• genotype
  • A confirmatory melt curve analysis of this major heritage group A individual resulted in a homozygous E4 genotype. (bsu.edu)
  • Fortunately, this compound is available as a nutritional supplement from New Beginnings Nutritionals and has been used at doses ranging from 500-4000 mg per day in the treatment of patients with a variety of disorders including Parkinson's disease, memory disorders, vascular cognitive impairment, vascular dementia, senile dementia, schizophrenia, Alzheimer's disease (especially effective in those with the epsilon-4 apolipoprotein E genotype), head trauma, and ischemic stroke. (greatplainslaboratory.com)
  • genes
  • Current research on the amyloid cascade hypothesis has identified rare mutations in three genes that encode the amyloid precursor protein (APP), presenilin 1 (PS-1), and presenilin 2 (PS-2) that cause the autosomal dominant, early-onset form of familial Alzheimer's disease. (wikipedia.org)
  • Mutations in ten different genes have been found to contribute to a heritable increased risk of breast cancer and other cancer syndromes. (wikipedia.org)
  • The recent advances in nutrigenomics studies are owed to the completion of human genome project and the new biomics technologies that provide means for the simultaneous determination of the expression of many thousands of genes at the mRNA (transcriptomics), metabolites (metabolomics) and protein (proteomics) levels. (wikipedia.org)
  • A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (senescence.info)
  • Database of human genes associated with cellular senescence. (senescence.info)
  • A recent genetics paper reports on evidence that changes in six genes involved in human brain development occurred around 50,000 to 200,000 years ago. (memory-key.com)
  • Late onset Alzheimer's disease is associated with one of the genes that is responsible for the production of the blood protein apolipoprotein E. Genetic factors also result in the abnormal deposition of a protein in the brain called beta amyloid. (enetmd.com)
  • Alzheimer's
  • Marked genetic heterogeneity is correlated to multiple levels of causation in many common human diseases including cystic fibrosis, Alzheimer's disease, autism spectrum disorders, inherited predisposition to breast cancer,and non-syndromic hearing loss. (wikipedia.org)
  • E4 has been implicated in atherosclerosis, Alzheimer's disease, impaired cognitive function, reduced hippocampal volume, HIV, faster disease progression in multiple sclerosis, unfavorable outcome after traumatic brain injury, ischemic cerebrovascular disease, sleep apnea, accelerated telomere shortening and reduced neurite outgrowth. (wikipedia.org)
  • Data from genome-wide association studies of more than 200,000 individuals has revealed a genetic overlap between Alzheimer's disease and two significant cardiovascular disease risk factors: high levels of inflammatory C-reactive protein (CRP) and plasma lipids. (memory-key.com)
  • Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. (springer.com)
  • hyperlipoproteinemia
  • Individuals with an E2/E2 combination may clear dietary fat slowly and be at greater risk for early vascular disease and the genetic disorder type III hyperlipoproteinemia-94.4% of such patients are E2/E2, while only ∼2% of E2/E2 develop the disease, so other environmental and genetic factors are likely to be involved (such as cholesterol in the diet and age). (wikipedia.org)
  • genome project
  • Many of the strides made in genetic diagnostics are direct results of the Human Genome Project, an international thirteen-year effort begun in 1990 by the U.S. Department of Energy and the National Institutes of Health, which mapped and sequenced the human genome in its entirety. (encyclopedia.com)
  • cognitive
  • In doing this, we have discovered that many varieties of microbes are present in the brains of individuals with AD and mild cognitive impairment (MCI) but not in the brains of non-demented control individuals. (midwestern.edu)
  • This implies that there may be damage to the blood-brain barrier in individuals with affected cognitive status, with this damage allowing microbes from the bloodstream to enter the brain. (midwestern.edu)
  • risk
  • A good screening test is relatively inexpensive, easy to use and interpret, and helps identify which individuals in the population are at higher risk of developing a specific disease. (encyclopedia.com)
  • plasma
  • Large and medium LDL comprise the most abundant species in plasma of the most healthy individuals, but there are two forms of small LDL, exhibiting reduced receptor binding, greater endothelial transport, greater arterial proteoglycan binding, and greater susceptibility to oxidation. (diabetesjournals.org)
  • Degree
  • The degree of impairment shows substantial variation between individuals, as is also observed in the senescence of other functions. (hindawi.com)
  • population
  • As life expectancy and the proportion of older individuals in the population continue to increase, dementia will become an ever more significant health problem, one that is compounded by its effects on the families of affected individuals. (springer.com)
  • increase
  • These mutations may have helped increase the connectivity of our neurons, making us smarter. (memory-key.com)
  • If the course of dementia is not modified by treatment, the number of individuals who will be affected by degenerative dementia in the coming decades will increase dramatically [1, (springer.com)
  • data
  • Species specific: extremely low recognition of human Apo E. No data available regarding rat activity. (mybiosource.com)
  • substantial
  • Such CNVs present acute difficulties in counseling symptomatic and asymptomatic individuals and have substantial potential for stigmatization of both groups, as well as raising difficulties when detected in prenatal diagnosis. (biomedcentral.com)
  • people
  • For example, people with an enzyme deficiency caused by mutations in the enzyme phenylalanine hydroxylase cannot metabolize foods containing the amino acid phenylalanine and must modify their diets to minimize consumption. (wikipedia.org)
  • levels
  • This diet changes lipid levels in individuals with phenotype A by reducing cholesterol content of LDL particles, without reducing particle number, while individuals with phenotype B show reduced conversion of VLDL2 to LDL2 with increased levels of large VLDL particles, resulting in greater numbers of remnant particles ( 4 ). (diabetesjournals.org)
  • mouse
  • The vaccine AN-1792 showed promise in mouse and early human trials, but in a 2002 Phase II trial, 6% of subjects (18 of 300) developed serious brain inflammation resembling meningoencephalitis, and the trial was stopped. (wikipedia.org)
  • high
  • A low-fat, high-carbohydrate diet may have adverse effect in increasing phenotype B expression ( 2 ) but, unexpectedly, particularly reduces LDL cholesterol in individuals with phenotype B ( 3 ). (diabetesjournals.org)
  • specific
  • However the dissimilarity between murine and human immune systems led to the clinical failure of these antibodies, except in some specific circumstances. (wikipedia.org)
  • open
  • 42 of these studies were open, human phase three trials, the last step before United States Food and Drug Administration (FDA) approval and marketing. (wikipedia.org)