemia. (hindawi.com)
These recommendations were developed by the U.S. Public Health Service to address the increasing epidemic of human immunodeficiency virus (HIV) infection among women and their infants. (cdc.gov)
During the past decade, human immunodeficiency virus (HIV) infection has become a leading cause of morbidity and mortality among women, the population accounting for the most rapid increase in cases of acquired immunodeficiency syndrome (AIDS) in recent years. (cdc.gov)
The COVID-19 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a story about the numbers. (elifesciences.org)
ii) the characteristics of the infection of a single human host. (elifesciences.org)
7. Rarely, human infection results from blood transfusion or organ transplantation. (msdmanuals.com)

Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44). (uib.no)

Activation of tissue-specific gene expression of the components of the renin-angiotensin system (RAS) in humans may play an important role in cardiovascular regulation and pathophysiology. (jci.org)
and regulation of transcription by RNA polymerase II. (nih.gov)

To understand if polarization of macrophages can lead to a procoagulant macrophage subset we polarized human monocyte derived macrophages to a proinflammatory and an alternative activation state. (haematologica.org)
These results support a model in which, instead of a global enhancement of downstream enzymatic activities, proline isomerases selectively boost the activity of a subset of CTD regulatory factors specific for cis-proline. (rcsb.org)

In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. (haematologica.org)

In order to study changes of gene expression in small tissue samples (e.g., renal biopsies) obtained from patients, we established a competitive PCR assay for quantification of renin, using a 155-basepair deletion mutant of the human renin cDNA as an internal standard. (jci.org)
Using bioinformatics, a luciferase reporter assay and western blot analyses, the current study identified that runt‑related transcription factor 2 (RUNX2) was a target of miR‑205 in PC and overexpression of miR‑205 suppressed the expression of RUNX2. (spandidos-publications.com)
We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)

Usage information: Gene expression of the renin-angiotensin system in human tissues. (jci.org)
Gene expression of the renin-angiotensin system in human tissues. (jci.org)
Studies of human tissue RAS expression, however, have been limited by the lack of availability of sufficient amounts of fresh human tissues and a sensitive method for detecting specific mRNAs. (jci.org)
A number of studies have demonstrated that altered expression of miRs serves critical roles in human cancers by directly regulating cell behaviors ( 5 - 7 ). (spandidos-publications.com)
miR-205 expression in humans was validated by Landgraf et al ( 8 ), however, its role in tumor progression is contradictory ( 9 - 12 ). (spandidos-publications.com)
By contrast, miR-205 expression has been identified to be significantly increased in several human cancer types, including ovarian cancer, endometrial cancer and laryngeal squamous cell carcinoma, in which it was identified to function as an oncoprotein ( 10 , 11 , 13 ). (spandidos-publications.com)
Significant downregulation of β-defensin1 gene ( DEFB1 ) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)
both E2F1 and c-Myc are stimulating factors of H19 expression, and the H19 lncRNA functions as a downstream effector of c-Myc and E2F1 in tumor development and progression [ 11 ]. (jcancer.org)
In the present study, we investigated the effect of arsenite on the expression of TF in human aortic smooth muscle cells (HASMCs) and the underlying molecular mechanisms. (go.jp)
0001). Families with breast cancer also had a propensity for multiple melanomas in females, suggesting that a sex-dependent factor may modify the phenotypic expression of CDKN2A alterations. (lu.se)

The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Depart- ment of Health and Human Services, Atlanta, GA 30333. (cdc.gov)
An estimated 11% of residents ≥ 6 years in the US are seropositive, which indicates that they have been infected, and more than 60% of some populations in other regions have been infected (see Centers for Disease Control and Prevention: Epidemiology & Risk Factors ). (msdmanuals.com)

The latter is found in phages as well as eukaryotic chloroplasts and mitochondria, and is related to modern DNA polymerases. (wikipedia.org)
Eukaryotic and archaeal RNA polymerases have a similar core structure and work in a similar manner, although they have many extra subunits. (wikipedia.org)

Alternative polarization with interleukin-4 and IL-13 led to a macrophage phenotype characterized by increased tissue factor (TF) production and release and by an increase in extracellular vesicle production. (haematologica.org)
This study should provide the methodological basis for future studies of tissue RAS in human physiology and disease. (jci.org)
3 Moreover, perfusion of human anterior eye segments with TGF-β2 in concentrations comparable to those measured in the AH of patients with POAG resulted in an increase of IOP and an increase of ECM in the outflow tissue. (arvojournals.org)
Tissue factor (TF) is the initiator of the coagulation cascade, constitutively expressed in subendothelial cells such as vascular smooth muscle cells and initiating rapid coagulation when the vascular vessel is damaged. (go.jp)
Humans can become infected by ingesting undercooked meat containing tissue cysts. (msdmanuals.com)

The 2006 Nobel Prize in Chemistry was awarded to Roger D. Kornberg for creating detailed molecular images of RNA polymerase during various stages of the transcription process. (wikipedia.org)
Cloning of a human parvovirus by molecular screening of respiratory tract samples. (scienceopen.com)
The underlying molecular mechanisms and the responsible pathogenic factors leading to these changes in outflow resistance remain unknown. (arvojournals.org)

Runt-related transcription factor 2 (RUNX2), a member of the RUNX family, functions as a critical regulator for osteoblast differentiation ( 14 ). (spandidos-publications.com)
The researchers concluded that further investigation of Ovol1 and Ovol2 functions in human spermatogenesis might lead to a novel therapy. (medscape.com)

Understanding factors required for DNA replication will enrich our knowledge of this important process and potentially identify vulnerabilities that can be exploited in cancer therapy. (aacrjournals.org)
Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)

In February 1994, the National Institutes of Health announced interim results from a multicenter, placebo-controlled clinical trial (AIDS Clinical Trials Group {ACTG} protocol 076), indicating that administration of zidovudine (ZDV) to a selected group of pregnant women infected with human immunodeficiency virus (HIV) and to their newborns reduced the risk for perinatal HIV transmission by approximately two thirds. (cdc.gov)
The following persons either served as consultants at the workshop for developing the recommendations for HIV counseling and voluntary testing for pregnant women or were members of the U.S. Public Health Service Task Force on the Use of Zidovudine to Reduce Perinatal Transmission of Human Immunodeficiency Virus. (cdc.gov)
Recommendations of the U.S. Public Health Service Task Force on the Use of Zidovudine to Reduce Perinatal Transmission of Human Immunodeficiency Virus. (cdc.gov)
Human immunodeficiency virus (HIV) is divided into type 1 (HIV-1) and type 2 (HIV-2). (umsystem.edu)

Statistical data have shown that the amount of this factor is significantly increased in the AH of approximately 50% of patients with POAG. (arvojournals.org)
Both patients were hospitalized with sepsis due to pneumonia and had known risk factors for melioidosis. (cdc.gov)

Acetylases are now known to modify a variety of proteins, including transcription factors, nuclear import factors and alpha-tubulin. (embl-heidelberg.de)
The domains are well conserved from yeast to humans, and are also found in plant proteins. (mshri.on.ca)

We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs. (go.jp)

Lurbinectedin is under clinical development by Jazz Pharmaceuticals and currently in Phase II for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer). (pharmaceutical-technology.com)
According to GlobalData, Phase II drugs for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer) have a 49% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
Olaparib is also approved by US Food and Drug Administration (FDA), European Medicines Agency (EMA) and in other countries for treating women with BRCA-mutated, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer. (cancersa.org.au)
The status of the erbB-2 (human epidermal growth factor receptor 2/neu) proto-oncogene in canine osteosarcoma (OSA) has not been reported previously. (cdc.gov)

Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. (jci.org)
The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells. (nih.gov)
Human milk was also tested for antiviral activity against these viruses. (microbiologyresearch.org)
1991. Genetic activity of the human carcinogen sulphur mustard towards salmonella and the mouse bone marrow. (cdc.gov)
Interestingly, A3G had similar inhibitory activity against a related viral RT (from Moloney Murine Leukemia Virus), but no activity against DNA polymerase I. (umsystem.edu)

The FF domain is present in a variety of nuclear transcription and splicing factors, as well as the p190 family of RhoGAPs. (mshri.on.ca)

Primary human bronchial epithelial cells HBEp cells. (cdc.gov)
In the present study, we investigated the therapeutic potential of TRAIL in primary human glioma cells. (aacrjournals.org)
We established a stable culture model for isolated primary human glioma cells. (aacrjournals.org)

The Mediator complex directs signals from DNA-binding transcription factors to RNA polymerase (Pol) II. (nih.gov)
Despite this pivotal position, mechanistic understanding of Mediator in human cells remains incomplete. (nih.gov)
Collectively, our work positions human Mediator as a globally acting coactivator that selectively safeguards the functionality of cell type-specifying transcriptional networks. (nih.gov)

Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2. (oncotarget.com)
We previously created a rat model of cancer cachexia using MKN45cl85 and 85As2 cells derived from human gastric cancer. (oncotarget.com)

It can infect both animals and humans through direct contact with non-intact skin (such as cuts or wounds) or mucous membranes, inhalation, or ingestion. (cdc.gov)

Purification and characterization of two forms of human transcription factor IIIC. (nih.gov)

It is a synthetic alkaloid which targets RNA polymerase II. (pharmaceutical-technology.com)

To clarify the mechanism underlying the difference in the cachexia-inducing ability of these cells, we conducted DNA microarray analysis, focusing on cell proliferation and the production of leukemia inhibitory factor (LIF), a cachexia-inducing factor. (oncotarget.com)

Integrator binds Pol II and the pausing factors DSIF and NELF to exclude binding of the elongation factors SPT6 and PAF1 complex. (rcsb.org)

Classical polarization is usually associated with a proinflammatory response, including the increased production of tumor necrosis factor (TNF)-α, IL-1, and IL-6. (haematologica.org)
The antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in gliomas has thus far only been thoroughly established in tumor cell lines. (aacrjournals.org)

Ovol1 and Ovol2, a family of zinc finger transcription factors, are expressed in spermatocytes at the pachytene stage and are suggested to be critical regulators of pachytene progression in male germ cells. (medscape.com)

Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. (nih.gov)

dyspnea (63% vs 11%) and wheezing (75% vs 22%) were more common in children with human bocavirus. (bvsalud.org)

In the past 3 years, several novel respiratory viruses, including human metapneumovirus, severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and human coronavirus NL63, were discovered. (scienceopen.com)

C. concisus primarily colonizes the human oral cavity and some strains can be translocated to the intestinal tract. (frontiersin.org)

Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)

Anatomy12

Organisms23

Diseases3

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes80

Disciplines and Occupations1

Information Science4

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Chain12

Genes9

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Inhibit1

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Regulates2

Species16

RNAP2

RRNA1

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Protein5

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Infection6

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Regulation2

Subset2

Monocytes1

Assay3

Expression10

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Tissue5

Molecular3

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Immunodeficiency virus4

Patients2

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Animals and humans1

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