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Bone Morphogenetic ProteinsBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Bone Morphogenetic Protein 7Bone Morphogenetic Protein Receptors, Type IBone Morphogenetic Protein ReceptorsBone Morphogenetic Protein 6Bone Morphogenetic Protein Receptors, Type IIBone and BonesBone Morphogenetic Protein 5Smad1 ProteinSmad ProteinsBone Morphogenetic Protein 3Smad5 ProteinBone Morphogenetic Protein 15Bone Morphogenetic Protein 1Transforming Growth Factor betaBone RemodelingSmad6 ProteinSmad8 ProteinSignal TransductionOsteogenesisGrowth Differentiation Factor 2Cell DifferentiationOsteoblastsBone RegenerationBone DensityReceptors, Growth FactorGrowth Differentiation FactorsGrowth Differentiation Factor 5Bone DevelopmentGene Expression Regulation, DevelopmentalGrowth Differentiation Factor 9Bone MatrixBone ResorptionActivin Receptors, Type IGrowth Differentiation Factor 6ActivinsIntercellular Signaling Peptides and ProteinsCells, CulturedSmad4 ProteinBone NeoplasmsActivin Receptors, Type IIBone MarrowBone DiseasesBone Marrow CellsFollistatinBody PatterningMesodermActivin ReceptorsCarrier ProteinsInhibitor of Differentiation Protein 1In Situ HybridizationSmad Proteins, Receptor-RegulatedAlkaline PhosphataseTolloid-Like MetalloproteinasesTrans-ActivatorsBone TransplantationProteinsMSX1 Transcription FactorXenopus ProteinsOssification, HeterotopicCore Binding Factor Alpha 1 SubunitChondrogenesisRNA, MessengerStem CellsReverse Transcriptase Polymerase Chain ReactionCalcification, PhysiologicHypertension, PulmonaryMyositis OssificansHedgehog ProteinsSmad7 ProteinBone SubstitutesWnt ProteinsHepcidinsHomeodomain ProteinsChondrocytesCell LineOsteocalcinChick EmbryoCell ProliferationMice, Inbred C57BLMorphogenesisEctodermCartilageGene Expression RegulationTranscription FactorsMolecular Sequence DataSkullCell LineageDNA-Binding ProteinsEmbryo, NonmammalianRecombinant ProteinsWnt3A ProteinMice, KnockoutZebrafish ProteinsMesenchymal Stromal CellsReceptors, Transforming Growth Factor betaFractures, BoneMice, Transgenic
BMPsRegenerationAbstractRecombinantStromal cells19951996Isolated from bone marrowMesenchymal stemSuperfamilyMammalianOsseointegrationTissueOsteogenesisOsteoinductiveOsteogenic differentiationFibroblast growthResorptionGraftsRole in boneInducesCartilage and bone formationInduceGraftDiseasesSmadReceptorsPathwayMarrow stromalSegmental bone1997Extracellular matrixVivoDefectsDifferentiateProprotein convertasesRegulators of bone formationLocalizationSMADsFractureIntracellularSkeletalClinicalGrowth factorsRegulationFormationMRNAOsteoporosisHomologGenesLarge boneDental pulpOsteoblastsInductionMSCsEncodesMoleculesStem CellSmad7
BMPs14
  • BMP1 belongs to the peptidase M12A family of bone morphogenetic proteins (BMPs). (wikipedia.org)
  • It was initially discovered to work like other BMPs by inducing bone and cartilage development. (wikipedia.org)
  • Along with other BMPs, including BMP-2, -4 and -7, which are well known as potent osteoinductive growth factors, GDF-5 plays important roles in the development of bones, cartilage and tendons, as evidenced by the tendency for the gene and protein expression levels of GDF-5 to increase over time in these tissues. (ispub.com)
  • Bone morphogenetic proteins (BMPs) are osteoinductive substances and have been used in bone regeneration. (bvsalud.org)
  • It may be feasible in the near future for BMPs to replace autologous and allogenic bone grafts. (allenpress.com)
  • BMPs comprise the largest subfamily of TGF-beta and belong to a group of noncollagen proteins. (allenpress.com)
  • Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily, which includes the families of TGF-βs, BMPs, activins and inhibins. (ijbs.com)
  • BMPs were originally identified because of their ability to induce endochondral bone formation and are important regulators of key events in the process of bone formation during embryogenesis, postnatal growth, remodelling and regeneration of the skeleton [ 1 , 2 , 3 ]. (ijbs.com)
  • Comparisons with other BMPs known for their ability to stimulate bone growth have suggested that BMP-13 is not strongly osteo-inductive [ 9 , 10 , 11 , 12 ]. (ijbs.com)
  • The function of BMPs in bone remodelling and fracture repair is associated with the recruitment of stem cells from surrounding tissues and with effects on the osteogenic lineage commitment of these cells. (ijbs.com)
  • Bone morphogenic proteins (BMPs) play a key role in bone formation. (biomedcentral.com)
  • Bone morphogenic proteins (BMPs) promote osteogenesis, chondrogenesis and adipogenesis of mesenchymal progenitor cells [ 1 ]. (biomedcentral.com)
  • The biological activity of recombinant human (rh)BMPs (2, 4 and 7) has been defined by using a variety of animal models. (biomedcentral.com)
  • We illustrated for the first time in a human model the three main stages of osteogenic development, and we could show the diverse regulation of the SMAD pathways by TGF-β2 and BMPs. (biomedcentral.com)
Regeneration15
  • Bone Regeneration. (bvsalud.org)
  • Although different stem cells, morphogens and scaffolds can be combined to simulate natural odontogenic regeneration, it is crucial to determine which options most closely replicate the characteristics of human dental tissues. (scielo.br)
  • Nakashima M. Bone morphogenetic proteins in dentin regeneration for potential use in endodontic therapy. (scielo.br)
  • They have become a likely treatment option, given their action on regeneration and remodeling of bone lesions and increasing the bone response around alloplastic materials. (allenpress.com)
  • The application of specific growth factors for osteoinduction without using a bone graft constitutes a real impact on bone regeneration. (allenpress.com)
  • In this review, we will highlight the role of the BMP in bone, periodontal and dental regeneration. (allenpress.com)
  • Grafting with autogenous bone, guided bone regeneration (GBR), distraction osteogenesis, and tissue engineering have been developed to perform intraoral bone augmentation in dentistry. (allenpress.com)
  • A variety of growth factors (GFs)-including bone morphogenetic protein (BMP), platelet-derived growth factor (PDGF), and peptides of the parathyroid hormone (PTH)-have been tested for local bone regeneration. (allenpress.com)
  • Regeneration of large bone defects is a common clinical problem. (dovepress.com)
  • Our results suggested that PEI-al nanocomposites efficiently deliver the BMP-2 gene to bone marrow mesenchymal stem cells and that BMP-2 gene-engineered cell sheet is an effective way for promoting bone regeneration. (dovepress.com)
  • Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)
  • Hence, they are of high interest for supporting bone regeneration and wound healing. (degruyter.com)
  • By way of this review, a deeper understanding of the basic mechanisms of β-TCP for bone repair will be achieved which will aid in the optimization of strategies to promote bone repair and regeneration. (frontiersin.org)
  • The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
  • Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
Abstract1
  • abstract： STUDY DESIGN:This study was designed to determine whether Augment Bone Graft (Augment, Biomimetic Therapeutics, Inc., Franklin, TN) and Augment Injectable Bone Graft (Augment Injectable, Biomimetic Therapeutics, Inc., Franklin, TN), 2 combination devices comprising recombinant human platelet-derived growth factor-BB an. (shengsci.com)
Recombinant4
  • An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. (scielo.br)
  • Her current research focuses on CD34+ stem cells isolated from cord blood, and she was the first to investigate the effect of recombinant human bone morphogenetic protein-2 on untreated and CD34-selected umbilical cord blood. (textbooks.dad)
  • Recombinant human BMP-2 and BMP-7 are used clinically to augment bone formation in spinal fusion and many other applications in which bone induction is desired [ 4 ]. (ijbs.com)
  • Consequently, it was expected that topical application of recombinant human (rh)BMP-2 and rhBMP-7 would improve the healing of complex fractures. (biomedcentral.com)
Stromal cells3
19954
  • Currently, she is a member of the ASCP Editorial Advisory Board: Medscape Pathology and Laboratory Medicine but has served as Chair of the Research and Development Committee of the American Society of Clinical Pathologists Board of Registry from 1995 to 1998. (textbooks.dad)
  • Haller, K., Stubenrauch, F. and Pfister, H. (1995) Differentiation-Dependent Transcription of the Epidermodysplasia Verruciformis-Associated Human Papillomavirus Type 5 in Benign Lesions. (scirp.org)
  • A pig sperm protein that binds to the extracellular matrix of the egg in a species-specific manner was recently identified and named zonadhesin (Hardy, D. M., and Garbers, D. L. (1995) J. Biol. (embl.de)
  • Noreen S. Cunningham, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland, A. Hari Reddi, and Se-Jin Lee (1995) Growth/Differentiation Factor-10: A new member of the transforming growth factor-ß superfamily related to bone morphogenetic protein-3. (sejinlee.org)
19962
  • Dr. Harmening was a member of the National Commission on Allied Health Implementation Task Force of the Department of Health and Human Services from 1996 to 1998. (textbooks.dad)
  • Int Endod J 1996 Mar;29(2):118-124. (thejcdp.com)
Isolated from bone marrow2
Mesenchymal stem4
  • PEI-al nanocomposites carrying BMP-2 gene could efficiently transfect bone marrow mesenchymal stem cells. (dovepress.com)
  • The normal process of fracture repair begins with an immediate inflammatory response as the innate immune system (macrophages, monocytes, neutrophils, and NK cells) responds with a variety of cytokines that recruit and activate several cell types, including osteoprogenitor mesenchymal stem cells (MSCs), to the site of injury [ 1 , 2 ]. (hindawi.com)
  • We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
  • Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
Superfamily5
Mammalian3
  • Mammalian von Willebrand factor (VWF), a multifunctional protein involved in maintaining homeostasis. (embl.de)
  • Mammalian bone morphogenetic protein-binding (BMP-binding) endothelial regulator protein. (embl.de)
  • Figure 2: Core signalling in the mammalian TGFβ-SMAD pathways. (nature.com)
Osseointegration1
  • Otherwise, the chances of success in osseointegration procedures and bucco-facial rehabilitation that aim to provide the patient with the bone volume lost are greatly reduced. (bvsalud.org)
Tissue11
  • Literature Review: to allow either the installation of implants or the correction of bone defects, high quality bone tissue is required. (bvsalud.org)
  • The search for materials presenting characteristics similar to those achieved with autograft, aiming to reduce morbidity in procedures of restoration of lost bone structures, allowed research to develop toward synthetic materials, such as the rhBMP-2, which is the main morphogenetic protein inducer of bone tissue. (bvsalud.org)
  • Tissue Eng Part A. 2008;14(2):285-94. (scielo.br)
  • Recently, stem cell sheet has been an emerging strategy in bone tissue engineering. (dovepress.com)
  • 2 , 3 Bone tissue engineering (BTE) attempts to solve the referred problems mentioned. (dovepress.com)
  • Osteoporosis is a disease of the skeletal system that is characterized by deterioration of bone tissue, along with a decrease in bone mass. (naturalmedicinejournal.com)
  • Bone is a living tissue that maintains a balance through the bone-building activity of osteoblasts, with the reabsorptive activity of osteoclasts. (naturalmedicinejournal.com)
  • To determine if the same relationship exists in human tumors, we examined tissue samples of breast cancer from human subjects. (biomedcentral.com)
  • Amidst this, tissue engineering using stem cells has emerged as a hot topic of research and is a promising alternative to the traditional techniques of bone grafting. (openorthopaedicsjournal.com)
  • Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
  • Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. (wjgnet.com)
Osteogenesis3
  • To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)
  • The expression of osteogenesis-related gene was increased, which demonstrated that released BMP-2 could effectively induce the cell sheet osteogenic differentiation in vitro. (dovepress.com)
  • While some signals are mitogenic and proosteogenic, others function to inhibit osteogenesis and increase bone resorption, and it appears that a well-controlled, delicate balance of inflammatory factors is necessary for proper fracture repair [ 3 - 6 ]. (hindawi.com)
Osteoinductive3
  • 7 , 16 - 18 Only a small number (BMP-2, BMP-4, BMP-6, BMP-7, and BMP-14) seem to have osteoinductive functions. (allenpress.com)
  • 19 , 20 , 23 , 25 BMP-2 and BMP-7 are especially known for their osteoinductive qualities. (allenpress.com)
  • 1 The obstacles of current bone substitutes include the limited amounts of donor bone, the bone resorption of autografts, the risk of disease transmission and graft rejection of allografts, and the shortage of osteoinductive property for synthetic grafts. (dovepress.com)
Osteogenic differentiation1
  • In conclusion, BMP-13 inhibited osteogenic differentiation of MSCs, implying that functional mutations or deficiency of BMP-13 may allow excess bone formation. (ijbs.com)
Fibroblast growth5
  • Other growth factors involved in vascular remodeling include platelet‐derived growth factor (PDGF), epithelial growth factor (EGF), and fibroblast growth factor (FGF‐2). (comprehensivephysiology.com)
  • FGF2 , also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene . (wikidoc.org)
  • Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated basic FGF, Heparin-binding growth factor-2, and Endothelial cell growth factor-2. (wikidoc.org)
  • [3] [5] FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules. (wikidoc.org)
  • Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1 , [13] RPL6 [14] and ribosomal protein S19 . (wikidoc.org)
Resorption2
Grafts1
  • Objective: to examine the influence of rhBMP-2 in bucco- facial grafts, presenting recent research on animals and humans, as well as different approaches to clinical application and the results obtained by the authors. (bvsalud.org)
Role in bone1
  • Hence, it may be observed that these proteins play an important role in bone formation. (bvsalud.org)
Induces2
  • It induces bone and cartilage development. (wikipedia.org)
  • Nasal mucosal inflammation induces remodeling processes within the mucosa characterized by changes in extracellular matrix (ECM) protein deposition, macrophage and lymphocyte infiltration, and histological structure. (molcells.org)
Cartilage and bone formation1
  • BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. (wikipedia.org)
Induce3
  • 3 To overcome some of these difficulties, research has been driven toward the use of bioactive molecules to induce local bone formation. (allenpress.com)
  • For example, when implanted with a suitable matrix, these rhBMPs have been shown to enhance allograft incorporation and induce new bone formation at various skeletal sites. (biomedcentral.com)
  • It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins . (wikidoc.org)
Graft2
  • In the United States, these proteins are commercially available INFUSE Bone Graft since its approval by the Food and Drug Administration in July 2002 for its use in anterior lumbar interbody fusion. (allenpress.com)
  • Augment bone graft products compare favorably with autologous bone graft in an ovine model of lumbar interbody spine fusion. (shengsci.com)
Diseases5
  • 2. Find values for the kinetic parameters from experimental b pathway have been detected in several human diseases, estimates or by fitting the model to experimental kinetic most notably in many forms of cancer, and in fibrotic diseases data. (lu.se)
  • Thus any process or systemic condition that alters this optimal inflammatory milieu, such as bone diseases like osteoporosis or severe trauma, steroid therapy, diabetes, or advanced age, can disrupt the normal fracture healing process, resulting in nonunions or delayed healing, pain, disfigurement, and loss of function. (hindawi.com)
  • Dysregulation of osteoclasts can cause bone diseases such as osteopetrosis and osteoporosis. (sciforschenonline.org)
  • An imbalance in this process may cause pathological loss of bone mass as seen with delayed fracture healing, osteoporosis and other metabolic bone diseases. (biomedcentral.com)
  • Our research is devoted to develop disease models based on genetic mutations that cause human diseases, and to understand basic molecular pathology using these models. (umn.edu)
Smad2
  • We then investigated expression levels of genes involved in BMP signaling and regulation (for example, Smad1/5/8, TGFβ receptors type I and II, noggin, sclerostin, BMP and activin receptor membrane bound inhibitor (BAMBI), v-ski sarcoma viral oncogene homolog (Ski), Ski-related novel protein N (SnoN) and Smad ubiquitination regulatory factors (Smurfs)) and confirmed the expression of regulated genes at the protein level. (biomedcentral.com)
  • The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)
Receptors2
  • The receptor (5‐HTR) and transporter (5‐HTT) of serotonin (5‐HT), and VPAC [the receptors of vasoactive intestinal peptide (VIP)] are all coupled to G‐protein 128,136. (comprehensivephysiology.com)
  • Numerous secreted and cell surface proteins relevant to airway inflammation and remodeling are initially synthesized as inactive precursor proteins, including growth/differentiation factors and their associated receptors, enzymes, adhesion molecules, neuropeptides, and peptide hormones. (molcells.org)
Pathway2
  • Step 2 often presents the main limitation for a pathway or a simple ON/OFF language as means to draw conclusions modeling approach. (lu.se)
  • Functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis resulted in the differentially expressed proteins in the FM and OA groups are mostly involved in the coagulation and complement system-related pathways, serotonin pathways, dopamine pathways, glutamate pathways and acute phase reactions. (ncl.edu.tw)
Marrow stromal1
Segmental bone1
  • Large segmental bone loss and bone resection due to trauma and/or the presence of tumors and cysts often results in a delay in healing or non-union. (frontiersin.org)
19972
  • Rickinson, A.B. and Moss, D.J. (1997) Human Cytotoxic T Lymphocyte Responses to Epstein-Barr Virus Infection. (scirp.org)
  • J Am Vet Med Assoc, 210(2):235-239,1997. (tcvs-mn.com)
Extracellular matrix1
  • Glycosaminoglycans (GAGs) are multifunctional polysaccharides of the extracellular matrix (ECM) responsible for ECM hydration and binding of cations and proteins due to their negative charge. (degruyter.com)
Vivo7
  • The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. (wikipedia.org)
  • This is important because it is close to the pH of the human body, where BMP1 resides in vivo. (wikipedia.org)
  • The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. (scielo.br)
  • 17 , 19 - 24 BMP-2, −4, and −7 have been shown to stimulate de novo, in vitro, and in vivo bone formation in various animal models. (allenpress.com)
  • To further test the osteogenic potential of the cell sheet in vivo, enhanced green fluorescent protein or BMP-2-producing cell sheets were treated on the cranial bone defects. (dovepress.com)
  • However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. (biomedcentral.com)
  • In this study we asked if human MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if cultivation conditions exert any influence on their stem cell maintenance. (biomedcentral.com)
Defects1
  • Bone loss caused by congenital defects, traumatic injury, cancer, reconstructive surgery, or periodontal disease has aroused widespread concern all over the world. (dovepress.com)
Differentiate2
  • Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms. (hindawi.com)
  • Particular syndromes of hamartomatous polyposis are often characterized by the manifestation of similar symptoms, especially at the initial stage of the development of the disease the clinical pictures in many cases do not make it possible to differentiate them (2). (czytelniamedyczna.pl)
Proprotein convertases2
  • Constam, D. B. & Robertson, E. J. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. (nature.com)
  • Therefore, these precursor proteins require post-translational cleavage by proprotein convertases (PCs) to become fully functional. (molcells.org)
Regulators of bone formation1
Localization1
  • Enrichment analysis for protein localization showed that mainly intracellular and cell-associated interacting proteins were identified. (degruyter.com)
SMADs1
Fracture1
  • After reaching a fracture threshold, bone that was normally able to withstand a minor stress, such as a fall or blow, becomes subject to break or fracture more easily. (naturalmedicinejournal.com)
Intracellular1
  • The identification of the intracellular sGAG-interacting proteins could help to unravel these functions. (degruyter.com)
Skeletal4
  • Bone morphogenetic protein-13 (BMP-13) plays an important role in skeletal development. (ijbs.com)
  • However, this relationship may not be valid for individual alcohol consumers, as small quantities of alcohol can have detrimental skeletal effects and not all studies report clinically relevant bone loss with long-duration alcohol abuse. (springer.com)
  • We propose that the interplay between intrinsic factors (e.g., age, sex, skeletal site) and extrinsic factors (e.g., age of onset of drinking, duration of drinking, comorbidities) influence the precise impact of alcohol consumption on bone health. (springer.com)
  • Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol. (springer.com)
Clinical5
  • However, GBR has different clinical limitations, including increased treatment time, 1 limited predictability for vertical bone augmentation, 1 risk of infection subsequent to membrane exposure, 2 and technique sensitivity. (allenpress.com)
  • In this role, Denise developed an online continuing education program for laboratory professionals and physicians called SUCCESS, a Series of Unique Consistent Continuing Education Self-Study programs She has been the principal investigator for seven grants from Health and Human Services and has completed over fifteen clinical trials. (textbooks.dad)
  • However, conflicting results indicate the clinical use of β-TCP for bone repair remains questionable in several specific experiment models. (frontiersin.org)
  • Ultimately, there is a need for randomised controlled trials on human populations to apply these findings to a clinical setting. (openorthopaedicsjournal.com)
  • clinical nutrition as a specialty goes here HN - 2008 BX - Nutrition FX - Diet FX - Food DH - Child Nutrition DI - 052504 MN - SP6.021.062 MS - Nutrition of children aged 2-10 years. (bvsalud.org)
Growth factors1
  • To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)
Regulation1
  • The association between loss or down-regulation of E-cadherin, an epithelial cell-cell adhesion protein, and progression of breast cancer has been extensively documented [ 3 , 4 ]. (biomedcentral.com)
Formation2
  • Our finding provides an insight into the molecular mechanisms and the therapeutic potential of BMP-13 in restricting pathological bone formation. (ijbs.com)
  • The results indicated that the BMP-2-producing cell sheet group was more efficient than other groups in promoting bone formation in the defect area. (dovepress.com)
MRNA3
  • Results showed that endogenous BMP-13 mRNA expression was higher than BMP-2 or -7 during MSC growth. (ijbs.com)
  • Expression of mouse zonadhesin mRNA is evident only within the testis, and the protein is found exclusively on the apical region of the sperm head. (embl.de)
  • Daniel Linzer, Se-Jin Lee , Linda Ogren, Frank Talamantes, and Daniel Nathans (1985) Identification of proliferin mRNA and protein in mouse placenta. (sejinlee.org)
Osteoporosis4
Homolog1
  • In this review article, we provide a comprehensive overview of the role of key epigenetic targets in PAH pathogenesis, including DNA methyltransferase (DNMT), ten-eleven translocation enzymes (TET), switch-independent 3A (SIN3A), enhancer of zeste homolog 2 (EZH2), histone deacetylase (HDAC), and bromodomain-containing protein 4 (BRD4). (bvsalud.org)
Genes1
Large bone2
  • Currently, the bone autograft is the most frequently used strategy to manage large bone loss. (frontiersin.org)
  • Large bone loss as a result of trauma, tumor removal, infection, and developmental congenital disorders, often leads to delayed healing or non-union, and remains a critical challenge for orthopedic surgeons. (frontiersin.org)
Dental pulp1
  • Growth/differentiation factor-5 (GDF-5) belongs to the bone morphogenetic protein (BMP) family, which is expressed in dental pulp tissues. (ispub.com)
Osteoblasts4
  • Indeed, BMP-13 expression was absent from osteoblasts or newly formed osteocytes, rather BMP-13 was strongly detected in chondrocytes in a human osteophyte (bone spur) study [ 13 ]. (ijbs.com)
  • Therefore, in the present work we investigated the influence of rhTGFβ 1 on rhBMP signaling in primary human osteoblasts, with the aim of more specifically delineating the underlying regulatory mechanisms. (biomedcentral.com)
  • While bone is formed by osteoblasts, which are of mesenchymal origin, it is resorbed by osteoclasts that are derived from the hematopoietic system. (biomedcentral.com)
  • To address this question we first developed human oligonucleotide microarrays with 30.000 elements and then performed large-scale expression profiling of long-term expanded MSC and MSC during differentiation into osteoblasts. (biomedcentral.com)
Induction1
  • By the late 1980s, the active factor responsible for the induction of bone was identified: BMP. (allenpress.com)
MSCs3
  • Insight into this paradigm can provide valuable clues in identifying cellular and noncellular targets that can potentially be modulated to enhance both natural bone healing and bone repair augmented by the exogenous addition of MSCs. (hindawi.com)
  • Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
  • MSCs significantly reversed the imbalance of glycolysis in sperm and testis induced by testicular torsion-detorsion, as evidenced by increasing the expression of phosphoglycerate kinase 2 and glyceraldehyde-3-phosphate dehydrogenase-spermatogenic, activating Akt, and increasing glycogen synthase kinase 3 (GSK3), which led to the increase in glycolysis cascades and ATP production. (biomedcentral.com)
Encodes1
  • The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
Molecules1
  • A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
Stem Cell2
  • Human stem cell factor contributed the activation of Akt/GSK3 axis when sperm suffered from testicular torsion-detorsion-induced germ cell injury. (biomedcentral.com)
  • MSC-secreted stem cell factor (SCF) played a role in promoting spermatogenesis in the recipient [ 2 ]. (biomedcentral.com)
Smad71