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  • antigen
  • The human T cell receptor for antigen (Ti) has recently been identified on IL-2 dependent T cell clones as a 90 kd disulfide-linked heterodimer comprised of one 49-51 kd alpha (alpha) and one 43 kd beta (beta) chain. (ox.ac.uk)
  • inhibition
  • This, combined with the inhibition of IL-12 signalling in human T cells and curcumin synergistic effect with IFN-B observed in this study on immune cells from both normal volunteers and MS patients, could place curcumin as a potential therapeutic agent in the treatment of MS. (thisisms.com)
  • IL-10 may autoregulate its expression via a negative feed-back loop involving autocrine stimulation of the IL-10 receptor and inhibition of the p38 signaling pathway. (wikipedia.org)
  • ligand
  • The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. (wikipedia.org)
  • It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. (wikipedia.org)
  • Our investigations are aimed at understanding the molecular recognition properties governing the interactions of receptors with their ligands, and the subsequent molecular events which couple ligand recognition to receptor activation. (stanford.edu)
  • The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. (wikipedia.org)
  • The receptor binding affinity Dissociation constant Kd (i.e. ligand concentration needed to bind with 50% of available EP1 receptors) is ~13 nM for PGE2 and ~10 nM for PGE1 with the human receptor and ~12 nM for PGE2 with the mouse receptor. (wikipedia.org)
  • There are several such agonists including butaprost free acid and ONO-AE1-259-01 which have Ki inhibitory binding values (see Biochemis try#Receptor/ligand binding affinity) of 32 and 1.8 NM, respectively, and therefore are respectively ~2.5-fold less and 7-fold more potent than PGE2. (wikipedia.org)
  • affinity
  • The high and intermediate affinity forms also associate with a gamma subunit. (mybiosource.com)
  • Prostaglandin E2 receptor 2 (53kDa), also known as EP2, is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER2: it is one of four identified EP receptors, the others being EP1, EP3, and EP4, which bind with and mediate cellular responses to PGE2 and also, but with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). (wikipedia.org)
  • regulates
  • EP2 also activates the a) GSK-3 pathway which regulates cell migratory responses and innate immune responses including pro-inflammatory cytokine and interleukin production and b) Beta-catenin pathway which regulates not only cell-cell adhesion but also activates the Wnt signaling pathway which, in turn, stimulates the transcription of genes responsible for regulating cell migration and proliferation. (wikipedia.org)
  • Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. (wikipedia.org)
  • expression
  • Curcumin increased IFN-alpha-induced IL-10 and IFNAR1 expression. (thisisms.com)
  • Prior exposure to curcumin decreased IFN-alpha-induced IFNAR2 expression and did not modify the level of IFN-alpha-induced pSTAT4 generation. (thisisms.com)
  • The expression of IL-10 is minimal in unstimulated tissues and seems to require triggering by commensal or pathogenic flora. (wikipedia.org)
  • IL-10 expression is tightly regulated at the transcriptional and post-transcriptional level. (wikipedia.org)
  • Additionally, IL-10 expression is extensively regulated at the post-transcriptional level, which may involve control of mRNA stability via AU-rich elements and by microRNAs such as let-7 or miR-106. (wikipedia.org)
  • Expression of IL-10 from transfected tumor cell lines. (wikipedia.org)
  • From analyses of global gene expression profile data, a nonrandom amount of overlap was observed between the set of genes associated with estrogen receptor negative (ER-), hormone independent breast cancer and the set of genes associated with androgen independent (AI) prostate cancer. (biomedcentral.com)
  • The present invention relates to cellular senescence, markers of cellular senescence, and methods and reagents for identifying senescent cells and agents that alter senescent gene expression expression of cells, as well as for detecting, diagnosing, preventing, and treating senescence-related diseases and conditions in humans and other mammals. (google.es)
  • EP2 expression in fibroblasts from the lungs of mice with Bleomycin-induced pulmonary fibrosis and humans with Idiopathic pulmonary fibrosis is greatly reduced. (wikipedia.org)
  • secretion
  • An increase in repair macrophages (M2) is coupled with secretion of IL-10 and TGF-β that result in a diminution of pathological inflammation. (wikipedia.org)
  • stimulation
  • Interleukin 4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of B cells into plasma cells. (wikipedia.org)
  • activation
  • Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit. (semanticscholar.org)
  • IL-10 induction involves ERK1/2, p38 and NF-κB signalling and transcriptional activation via promoter binding of the transcription factors NF-κB and AP-1. (wikipedia.org)
  • Lack of IL-10 has been shown to cause COX activation and resultant Thromboxane receptor activation to cause vascular endothelial and cardiac dysfunctions in mice. (wikipedia.org)
  • Activation of the receptor increases proliferation of CD8+ effector T cells. (wikipedia.org)
  • Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. (genecards.org)
  • EP2 is classified as a relaxant type of prostanoid receptor based on its ability, upon activation, to relax certain types of smooth muscle (see Prostaglandin receptors). (wikipedia.org)
  • That is, following agonist-induced activation, the other prostaglandin (as well as most types of G protein coupled receptors) quickly become desensitized, often internalized, and whether or not internalized, incapable of activating their G protein targets. (wikipedia.org)
  • Activated T cells can either induce their own proliferation and differentiation (autocrine signalling), or that of other T cells (paracrine signalling) - both involve IL-2 binding to the IL-2 receptor on T cells (upregulated upon cell activation, under the induction of macrophage-secreted IL-1). (wikipedia.org)