• pathways
  • Extensive IL-10 locus remodeling is observed in monocytes upon stimulation of TLR or Fc receptor pathways. (wikipedia.org)
  • The Gαs- Gβγ complexes dissociate into their Gαs and Gβγ subunits which in turn regulate cell signaling pathways. (wikipedia.org)
  • To determine effects of 1) parenteral nutrition (PN) 2) exogenous Lymphotoxin β receptor (LTβR) stimulation in PN animals and 3) exogenous LTβR blockade in chow animals on NF-κB activation pathways and products: MAdCAM-1, chemokine (C-C motif) Ligand (CCL) 19, CCL20, CCL25, interleukin (IL)-4 and IL-10. (pubmedcentralcanada.ca)
  • Lack of enteral stimulation during PN decreases both canonical and non-canonical NF-κB pathways in PP. LTβR stimulation during PN feeding completely restores PP non-canonical NF-κB activity, MAdCAM-1, IL-4, IL-10, and partly the canonical pathway. (pubmedcentralcanada.ca)
  • The effects of cytokines on the immune response depend on a number of factors, such as their local concentrations, receptor expression patterns and the integration of multiple signalling pathways in response to immune cells [ 1 ]. (omicsonline.org)
  • Indeed, the life cycle of HIV is closely related to the activation state of its host cells since it depends on host cell surface receptor expression for entry, and also on many cellular pathways and transcription machinery for viral gene expression. (omicsonline.org)
  • inhibition
  • IL-10 may autoregulate its expression via a negative feed-back loop involving autocrine stimulation of the IL-10 receptor and inhibition of the p38 signaling pathway. (wikipedia.org)
  • 2001
  • Of the estimated 40 million HIV-seropositive patients in 2001, 70% were from sub-Saharan Africa, residence of less than 10% of the human population [ 4 , 5 ]. (omicsonline.org)
  • affinity
  • The high and intermediate affinity forms also associate with a gamma subunit. (mybiosource.com)
  • Prostaglandin E2 receptor 2 (53kDa), also known as EP2, is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER2: it is one of four identified EP receptors, the others being EP1, EP3, and EP4, which bind with and mediate cellular responses to PGE2 and also, but with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). (wikipedia.org)
  • The receptor binding affinity Dissociation constant Kd (i.e. ligand concentration needed to bind with 50% of available EP1 receptors) is ~13 nM for PGE2 and ~10 nM for PGE1 with the human receptor and ~12 nM for PGE2 with the mouse receptor. (wikipedia.org)
  • There are several such agonists including butaprost free acid and ONO-AE1-259-01 which have Ki inhibitory binding values (see Biochemis try#Receptor/ligand binding affinity) of 32 and 1.8 NM, respectively, and therefore are respectively ~2.5-fold less and 7-fold more potent than PGE2. (wikipedia.org)
  • ligand
  • The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. (wikipedia.org)
  • It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. (wikipedia.org)
  • The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. (wikipedia.org)
  • stimulation
  • Interleukin 4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of B cells into plasma cells. (wikipedia.org)
  • secretion
  • An increase in repair macrophages (M2) is coupled with secretion of IL-10 and TGF-β that result in a diminution of pathological inflammation. (wikipedia.org)
  • expression
  • The expression of IL-10 is minimal in unstimulated tissues and seems to require triggering by commensal or pathogenic flora. (wikipedia.org)
  • IL-10 expression is tightly regulated at the transcriptional and post-transcriptional level. (wikipedia.org)
  • Additionally, IL-10 expression is extensively regulated at the post-transcriptional level, which may involve control of mRNA stability via AU-rich elements and by microRNAs such as let-7 or miR-106. (wikipedia.org)
  • Expression of IL-10 from transfected tumor cell lines. (wikipedia.org)
  • The present invention relates to cellular senescence, markers of cellular senescence, and methods and reagents for identifying senescent cells and agents that alter senescent gene expression expression of cells, as well as for detecting, diagnosing, preventing, and treating senescence-related diseases and conditions in humans and other mammals. (google.es)
  • EP2 expression in fibroblasts from the lungs of mice with Bleomycin-induced pulmonary fibrosis and humans with Idiopathic pulmonary fibrosis is greatly reduced. (wikipedia.org)
  • tumor
  • or dosing with IL-10 leads to control of primary tumor growth and decreased metastatic burden. (wikipedia.org)
  • Here, we produce monoclonal antibodies to a human tumor (REX) derived from an earlier stage of thymic differentiation in order to determine whether clonotypic structures are expressed and to define the ontogeny of Ti. (ox.ac.uk)
  • proliferation
  • Activation of the receptor increases proliferation of CD8+ effector T cells. (wikipedia.org)
  • Activated T cells can either induce their own proliferation and differentiation (autocrine signalling), or that of other T cells (paracrine signalling) - both involve IL-2 binding to the IL-2 receptor on T cells (upregulated upon cell activation, under the induction of macrophage-secreted IL-1). (wikipedia.org)
  • stimulates
  • Normally, lymphotoxin α and β (LT α1β2) expressed on activated T&B cells stimulates the lymphotoxin β receptor (LTβR). (pubmedcentralcanada.ca)
  • Interleukin 3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the addition of IL-7, into lymphoid progenitor cells. (wikipedia.org)