AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Parathyroid HormoneReceptor, Parathyroid Hormone, Type 1Receptor, Parathyroid Hormone, Type 2Receptors, Parathyroid HormoneTeriparatideParathyroid GlandsParathyroid Hormone-Related ProteinParathyroid NeoplasmsHypoparathyroidismParathyroid DiseasesHyperparathyroidismThiohydantoinsOsteoblastomaBone and BonesPseudohypoparathyroidismReceptors, PeptideOsteosarcomaReceptors, Calcium-SensingHypercalcemiaCalciumPeptide FragmentsParathyroidectomyHyperparathyroidism, SecondaryReceptors, Thyroid HormoneCyclic AMPBone DensityHypocalcemiaAdenomaOsteoporosisHormonesOsteoblastsArrestinsPhosphorusPhosphatesHyperparathyroidism, PrimaryMolecular Sequence DataCalcitriolAmino Acid SequenceVitamin DInjections, SubcutaneousThyroid HormonesSodium-Hydrogen AntiporterThyroid Hormone Receptors betaSignal TransductionReceptors, Cell SurfaceCell LineLigandsThyroid Hormone Receptors alphaCalcitoninCOS CellsKidneyRecombinant ProteinsBase SequenceFollicle Stimulating HormoneBone ResorptionUremiaLuteinizing HormoneHyperplasiaRadioimmunoassayBone RemodelingReceptors, SomatotropinProtein BindingVitamin D DeficiencyCalcifediolThyroidectomyRenal OsteodystrophyTriiodothyronineOsteocalcinAdenylate CyclaseProtein Structure, TertiaryCell MembraneAlkaline PhosphataseKidney Failure, ChronicErgocalciferolsGonadal Steroid HormonesHydroxycholecalciferolsGonadotropin-Releasing HormoneRenal DialysisDihydroxycholecalciferolsOsteoporosis, PostmenopausalCattleKineticsCalcium, DietaryOpossumsPhosphorus, DietaryHypophosphatemiaReceptors, Thyrotropin-Releasing HormoneRNA, MessengerHuman Growth HormoneCholecalciferolCalcium CarbonateDose-Response Relationship, DrugCells, CulturedCalcium GluconateTime FactorsBone Diseases, MetabolicNaphthalenesAdrenocorticotropic HormoneSodium-Phosphate Cotransporter ProteinsTechnetium Tc 99m Sestamibi
PTHrPPeptide receptorGPCRsCorticotropin-releasing factoActivatorLigandsSerumEndocrineProtein-coupled receptor2022TumorsAntigenGlandsDiabetes mellitusVasoactive intestiBone metabolismSuperfamilyPolymorphismHypercalcemiaNuclear receptorsLigand-receptorKidneyVitaminTransmembraneRegulationGPCRCalciumGenesGenotypesPolymorphismsAntagonistOsteoblastsStimulateHypoparathyroidismProteinsMutationsThyroidBIOMARKERSMolecularImmunoassayMetabolicSignalingBinds2000SecretinPhosphateSusceptibilityRenalPlasmaClinicalCASRRegulatory
PTHrP11
Peptide receptor2
GPCRs9
  • G protein-coupled receptors (GPCRs) generally accommodate specific ligands in the orthosteric-binding pockets. (bvsalud.org)
  • Structural analysis of class B G-protein-coupled receptors (GPCRs), cell-surface proteins that respond to peptide hormones, has been restricted to the amino-terminal extracellular domain, thus providing little understanding of the membrane-spanning signal transduction domain. (nature.com)
  • G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. (embl.de)
  • The cannabinoid 1 receptor (CB 1 R) is one of the most abundant G protein-coupled receptors (GPCRs) in the central nervous system, with key roles during neurotransmitter release and synaptic plasticity. (aspetjournals.org)
  • In this review, we discuss functional selectivity of the cannabinoid 1 receptor (CB 1 R), one of the most highly expressed GPCRs in the central nervous system. (aspetjournals.org)
  • The superfamily of G protein-coupled receptors (GPCRs) is one of the largest gene families in most mammals and the most exploited in terms of drug discovery. (biomedcentral.com)
  • We established relationships between human, dog, rat and mouse GPCRs resolving orthologous pairs and species-specific duplicates. (biomedcentral.com)
  • The repertoire of dog non-olfactory GPCRs is more similar to the repertoire in humans as compared with the one in rodents. (biomedcentral.com)
  • Our recent annotation of the G protein-coupled receptors (GPCRs) within the chicken genome showed that over 60% of the Genscan gene predictions with a human ortholog needed curation. (biomedcentral.com)
Corticotropin-releasing facto2
  • The corticotropin-releasing factor receptor type 1 is a class B receptor which mediates the response to stress and has been considered a drug target for depression and anxiety. (nature.com)
  • Here we report the crystal structure of the transmembrane domain of the human corticotropin-releasing factor receptor type 1 in complex with the small-molecule antagonist CP-376395. (nature.com)
Activator5
  • When the receptor is activated through PTH binding, osteoblasts express RANKL (Receptor Activator of Nuclear Factor kB Ligand), which binds to RANK (Receptor Activator of Nuclear Factor kB) on osteoclasts. (wikipedia.org)
  • indicate that a factor secreted by fibroblast/osteoblast (receptor activator of nuclear factor ligand (RANKL)) binds to stromal-monocyte derived cells to induce giant cell formation that might be reactive [ 8 ]. (hindawi.com)
  • Serum beta-crosslaps (beta-CTx), osteoprotegerin (OPG), receptor activator of nuclear factor-kappa B ligand (RANKL), urinary deoxypyridinoline (DPD) and ferritin levels were compared between the groups. (biomedcentral.com)
  • Osteoprotegerin (OPG) and the receptor activator of nuclear factor-kappa B (RANK)/receptor activator of nuclear factor-kappa B ligand (RANKL) are the major cytokines related to the regulation of bone resorption [ 9 ]. (biomedcentral.com)
  • The action of adipokines on the expression of receptor activator of nuclear factor kappa β ligand (RANKL) and osteoprotegerin (OPG) and on an increase in sclerostin could be related to these changes. (unesp.br)
Ligands1
  • This complexity presents multiple challenges, including the correct classification of receptor ligands, the identification of the signaling pathways regulated by each wave, and the underlying molecular mechanisms and physiologic impacts of these waves. (aspetjournals.org)
Serum6
  • Blood samples were taken for routine biochemistry, serum 25-hydroxyvitamin D [25(OH)3] and plasma parathyroid hormone (PTH) levels. (who.int)
  • Predictors and relationships of serum 25 hydroxyvitamin D concentration with bone turnover markers, bone mineral density, and vitamin D receptor genotype in Emirati women. (cdc.gov)
  • The definitive diagnosis requires (1) the presence of secretory diarrhea, (2) elevated serum VIP levels, and (3) the identification of a pancreatic endocrine tumor. (medscape.com)
  • Description: A sandwich ELISA kit for detection of Protease Activated Receptor 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lotusbiotechnologies.com)
  • Cholecalciferol is bound to serum vitamin D-binding protein (DBP) and through a two-step enzymatic pathway involving 25-hydroxylase of the liver and 1α-hydroxylase (CYP27B1) of the kidney and extrarenal tissues, it is converted to the biologically active hormone calcitriol (1α,25(OH) 2 D 3 ) [ 1 ]. (biomedcentral.com)
  • Although 1,25(OH) 2 D 3 is the biologically active form of vitamin D the vitamin D status is mainly assessed by the measurement of serum 25(OH)D 3 concentration. (biomedcentral.com)
Endocrine5
  • My other research interests lie within studies surrounding neuroendocrinology that examine a range of topics, including the physiological response to stress through the hypothalamic-pituitary-adrenal axis, neuropeptides and their signaling pathways, gene regulation in the hypothalamus and pituitary gland, diseases of the pituitary and other endocrine glands, hormone receptors and actions on target tissues, and neuroendocrine-immune interactions. (nih.gov)
  • Multiple endocrine neoplasia type 2 (MEN2) is a rare genetic polyglandular cancer syndrome, characterized by the 100% prevalence of medullary thyroid carcinoma (MTC) and an increased risk of develop other specific tumors affecting additional glands of the endocrine system. (rarediseases.org)
  • The endocrine system is the network of glands that secrete hormones into the bloodstream to reach distant target tissues and organs within the body. (rarediseases.org)
  • MEN2 endocrine tumors may secrete excessive amounts of hormones into the bloodstream, which can result in a variety of symptoms. (rarediseases.org)
  • Three are the endocrine glands most often affected in MEN2 syndrome: the thyroid, the adrenal glands and, only in the MEN2A variants, the parathyroids. (rarediseases.org)
Protein-coupled receptor3
  • NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor. (nature.com)
  • Pioszak, A. A. & Xu, H. E. Molecular recognition of parathyroid hormone by its G protein-coupled receptor. (nature.com)
  • The extracellular calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor (GPCR) that is expressed at multiple sites, including the parathyroids and kidneys. (ox.ac.uk)
20226
  • The National Center for Advancing Translational Sciences (NCATS) Advisory Council held a meeting in open session on May 19, 2022, from 1:01 p.m. to 4:34 p.m. (nih.gov)
  • EDT, and on May 20, 2022, from 1:01 p.m. to 4:46 p.m. (nih.gov)
  • She pointed out that the meeting wil span two days, May 19 and 20, 2022, from 1:00 p.m. to 5:00 p.m. (nih.gov)
  • Members approved the minutes from the January 2022 Council meeting with 10 ayes, zero nays, and 1 abstention. (nih.gov)
  • Pediatric Radiology Page: 1-13, November 2022. (upenn.edu)
  • Human Mutation September 2022. (upenn.edu)
Tumors2
  • Hypercalcemia secondary to gastrointestinal stromal tumors: parathyroid hormone-related protein independent mechanism? (medscape.com)
  • characterized by the uniform presence of MTC in association with tumors of the inner part of the adrenal gland called pheocromocytoma (PHEO) or tumors of the parathyroid gland called adenoma or both in some patients. (rarediseases.org)
Antigen1
  • Under these conditions, proliferation elicited by Recombinant Human FGF-23 (1 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human FGF-23 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2604). (rndsystems.com)
Glands4
Diabetes mellitus4
  • The frequency of autoimmune diseases such as type 1 diabetes mellitus (Staples et al. (vitamindwiki.com)
  • The studied TaqI polymorphism did not show any association with type 1 diabetes mellitus at allelic or genotypic levels, [ 23 ] nor with developing a risk for urolithiasis [ 24 ]. (biomedcentral.com)
  • Type 1 diabetes mellitus (T1DM) is regarded to be immune-mediated and vitamin D prevents the development of diabetes in the NOD mouse. (biomedcentral.com)
  • Type 1 diabetes mellitus (T1DM) is a multifactorial disease with a strong genetic component [ 1 ]. (biomedcentral.com)
Vasoactive intesti2
  • Vasoactive intestinal peptide stimulation of human renal adenylate cyclase in vitro. (ox.ac.uk)
  • 1. A direct action of vasoactive intestinal peptide (VIP) upon human kidney was sought by measurement of renal adenylate cyclase in tissue homogenates and plasma membranes isolated from tissue samples excised for therapeutic reasons. (ox.ac.uk)
Bone metabolism2
  • Vitamin D is the main hormone of bone metabolism. (hindawi.com)
  • Vitamin D is the main hormone regulating calcium phosphate homeostasis and mineral bone metabolism. (hindawi.com)
Superfamily2
  • The cellular actions of 1,25(OH)2D3 are mediated by the VDR, a ligand-dependent transcription regulator molecule belonging to the superfamily of nuclear receptors. (vitamindwiki.com)
  • In a wide variety of cell types vitamin D exerts its effects by binding to the vitamin D receptor (VDR), a member of the nuclear steroid receptor superfamily and an intracellular transcription factor [ 2 ]. (biomedcentral.com)
Polymorphism7
  • No significant differences among FokI and TaqI vitamin D receptor genes polymorphism regarding positive and negative RF or ACCPs were found. (biomedcentral.com)
  • Vitamin D status and the Cdx-2 polymorphism of the vitamin D receptor gene are determining factors of bone mineral density in young healthy postmenopausal women. (cdc.gov)
  • Vitamin D status in female students and its relation to calcium metabolism markers, lifestyles, and polymorphism in vitamin D receptor. (cdc.gov)
  • R990G polymorphism of calcium sensing receptor gene is associated with high parathyroid hormone levels in subjects with vitamin D deficiency: a cross-sectional study. (cdc.gov)
  • We studied the association between T1DM and the initiation codon polymorphism in exon 2 of the vitamin D receptor gene in a Japanese population. (biomedcentral.com)
  • We also investigated associations between the vitamin D receptor polymorphism and GAD65-antibody (Ab) positivity. (biomedcentral.com)
  • Our findings suggest that the vitamin D receptor initiation codon polymorphism influences genetic susceptibility to T1DM among the Japanese. (biomedcentral.com)
Hypercalcemia2
  • Nearly 6% of these patients have associated MEN-1 syndrome with resultant hypercalcemia secondary to hyperparathyroidism. (medscape.com)
  • Although VIP has osteolytic activity, neither this mechanism nor elevated parathyroid hormone-binding protein levels in these patients have been established conclusively as the cause of hypercalcemia. (medscape.com)
Nuclear receptors1
  • At the cellular level, effectors include nuclear receptors that bring about changes in gene expression through up-regulation or down-regulation and act in negative feedback mechanisms. (wikipedia.org)
Ligand-receptor1
  • This concept, based on numerous analytical observations from different laboratories, challenged our classic definition of a ligand's intrinsic efficacy (i.e., the property of a ligand/receptor pair to elicit the full set of biologic responses). (aspetjournals.org)
Kidney3
  • This "classical" PTH receptor is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, it is expressed on the surface of osteoblasts. (wikipedia.org)
  • Acute kidney injury (AKI) is a highly prevalent condition with dire acute and chronic consequences [ 1 ]. (karger.com)
  • STAGES OF BREAST DEVELOPMENT: NORMAL TO METASTATIC DISEASE Release Date: September 2, 1999 PA NUMBER: PA-99-162 National Cancer Institute National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Aging National Institute of Environmental Health Sciences THIS PA USES THE "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. (nih.gov)
Vitamin14
  • However, the ubiquitary nature of vitamin D receptor (VDR) suggests potential for widespread effects, which has led to new research exploring the effects of vitamin D on a variety of tissues, especially in the skeletal muscle. (hindawi.com)
  • The discovery that a variety of tissues can express vitamin D receptor (VDR) has opened new ways of research related to vitamin D biological effects and molecular pathways [ 1 - 3 ]. (hindawi.com)
  • The vitamin D receptor (VDR) is a nuclear, ligand-dependent transcription factor that in complex with hormonally active vitamin D, 1,25(OH)2D3, regulates the expression of more than 900 genes involved in a wide array of physiological functions. (vitamindwiki.com)
  • A recent acknowledgment that the majority of immune cells expresses the vitamin D receptor (VDR) (Kreutz et al. (vitamindwiki.com)
  • Vitamin D is a steroid hormone whose production and metabolism begins in the skin with exposure to ultraviolet beta rays. (massey.ac.nz)
  • Researchers at Massey were the first to conduct such a trial and demonstrate a role for vitamin D deficiency in the development of insulin resistance, a condition which can lead to type 2 diabetes. (massey.ac.nz)
  • This study aimed to compare vitamin D receptor (VDR) FokI and TaqI genotypes in terms of parathyroid hormone (PTH) and some biomarkers of inflammation and susceptibility to rheumatoid arthritis (RA) disease. (biomedcentral.com)
  • Sensitivity to vitamin D supplementation is influenced by genetic variations in the vitamin D receptor (VDR) genes and is controlled by both genetic and environmental factors [ 1 ]. (biomedcentral.com)
  • The VDR genes provide instructions for making a protein called vitamin D receptor (VDR), which allows the body to respond to vitamin D. Vitamin D receptor genes may be responsible for some important biological functions in the human body [ 2 ] (Fig. 1 ). (biomedcentral.com)
  • Prevalence and functional significance of 25-hydroxyvitamin D deficiency and vitamin D receptor gene polymorphisms in Asian Indians. (cdc.gov)
  • Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre- and postmenopausal women. (cdc.gov)
  • This secosteroid hormone also regulates the expression of a large number of genes in reproductive tissues implicating a role for vitamin D in female reproduction. (biomedcentral.com)
  • Human and animal data suggest that low vitamin D status is associated with impaired fertility, endometriosis and polycystic ovary syndrome. (biomedcentral.com)
  • In North America and Western Europe only small amounts of vitamin D, a fat-soluble secosteroid hormone, enter the metabolic circle via dietary uptake (e.g. from fish), although dietary supplement intake has increased in recent years (Figure 1 ). (biomedcentral.com)
Transmembrane2
  • A putative transmembrane receptor may be responsible for nongenomic effects leading to rapid influx of calcium within muscle cells. (hindawi.com)
  • These receptors contain seven transmembrane regions, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins (however there is no significant sequence identity between these families, the secretin-like receptors thus bear their own unique '7TM' signature). (embl.de)
Regulation2
  • 8. D5 dopamine receptor regulation of phospholipase D. (nih.gov)
  • The regulation of VDR expression is one of the main mechanisms through which target cells respond to calcitriol so that polymorphisms of this receptor can change the usual mode of functioning. (biomedcentral.com)
GPCR2
  • An accurate comparison of the GPCR repertoires in dog and human is valuable for the prediction of functional similarities and differences between the species. (biomedcentral.com)
  • We found that 12 dog GPCR genes are missing in humans while 24 human GPCR genes are not part of the dog GPCR repertoire. (biomedcentral.com)
Calcium2
  • Les répondants devaient aussi préciser s'ils prenaient des compléments en vitamine D, quelle était leur consommation d'aliments riches en calcium et dans quelle mesure ils s'exposaient au soleil. (who.int)
  • Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism. (ox.ac.uk)
Genes3
  • Previous studies have reported the role of genes in different metabolic processes in the human body, and any variation in gene polymorphisms could lead to disturbances in these processes and different diseases. (biomedcentral.com)
  • Every receptor gene in this family is encoded on multiple exons, and several of these genes are alternatively spliced to yield functionally distinct products. (embl.de)
  • HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
Genotypes1
Polymorphisms1
  • Several polymorphisms of the human VDR gene FokI have resulted in VDR proteins with diverse structures, such as extended f-VDR or smaller f-VDR. (biomedcentral.com)
Antagonist2
  • Figure 3: Comparison of the antagonist-bound structures of CRF 1 R and D 3 R. (nature.com)
  • 4. The stimulation of renal adenylate cyclase by VIP appeared to be specific because stimulation by glucagon was additive to that obtained with VIP, and the VIP receptor antagonist (4 Cl-D-Phe6, Leu17)-VIP inhibited the VIP-dependent stimulation of adenylate cyclase activity. (ox.ac.uk)
Osteoblasts2
Stimulate1
  • Bone morphogenetic proteins (BMPs) signal specific BMP type I and type II receptors, and stimulate the activation of R-Smad1, 5 and 8. (springer.com)
Hypoparathyroidism1
  • Gain-of-function mutations, on the other hand, result in the hypocalcemic disorders of autosomal dominant hypocalcemia and Bartter syndrome type V. Moreover, autoantibodies directed against the extracellular domain of the CaSR have been found to be associated with FHH in some patients, and also in some patients with hypoparathyroidism that may be part of autoimmune polyglandular syndrome type 1. (ox.ac.uk)
Proteins5
  • The activity of this receptor is mediated by Gs G proteins, which activate adenylyl cyclase. (wikipedia.org)
  • Ligand binding triggers a receptor allosteric conformational change that leads to the activation of intracellular transducers, G proteins and ß-arrestins. (bvsalud.org)
  • Over the last several years, we have significantly expanded our understanding of the mechanisms and pathways downstream from the CB 1 R. The identification of receptor mutations that can bias signaling to specific pathways and the use of siRNA technology have been key tools to identifying which signaling cascades are controlled by G proteins or β -arrestins. (aspetjournals.org)
  • First, we review the different signaling waves characterizing functional selectivity of the CB 1 R that are mediated by G proteins and β -arrestins. (aspetjournals.org)
  • FGF proteins contain a 120 amino acid (aa) core FGF domain that exhibits a beta -trefoil structure (1, 2). (rndsystems.com)
Mutations1
  • Studies of disease-causing CASR mutations have provided insights into structure-function relationships and highlighted intra-molecular domains that are critical for ligand binding, intracellular signaling, and receptor trafficking. (ox.ac.uk)
Thyroid2
  • Subjects with a history of neuroendocrine disorder (thyroid, parathyroid disorder, and anticonvulsant usage), chronic renal and liver disease, systemic steroid usage, menopause, cigarette smoking, or excessive alcohol usage were excluded from the study. (medscape.com)
  • The thyroid converts iodine into thyroid hormones, which are essential to regulate the chemical processes (metabolism) of virtually every cell in the body. (rarediseases.org)
BIOMARKERS3
  • Tracking human neurologic disease status in mouse brain/plasma using reporter-tagged, EV-associated biomarkers. (harvard.edu)
  • We conducted linear regressions analyses (adjusted for sex, waist circumference, physical activity, hormone use, and season) to assess the relationship between 25-hydroxyvitamin D and biomarkers of dysglycemia, dyslipidemia, and inflammation in the study population. (cdc.gov)
  • It was noticed that will C2 as well as C3 misshaped less with higher conditions compared to some other combinations of comA type of AhR-mediated toxicity disc-on-plate examination technique was used to determine the put on actions involving metal binders doing work in the production involving precious stone heavy-laden fluid biomarkers instruments. (peptide-solubility.com)
Molecular3
  • Gether, U. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. (nature.com)
  • Molecular signatures of G-protein-coupled receptors. (nature.com)
  • and (5) form deposits capable of surviving in the new environment 10 ( Fig. 19-1, A ). The basic biology, molecular mechanisms, and genetic and epigenetic changes that drive these steps are extremely complex and probably differ depending on the source of the metastasis and specific type of tumor. (basicmedicalkey.com)
Immunoassay1
Metabolic1
  • My work for the Division of Diabetes, Endocrinology, and Metabolic Diseases also includes evaluation of human subject protection for all clinical research. (nih.gov)
Signaling8
  • 1. Role of phospholipase D in parathyroid hormone type 1 receptor signaling and trafficking. (nih.gov)
  • 20. Parathyroid hormone receptor directly interacts with dishevelled to regulate beta-Catenin signaling and osteoclastogenesis. (nih.gov)
  • Classic TGF-β signaling involves the binding of TGF-β to TGF-β type II receptors (TβRIIs), recruitment of type I receptors (TβRIs), transphosphorylation by TβRII kinase, and the subsequent phosphorylation of receptor regulated (R-)Smad2 and Smad3. (springer.com)
  • The impact of 1,25(OH)2D3-VDR signaling on immune function has been the focus of many recent studies as a link between 1,25(OH)2D3 and susceptibility to various infections and to development of a variety of inflammatory diseases has been suggested. (vitamindwiki.com)
  • Here, we review our current knowledge on CB 1 R signaling, with particular emphasis on the mechanisms and cascades mediated by β -arrestins downstream from the CB 1 R. (aspetjournals.org)
  • We discuss the in vivo data from wild-type, knockout, and knock-in mice and conclude by highlighting intriguing problems and suggesting areas where further research is needed to understand the physiologic roles and therapeutic potential of β -arrestin-mediated signaling of the CB 1 R. (aspetjournals.org)
  • When the signal is received and acted on, negative feedback is provided to the receptor that stops the need for further signaling. (wikipedia.org)
  • AEA) and 2-arachidonoylglycerol (2-AG) via a retrograde signaling process in which these compounds are synthesized by and released from postsynaptic neurons, and travel back to the presynaptic terminal to bind to the CB1 receptor for modulation of neurotransmitter release to obtain homeostasis. (wikipedia.org)
Binds1
  • Atomic details of the interactions of the receptor with the non-peptide ligand that binds deep within the receptor are described. (nature.com)
20003
  • 2000. Vol. 1: 343-352. (medscape.com)
  • 2000). The concentration of cyanidin-3-O-(6″-O-malonyl)-glucoside was significantly higher in cool-cultivated than in warm-cultivated small heads ( Fig. 3 and Table 1). (c-metinhibitors.com)
  • Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No.017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800), or at http://odphp.osophs.dhhs.gov/pubs/hp2000 . (nih.gov)
Secretin1
  • It is a member of the secretin family of G protein-coupled receptors. (wikipedia.org)
Phosphate2
  • 10/15/2005) TOTAL DESCRIPTORS = 943 MH - 1-Acylglycerol-3-Phosphate O-Acyltransferase UI - D051103 MN - D8.811.913.50.173 MS - An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. (nih.gov)
  • use DICARBOXYLIC ACIDS 1970-1979 MH - 3-Phosphoshikimate 1-Carboxyvinyltransferase UI - D051229 MN - D8.811.913.225.735 MS - An enzyme of the shikimate pathway of AROMATIC AMINO ACID biosynthesis, it generates 5-enolpyruvylshikimate 3-phosphate and ORTHOPHOSPHATE from PHOSPHOENOLPYRUVATE and SHIKIMATE-3-PHOSPHATE. (nih.gov)
Susceptibility1
  • The dog also has more similarities in general physiology, anatomy, disease susceptibility, morphological variation and behavioural traits to humans than the most frequently used experimental animals, mouse and rat. (biomedcentral.com)
Renal2
  • 3. Half-maximal stimulation of human renal cortical plasma membrane adenylate cyclase was observed with a mean value of 35 nM-VIP. (ox.ac.uk)
  • Another effect of PTH is the stimulation of renal 1,25(OH) 2 D 3 production with possibly misleading 1,25(OH) 2 D 3 concentrations within the normal range. (biomedcentral.com)
Plasma2
  • 2. Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. (nih.gov)
  • Plasma triglycer- ides and around ten days 1-2 g/day of granulosa theca cell proliferation. (lorenzopetrantoni.com)
Clinical2
  • The Diabetes: Treatment, Prevention, and Complications Program supports both basic and clinical studies aimed at addressing the prevention, treatment and pathophysiology of type 1 and type 2 diabetes across the lifespan. (nih.gov)
  • Dr. Ng's clinical practice involves the care of patients with all types of gastrointestinal cancers. (dana-farber.org)
CASR1
  • The human CASR gene, located on chromosome 3q21.1, encodes a 1078 amino acid protein. (ox.ac.uk)
Regulatory1