Human airway asthma airway resistance. Medical search. Frequent questions

The aim of this study was to compare air-trapping as quantified by high-resolution computed tomography (HRCT) of the chest with measures of lung function and airway inflammation in children with mild to moderate asthma. (nih.gov)
As is the case for characteristics such as clinical presentation, physiological findings and the nature of airway inflammation 1 , it is also clear that individual patients vary in their responsiveness to medications 2 . (ersjournals.com)
Several studies have demonstrated that IL-17F plays a pivotal role in allergic airway inflammation and induces several asthma-related molecules such as CCL20. (hindawi.com)
IL-17F-induced CCL20 may attract Th17 cells into the airway resulting in the recruitment of additional Th17 cells to enhance allergic airway inflammation. (hindawi.com)
IL-17F is expressed in activated CD4 + T cells, basophils, and mast cells, three important cell types involved in allergic airway inflammation [ 3 ]. (hindawi.com)
In COPD, there is epithelial mucous metaplasia, airway wall fibrosis, and inflammation associated with loss of surrounding alveolar attachments to the outer wall of small airways: bronchiolar smooth muscle is increased also. (nih.gov)
We hypothesized that GLP-1R agonists reduce platelet activation and downstream platelet-mediated airway inflammation in AERD. (bvsalud.org)
These data advance the GLP-1R axis as a new target for platelet-mediated inflammation warranting further study in asthma. (bvsalud.org)
There are probably dozens of laboratories in the world that study asthma, allergic asthma, and allergic inflammation and its various iterations. (scireq.com)
Targeting the oxoeicosanoid (OXE) receptor with a selective antagonist inhibits allergen-induced pulmonary inflammation in non-human primates. (ucdavis.edu)
Enweasor C, Flayer CH, Haczku A. Ozone-Induced Oxidative Stress, Neutrophilic Airway Inflammation, and Glucocorticoid Resistance in Asthma. (ucdavis.edu)
Piperine can also reduce airway inflammation caused by asthma and recurrent allergies. (asknestle.in)
H4 stimulation has also recently been shown to cause inhibition of airway resistance and inflammation in a murine model of allergic asthma. (drugdiscoveryopinion.com)
GCs, usually in the form of prednisolone, supposedly reduce airway inflammation and prevent fibrosis. (ingridking.com)
Research advances over the past several years suggest that cysLT1 also mediates the ability of cysLTs to modulate inflammation, immune responses, and airway remodeling. (springer.com)
Airways inflammation in type-2 low asthma or COPD is potentially driven by persistent bacterial colonization of the lower airways by bacteria such as non-encapsulated Haemophilus influenzae (NTHi). (ox.ac.uk)
These data suggest that NTHi is internalized transiently by airway epithelial cells and has capacity to drive inflammation in airway epithelial cells. (ox.ac.uk)
Quantitative CT Evidence of Airway Inflammation in WTC Workers and Volunteers with Low FVC Spirometric Pattern. (omicsdi.org)
We used quantitative CT (QCT) to investigate proximal and distal airway inflammation and emphysema in participants with stable low FVC pattern. (omicsdi.org)
Further confirmative data in the allergic asthma model demonstrated that CRAC played a central role in the airway inflammation and late asthmatic response (LAR). (docsbay.net)
Asthma is characterised by airway inflammation, cough, bronchial hyperresponsiveness, and variable airflow obstruction (e.g. (docsbay.net)
Patients with severe asthma may have neutrophilic airway inflammation and skew towards a more Th1 type response [6] characterised by the production of cytokines such as IFNγ and IL-2. (docsbay.net)
After that, the airway walls swell with inflammation and can actually ulcerate. (vin.com)
Inflammation and mucus build up within the airways, causing their walls to appear thickened in the radiograph. (vin.com)
The exaggerated responses of patients with airway disease have been ascribed to numerous factors like reduced resting airway caliber, presence of mucosal edema and inflammation and the volume of airway secretions. (isanagpur.org)
Asthma is characterized by a narrowing and inflammation of the bronchi, with symptoms of dyspnea, fatigue and exercise limitation. (bvsalud.org)
The Global Initiative for Asthma defines asthma as a heterogeneous disease characterized by chronic inflammation of the airways, with a history of respiratory symptoms, such as wheezing, dyspnea, chest tightness, cough and variable airflow limitation 1 . (bvsalud.org)

We conclude that short-term NO2 exposure at about 500 micrograms.m3 slightly affects human bronchial responsiveness in subjects with mild asthma. (ersjournals.com)
While IV administration of high-doses of latanoprost in monkeys (i.e., 50-150 times the usual human dose) has been associated with transient increases in airway resistance and blood pressure, latanoprost ophthalmic solution has been used in individuals with bronchial asthma without inducing bronchoconstriction. (regrowth.com)
In asthma the epithelium appears to be more fragile than that of COPD, the epithelial reticular basement membrane (RBM) is significantly thicker, there is marked enlargement of the mass of bronchial smooth muscle, and emphysema does not occur in the asthmatic nonsmoker. (nih.gov)
The number of bronchial vessels and the area of the wall occupied by them increase in severe corticosteroid-dependent asthma: it is likely that these increases also occur in severe COPD as they do in bronchiectasis. (nih.gov)
Not surprisingly, our vet concurred with the radiology specialist that Uli showed classic asthma pathology related to restricted airways and defined bronchial, interstitial cell and alveolar disruption. (ingridking.com)
Human and cat airways are lined with muscle cells that allow for flexibility of the long bronchial tubes. (ingridking.com)
Previous work in our group has demonstrated that a physiologically relevant dose of TGF-β1 is capable of driving EMT in primary human bronchial epithelial cells (PBEC) isolated from lung-transplant recipients, an effect that was accentuated by TNFα. (ndltd.org)
We studied NTHi infection of primary human bronchial epithelial cells (PBECs), primary nasal epithelial cells (NECs) and epithelial cell lines from upper and lower airways. (ox.ac.uk)
More recently, Th17 lymphocytes have also been implicated in severe asthma [7], as these cells produce IL-17 which stimulates bronchial epithelial cells, smooth muscle cells and fibroblasts to secrete neutrophil chemoattractants such as CXCL8 [8]. (docsbay.net)
Nevertheless, the study of bronchial small airways is much less common. (e-booksdirectory.com)
The main target of this book is to provide a bronchial small airways original research from different experts in the field. (e-booksdirectory.com)
Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research Journal of Allergy. (nottingham.ac.uk)
Within the airway wall sensory receptors alter bronchial smooth muscle tone through the parasympathetic vagal pathways. (isanagpur.org)

GLP-1R agonists decrease lung IL-33 release and airway hyperresponsiveness in mouse asthma models. (bvsalud.org)
IL-33 induces airway hyperresponsiveness, but its role in airway remodeling and steroid resistance is unknown. (ox.ac.uk)
airway hyperresponsiveness was only partially reduced. (ox.ac.uk)
Airway hyerreactivity actually encompasses both airway sensitivity (the dose of agonist at which the FEV1 begins to fall) and airway hyperresponsiveness (the slope of the dose-response curve thereafter). (isanagpur.org)
On day 10, they received an intranasal dose of TDI (0.1%) mation, and nonspecific airway hyperresponsiveness in or vehicle. (cdc.gov)

In those asthmatic patients in whom Airlast ( ANTI-INFLAMMATORY_ANTI-BRONCHOCONSTRICTIVE) is indicated in asthma, Airlast ( ANTI-INFLAMMATORY_ANTI-BRONCHOCONSTRICTIVE) can also provide symptomatic relief of seasonal allergic rhinitis. (pillintrip.com)
Asthmatic airway constriction can happen spontaneously, in reaction to stress or anxiety, or as a type of allergic reaction. (vin.com)
Indeed, diagnosing asthma can be complicated, and it is famously underdiagnosed because up to 23% of asthmatic cats can have completely normal radiographs. (vin.com)
3) The mention of such airway hyperactivity immediately focuses on the asthmatic with intermittent bouts of severe airflow obstruction. (isanagpur.org)
If you are highly allergic, or asthmatic, you probably know that the drugs in asthma can inhibit the enzyme called phosphodiesterase . (ocfaq.com)

The aim of this review is to examine the current literature for the most recent updates on health effects of specific air pollutants and their impact on asthma, chronic obstructive pulmonary disease, lung cancer, and respiratory infection. (cdc.gov)
Asthma, chronic obstructive pulmonary disease, lung cancer, and respiratory infections all seem to be exacerbated because of exposure to a variety of environmental air pollutants with the greatest effects because of particulate matter, ozone, and nitrogen oxides. (cdc.gov)
Due to the elastic nature of the tissue that supports the small airways airway resistance changes with lung volume. (wikipedia.org)
It is not practically possible to measure airway resistance at a set absolute lung volume, therefore specific airway resistance attempts to correct for differences in lung volume at which different measurements of airway resistance were made. (wikipedia.org)
Similarly to specific airway resistance, specific airway conductance attempts to correct for differences in lung volume. (wikipedia.org)
Asthma and chronic obstructive lung disease (COPD) are both inflammatory conditions of the lung associated with structural "remodeling" inappropriate to the maintenance of normal lung function. (nih.gov)
A single dose of liraglutide inhibited Lys-ASA-induced increases in airway resistance and decreased markers of platelet activation and recruitment to the lung in AERD-like mice. (bvsalud.org)
Dr. Vercelli's group research the complex interactions between genetics, epigenetics and the environment that control the susceptibility to complex lung diseases, such as allergy and asthma. (scireq.com)
This study confirms our earlier observations that detection of small airways obstruction and/or emphysema, in symptomatic smokers with normal routine spirometry, requires analysis of expiratory airflow at low lung volumes, including FEF 75 . (omicsdi.org)
ted the effects of CRAC channel inhibitor Synta 66 on human asthma lung lymphocytes and in an OVA model of allergic asthma. (docsbay.net)
We show in human lung lymphocytes Synta 66 inhibits CD2/3/28 induced IL-2, IL-17, IL-13, IFNγ and IL-10 in a concentration dependent manner in healthy and severe asthma donors, with over 60% inhibition observed for all cytokines. (docsbay.net)
For example, in humans, we know that while actual symptoms of asthma occur in episodes, the airways of the lung are diseased all the time. (vin.com)
Airway hyperactivity has often been depicted as a simple autonomic imbalance with a relatively increased parasympathetic activity in the lung. (isanagpur.org)
the lung and airways. (cdc.gov)

This data suggest that quantitative HRCT may be a useful tool in the evaluation of peripheral airflow obstruction in children with asthma. (nih.gov)
In cases of upper airway obstruction the development of turbulent flow is a very important mechanism of increased airway resistance, this can be treated by administering Heliox, a breathing gas which is much less dense than air and consequently more conductive to laminar flow. (wikipedia.org)
Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study. (uib.no)
exercise-induced laryngeal obstruction or asthma? (uib.no)
Exposures of 50 to 100 ppm may be tolerated for more than 30 to 60 minutes, but higher or longer exposures can cause death from airway obstruction. (cdc.gov)
This reflects isolated detection of small airways obstruction and/or emphysema. (omicsdi.org)
Dependence upon normal routine spirometry may result in clinical and physiologic delay in the diagnosis and treatment in symptomatic smokers with emphysema and small airways obstruction. (omicsdi.org)

Airway resistance (Raw), thoracic gas volume (TGV) and specific airway resistance (sRaw) were measured before, during and after exposure, and the breathing pattern was monitored during the whole session. (ersjournals.com)

It is not known to what extent these strains can invade airway epithelial cells, persist intracellularly and activate epithelial cell production of proinflammatory cytokines, and how this differs between the upper and lower airways. (ox.ac.uk)

Since hypoxia can be a feature of respiratory disorders, such as asthma and chronic obstructive pulmonary disease, it may be of importance to determine if airway smooth muscle function is altered under hypoxic conditions. (gla.ac.uk)
Molecular, genetic and cellular mechanisms underlying Asthma & Chronic Obstructive Pulmonary Disease. (nottingham.ac.uk)
Haemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease. (cdc.gov)

In respiratory physiology, airway resistance is the resistance of the respiratory tract to airflow during inhalation and exhalation. (wikipedia.org)
There are several important determinants of airway resistance including: The diameter of the airways Whether airflow is laminar or turbulent In fluid dynamics, the Hagen-Poiseuille equation is a physical law that gives the pressure drop in a fluid flowing through a long cylindrical pipe. (wikipedia.org)
Resistance to airflow in the respiratory tract is largely determined by the degree of tone in the smooth muscle layer surrounding the airways. (gla.ac.uk)

Moreover, IL-17F is involved in airway remodeling and steroid resistance. (hindawi.com)

Airway hyperreactivity is a specific term that means that the airways are hyperreactive to a variety of stimuli including methacholine, histamine, hypertonic saline, distilled water, exercise, or eucapnic hyperventilation. (isanagpur.org)

An individual small airway has much greater resistance than a large airway, however there are many more small airways than large ones. (wikipedia.org)
Discordant Spirometry and Impulse Oscillometry Assessments in the Diagnosis of Small Airway Dysfunction. (omicsdi.org)
Spirometry is commonly used to assess small airway dysfunction (SAD). (omicsdi.org)

Chronic infections of the airways in people with asthma and chronic obstructive pulmonary disorder (COPD) are also often poly-microbial. (cam.ac.uk)
The clinically observed distinctions between asthma and COPD are reflected by differences in the remodeling process, the patterns of inflammatory cells and cytokines, and also the predominant anatomic site at which these alterations occur. (nih.gov)
The hypertrophy of submucosal mucus-secreting glands is similar in extent in asthma and COPD. (nih.gov)
In COPD the changes begin later in life and the associated inflammatory response differs from that in asthma. (nih.gov)
In 2004, Dr Sayers joined the University of Nottingham as a Lecturer and has developed a research group focussed to understanding the cellular and molecular mechanisms underlying asthma and COPD. (nottingham.ac.uk)
Asthma and COPD are complex diseases involving both genetic and environmental factors resulting in disease expression. (nottingham.ac.uk)

Airlast ( ANTI-INFLAMMATORY_ANTI-BRONCHOCONSTRICTIVE) is also indicated in the prophylaxis of asthma in which the predominant component is exercise-induced bronchoconstriction. (pillintrip.com)
Relationship between anatomic airway dead space (Vd) and airway resistance (Raw) in the normal control state and after bronchodilation and bronchoconstriction. (isanagpur.org)
Airway edema and histamine reflexes also elicit their activity, which results in reflex cough, bronchoconstriction, and mucus secretion. (isanagpur.org)

2022 was the year my human life intertwined with multiple cats' lives. (ingridking.com)

May cause airway narrowing and increased airway resistance in children with asthma or a history of recent upper airway infection. (nih.gov)
The brochure provides parents of children with asthma with the information they need to improve their children's quality of life. (e-booksdirectory.com)
There is a lack of evidence in scientific literature about the efects and possible benefits of IMT and breathing exercises in children with asthma. (bvsalud.org)

Summary: Continued vigilance will be essential to lessen the effects of air pollution on human health and pulmonary disease. (cdc.gov)
The asthma studies necessitated the establishment of a pulmonary function laboratory with extensive capabilities for testing nonhuman primates under the direction of a pulmonary physiologist to assess function in animals undergoing exposure. (ucdavis.edu)
Pulmonary arterial hypertension is a rare and progressive disease associated with increased pulmonary vascular resistance that, if unrelieved, progresses to right ventricular pressure overload, dysfunction, right heart failure, and premature death. (e-booksdirectory.com)

A study has found that much higher doses of antibiotics are needed to eliminate a bacterial infection of the airways when other microbes are present. (cam.ac.uk)
To get their results the team developed a simplified model of the human airways, containing artificial sputum ('phlegm') designed to chemically resemble the real phlegm coughed up during an infection, packed with bacteria. (cam.ac.uk)
This document provides guidance for follow-up and antiviral chemoprophylaxis of close contacts of cases of human infection with novel influenza A viruses associated with severe human disease or with the potential to cause severe human disease . (cdc.gov)
Public health personnel should attempt to identify as soon as possible and monitor all close contacts of confirmed or probable cases of human infection with novel influenza A viruses associated with severe human disease for new illness. (cdc.gov)
In human infection with Plasmodium falciparum , as well as in murine models of malaria, increased levels of histamine have been shown to be associated with severity of infection. (drugdiscoveryopinion.com)
Infection with influenza A virus (IAV) may also magnify pre-existing airway remodeling leading to asthma exacerbation. (biomedcentral.com)
Foci of infection in the oral cavity and their relationship with the overall health of the human body have been long studied among healthcare practitioners throughout history. (medscape.com)

First, excess mucus forms in the airways. (vin.com)

Type-2 low asthma affects 30-50% of people with severe asthma and includes a phenotype characterized by sputum neutrophilia and resistance to corticosteroids. (ox.ac.uk)
Patients are usually labeled with "reactive airways" if they have a history of cough, sputum production, wheeze, or dyspnea. (isanagpur.org)

The expression of IL-17F is seen in the airway of asthmatics and its level is correlated with disease severity. (hindawi.com)
The incidence of asthma is increasing globally and whilst current treatments manage a proportion of patients, the drugs have unwanted side effects and fail to adequately control a sub-group of the more severe asthmatics. (docsbay.net)
Initial data demonstrated that the NFAT pathway is increased in stimulated lymphocytes collected from asthmatics and in a pre-clinical asthma model. (docsbay.net)
pBECs from subjects ( n = 5) with severe asthma and non-asthmatics were cultured as submerged monolayers or at the air-liquid-interface (ALI) conditions and incubated with IAV H1N1 (MOI 5) for up to 24 h. (biomedcentral.com)
Airway remodelling in asthmatics is defined as structural abnormalities including, epithelial integrity loss, basement membrane thickening, and goblet cell and submucosal gland enlargement [ 1 ]. (biomedcentral.com)
Airway remodelling may predispose asthmatics to exacerbations [ 2 ]. (biomedcentral.com)

Data was collected at zero end-expiratory pressure (ZEEP) and with continuous positive airway pressure (CPAP) ventilation, at positive end-expiratory pressure (PEEP) settings of 4 and 8 cmH2O. (physionet.org)
The panel makes a conditional recommendation for interleukin (IL)-6 receptor antagonist monoclonal antibody treatment and high-flow nasal oxygen or continuous positive airway pressure in patients with hypoxaemic respiratory failure. (bvsalud.org)

They evaluated markers of induced diabetes, levels of eosinophils and airway resistance ( PMC7747657 ). (ingridking.com)
Synta 66 also repressed OVA induced airway cellular recruitment showing a reduction in neutrophils and eosinophils. (docsbay.net)

These data provide evidence to suggest that Synta 66 may have therapeutic potential in the treatment of severe asthma. (docsbay.net)
Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma. (cdc.gov)

It is less well appreciated that significant numbers of asthma patients are also refractory to treatment with inhaled corticosteroids 3 , 7 and β-adrenergic agonists 8 . (ersjournals.com)
Although recent evidence suggests that smoking may influence responses to inhaled corticosteroids 19 , little else is known about the influence of acquired factors on responses to asthma therapy. (ersjournals.com)
Inhaled corticosteroids (ICS) are the mainstay of anti-inflammatory therapy for asthma. (docsbay.net)
Airlast ( ANTI-INFLAMMATORY_ANTI-BRONCHOCONSTRICTIVE) is indicated in the treatment of asthma as add-on therapy in those patients with mild to moderate persistent asthma who are inadequately controlled on inhaled corticosteroids and in whom â€œas-neededâ€ short acting Î²-agonists provide inadequate clinical control of asthma. (pillintrip.com)

More simply, this means the airways of the lungs are inflamed, plus they are extra reactive to mental stress or respiratory irritants, and the flow of air through the lungs is reduced (either sometimes or all the time). (vin.com)

Functional studies have suggested that IL-17F is involved in asthma pathology. (hindawi.com)
In this review, we discuss the finding that IL-17F has a key role in asthma pathology and is a novel drug target for asthma. (hindawi.com)
BACKGROUND: TH2 cytokines are not responsible for the ongoing symptoms and pathology in children with severe therapy-resistant asthma (STRA). (ox.ac.uk)

When these muscle cells enlarge and lose their inherent flexibility or are restricted from contracting or relaxing by surrounding fibrotic cells, the airways thicken and make breathing more difficult. (ingridking.com)
Obliterative Bronchiolitis (OB) is the pathological correlate of Bronchiolitis Obliterans Syndrome (BOS) a progressive disease that results in the fibrotic obliteration and blockage of the airways. (ndltd.org)
TAK1 was also shown to be more strongly activated in fibrotic human airway sections compared to control, suggesting that the findings have direct disease relevance. (ndltd.org)

The year had just begun when the initial diagnosis of feline asthma blindsided my family. (ingridking.com)
The next step toward making a diagnosis of feline asthma is the chest radiograph, assuming the cat is not in too much distress to hold still for this procedure. (vin.com)

Asthma is a recurring respiratory compromise featuring the constriction (narrowing) of the lung's airways. (vin.com)
Finally, the airway muscles go into spasms leading to constriction. (vin.com)
Airway constriction leads to an inability to draw a deep breath, intolerance to exercise, coughing, and musical sighing sounds called "wheezes," though not all these symptoms may be apparent at the same time. (vin.com)
Relieving and preventing airway constriction is the main focus of treatment. (vin.com)
A mild tonic constriction exists in all normal human airways. (isanagpur.org)

A recent comparative clinical trial looked at a small cohort of asthma affected cats treated with oral prednisolone (n=4) or an inhaled GC, fluticasone (n=5). (ingridking.com)
A key step in this is thought to be via the transcription factor NFAT which in turn can be activated though Ca2+ release-activated Ca2+ (CRAC) channelsThe aim of this work was to investigate the role of CRAC in clinical and pre-clinical models of allergic asthma. (docsbay.net)
Dr Sayers has maintained his research interest in the molecular basis of asthma and allergy spending time with the Asthma Genetics Group in Southampton, UK (1998-2001) and in pre-clinical drug development in New Zealand at Genesis Research and Development Corporation and the Malaghan Institute (2001-2003). (nottingham.ac.uk)
Pre-clinical drug development in asthma. (nottingham.ac.uk)
The feline condition was named asthma because of the clinical features shared with the human disease. (vin.com)
We do not know yet if feline airways are also diseased all the time or if the actual airway structural changes occur only when there are clinical signs of distress. (vin.com)
There are also existing clinical studies on humans. (ocfaq.com)

Reactive airways" and "reactive airways disease" are highly nonspecific terms. (isanagpur.org)

Beginning in 2000, under the leadership of Dr. Charles G. Plopper (UC Davis School of Veterinary Medicine, Emeritus), an important and major effort was initiated to study the development and exacerbation of asthma by oxidant air pollutants in nonhuman primates. (ucdavis.edu)

you didn't start out in a completely independent field within hematology or immunology and then find your way to airway defense? (scireq.com)
Overview and Understanding of Human Circadian Immunology -- 5. (nshealth.ca)

Although not fully substantiated, allergens can trigger asthma-like symptoms in lab settings, leading to the hypothesis that, at least in some cases, triggers may be found and eliminated in the environment, as is done for many human cases. (ingridking.com)
There is little doubt of the efficacy of oral GCs in the treatment of human and feline asthma symptoms. (ingridking.com)
ICS, however, are associated with unwanted side effects and many asthma patients have persistent symptoms despite taking high ICS doses [2, 3]. (docsbay.net)
In the UK the prevalence of asthma is particularly high, a recent report showed that in Scotland more than 18% of people experienced asthma symptoms and in England and Wales similar figures were reported, 17% and 15.3% respectively (Global Initiative for Asthma 2004). (nottingham.ac.uk)
4 found a high prevalence of asthma symptoms among schoolchildren. (bvsalud.org)

The recommended dose for adults and adolescents 15 years of age and older with asthma, or with asthma and concomitant seasonal allergic rhinitis, is one 10 mg tablet daily to be taken in the evening. (pillintrip.com)
However, it is important to emphasize that heightened airway reactivity also occurs in patients with chronic bronchitis and emphysema as well as allergic rhinitis and upper and lower respiratory tract infections. (isanagpur.org)
Differentiating Upper Airways Resistance in Adenoid Hypertrophy, Allergic Rhinitis, and Obstructive Sleep Apnea: Imaging and Approaches -- 21. (nshealth.ca)

A more limited body of evidence suggests that obesity may also increase the severity of asthma, as weight loss by various means resulted in improved disease control in several small series 31 - 35 . (ersjournals.com)
Substances and Disease Registry or the U.S. Department of Health and Human Services. (cdc.gov)
Asthma is a common and frequent disease. (hzhongtai.com)
In asthma several of these structural alterations begin early in the disease process, even in the child. (nih.gov)
Platelets are key contributors to allergic asthma and aspirin-exacerbated respiratory disease (AERD), an asthma phenotype involving platelet activation and IL-33-dependent mast cell activation. (bvsalud.org)
Dr. Donata Vercelli is a Regents Professor at The University of Arizona, as well as Director of the Arizona Center for the Biology of Complex Diseases, and Associate Director for the Asthma and Airway Disease Research Center. (scireq.com)
HDM-induced allergic airways disease (AAD) in neonatal ST2(-/-) mice lacking the IL-33 receptor was assessed, together with collagen production after IL-33 administration. (ox.ac.uk)
Novel influenza A viruses have caused sporadic infections resulting in severe human disease and substantial mortality among detected cases to date . (cdc.gov)
Limited, non-sustained human-to-human transmission of some novel influenza A viruses associated with severe human disease likely occurred or cannot be excluded in some case clusters that have occurred worldwide . (cdc.gov)
The public health goal of this interim guidance is to prevent further spread of novel influenza A viruses associated with severe human disease if there are infected persons in the United States. (cdc.gov)
Persons with an unprotected exposure to novel influenza A virus associated with severe human disease in a laboratory setting may have a high-risk or moderate-risk exposure, and need to be evaluated case by case. (cdc.gov)
These tissue and organs changes are well characterized in human disease. (ingridking.com)
For example, conditions such as high blood pressure, atrial fibrillation, diabetes, gastroesophageal reflux disease, headaches, depression and TMD can be an indicator of an airway disorder. (drchengs.com)
You may hear your veterinarian use these terms, and they are classical findings in airway disease. (vin.com)
The term "reactive airway disease" has been used differently. (isanagpur.org)
I'm also a professor at the University of Manchester and do quite a lot of research on different aspects of fungal disease, particularly aspergillosis, including resistance and new diagnostic tests, and I'm also the leader and president of the Global Action Fund for Fungal Infections, which has as its main objective to improve the quality of care and therefore the outcome of patients with fungal diseases across the world. (cdc.gov)

The findings of the present study point to BMI as a previously unrecognised factor influencing the placebo response in asthma, and suggest the possibility that it may differentially influence responses to these two types of controller medications. (ersjournals.com)
Airway dentistry employs a range of advanced technologies to assess your oral health and help dentists to decide on a course of treatment based on specific findings. (drchengs.com)
These in creating a mouse model for occupational asthma using HDI findings suggest that respiratory response to TDI depends on (hexamethylene diisocyanate), in which the sensitized mice prior frequency and concentration of dermal sensitization in mice. (cdc.gov)

The differentiation state of the airway epithelium is also important for innate immunity through the compartmentalization of receptors and mediator production [ 4 ]. (biomedcentral.com)

Therefore, diseases affecting the respiratory tract can increase airway resistance. (wikipedia.org)

No evidence of carcinogenic potential was observed in mice or rats given latanoprost by oral gavage in dosages up to 170 µg/kg daily (approximately 2800 times the recommended maximum human dose) for 20 or 24 months, respectively. (regrowth.com)

Airway resistance can also vary between inspiration and expiration: In emphysema there is destruction of the elastic tissue of the lungs which help hold the small airways open. (wikipedia.org)
WTC workers with spirometric low FVC have higher QCT-measured WAP compared to those with normal spirometries, but did not differ in distal airway and emphysema measurements, independently of obesity, smoking, and other covariates. (omicsdi.org)

If flow becomes turbulent, and the pressure difference is increased to maintain flow, this response itself increases resistance. (wikipedia.org)

In atopic patients with asthma, prebronchodilator baseline FEV1/FVC values showed a significant association with the H161R variant. (hindawi.com)
Are Dehumidifiers Good For Asthma Patients? (hzhongtai.com)
Dust mites and molds are the main allergens in asthma patients worldwide. (hzhongtai.com)
This is also the fundamental reason why asthma patients in southern China's wet areas are higher than those in northern areas. (hzhongtai.com)
Therefore, in the summer wet season, in order to control the humidity, in order to control the growth of mold, and create a comfortable and fresh environment for asthma patients, this requires practical dehumidification and moisture prevention measures. (hzhongtai.com)
If asthma patients live in a humid environment, they often relapse and cough. (hzhongtai.com)
The dehumidifier reduces the number of asthma attacks by removing too much water in the air, which can minimize bacteria and pollutants in the home and protect the health of patients. (hzhongtai.com)
Liraglutide, a Food and Drug Administration-approved GLP-1R agonist for treatment of type 2 diabetes and obesity, attenuates in vivo platelet activation in an AERD murine model and in vitro activation in human platelets in patients with and without AERD. (bvsalud.org)
IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma. (ox.ac.uk)
OBJECTIVE: We sought to investigate the relationship between IL-33 and airway remodeling in pediatric patients with STRA. (ox.ac.uk)
IL-33 expression was quantified in endobronchial biopsy (EB) specimens from children with STRA and related to remodeling, and collagen production by airway fibroblasts from pediatric patients stimulated with IL-33 and budesonide was quantified. (ox.ac.uk)
CONCLUSION: IL-33 is a relatively steroid-resistant mediator that promotes airway remodeling in patients with STRA and is an important therapeutic target. (ox.ac.uk)
Cysteinyl (cys) LTs C 4 , D 4 , and E 4 are long known to contribute to airway contractile responses via ligation of the cysLT1 receptor, and cysLT1 antagonists are beneficial in some patients with asthma. (springer.com)
Such an effect in patients with asthma or other bronchospastic conditions is potentially dangerous. (nih.gov)
Patients should be advised to continue taking Airlast ( ANTI-INFLAMMATORY_ANTI-BRONCHOCONSTRICTIVE) even if their asthma is under control, as well as during periods of worsening asthma. (pillintrip.com)
Anesthetizing patients with "reactive airway" remains a challenge to the anesthesiologist. (isanagpur.org)
There is always a possibility of catastrophic bronchospasm and other respiratory complications associated with anesthesia in patients with reactive airways. (isanagpur.org)
Anesthesiologist has to be selective regarding the choice of anesthesia technique and the use of drugs in these patients to avoid the provocation of bronchospasm and other airway related complications and if it occurs should recognize and manage appropriately. (isanagpur.org)
found a surprisingly low frequency of perioperative bronchospasm in patients with asthma. (isanagpur.org)
Preoperative identification of patients with reactive airways is important in planning a rational approach for anesthetic care. (isanagpur.org)
After the increase in summer 2021, no evidence of higher levels of intensive care unit (ICU) admission, mortality, genetic relatedness of isolates from different patients, or increased antimicrobial resistance of isolates was observed. (medscape.com)

The physiological importance of this normal resting tone is an airway size that provides balance between anatomic dead space and airway resistance to gain efficiency in both gas exchange and work of breathing (Fig. 1). (isanagpur.org)

Reliability of translaryngeal airway resistance measurements during maximal exercise. (uib.no)

We tested the effect of the GLP-1R agonist liraglutide on lysine-aspirin (Lys-ASA)-induced changes in airway resistance, and platelet-derived mediator release in a murine AERD model. (bvsalud.org)

A longitudinal study reveals persistence of antimicrobial resistance on livestock farms is not due to antimicrobial usage alone. (ox.ac.uk)
Sarah Gregory] Antimicrobial resistance has become, as we all know, a huge problem in recent years. (cdc.gov)
Antimicrobial resistance to ceftriaxone and azithromycin has not been reported. (cdc.gov)

This study was designed to gather information about the effects of the IMT and breathing exercises in the pediatric population diagnosed with asthma. (bvsalud.org)

Dr. Denning] Antibacterial resistance is caused by many different things, but one of them, for example, is using antibacterials in food for animals to improve the growth of animals, which is clearly unhelpful if they're antimicrobials that lead to resistance of human pathogens. (cdc.gov)
There are 18 H types and 11 NA types, giving 198 possible combinations, but only a few are human pathogens. (msdmanuals.com)

Cats and humans share many of the same airway damage in either category of symptomatic asthma. (ingridking.com)

The three microbes used in the experiment were the bacteria Pseudomonas aeruginosa and Staphylococcus aureus , and the fungus Candida albicans - a combination commonly present in the airways of people with cystic fibrosis. (cam.ac.uk)
Poly-microbial infections are common in the airways of people with cystic fibrosis. (cam.ac.uk)

ii) The effect of chronic hypoxia on contractile responses in rat isolated airways. (gla.ac.uk)
In chronically hypoxic rats, however, the airway smooth muscle appears to be more sensitive to nitric oxide than control rats, which may explain why contractile responses are significantly smaller in the chronically hypoxic rats. (gla.ac.uk)
Finally CRAC inhibitor Synta 66 acts via NFAT to reduce in vivo and in vitro asthma associated responses. (docsbay.net)

We'll be talking about antibiotic resistance and fungal infections. (cdc.gov)

These are real-life experiments that have shown over and over again, with an amazing reproducibility, how powerful these environmental influences are in conferring protection against asthma and allergies. (scireq.com)

Variations in responsiveness to asthma medications are potentially explained by genetically determined differences in expression of drug target molecules 9 . (ersjournals.com)

leaders into vivo great foundations joints quoted read to a 8th download m ideals in banach spaces and with methods by the UN prior Rapporteur on Torture and here covering a National Human Rights Action Plan for the UN in 2009( Foot 2012: 342). (cdmw.de)
Monitoring Asthma During Sleep: Methods and Techniques -- 15. (nshealth.ca)

The following descriptors were used: asthma, inspiratory muscle training, breathing exercises and child in Portuguese, English and Spanish. (bvsalud.org)

The results exacerbate the airway resistance and simply induce asthma. (hzhongtai.com)
Sensitive triggering factors such as dust, dust mites, mold, mold, pollen and smoke can diffuse in the air and easily induce asthma. (hzhongtai.com)
1999). Animal models are needed not only to understand how prior to intranasal challenge influences the respiratory response chemicals may induce asthma, but also to improve our ability to using toluene diisocyanate (TDI), a known respiratory sensitizer. (cdc.gov)

iv) The effect of hypoxia on the proliferation of cultured human airway smooth muscle cells. (gla.ac.uk)

Anatomy35

Organisms9

Diseases42

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment64

Psychiatry and Psychology5

Phenomena and Processes63

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science4

Named Groups1

Health Care12

Inflammation27

Bronchial13

Hyperresponsiveness5

Asthmatic5

Lung14

Obstruction7

Specific airway resistance1

Epithelial cells1

Chronic obstruc3

Airflow3

Remodeling and steroid resistance1

Hyperreactivity1

Small airway3

COPD6

Bronchoconstriction3

20221

Children with asthma3

Pulmonary3

Infection7

Mucus1

Sputum2

Asthmatics6

Continuous positive2

Eosinophils2

Severe asthma2

Corticosteroids4

Irritants1

Pathology3

Fibrotic3

Diagnosis of feline asthma2

Constriction5

Clinical7

Nonspecific1

Exacerbation of asthma1

Immunology2

Symptoms5

Allergic rhinitis3

Disease16

Findings3

Epithelium1

Respiratory tract1

Dose1

Emphysema2

Increases1

Patients21

Anatomic1

Measurements1

Mediator1

Antimicrobial resistance3

Pediatric1

Pathogens2

Symptomatic1

Fibrosis2

Responses3

Antibiotic Resistance1

Allergies1

Potentially1

METHODS2

Inspiratory1

Induce asthma3

Proliferation1