• embryos
  • Methods -In situ hybridisation was used to study mRNA expression of MUC2, MUC3, MUC4, MUC5B, MUC5AC, and MUC6 in 32 human embryos and fetuses (6.5-27 weeks gestation). (bmj.com)
  • Thus, to assess whether expression of mucin genes is linked to the stage of epithelial cytodifferentiation, we studied the expression of six mucin genes in the small and large intestine of 32 human embryos and fetuses aged between 6.5 and 27 weeks of gestation. (bmj.com)
  • Sometimes these are referred to as post-implantation tissue to distinguish it from surplus embryos from IVF fertility treatments. (theconversation.com)
  • organs
  • While it is likely to be some time before the technique can be used to generate transplant organs, it could be used almost immediately to grow different human tissue on which to test new drugs, Weiss says. (medicalxpress.com)
  • Scandals such as at Alder Hey, where in 2001 medical researchers were found to have illegally harvested organs and tissue from dead children, caused a public outcry. (theconversation.com)
  • neonatal
  • Severe HDFN, resulting in neonatal/fetal death or the need for a blood transfusion during pregnancy or within 1 week after delivery, most often occurs due to anti-D (33%), anti-K (26%), followed by anti-c (10%) and anti-E (2%) ( 2 ). (frontiersin.org)
  • ESCs
  • Consequently, human ESCs have been decidualized in culture with chemical analogs of cAMP and progesterone together. (wikipedia.org)
  • In vitro decidualization results in similar morphological changes to the human ESCs as well as upregulated production of decidualization markers such as IGFBP1 and prolactin. (wikipedia.org)
  • Similar to ESCs, these iPSCs had unlimited self-renewal and were pluripotent, contributing to lineages from all three germ layers in the context of embryoid bodies, teratomas, and fetal chimeras. (wikipedia.org)
  • formation
  • The method prevents complex formation between tissue factor and factor VII/VIIa and thus inhibits coagulation of blood in extracorporeal procedures such as cardiopulmonary bypass and other shunt procedures. (google.com)
  • intestinal
  • Osteonectin has been localized in a variety of tissues, but is found in greatest abundance in osseous tissue, tissues characterized by high turnover (such as intestinal epithelium), basement membranes, and certain neoplasms. (wikipedia.org)
  • membrane
  • Mice cannot be infected with HIV-1, because sequence differences in mouse homologues of the human proteins required for HIV replication prevent their interaction with essential HIV proteins critical for HIV replication such as Env, Tat [ 2 , 3 ] and Rev [ 3 , 4 ], as well as prevent and potentially limit efficient assembly and budding of virus from the cell membrane. (biomedcentral.com)
  • This allows maternal blood to come into direct contact with the fetal chorion, a membrane between the fetal and maternal tissues, and allows for nutrient and gas exchange. (wikipedia.org)
  • Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene. (wikipedia.org)
  • serum
  • After albumin, immunoglobulin G (IgG) are the most abundant proteins in human serum, with IgG1 and IgG3 being the most abundant subclasses directed against protein antigens. (frontiersin.org)
  • The ideal criteria for cell lines for the purpose of cultured meat production include: immortality, high proliferative ability, surface independence, serum independence, and tissue-forming ability. (wikipedia.org)
  • Today the status quo for growing animal tissue in culture involves the use of fetal bovine serum (FBS). (wikipedia.org)
  • After the creation of the cell lines, efforts to remove serum from the growth media are key to the advancement of cellular agriculture as fetal bovine serum has been the target of most criticisms of cellular agriculture and cultured meat production. (wikipedia.org)
  • cellular
  • In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. (lu.se)
  • While some methods and protocols from human and mouse cell culture may apply to agricultural cellular materials, it has become clear that most do not. (wikipedia.org)
  • development
  • The Carnegie Collection, founded in 1914, contains thousands of human foetuses and gives its name to the Carnegie stages that chart foetal development. (theconversation.com)
  • Developmental genetics seeks to identify the genes that are active at particular stages of human development. (theconversation.com)
  • A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. (wikipedia.org)
  • The interatrial septum forms during the first and second months of fetal development. (wikipedia.org)
  • The first is the development of the septum primum, a crescent-shaped piece of tissue forming the initial divider between the right and left atria. (wikipedia.org)
  • During fetal development, this opening allows blood to be shunted from the right atrium to the left. (wikipedia.org)
  • Archer posited that decrements in maternal metabolic control altered fetal pancreatic beta cell, adipocyte (fat cell) and myocyte (muscle cell) development thereby inducing an enduring competitive advantage of adipocytes in the acquisition and sequestering on nutrient energy. (wikipedia.org)
  • protein
  • The protein is also called human IAP-like Protein (hILP), because it is not as well conserved as the human IAPS: hIAP-1 and hIAP-2. (wikipedia.org)
  • XIAP is the most potent human IAP protein currently identified. (wikipedia.org)
  • Neuronal apoptosis inhibitor protein (NAIP) was the first homolog to baculoviral IAPs that was identified in humans. (wikipedia.org)
  • Zinc finger protein SNAI2 is a protein that in humans is encoded by the SNAI2 gene. (wikipedia.org)
  • 2-Oxoglutarate receptor 1 (OXGR1), also known as cysteinyl leukotriene receptor E (CysLTE) and GPR99, is a protein that in humans is encoded by the OXGR1 (also termed GPR99) gene. (wikipedia.org)
  • Human leptin is a 16-kDa protein of 167 amino acids. (wikipedia.org)
  • EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene. (wikipedia.org)
  • Coiled-coil domain-containing protein 138, also known as CCDC138, is a human protein encoded by the CCDC138 gene. (wikipedia.org)
  • There exist several hypertensive states of pregnancy: Gestational hypertension Gestational hypertension is usually defined as having a blood pressure higher than 140/90 measured on two separate occasions, more than 6 hours apart, without the presence of protein in the urine and diagnosed after 20 weeks of gestation. (wikipedia.org)
  • Methods
  • Anti-tissue factor monoclonal antibodies produced by hybridoma cell lines TFS-5G9 or TF9-6B4 may be used in the claimed methods. (google.com)
  • characteristics
  • This review describes past findings leading up to these new discoveries, summarizes the evidence for and characteristics of NK cell memory, and discusses the attempts and future challenges to identify these long-lived memory NK cell populations in humans. (jimmunol.org)
  • Sex differences in human physiology are distinctions of physiological characteristics associated with either male or female humans. (wikipedia.org)
  • expression
  • Results -Three mucin genes, MUC2, MUC4, and MUC5AC, were differently expressed in fetal intestine compared with expression in normal adults. (bmj.com)
  • recombinant
  • The vast majority of insulin currently used worldwide is now biosynthetic recombinant "human" insulin engineered by yeast or bacteria. (wikipedia.org)
  • Genome
  • The human genome consists of two copies of each of 23 chromosomes (a total of 46). (wikipedia.org)
  • Cell doi:10.1016/j.cell.2012.01.022 (volume 148 issue 3 pp.447 - 457) Human CCL20 genome location and CCL20 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • germ
  • The fact that we are able to produce endoderm, mesoderm, and ectoderm gives us great hope that we can take each of these germ layers and hopefully grow any kind of tissue we want," he says. (medicalxpress.com)
  • mice
  • Some developmental genetics research can be conducted using non-human animals such as mice, but the most accurate and usable data comes from using human tissue. (theconversation.com)
  • They have mainly been studied in humans and model organisms such as mice and rats. (wikipedia.org)
  • Consistent with Coleman's and Leibel's hypothesis, several subsequent studies from Leibel's and Friedman's labs and other groups confirmed that the ob gene encoded a novel hormone that circulated in blood and that could suppress food intake and body weight in ob and wild type mice, but not in db mice. (wikipedia.org)
  • coagulation
  • Traditional models of coagulation developed in the 1960s envisaged two separate cascades, the extrinsic (tissue factor (TF)) pathway and the intrinsic pathway. (wikipedia.org)
  • This invention provides a method of inhibiting coagulation in extracorporeal circulation in a subject, comprising administration of a therapeutically effective amount of a monoclonal antibody which inhibits the ability of tissue factor to bind to factor VII/VIIa. (google.com)
  • colon
  • Overexpression of osteonectin is reported in many human cancers such as breast, prostate and colon. (wikipedia.org)
  • antigens
  • These antigens are known as human leukocyte antigens (HLAs). (thevaccinereaction.org)
  • HLAs help the immune system distinguish between your body's healthy tissue and antigens in foreign invaders. (thevaccinereaction.org)
  • However, we can also mount immune responses against foreign antigens found in other individuals of the same species (alloimmunization, frequently occurring during pregnancy or blood transfusion) or self-antigens, promoting allo- or autoimmune diseases, respectively. (frontiersin.org)
  • involves
  • Severe preeclampsia involves a blood pressure greater than 160/110, with additional medical signs and symptoms. (wikipedia.org)
  • Mutations
  • In 1995, Jose F. Caro's laboratory provided evidence that the mutations in the mouse ob gene did not occur in humans. (wikipedia.org)
  • A human mutant leptin was first described in 1997, and subsequently six additional mutations were described. (wikipedia.org)
  • cell
  • New technological developments in human genetics including cytogenics, cell culture, and prenatal diagnosis, combined with changes in state abortion laws to accommodate eugenic killing now made such a campaign both possible and practical. (all.org)
  • The use of northern blotting and in situ hybridisation techniques utilising specific nucleotide probes has shown a tissue and cell specific distribution of apomucin mRNAs. (bmj.com)
  • Our findings identify an early step to human NK cell commitment and provide new insights into the human hematopoietic hierarchy. (lu.se)
  • abortion
  • Anti-abortion campaigners see foetal tissue research as unethical, even though foetal tissue obtained from miscarriages, rather than abortions, can assist research into miscarriage and congenital abnormality. (theconversation.com)
  • Finally, Samantha reveals that the clones are the progeny of two original aliens, and worked at abortion clinics to gain access to fetal tissue. (wikipedia.org)
  • diseases
  • It's now well-known that genetics holds the key to understanding normal and abnormal human biology, from congenital diseases, to cancer and almost all major human diseases and impairments. (theconversation.com)
  • One of the ethical concerns was that the use of foetal tissue for treating serious diseases would lead to an increased demand for tissue and potentially influence a woman's decision to terminate a pregnancy. (theconversation.com)
  • Abnormalities in decidualization have been implicated in diseases such as endometriosis, in which impaired decidualization leads to ectopic uterine tissue growth. (wikipedia.org)