• Sequence
  • This approach should be applicable to pedigree and linkage analysis with the apolipoprotein B gene or other tandemly repeated sequence elements. (biomedsearch.com)
  • Sequence analysis suggested that putative CREBH response element (CREBHRE) is located in the human APOA5 promoter region and is highly conserved in both human and rodent. (hindawi.com)
  • However, two naturally occurring point mutations in human apoC3 coding sequence, namely Ala23Thr and Lys58Glu have been shown to abolish the intracellular assembly and secretion of triglyceride-rich VLDL particles from hepatic cells. (wikipedia.org)
  • apoE
  • Methods - Aged apoE knock out (KO) mice, mice overexpressing APP751 in the apoE KO background and mice expressing either human apoE3 or apoE4 and APP751 in the apoE KO background were exposed to permanent occlusion of the middle cerebral artery (MCA). (ahajournals.org)
  • Results - Overexpression of human APP751 significantly increased the infarct volumes in apoE KO mice. (ahajournals.org)
  • Furthermore, this APP751-induced ischemic vulnerability was attenuated by the coexpression of either human apoE isoform. (ahajournals.org)
  • Apolipoprotein E (ApoE) is a class of proteins involved in the metabolism of fats in the body. (wikipedia.org)
  • Recent findings with apoA-I and apoE suggest that the tertiary structures of these two members of the human exchangeable apolipoprotein gene family are related. (wikipedia.org)
  • They are enzyme coenzymes (C-II for lipoprotein lipase and A-I for lecithin-cholesterol acyltransferase) Lipid transport proteins Ligands for interaction with lipoprotein receptors in tissues ( apoB100 and apoE for LDL-receptors, apoA-I for HDL receptors) There are two major types of apolipoproteins. (wikipedia.org)
  • lipids
  • GPX3 has been found associated with HDL in human plasma, and its hydroperoxide-reducing activity might be important in protecting the endothelium from the toxic effects of oxidized lipids. (ahajournals.org)
  • However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating the lipoprotein particle that is itself water-soluble, and can thus be carried through water-based circulation (i.e., blood, lymph). (wikipedia.org)
  • liver
  • Taken together, our results demonstrated that human APOA5 is directly regulated by CREBH via CREBHRE and provided a new insight into the role of this liver-specific bZIP transcription factor in lipoprotein metabolism and triglyceride homeostasis. (hindawi.com)
  • mammalian
  • Since apo(a)/Lp(a) derived rather recently in mammalian evolution - only old world monkeys and humans have been shown to harbour Lp(a) - its function might not be vital, but just evolutionarily advantageous under certain environmental conditions, e.g. in case of exposure to certain infectious diseases. (wikipedia.org)
  • promoter
  • To clarify whether the human APOA5 promoter is regulated by CREBH, we analyzed the human APOA5 promoter region using a transient transfection assay and determined that transfection of CREBH induced human APOA5 promoter activity. (hindawi.com)
  • Here, we report that a CREBHRE is located in the promoter of human APOA5, which is a critical region for the transcriptional regulation of the APAO5 gene by CREBH. (hindawi.com)
  • enzyme
  • In contrast, incubation of isolated human apoA-II with control mouse plasma at 37°C decreased PON1 activity and displaced the enzyme from HDL. (ahajournals.org)
  • plasma
  • Especially, it has been reported that CREBH is required for the maintenance of normal plasma TG levels, and hypomorphic or null mutations of CREBH associated with hypertriglyceridemia in human [ 14 ]. (hindawi.com)
  • Lp(a) carries cholesterol and binds atherogenic proinflammatory oxidized phospholipids as a preferential carrier of oxidized phospholipids in human plasma, which attract inflammatory cells to vessel walls and leads to smooth muscle cell proliferation. (wikipedia.org)
  • Human plasma apolipoproteins A-IV-0 and A-IV-3. (wikipedia.org)
  • The product of this gene is one of the minor apolipoproteins found in plasma. (wikipedia.org)