• cells
  • 18 , 19 NF-κB activity can also be elevated by several stress factors in human pancreatic cancer cells, such as hypoxia, acidosis, nitric oxide and proinflammatory cytokines. (wiley.com)
  • Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. (wikipedia.org)
  • Whereas some cells (for example, cardiac and skeletal muscle fibers, CNS neurons) last a lifetime, others (for example, epithelial and glandular cells, erythrocytes) have limited life-spans, at the end of which they are genetically programmed for self-destruction by apoptosis, usually to be replaced by others formed by mitosis from surviving cells. (thefreedictionary.com)
  • Apoptosis also plays an essential role in morphogenesis and tissue homeostasis by eliminating transitory organs and tissues (for example, pronephros and mesonephros) and cells formed in excess of bodily needs during embryogenesis, as well as cells that have been damaged or virally infected. (thefreedictionary.com)
  • Nevertheless, these JCV-infected cells show a low level of apoptosis, at both the early and late stages of infection. (sigmaaldrich.com)
  • These data show how parallel apoptotic pathways act together to suppress MYC-induced transformation, and how mutant MYC proteins, by selectively disabling a p53-independent pathway, enable tumour cells to evade p53 action during lymphomagenesis. (diva-portal.org)
  • Cells become resistant to oxidant-induced apoptosis when Cys to Ala cofilin mutants are over-expressed. (aacrjournals.org)
  • Moreover, over-expression of wild-type cofilin causes a 2-fold increase in the sensitivity of cells to oxidant-induced apoptosis. (aacrjournals.org)
  • Factors that regulate the induction of apoptosis of tumour cells are potential candidates for therapeutic intervention for the majority of cancers. (ox.ac.uk)
  • However we show that some observed effects, which appear to support the hypothesis that OPG prevents TRAIL-induced apoptosis of tumour cells, may be due to variation of the TRAIL response of sub-clones of tumour cells, even within a cloned population. (ox.ac.uk)
  • The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. (nih.gov)
  • Results show that Cks1 and Cks2 promoted proliferation and prevented apoptosis of hepatocellular carcinoma HepG2 cells. (nih.gov)
  • Title: Depletion of Cks1 and Cks2 expression compromises cell proliferation and enhance chemotherapy-induced apoptosis in HepG2 cells. (nih.gov)
  • Increased expression levels of the Ifi202 mRNA and nuclear localization of p202 protein in immune cells are associated with the development of autoimmunity in certain strains of mice. (wikipedia.org)
  • Using in B6.Nba2 lupus susceptible mice as the animal model, researchers were able to show increased expression of Ifi202 inhibits p53-mediated apoptosis of splenic B cells. (wikipedia.org)
  • Overexpression of p202 in cells decreased the p53 mediated apoptosis. (wikipedia.org)
  • A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells. (wikipedia.org)
  • Through her work with two genera of retroviruses, Quackenbush determined mutations to Gammaretrovirus (feline leukemia virus) makes them less lethal, and Epsilretrovirus (walleye dermal sarcoma virus) contains sequences that encode for cyclin proteins, leading to the proliferation of normal cells and eventually giving a means for cancer cells to become abundant Her most notable work focuses on feline leukemia virus. (wikipedia.org)
  • TIGAR is a recently discovered enzyme that primarily functions as a regulator of glucose breakdown in human cells. (wikipedia.org)
  • Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. (wikipedia.org)
  • CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells. (wikipedia.org)
  • Activation of CD47 with TSP-1 increases proliferation of human U87 and U373 astrocytoma cells but not normal astrocytes. (wikipedia.org)
  • Expression of several stem cell markers, including c-Myc, is elevated in CD47-null endothelial cells and a human T cell line lacking CD47. (wikipedia.org)
  • Jurkat cells and peripheral blood mononuclear cells (PBMC) incubated with the monoclonal antibody Ad22 results in apoptosis within 3 hours. (wikipedia.org)
  • It exerts its biological functions through binding to signalling proteins of the MAPKK level of the MAPK pathway, therefore eliciting a regulatory role in the function of this pathway which mediates proliferation, apoptosis and differentiation in cells. (wikipedia.org)
  • One such signaling event is the introduction of granzyme B, which can activate initiator caspases, into cells targeted for apoptosis by killer T cells. (wikipedia.org)
  • Mangosteen (Garcinia Mangostana) extract has been shown to inhibit the activation of caspase 3 in B-amyloid treated human neuronal cells. (wikipedia.org)
  • Amino Acid Seq
  • For example, its active site contains a cysteine residue (Cys-163) and histidine residue (His-121) that stabilize the peptide bond cleavage of a protein sequence to the carboxy-terminal side of an aspartic acid when it is part of a particular 4-amino acid sequence. (wikipedia.org)
  • Mutations
  • This protein family is of great clinical importance currently because mutations in this domain have been identified in multiple human disorders. (wikipedia.org)
  • However, mutations affecting the RING Finger do not significantly affect apoptosis, indicating that the BIR domain is sufficient for the protein's function. (wikipedia.org)
  • cell
  • 20 Accumulating evidence from in vitro and in vivo studies suggests an important role for NF-κB in the regulation of apoptosis, cell adhesion and oncogenesis. (wiley.com)
  • BRCA1 encodes a tumour suppressor protein that plays pivotal roles in homologous recombination (HR) DNA repair, cell-cycle checkpoints, and transcriptional regulation. (biomedsearch.com)
  • Cell division cycle and apoptosis regulator protein 1 is a protein that in humans is encoded by the CCAR1 gene. (wikipedia.org)
  • Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type MYC at promoting B cell lymphomagenesis in mice. (diva-portal.org)
  • Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anti-tumour molecule since its activity is specific for tumour cell populations. (ox.ac.uk)
  • These results highlight potential limitations of experiments designed to test contribution of factors affecting intrinsic apoptosis susceptibility using cloned tumour cell populations. (ox.ac.uk)
  • The vector of anti-survivin T cell receptor (TCR) is constructed for the engineering of T cell to target Human survivin. (creative-biolabs.com)
  • Normally, TIGAR manufacture by the body is activated by the p53 tumour suppressor protein after a cell has experienced a low level of DNA damage or stress. (wikipedia.org)
  • As well as its most well known role in apoptosis, FADD has also been seen to play a role in other processes including proliferation, cell cycle regulation and development. (wikipedia.org)
  • Binding of TSP-1 to CD47 influences several fundamental cellular functions including cell migration and adhesion, cell proliferation or apoptosis, and plays a role in the regulation of angiogenesis and inflammation. (wikipedia.org)
  • instead, Tribbles proteins function as scaffold proteins, which bind their substrates to localize them to or from their function Expression of Tribbles-1 is highly variable, constantly changing with respect to time and cell-type, which suggests a large amount of regulation that exists in the cell. (wikipedia.org)
  • cytochrome
  • Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. (wikipedia.org)
  • In intrinsic activation, cytochrome c from the mitochondria works in combination with caspase-9, apoptosis-activating factor 1 (Apaf-1), and ATP to process procaspase-3. (wikipedia.org)
  • In the development of lung cancer NCI-H460, the overexpression of XIAP not only inhibits caspase, but also stops the activity of cytochrome c (Apoptosis). (wikipedia.org)
  • SuperFamily
  • Studying modifiers of apoptotic responses, such as members of the tumour necrosis factor receptor superfamily, may give clues as to how induction of apoptosis in tumours could be maximized to enhance the benefit of treatment regimes. (ox.ac.uk)
  • progression
  • This research investigated the role of retroviral cyclin (RV-cyclin) in sarcoma progression in walleyes as a comparable study to human cancer. (wikipedia.org)
  • 2001
  • Viral regulatory and accessory proteins at the US National Library of Medicine Medical Subject Headings (MeSH) Akari H, Bour S, Kao S, Adachi A, Strebel K (November 2001). (wikipedia.org)
  • cellular
  • Through the different domains of this protein, the function of NBEAL1 is predicted to be involved in the following cellular mechanisms: vesicle trafficking, membrane dynamics, receptor signaling, pre-mRNA processing, signal transduction and cytoskeleton assembly. (wikipedia.org)
  • Bcl2
  • Disruption of apoptosis through enforced expression of Bcl2, or loss of either Bim or p53 function, enables wild-type MYC to produce lymphomas as efficiently as mutant MYC. (diva-portal.org)