• antigen
  • The human T cell receptor for antigen (Ti) has recently been identified on IL-2 dependent T cell clones as a 90 kd disulfide-linked heterodimer comprised of one 49-51 kd alpha (alpha) and one 43 kd beta (beta) chain. (ox.ac.uk)
  • We are currently pursuing new mass spectrometry approaches to identify peptides arrayed on individual types of antigen-presenting cells, and defining at a molecular level the extent of T cell recognition of individual immunodominant epitopes as well as non-immunodominant epitopes.In the next year, we expect to apply these tools and approaches for characterizing human immune recognition to the area of tumor immunology. (dana-farber.org)
  • affinity
  • The high and intermediate affinity forms also associate with a gamma subunit. (mybiosource.com)
  • The low affinity form is a monomer of the alpha subunit (also called CD25) and is not involved in signal transduction. (wikipedia.org)
  • Prostaglandin E2 receptor 2 (53kDa), also known as EP2, is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER2: it is one of four identified EP receptors, the others being EP1, EP3, and EP4, which bind with and mediate cellular responses to PGE2 and also, but with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). (wikipedia.org)
  • The receptor binding affinity Dissociation constant Kd (i.e. ligand concentration needed to bind with 50% of available EP1 receptors) is ~13 nM for PGE2 and ~10 nM for PGE1 with the human receptor and ~12 nM for PGE2 with the mouse receptor. (wikipedia.org)
  • There are several such agonists including butaprost free acid and ONO-AE1-259-01 which have Ki inhibitory binding values (see Biochemis try#Receptor/ligand binding affinity) of 32 and 1.8 NM, respectively, and therefore are respectively ~2.5-fold less and 7-fold more potent than PGE2. (wikipedia.org)
  • inhibition
  • This, combined with the inhibition of IL-12 signalling in human T cells and curcumin synergistic effect with IFN-B observed in this study on immune cells from both normal volunteers and MS patients, could place curcumin as a potential therapeutic agent in the treatment of MS. (thisisms.com)
  • IL-10 may autoregulate its expression via a negative feed-back loop involving autocrine stimulation of the IL-10 receptor and inhibition of the p38 signaling pathway. (wikipedia.org)
  • heterodimer
  • Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. (wikipedia.org)
  • Our laboratory continues to work on fundamental processes by which T lymphocytes recognize foreign pathogens including viruses such as smallpox, vaccinia, HIV, and influenza A. We have analyzed the basic function and structure of the T cell receptor (TCR) components: TCRalphabeta heterodimer, CD3epsilongamma and CD3epsilondelta heterodimers, and CD3zetazeta homodimer. (dana-farber.org)
  • antibody
  • IL-22 receptor alpha 1 antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human IL-22 receptor alpha 1 precursor. (genetex.com)
  • Western blot analysis of IL-22 receptor expression in human HepG2 cell lysate with IL-22 receptor antibody at 1 μg /ml. (genetex.com)
  • Immunocytochemistry of IL-22 receptor in HepG2 cells with IL-22 receptor antibody at 10 μg/mL. (genetex.com)
  • The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody. (drugbank.ca)
  • It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha. (drugbank.ca)
  • ligand
  • The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. (wikipedia.org)
  • Our investigations are aimed at understanding the molecular recognition properties governing the interactions of receptors with their ligands, and the subsequent molecular events which couple ligand recognition to receptor activation. (stanford.edu)
  • It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. (wikipedia.org)
  • The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. (wikipedia.org)
  • immune
  • The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. (genecards.org)
  • The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (wikipedia.org)
  • EP2 also activates the a) GSK-3 pathway which regulates cell migratory responses and innate immune responses including pro-inflammatory cytokine and interleukin production and b) Beta-catenin pathway which regulates not only cell-cell adhesion but also activates the Wnt signaling pathway which, in turn, stimulates the transcription of genes responsible for regulating cell migration and proliferation. (wikipedia.org)
  • The therapeutic efficacy of Anthrax immune globulin human can be decreased when used in combination with Basiliximab. (drugbank.ca)
  • Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. (wikipedia.org)
  • soluble
  • MBS743209 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Soluble Interleukin 2a receptor (IL-2sRa) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • tumor
  • Expression of IL-10 from transfected tumor cell lines. (wikipedia.org)
  • or dosing with IL-10 leads to control of primary tumor growth and decreased metastatic burden. (wikipedia.org)
  • Here, we produce monoclonal antibodies to a human tumor (REX) derived from an earlier stage of thymic differentiation in order to determine whether clonotypic structures are expressed and to define the ontogeny of Ti. (ox.ac.uk)
  • expression
  • Curcumin increased IFN-alpha-induced IL-10 and IFNAR1 expression. (thisisms.com)
  • Prior exposure to curcumin decreased IFN-alpha-induced IFNAR2 expression and did not modify the level of IFN-alpha-induced pSTAT4 generation. (thisisms.com)
  • The expression of IL-10 is minimal in unstimulated tissues and seems to require triggering by commensal or pathogenic flora. (wikipedia.org)
  • IL-10 expression is tightly regulated at the transcriptional and post-transcriptional level. (wikipedia.org)
  • Additionally, IL-10 expression is extensively regulated at the post-transcriptional level, which may involve control of mRNA stability via AU-rich elements and by microRNAs such as let-7 or miR-106. (wikipedia.org)
  • The present invention relates to cellular senescence, markers of cellular senescence, and methods and reagents for identifying senescent cells and agents that alter senescent gene expression expression of cells, as well as for detecting, diagnosing, preventing, and treating senescence-related diseases and conditions in humans and other mammals. (google.es)
  • EP2 expression in fibroblasts from the lungs of mice with Bleomycin-induced pulmonary fibrosis and humans with Idiopathic pulmonary fibrosis is greatly reduced. (wikipedia.org)
  • stimulation
  • Interleukin 4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of B cells into plasma cells. (wikipedia.org)
  • structural
  • A common TCR quaternary change rather than conformational alterations can better facilitate structural signal initiation, given the vast array of TCRs and their specific pMHC ligands.Using computational methods, we have also defined the rules concerning the nature of peptides that bind to individual human MHC molecules, including multiple allelic variants, and developed bioinformatic approaches to create computational vaccinology. (dana-farber.org)